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KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA KOMORBİDİTE DURUMU

Year 2017, Volume: 31 Issue: 3, 145 - 155, 01.12.2017

Abstract

Amaç: KOAHda en sık görülen komorbiteler; iskelet kas anormallikleri, hipertansiyon, diabet, koroner arter hastalıkları, kalp yetmezliği, kanser, pulmoner vasküler hastalıklar ve serebro vasküler hastalıklardır. KOAHta en sık rastlanan komorbid hastalıkları tespit ederek, komorbit sıklığın KOAH ta cinsiyet, inflamasyon ve şidetlle olan ilşkisini araştırdık. Yöntem ve Gereç: Çalışmaya 179 KOAH hastası alındı. Hastaların solunum fonksiyon testi (SFT), arteryel kan gazı (AKG), C-reaktif protein (CRP), hemoglobin (Hgb), hemotokrit (Htc) ve ortalama eritrosit hacmi (MCV) değerleri kaydedildi. Bulgular: Çalışmaya alınan olguların yaş ortalaması 64.51±11.04 idi. Hastaların %64.8inde en az bir komorbidite vardı. Olgularda en sık görülen komorbiditeler (%60.9) hipertansiyon (HT), (%27.4) diyabet (DM), (%33) koroner arter hastalığı (KAH), (%20.1), konjestif kalp yetmezliği (KKY), (%8.4) serebro vasküler hastalık (SVH), (%19.6) depresyon, (%13.4) anemi, (%11.2) peptik ülser, (%15.6) gastro özefagial reflü (GÖR), (%3.4) akciğer kanseri, (%15.6) osteoporoz, (%8.9) obstrüktif uyku apne sendromu (OSAS), (%4.5) kronik böbrek yetmezliği (KBY), (%9.5) periferik damar hastalığı (PDH), (%4.5) pulmoner hipertansiyon (PHT) idi. Sonuç: Sonuç olarak çalışmamızda en sık rastlanan komorbiditelerin hipertansiyon, koroner arter hastalığı ve diabet olduğu saptandı.

