SARKOİDOZİSİN EŞLİK ETTİĞİ SJÖGREN SENDROMU OLGULARI

Year 2016, Volume: 30 Issue: 2, 117 - 122, 01.10.2016

Ayşegül Şentürk Hatice Kılıç Şükran Erten Tuba Öğüt Habibe Hezer H. Canan Hasanoğlu

Abstract

Sjogren sendromu (SS) ekzokrin bezlerin lenfositik infiltrasyonları ile seyreden kronik, otoimmün inflamatuvar bir hastalıktır. Keratokonjunktivitis sikka (kuru göz) ve kserostomi (kuru ağız ) ile karekterizedir. Tek başına gelişirse primer, kollajen doku hastalıkları ile ilişkili ise sekonder olarak adlandırılır. Romatoid artrit, daha nadir olarak SLE, polimyozit (PM), skleroderma gibi diğer romatolojik hastalıklara eşlik edebilir. Sarkoidoz ise nonkazeifiye granülomlarla karakterizedir. Etyolojisi ve patogenezi tam olarak bilinmemektedir. Sıklıkla 20-40 yaşları arasında görülür. Sarkoidoz öncelikle akciğer olmak üzere tüm sistemleri etkileyebilir. Klinik belirtiler hastalığın süresine, tutulan organa, tutulumun yaygınlığına ve granülomatöz olayın aktivitesine bağlı olarak değişkenlik göstermektedir. Literatürde SS'nun sarkoidoz ile birlikteliği nadir görüldüğünden farklı klinik özellikteki üç olgu sunuldu.

Keywords

Sarkoidoz Sjögren sendromu Nonkazeifiye granülom Lenfoma

CASES WITH SJOGRENS SYNDROME ACCOMPANIED BY SARCOIDOSIS

Abstract

Sjögren's syndrome (SS) is a rare autoimmune disease characterized by glandular and extraglandular organ involvement. It is characterized with keratoconjunctivitis sicca (dry eyes) and xerostomia (dry mouth). The disease develops a stand-alone primary, associated with connective tissue disease is referred to as the secondary and also associated with other rheumatic diseases (such as rheumatoid arthritis, rarely SLE, polymyositis etc.). Sarcoidosis is a disease characterized by non-caseous granulomas. The etiology and pathogenesis is not understood. It usually occurs between the ages of 20-40. Sarcoidosis can affect the entire system, including primarily the lungs. Clinical signs of disease duration, the structures involved, the extent of involvement and granulomatous event varies depending on the activity. Three cases with different clinical features are presented since coexistence of SS and sarcoidosis is a rare condition.

Keywords

Sarcoidosis Sjögren's syndrome Noncaseating granuloma Lymphoma

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