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EBUS-TBİA ESNASINDA DOPPLER MOD İLE DEĞERLENDİRİLEN VASKÜLER İMAJ PATERNİNİN BENİGN VE MALİGN LENF NODU AYIRIMINDAKİ DEĞERİ

Year 2017, Volume: 31 Issue: 2, 87 - 92, 01.10.2017

Abstract

Giriş: Endobronşiyal ultrasonografi kılavuzluğunda transbronşial iğne aspirasyonu (EBUS-TBİA), lenf nodu tanısı için yüksek verim sağlayan minimal invaziv bir prosedürdür. Bu çalışmanın amacı benign ve malign lenf nodunun (LN) ayırıcı tanısında EBUS-TBİA sırasında lenf bezlerinin doppler mod özelliklerinin kullanımını değerlendirmektir. Gereç ve Yöntem: EBUS, altta yatan hastalığa bakılmaksızın mediastinal lenfadenopatisi bulunan 151 hastaya uygulandı. LN' nin özelliklerini öngörmek için şu kriterler değerlendirildi; çap, şekil, sınır özellikleri, ekojenite, merkezi hiler yapı ve kan akışı. Kan akımı ölçütleri histopatolojik sonuçlar ile korele edildi ve duyarlılık, özgüllük, pozitif ve negatif prediktif değerler (PPV ve NPV) hesaplandı. Bulgular: Yüz elli bir hastada 229 LN analiz edildi. LN' larının %83.3' ü malign, %16.7'si benign olarak değerlendirilmişti. Grade 0 ve I kanlanmayı "benign", Grade II ve III kanlanmayı "malign" olarak tanımladığımızda duyarlılık, özgüllük, NPV, PPV ve tanısal doğruluk oranı sırasıyla %83.2, %66.7, %69.7, %82.3 ve %74.0 idi. Tartışma: Rutin EBUS işlemleri sırasında ultrason kriterlerinin değerlendirilmesi kolaylıkla uygulanabilir ve tekrar edilebilir. Power / Renkli Doppler modu ile LN' nin kanlanmasının değerlendirilmesi klinisyene doğru hedefte zaman tasarrufu açısından yardımcı olacaktır.

References

  • 1. Yasufuku K, Chiyo M, Koh E, Moriya Y, Iyoda A, Sekine Yet al. Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer. Lung Cancer 2005; 50: 347-54.
  • 2. Fujiwara T, Yasufuku K, NakajimaT, ChiyoM, Yoshida S, Suzuki Metal. The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system. Chest 2010;138; 641- 47.
  • 3. Ying M, Bhatia KS, Lee YP, Yuen HY, Ahuja AT. Review of ultrasonography of malignant neck nodes: greyscale, Doppler, contrast enhancement and elastography. Cancer Imaging. 2014 Jan 6;13(4):658-69.
  • 4. Voit C, Van Akkooi AC, Schäfer-Hesterberg G, et al. Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma. J Clin Oncol 2010; 28: 847–52.
  • 5. Wang Y, Dan HJ, Fan JH, Wen SB. Evaluation of the correlation between colour power Doppler flow imaging and vascular endothelial growth factor in breast cancer. J Int Med Res. 2010; 38(3): 1077-83.
  • 6. Nakajima T, Anayama T, Shingyoji M, Kimura H, Yoshino I, Yasufuku K. Vascular image patterns of lymph nodes for the prediction of metastatic disease during EBUS-TBNA for mediastinal staging of lung cancer.J Thorac Oncol. 2012;7(6):1009-14.
  • 7. Rusch VW, Asamura H, Watanabe H, et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the for the coming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2009; 4: 568–77.
  • 8. Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001;19:1207-25.
  • 9. Ho SS, Ahuja AT, Yeo W, Chan TC, Kew J, Metreweli C. Longitudinal colour Doppler study of superficial lymph nodes in non-Hodgkin-s lymphoma patients on chemotherapy. Clin Radiol 2000; 55: 110.
  • 10. Dangore-Khasbage S, Degwekar SS, Bhowate RR, et al. Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:255–263.
  • 11. Wu CH, Chang YL, Hsu WC, Ko JY, Sheen TS, Hsieh FJ. Usefulness of Doppler spectral analysis and power Doppler sonography in the differentiation of cervical lymphadenopathies. Am J Roentgenol 1998;171: 503–9.
  • 12. Schmid-Bindert G, Jiang H, Kahler G et al. Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: a new ultrasound scoring system. Respirology 2012; 17: 1190–98.
  • 13. Wang L, Wu W, Hu Y, Teng J, Zhong R, Han B, Sun J. Sonographic Features of Endobronchial Ultrasonography Predict Intrathoracic Lymph Node Metastasis in Lung Cancer Patients. Ann Thorac Surg. 2015; 100:1203-9.