References

  • 1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy fort he diagnosis, managment, and prevention of chronic obstructive pulmonary disease: uptated 2014. www.goldcopd.org/uploads/users/files/ GOLD_report2014_feb07.pd2-
  • 2. Agusti A. Thomas A Neff lecture: chronic obstructive pulmonary disease—a systemic disease. Proc Am Thorac Soc 2006; 3:478–81
  • 3. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a metaanalysis. Thorax 2004; 59:574–80
  • 4. Qaseem A,Wilt TJ, Weinberger SE, Hanania NA et al. Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. American College of Physicians (ACP),Clinical Guideline,179-92, 2011.
  • 5. Ferri FF. Chronic Obstructive Pulmonary Disease. Ferri's Clinical Advisor 5 Books in 1.Ferri FF (ed). 1;244-247,2013.
  • 6. Incalzi RA, Fuso L, Rosa M, et al. Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur Respir J 1997; 10: 2794-800
  • 7. Loukides S, Polyzogopoulos D. The effect of diabetes mellitus on the outcome of patients with chronic obstructive pulmonary disease exacerbated due to respiratory infections.Respiration 1996; 63: 170-3
  • 8. Rubinsztajn R, Chazan R. Mortality and comorbidity in hospitalized chronic obstructive pulmonary disease patients. Pneumonol Alergol Pol. 2011;79(5):343-6.
  • 9. Terzano C, Conti V, Di Stefano F, Petroianni A, Ceccarelli D, Graziani E, Mariotta S et al. Comorbidity, hospitalization, andmortality in COPD: results from a longitudinal study.Lung.2010 Aug; 188(4):321-9.
  • 10. Rutten FH, Cramer MJ, Lammers JW, Grobbee DE, Hoes AW. Heart failure and chronic obstructive pulmonary disease: An ignored combination? Eur J Heart Fail 2006; 8: 706-11.
  • 11. Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonarydisease. Thorax 2006; 61: 284-9.
  • 12. Laghi F, Adiguzel N, Tobin MJ. Endocrinological derangements in COPD. Eur Respir J 2009; 34: 975-96.
  • 13. ÇilliA, Uslu A, Öğüş C, Özdemir T. KOAH’da Komorbiditenin Prognoza Etkisi Tüberküloz ve Toraks Dergisi 2004; 52(1): 52-5
  • 14. Guralnik JM, Ersshler WB, Schrier SL, et al. Anemia in the elderly:a publichealth crisis in hematology. Hematology 2005; 1:528-32.
  • 15. American Thoracic Society. Standards for the diagnosis care of patients with COPD. Am J Respir Crit Care Med 1995; 152:77-121.
  • 16. Halpern MT, Zilberberg MD, Schmier JK, Lau EC, Shorr AF. Anemia, costs and mortality in chronic obstructive pulmonary disease. Cost Eff Resour Alloc 2006; 4: 17.
  • 17. Chambellan A, Chailleux E, Similowski T and the ANTADIR observatorygroup. Prognostic value of the hematocrit in patients with severeCOPD receivinglong term oxygen therapy. Chest 2005; 128:1201-8. 18. Tokmak M.Çağlayan B.KOAH’da Anemi Sıklığı Ve İlişkili Faktörler İstanbul 2000.
  • 19. Shorr AF, John D, Lee S, Margarita D, Marya DZ, Current Medical Research and Opninion 2008; 24:1123-30.
  • 20. Smith BJ, Laslett LL, Pile KD, et al. Randomized controlled trial of alendronate in airways disease and low bone mineral density. Chron Respir Dis 2004; 1: 131-7.
  • 21. Sin DD, Man JP, Man SF. The risk of osteoporosis in Caucasian men and women with obstructive airways disease. Am J Med 2003;114(1):10-4.
  • 22. Graat-Verboom L ,Wouters EF, Smeenk FW , van den Borne BE, Lunde R, Spruit MA. Current status of research on osteoporosis in COPD: a systematic review .Eur Respir J .2009 ; 34 ( 1 ): 209 - 18 .
  • 23. Öztürk O (2004) Duygulanım Bozuklukları, Ruh sağlığı ve Bozuklukları, FeryalMatbaası, Ankara, ss 295
  • 24. Elik P, Esen A, Akın M ve ark. Kronik obstrüktif akciğer hastalığı olgularında depresyon. Solunum Hastalıkları 1998;9:25-32
  • 25. Light RW, Merril EJ, Despars JA, et al. Prevalence of depression and anxiety in patients with COPD. Relationship to functional capacity. Chest 1985;87:35-8.
  • 26. Sözer K, Öngen G, Songar A (1990) Diffüz Obstrüktif Akciğer Hastalarında Depresyon ve Anksiyete Görülme Sıklığı, Solunum, 18:1-7.
  • 27. Özkan S (1994) Psikiyatrik Tıp: Konsültasyon Liyezon Psikiyatrisi, Roche, s: 109-13 İstanbul28. Aydın İ (2000) Tüberküloz ve KOAH’da Depresyon Anksiyete ve Yeti yitimi, Hacettepe Üniversitesi, Tıp Fakültesi, Psikiyatri A.B.D., Uzmanlık Tezi, Ankara
  • 28. Dahlen I, Jansob C (2002) Anxiety and Depression are Related to the Outcome ofEmergency Treatment in Patients With Chronic Obstructive Pulmonary Disease,Chest 122: 1633- 7.
  • 29. Hanania NA, Müllerova H, Locantore NW, et al. Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med2011; 183: 604-11.
  • 30. Hung WW, Wisnivesky JP, Siu AL, Ross JS. Cognitive decline among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 180: 134-7.
  • 31. Incalzi RA, Corsonello A, Pedone C, et al. Chronic renalfailure: A neglected comorbidity of COPD. Chest 2010;137: 831-7.
  • 32. Y.R. Van Gestel, M. Chonchol, S.E. Hoeks, et al, Association between chronic obstructive pulmonary disease and chronic kidney disease in vascular surgery patients, Nephrol. Dial. Transplant. (2009) 1–5.
  • 33. Mokhlesi B, Morris AL, Huang CF, Curcio AJ, Barrett TA, Kamp DW. Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest 2001;119:1043-8.
  • 34. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991; 144:12021218Rascon-Aguilar IE, Pamer M, Wludyka P, et al. Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest 2006; 130: 1096–101
  • 35. Yasuo Shimizu, Kunio Dobashi,4 Motoyasu Kusano1 and Masatomo Mori1 Different gastoroesophageal reflux symptoms of middle_aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients J. Clin. Biochem. Nutr. | March 2012 | vol. 50 | no. 2 | 169–75 doi: 10.3164/jcbn.11_75
  • 36. Köktürk N. Kronik Obstruktif Akciğer Hastalığında Komorbiteler. Bilgiç H, Karadağ M,Umut S, Erdinç E. Tanımdan Tedaviye Kronik Obstruktif Akciğer Hastalığı,6,Bursa: Galenos Yayıncılık 2008:73-82
  • 37. Kroeker EJ, Leon AS. The association of diffuse obstructive pulmonary emphysema and chronic gastroduodenal ulceration.Dis. Chest 1962; 42: 413–21
  • 38. Fiorentino L, Ancoli-Israel S. Obstructive sleep apnea in the elderly. In: Kushida CA (ed). Obstructive Sleep Apnea Diagnosis and Treatment. New York: Informa Healthcare, 2007: 281-93.)
  • 39. Köktürk O, Tatlıcıoğlu T, Fırat H, Çetin N. “Overlap Sendromu” kronik obstrüktif akciğer hastalarında obstrüktif sleep apne sendromu. Tüberküloz ve Toraks 1996;44:187-92.
  • 40. Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, et al. Sleep and sleep disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med 2003;167:7-14.
  • 41. Güllü Z, İtil O, Öztura İ, Aslan Ö, Ceylan E, Baklan B ve ark.. Kronik Obstrüktif Akciğer Hastalığı ve Obstrüktif Uyku Apne Sendromu Birlikteliği (Overlap sendromu). Toraks Dergisi 2002;3:161-7.
  • 42. Zamarrón C, García Paz V, Morete E, del Campo Matías F. Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences International Journal of COPD 2008;3:671-82.
  • 43. Weitzenblum E, Hirth C, Ducolone A, et al. Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax 1981;36:752-8.
  • 44. Scharf SM, Iqbal M, Keller C, et al. National Emphysema Treatment Trial (NETT) Group. Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 2002;166:314-22.
  • 45. Thabut G, Dauriat G, Stern JB, et al. Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Chest 2005; 127:1531-6

