Abstract
Giriş: Son yıllarda nötrofil lenfosit oranı (NLO)
yeni bir inflamatuat marker olarak önem kazanmaktadır.
Literatürde sarkoidoz, tüberküloz ve
interstisiyel akciğer hastalıkları ile NLO arasındaki
ilişki çok az çalışmada yer almıştır. Bu çalışmada
amacımız sarkoidoz ve interstisiyel akciğer hastalığı
tanısı almış hastalarda ilk başvuru sırasında
NLO arasında fark olup olmadığını değerlendirmektir.
Gereç ve Yöntem: Hastanemiz otomasyon sisteminde
2008-2014 yılları arasında ICD kodlama
sisteminden D86(sarkoidoz) ve J84 (Interstisiyel
akciğer hastalığı) ve alt kodları girilen hastalar
taramaya alındı. Bu hastaların dosyaları incelenerek
tanısı kesin olmayanlar çalışma dışı bırakıldı.
Çalışmaya dahil edilen hastaların ilk başvuru
sırasındaki yaş, cinsiyet, hematolojik parametreler,
C- reaktif protein (CRP), sedimentasyon, Angiyotensin
dönüştürücü enzim (ACE) ve NLO değerleri
kaydedildi ve heriki hastalık grubu bu parametreler
açısından karşılaştırıldı. Bulgular: Çalışmada hastane otomasyon sisteminde
sarkoidoz ve interstisiyel akciğer hastalığı
olarak tanı almış ve International Classification of
Disease diagnostic code (ICD) sistemine göre D86
ve J84 olarak kodlanmış 4709 hasta taramaya
alındı. Dahil edilme kriterlerine uyan 1039 hasta
analiz edildi. Sarkoidoz grubunda yaş ortalaması
49±14 olup % 67’si kadındı. İnterstisiyel akciğer
hastalıkları grubunda ortalama yaş 60±17 olup
% 57’si kadın idi. Gruplar arasında yaş ve cinsiyet
bakımından istatistiksel olarak anlamlı fark vardı.
İnterstisiyel akciğer hastalığı grubunda beyaz küre
sayısı, nötrofil, monosit ve lenfosit sayısı anlamlı
olarak yüksek saptandı (p<0.001). Öte yandan
sarkoidoz grubunda NLO 2.37±3.1,interstisiyel
akciğer hastalığı grubunda ise 2.45±4.4 olarak
hesaplandı ve aradaki fark istatistiksel olarak
anlamlı değildi (p=0.53).
Tartışma: Çalışmamızda sarkoidoz ve interstisiyel
hastalık grubunda ilk başvuruda NLO değerleri
arasında fark saptanmamıştır ve ilk başvuruda
ayırıcı tanıda yardımcı bir parametre olduğu
söylenemez. İleride planlanacak çalışmalarda, NLO
değerinin ayırıcı tanıdan ziyade bu hastalık
gruplarının takibinde kullanılması önerilebilir.
References
- 1. Kang MH, Go SI, Song HN, Lee A, Kim SH, Kang JH, Jeong BK, Kang KM, Ling H, LeeGW. The prognostic impact of the neutrophil-tolymphocyte ratio in patients with small-cell lung cancer . Br J Cancer 2014;111(3):452-60.
- 2. Templeton AJ, McNamara MG, Šeruga B, VeraBadillo FE, Aneja P, Ocaña A et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and metaanalysis. J Natl Cancer Inst 2014;106(6):124.
- 3. Sertoglu E, Uyanik M. Value of combination of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in primary percutaneous coronary intervention. Platelets 2015; 25:1-2.
- 4. Kurtul A, Murat SN, Yarlioglues M, Duran M, Celik IE, Kilic A, Ocek AH. Increased neutrophil-to-lymphocyte ratio predicts persistent coronary no-flow after wire insertion in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Clinics 2015; 70(1): 34- 40.
- 5. Sawant AC, Adhikari P, Narra SR, Srivatsa SS, Mills PK, Srivatsa SS. Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction. Cardiol J 2014;21(5):500-8.
- 6. Iliaz S, Iliaz R, Ortakoylu G, Bahadir A, Bagci BA, Caglar E. Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis. Ann Thorac Med 2014;9:232-5.