THE VALUE OF THE VASCULAR IMAGING PATTERN ASSESSED BY THE DOPPLER MODE DURING EBUS-TBNA IN DIFFERENTIATING BETWEEN BENIGN AND MALIGNANT LYMPH NODES

Year 2017, Volume: 31 Issue: 2, 87 - 92, 01.10.2017

Abstract

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high yield for lymph node diagnosis. The aim of this study was to assess the utility of doppler mode features of lymph nodes during EBUS-TBNA in differentiating benign and malignant lymph node (LN). Material and Methods: EBUS was performed in 151 patients with mediastinal lymphadenopathy irrespective of the underlying disease. The following criteria were evaluated to predict feature of LN: diameter, shape, distinct margin, echogenicity, central hilar structure and blood flow in a LN. Blood flow criteria were correlated with the histopathological results and the sensitivity, specificity, positivenegative predictive values (PPV and NPV) and diagnostic accuracy rate were calculated. Results: Two hundred twenty nine LN in 151 patients were analysed. 83.3% of LNs were found malignant, 16.7% of LNs were found benign. When we defined Grade 0 and I as benignand Grade II and III as malignant the sensitivity, specificity, NPV, PPV, and diagnostic accuracy rate were 83.2%, 66.7%, 69.7%, 82.3% and 74.0%, respectively. Discussion: The assessment of ultrasound criteria during routine EBUS examinations is feasible and reproducible. Vascular image patterns of LN using Power/Color Doppler mode will help the clinician in terms of time saving at right target.

References

  • 1. Yasufuku K, Chiyo M, Koh E, Moriya Y, Iyoda A, Sekine Yet al. Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer. Lung Cancer 2005; 50: 347-54.
  • 2. Fujiwara T, Yasufuku K, NakajimaT, ChiyoM, Yoshida S, Suzuki Metal. The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system. Chest 2010;138; 641- 47.
  • 3. Ying M, Bhatia KS, Lee YP, Yuen HY, Ahuja AT. Review of ultrasonography of malignant neck nodes: greyscale, Doppler, contrast enhancement and elastography. Cancer Imaging. 2014 Jan 6;13(4):658-69.
  • 4. Voit C, Van Akkooi AC, Schäfer-Hesterberg G, et al. Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma. J Clin Oncol 2010; 28: 847–52.
  • 5. Wang Y, Dan HJ, Fan JH, Wen SB. Evaluation of the correlation between colour power Doppler flow imaging and vascular endothelial growth factor in breast cancer. J Int Med Res. 2010; 38(3): 1077-83.
  • 6. Nakajima T, Anayama T, Shingyoji M, Kimura H, Yoshino I, Yasufuku K. Vascular image patterns of lymph nodes for the prediction of metastatic disease during EBUS-TBNA for mediastinal staging of lung cancer.J Thorac Oncol. 2012;7(6):1009-14.
  • 7. Rusch VW, Asamura H, Watanabe H, et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the for the coming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2009; 4: 568–77.
  • 8. Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001;19:1207-25.
  • 9. Ho SS, Ahuja AT, Yeo W, Chan TC, Kew J, Metreweli C. Longitudinal colour Doppler study of superficial lymph nodes in non-Hodgkin-s lymphoma patients on chemotherapy. Clin Radiol 2000; 55: 110.
  • 10. Dangore-Khasbage S, Degwekar SS, Bhowate RR, et al. Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:255–263.
  • 11. Wu CH, Chang YL, Hsu WC, Ko JY, Sheen TS, Hsieh FJ. Usefulness of Doppler spectral analysis and power Doppler sonography in the differentiation of cervical lymphadenopathies. Am J Roentgenol 1998;171: 503–9.
  • 12. Schmid-Bindert G, Jiang H, Kahler G et al. Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: a new ultrasound scoring system. Respirology 2012; 17: 1190–98.
  • 13. Wang L, Wu W, Hu Y, Teng J, Zhong R, Han B, Sun J. Sonographic Features of Endobronchial Ultrasonography Predict Intrathoracic Lymph Node Metastasis in Lung Cancer Patients. Ann Thorac Surg. 2015; 100:1203-9.
There are 13 citations in total.

Details

Other ID JA24SU37JJ
Journal Section Research Article
Authors

Nilgün Yilmaz Demirci This is me

Can Öztürk This is me

Publication Date October 1, 2017
Published in Issue Year 2017 Volume: 31 Issue: 2

Cite

APA Demirci, N. Y., & Öztürk, C. (2017). EBUS-TBİA ESNASINDA DOPPLER MOD İLE DEĞERLENDİRİLEN VASKÜLER İMAJ PATERNİNİN BENİGN VE MALİGN LENF NODU AYIRIMINDAKİ DEĞERİ. İzmir Göğüs Hastanesi Dergisi, 31(2), 87-92.