COMORBIDITY STATUS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Year 2017, Volume: 31 Issue: 3, 145 - 155, 01.12.2017

Abstract

Aim: Comorbidities are common in COPD and they may have important effects on prognosis. The most frequent comorbidities in COPD including; musculoskletal abnormalities, hypertension, diabetes, heart failure, cancers and coronary artery, pulmonary vascular and cerebrovascular diseases. The aim of this study is to detect the most common comorbidities in COPD. To investigate the association of comorbid incidence with gender, inflammation, and severity of COPD Material and Methods: Our study has been conducted on 179 patients diagnosed with COPD, Comorbidities of patients were recorded through direct conversation with them and researching their folder retrospectively. Certain parameters of patients were recorded such as arterial blood gas (ABG), C-reactive protein (CRP), hemoglobin (Hgb), hematocrit (Hct) and mild cellular volume (MCV) through analyzing of their folders retrospectively. Results: Mean age was 64.51±11.04 and 64,8% of patients had at least one comorbidity. The most common comorbidities included hypertension (HT; 60,9%), diabetes (DM; 27,4%), coronary artery disease (CAD; 33%), congestive heart failure (CHF; 20, 1%), cerebrovascular disease (CVD; 8,4%), depression (19,6%), anemia (13,4%), peptic ulcer (11,2%), gastroesophageal reflux (GER; 15,6%), lung cancer (3,4%), osteoporosis (15,6%), obstructive sleep apnea hypopnea syndrome (8,9%), chronic renal failure (4,5%), peripheral vessel disease (PVD; 9,5%) and pulmonary hypertension (PHT: 4.5%). Conclusion: As a result, according to our study hypertension, coronary artery disease and diabetes have been considered as the most common comorbidities.