- 7. Choi JE, Villarreal J, Lasala J, Gottumukkala V, Mehran RJ, Rice D, Yu J, Feng L, Cata JP. Perioperative neutrophil:lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study. Cancer Med 2015;4(6): 825-33.
- 8. Li MX, Liu XM, Zhang XF, Zhang JF, Wang WL, Zhu Y, et al. Prognostic role of neutrophilto-lymphocyte ratio in colorectal cancer: a systematicreviewand meta-analysis. Int J Cancer 2014;134(10):2403-13.
Abstract
ntroduction: In the last few years the neutrophilto-lymphocyte
rate (NLR) is gaining attention as a
new inflammatory marker. The aim of our study
was to investigate the NLR values of sarcoidosis
and interstitial lung disease patients at the first
admission to the hospital.
Material-method: The study consists of patients
diagnosed with the ICD codes D86 (sarcoidosis),
J84 (interstitiel lung disease) between 2008 and
2014 identified using the hospital automation
system.The age, ender,hematologic parameters, Creaktive
protein (CRP), sedimentation,angiotensin
converting enzyme (ACE) levels on first admission
to hospital were analyzed and the NLR values were
calculated. Both disease groups were compared
according to the present parameters.
Results: In our study 4704 patients diagnosed
with the ICD codes J84 (interstitial lung disease)
and D86 (sarcoidosis) in the hospital automation
system were evaluated and 1039 patients that met the inclusion criteria were included in the study.
The difference in age and gender between both
groups was statistically significant. The white
blood cell, neutrophil, monocyte and lymphocyte
count was higher in the interstitial lung disease
group than the sarcoidosis group and the
difference was significant statistically (p<0.001).
On the other hand the NLR was calculated as
2.37±3.1 in the sarcoidosis group and as
2.45±4.4 in the interstitial group however this
difference was not statistically significant
(p=0.53).
Discussion: In our study it is difficult to say that
the NLR values of patients at hospital admittance
benefit the doctor in differentiating sarcoidosis and
interstitial lung diseases.We recommend planning
future studies to investigate the value of NLR in
patient monitoring rather than differential
diagnosis.
References
- 1. Kang MH, Go SI, Song HN, Lee A, Kim SH, Kang JH, Jeong BK, Kang KM, Ling H, LeeGW. The prognostic impact of the neutrophil-tolymphocyte ratio in patients with small-cell lung cancer . Br J Cancer 2014;111(3):452-60.
- 2. Templeton AJ, McNamara MG, Šeruga B, VeraBadillo FE, Aneja P, Ocaña A et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and metaanalysis. J Natl Cancer Inst 2014;106(6):124.
- 3. Sertoglu E, Uyanik M. Value of combination of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in primary percutaneous coronary intervention. Platelets 2015; 25:1-2.
- 4. Kurtul A, Murat SN, Yarlioglues M, Duran M, Celik IE, Kilic A, Ocek AH. Increased neutrophil-to-lymphocyte ratio predicts persistent coronary no-flow after wire insertion in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Clinics 2015; 70(1): 34- 40.
- 5. Sawant AC, Adhikari P, Narra SR, Srivatsa SS, Mills PK, Srivatsa SS. Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction. Cardiol J 2014;21(5):500-8.
- 6. Iliaz S, Iliaz R, Ortakoylu G, Bahadir A, Bagci BA, Caglar E. Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis. Ann Thorac Med 2014;9:232-5.
- 7. Choi JE, Villarreal J, Lasala J, Gottumukkala V, Mehran RJ, Rice D, Yu J, Feng L, Cata JP. Perioperative neutrophil:lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study. Cancer Med 2015;4(6): 825-33.
- 8. Li MX, Liu XM, Zhang XF, Zhang JF, Wang WL, Zhu Y, et al. Prognostic role of neutrophilto-lymphocyte ratio in colorectal cancer: a systematicreviewand meta-analysis. Int J Cancer 2014;134(10):2403-13.
Details
| Other ID | JA62HN86DM |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | October 1, 2017 |
| Published in Issue | Year 2017 Volume: 31 Issue: 2 |