3D BIYO-YAZICILARDA KULLANILAN HİDROJELLER ÜZERİNE BİR İNCELEME

Year 2018, Volume: 2 Issue: 2, 68 - 75, 27.07.2018

Mehmet Topuz , Burak Dikici , Mehmet Gavgalı , Hakan Yılmazer

Abstract

Biyo-yazıcı işlemi,
farklı tıbbi alanlarda (doku mühendisliği, rejeneratif tıp veya diğer biyolojik
çalışmalar) tıbbi yapıları imal etmek için hücreler ve biyomateryaller gibi
biyolojik yapıların üretilmesi için bilgisayar destekli bir transfer işlemi
olarak tanımlanmaktadır. Üç boyutlu (3D) bio-yazıcı teknolojisi, özellikle
karaciğer, böbrekler, akciğerler ile vücuttaki diğer canlı organlar ile diğer
organların yazdırılmasında kullanılır. Hidrojeller, yüksek biyo-uyumlulukları
nedeniyle doku mühendisliği için hücre yüklemek için 3D biyo-yazıcıda yaygın
olarak kullanılmaktadır. Buna ek olarak, hidrojeller vücutta bulunan yumuşak
dokuları simüle etmesi, suda yüksek oranda şişebilme kaabiliyeti ve doğal yumuşak
dokularınki ile benzer mekanik özelliklere sahip olmasından dolayı birçok
araştırmacı hidrojel ile ilgilenmiştir ve onlara olan ilgi her geçen gün
artmaktadır. Genellikle (i) doğal hidrojeller ve (ii) sentetik hidrojel olarak
iki gruba ayrılırlar. Bu çalışmada hem doğal hem de sentetik hidrojeller
hakkında literatürdeki önemli belgeler derlenmiş olup ek olarak, hidrojellerin
3D biyo-yazıcı işlemi detaylı bir şekilde tartışılmıştır.

Keywords

3D Yazıcı, Bio-yazıcı, Hidrojeller

A REVIEW ON THE HYDROGELS USED IN 3D BIO-PRINTING

Abstract

The bio-printing
process describes as
a computer-aided transfer process for printing of biological structures such as cells and biomaterials to fabricate medical
constructions for different medical fields (tissue engineering, regenerative
medicine, or other biological studies). Especially, three-dimension (3D) bio-printing technology is used to print living
organs like livers, kidneys, lungs, and any other organs in the body. Hydrogels have been widely used in 3D bio-printing
to load cell for tissue engineering due to their high biocompatibility. In
addition, hydrogels simulate the soft tissues which present in the body,
swollen in water at high levels and have similar mechanical properties to those
of natural soft tissues, many researchers have been interested in hydrogels and
their reputations are increasing day by day. They are generally divided into
two groups as (i) natural hydrogels and (ii) synthetic hydrogels. Key documents
in the literature about both natural and synthetic hydrogels have been reviewed
in this study. Also, 3D bio-printing process of the hydrogels has been discussed as detailly.

Keywords

3D Printer, Bio-printing, Hydrogels

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