References

  • 1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy fort he diagnosis, managment, and prevention of chronic obstructive pulmonary disease: uptated 2014. www.goldcopd.org/uploads/users/files/ GOLD_report2014_feb07.pd2-
  • 2. Agusti A. Thomas A Neff lecture: chronic obstructive pulmonary disease—a systemic disease. Proc Am Thorac Soc 2006; 3:478–81
  • 3. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a metaanalysis. Thorax 2004; 59:574–80
  • 4. Qaseem A,Wilt TJ, Weinberger SE, Hanania NA et al. Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. American College of Physicians (ACP),Clinical Guideline,179-92, 2011.
  • 5. Ferri FF. Chronic Obstructive Pulmonary Disease. Ferri's Clinical Advisor 5 Books in 1.Ferri FF (ed). 1;244-247,2013.
  • 6. Incalzi RA, Fuso L, Rosa M, et al. Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur Respir J 1997; 10: 2794-800
  • 7. Loukides S, Polyzogopoulos D. The effect of diabetes mellitus on the outcome of patients with chronic obstructive pulmonary disease exacerbated due to respiratory infections.Respiration 1996; 63: 170-3
  • 8. Rubinsztajn R, Chazan R. Mortality and comorbidity in hospitalized chronic obstructive pulmonary disease patients. Pneumonol Alergol Pol. 2011;79(5):343-6.
  • 9. Terzano C, Conti V, Di Stefano F, Petroianni A, Ceccarelli D, Graziani E, Mariotta S et al. Comorbidity, hospitalization, andmortality in COPD: results from a longitudinal study.Lung.2010 Aug; 188(4):321-9.
  • 10. Rutten FH, Cramer MJ, Lammers JW, Grobbee DE, Hoes AW. Heart failure and chronic obstructive pulmonary disease: An ignored combination? Eur J Heart Fail 2006; 8: 706-11.
  • 11. Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonarydisease. Thorax 2006; 61: 284-9.
  • 12. Laghi F, Adiguzel N, Tobin MJ. Endocrinological derangements in COPD. Eur Respir J 2009; 34: 975-96.
  • 13. ÇilliA, Uslu A, Öğüş C, Özdemir T. KOAH’da Komorbiditenin Prognoza Etkisi Tüberküloz ve Toraks Dergisi 2004; 52(1): 52-5
  • 14. Guralnik JM, Ersshler WB, Schrier SL, et al. Anemia in the elderly:a publichealth crisis in hematology. Hematology 2005; 1:528-32.
  • 15. American Thoracic Society. Standards for the diagnosis care of patients with COPD. Am J Respir Crit Care Med 1995; 152:77-121.
  • 16. Halpern MT, Zilberberg MD, Schmier JK, Lau EC, Shorr AF. Anemia, costs and mortality in chronic obstructive pulmonary disease. Cost Eff Resour Alloc 2006; 4: 17.
  • 17. Chambellan A, Chailleux E, Similowski T and the ANTADIR observatorygroup. Prognostic value of the hematocrit in patients with severeCOPD receivinglong term oxygen therapy. Chest 2005; 128:1201-8. 18. Tokmak M.Çağlayan B.KOAH’da Anemi Sıklığı Ve İlişkili Faktörler İstanbul 2000.
  • 19. Shorr AF, John D, Lee S, Margarita D, Marya DZ, Current Medical Research and Opninion 2008; 24:1123-30.
  • 20. Smith BJ, Laslett LL, Pile KD, et al. Randomized controlled trial of alendronate in airways disease and low bone mineral density. Chron Respir Dis 2004; 1: 131-7.
  • 21. Sin DD, Man JP, Man SF. The risk of osteoporosis in Caucasian men and women with obstructive airways disease. Am J Med 2003;114(1):10-4.
  • 22. Graat-Verboom L ,Wouters EF, Smeenk FW , van den Borne BE, Lunde R, Spruit MA. Current status of research on osteoporosis in COPD: a systematic review .Eur Respir J .2009 ; 34 ( 1 ): 209 - 18 .
  • 23. Öztürk O (2004) Duygulanım Bozuklukları, Ruh sağlığı ve Bozuklukları, FeryalMatbaası, Ankara, ss 295
  • 24. Elik P, Esen A, Akın M ve ark. Kronik obstrüktif akciğer hastalığı olgularında depresyon. Solunum Hastalıkları 1998;9:25-32
  • 25. Light RW, Merril EJ, Despars JA, et al. Prevalence of depression and anxiety in patients with COPD. Relationship to functional capacity. Chest 1985;87:35-8.
  • 26. Sözer K, Öngen G, Songar A (1990) Diffüz Obstrüktif Akciğer Hastalarında Depresyon ve Anksiyete Görülme Sıklığı, Solunum, 18:1-7.
  • 27. Özkan S (1994) Psikiyatrik Tıp: Konsültasyon Liyezon Psikiyatrisi, Roche, s: 109-13 İstanbul28. Aydın İ (2000) Tüberküloz ve KOAH’da Depresyon Anksiyete ve Yeti yitimi, Hacettepe Üniversitesi, Tıp Fakültesi, Psikiyatri A.B.D., Uzmanlık Tezi, Ankara
  • 28. Dahlen I, Jansob C (2002) Anxiety and Depression are Related to the Outcome ofEmergency Treatment in Patients With Chronic Obstructive Pulmonary Disease,Chest 122: 1633- 7.
  • 29. Hanania NA, Müllerova H, Locantore NW, et al. Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med2011; 183: 604-11.
  • 30. Hung WW, Wisnivesky JP, Siu AL, Ross JS. Cognitive decline among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 180: 134-7.
  • 31. Incalzi RA, Corsonello A, Pedone C, et al. Chronic renalfailure: A neglected comorbidity of COPD. Chest 2010;137: 831-7.
  • 32. Y.R. Van Gestel, M. Chonchol, S.E. Hoeks, et al, Association between chronic obstructive pulmonary disease and chronic kidney disease in vascular surgery patients, Nephrol. Dial. Transplant. (2009) 1–5.
  • 33. Mokhlesi B, Morris AL, Huang CF, Curcio AJ, Barrett TA, Kamp DW. Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest 2001;119:1043-8.
  • 34. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991; 144:12021218Rascon-Aguilar IE, Pamer M, Wludyka P, et al. Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest 2006; 130: 1096–101
  • 35. Yasuo Shimizu, Kunio Dobashi,4 Motoyasu Kusano1 and Masatomo Mori1 Different gastoroesophageal reflux symptoms of middle_aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients J. Clin. Biochem. Nutr. | March 2012 | vol. 50 | no. 2 | 169–75 doi: 10.3164/jcbn.11_75
  • 36. Köktürk N. Kronik Obstruktif Akciğer Hastalığında Komorbiteler. Bilgiç H, Karadağ M,Umut S, Erdinç E. Tanımdan Tedaviye Kronik Obstruktif Akciğer Hastalığı,6,Bursa: Galenos Yayıncılık 2008:73-82
  • 37. Kroeker EJ, Leon AS. The association of diffuse obstructive pulmonary emphysema and chronic gastroduodenal ulceration.Dis. Chest 1962; 42: 413–21
  • 38. Fiorentino L, Ancoli-Israel S. Obstructive sleep apnea in the elderly. In: Kushida CA (ed). Obstructive Sleep Apnea Diagnosis and Treatment. New York: Informa Healthcare, 2007: 281-93.)
  • 39. Köktürk O, Tatlıcıoğlu T, Fırat H, Çetin N. “Overlap Sendromu” kronik obstrüktif akciğer hastalarında obstrüktif sleep apne sendromu. Tüberküloz ve Toraks 1996;44:187-92.
  • 40. Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, et al. Sleep and sleep disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med 2003;167:7-14.
  • 41. Güllü Z, İtil O, Öztura İ, Aslan Ö, Ceylan E, Baklan B ve ark.. Kronik Obstrüktif Akciğer Hastalığı ve Obstrüktif Uyku Apne Sendromu Birlikteliği (Overlap sendromu). Toraks Dergisi 2002;3:161-7.
  • 42. Zamarrón C, García Paz V, Morete E, del Campo Matías F. Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences International Journal of COPD 2008;3:671-82.
  • 43. Weitzenblum E, Hirth C, Ducolone A, et al. Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax 1981;36:752-8.
  • 44. Scharf SM, Iqbal M, Keller C, et al. National Emphysema Treatment Trial (NETT) Group. Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 2002;166:314-22.
  • 45. Thabut G, Dauriat G, Stern JB, et al. Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Chest 2005; 127:1531-6
There are 44 citations in total.

Details

Other ID JA64NK78KG
Journal Section Research Article
Authors

Kadir Soykök This is me

Sulhattin Arslan This is me

Yeltekin Demirel This is me

Publication Date December 1, 2017
Published in Issue Year 2017 Volume: 31 Issue: 3

Cite

APA Soykök, K., Arslan, S., & Demirel, Y. (2017). KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA KOMORBİDİTE DURUMU. İzmir Göğüs Hastanesi Dergisi, 31(3), 145-155.