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Year 2014, Volume: 2 Issue: 2, 58 - 62, 16.11.2015

Bilsev İnce , Mehmet Dadacı Zeynep Altuntaş Fatma Bilgen

Abstract

Aim Cutaneous malignancies often develop in traumatized, degenerative, and chronically inflamed skin or scar tissues. The observations indicated that cutaneous malignancies often arise in burn scars (Marjolin's ulcer), venous ulcers, compression wounds, cystostomy sites, chronic pilonidal sinus, hidradenitis suppurativa, lupus scars, chronic lymphedema, traumatic wounds, and sites of chronic osteomyelitis. The current study presents a differential diagnosis and treatment approach in patients who received wound care and treatment due to the presence of chronic wounds and in whom biopsy revealed malignancy. Material and Methods Five patients who presented to the clinic due to chronic wounds between 2008 and 2012 and in whom biopsy revealed carcinomas were included in the study. The patients were retrospectively reviewed in terms of previously administered therapies, pathological diagnosis, predisposing factors, time to malignant degeneration, reconstruction techniques, complications, and recurrence. Results The pathological carcinoma in three patients and squamous cell carcinoma examination

Keywords

chronic wound malignancy cutaneous

References

  • Daya M, Balakrishan T. Advanced Marjolin’s ulcer of
  • the scalp in a 13-year-old boy treat by excision and free tissue transfer: Case report and review of literature. Indian J Plast Surg 2009; 42(1): 106-11.
  • Onesti MG, Fino P, Fioramonti P, Amorosi V, Scuderi N. Ten tears of experience in chronic ulsers and malignant transformation. Int Wound J 2013, doi: 10.1111/iwj.12134.
  • Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s Ulcer: modern analysis of an ancient problem. Plast Reconstr Surg 2009; 123(1): 184-91.
  • Cocchetto V, Magrin P, Paulo RA, Aidé M, Monte Razo L, Pantaleão L. Squamous cell carsinoma in chornic wound: Marjolin ulcer. Derm Online J 2013; 19(2):7.
  • Alamı M, Mahfoud M, El Bardouni A, Berrada MS, El
  • Yaacoubi M. Squamous cell carcinoma arising from chronic osteomyelitis. Acta Orthop Traumatol Turc 2011; 45(3): 144-8.
  • Burns T, Breattnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology. Massachusetts: Blackwell; 2004.
  • Kundakçı N, Erdem C. Lepra ve diğer mikobakteriyel
  • deri infeksiyonları. Dermatoloji’de. Ed. Tüzün Y, Gürer MA, Serdaroğlu S, Oğuz O, Aksungur VL. 3. Baskı. İstanbul, Nobel Tıp Kitabevi, 2008; 433-58.
  • Dormand EL, Ridha H, Vesely MJ. Long-term outcome of Squamous Cell Carcinoma of the upper and lower limbs. J Plast Reconstr Aesthet Surg. 2010; 63: 1705- 11.
  • Samira Y, Sérgio H, Michalany NS, de Almeida FA,
  • Jane T. Squamous cell carcinoma in chronic ulcer in lepromatous leprosy. Dermatol Surg 2009; 35: 2025- 30.
  • Enoch S, Miller DR, Price PE, Harding KG: Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature. Int Wound J 2004; 1: 165-75
  • Trent JT, Kirsner RS. Wound and Malignancy. Adv Skin Wound Care 2003; 16: 31-4. 12. Wolff K,
  • Goldsmith L, Katz S, Gilchrest
  • B, Paller A, Leffell D. Fitzpatrick’s Dermatology in
  • General Medicine. 7ed. United States : McGraw-Hill, 2008; 319-74.
  • Melo CR, Melo SR. Carsinoma cuniculatum of the buttock: an unusual case with an inverted growth. Dermatologica 1989; 179: 38-41.
  • Karadağ AS, Akdeniz N, Çalka Ö, Çeçen İ, Bayram İ,
  • Ceylan F. Plantar Ülser Zemininde Skuamöz Hücreli Karsinom Gelişen Bir Lepra Olgusu. Dermatoz 2010; 1(4): 185-7.
  • Kumaravel S. Neoplastic transformation of chronic ulcers in leprosy patients: a retrospespective study of 23 consecutive cases. Indian J lepr 1998; 70: 179-87.
  • Combemale P, Bousquet M, Kanitakis J, Bernard P. Malignant transformation of leg ulcer: a retrospective study of 85 cases. J Eur Acad Dermatol Venereol 2007; 21: 935-47.
  • Weedon D. Weedon’s Skin Pathology. 3rd ed. London:
  • Churchill Livingstone Elsevier, 2010: 982-95.

Kronik Yara Görünümlü Karsinomlar

Year 2014, Volume: 2 Issue: 2, 58 - 62, 16.11.2015

Bilsev İnce , Mehmet Dadacı Zeynep Altuntaş Fatma Bilgen

Abstract

Kutanöz maligniteler sıklıkla travmatize, degeneratif ve kronik inflame cilt veya skar dokusundan gelişir. Yapılan incelemelerde kutanöz malignitelerin sıklıkla yanık skarları (Marjolin ülser), venöz ülserler, bası yaraları, sistostomi alanları, kronik pilonidal sinüs, hidradenitis süpürativa, lupus skarları, kronik lenfödem, travmatik yaralar, kronik osteomiyelit alanlarında geliştiği gösterilmiştir.
Bu çalışmamızda kronik yara görünümü nedeniyle yara bakımı tedavisi almasına rağmen iyileşme göstermeyen, biyopsi sonucunda malignite tespit edilen hastalarda ayırıcı tanı ve uygulanan tedavi yaklaşımlarımız sunulmaktadır.
2008-2012 yılları arasında kliniğimize kronik yara nedeniyle başvurup biyopsi sonucu karsinom çıkan beş hasta çalışmaya alındı. Hastalar daha önce aldıkları tedavi, patolojik tanıları, predispozan faktörler, malign dejenerasyon süresi, rekonstrüksiyon teknikleri, komplikasyon ve nüks açısından retrospektif incelendi.
Patolojik inceleme sonucunda 3 hastada verrüköz karsinom, 2 hastada skuamoz hücreli karsinom belirlendi. En yaygın rastlanan histolojik tümör tipi squamoz hücreli karsinomdur.
Ciltteki kronik irritasyonun veya yumuşak dokunun farklı büyüme faktörlerine maruz kalmasının, aynı zamanda inflamasyona bağlı olarak bu bölgede ortaya çıkan sitotoksik faktörlerin malign transformasyonda önemli rol oynadığı düşünülmektedir
Kronik yaralı hastalarda karsinom gelişimini engellemede, iyi yara bakımı, travmadan kaçınmak, iyileşmeyen ülserlerden biyopsi alarak erken tanı konulması önemlidir. Uzun süreli iyileşmeyen açık yarası olan ve risk faktörleri bulunan hastalarda kutanöz malignite gelişebileceği akılda tutulmalıdır.
Anahtar kelimeler: kronik yara, malignite, kutanöz

Keywords

kronik yara malignite kutanöz

References

  • Daya M, Balakrishan T. Advanced Marjolin’s ulcer of
  • the scalp in a 13-year-old boy treat by excision and free tissue transfer: Case report and review of literature. Indian J Plast Surg 2009; 42(1): 106-11.
  • Onesti MG, Fino P, Fioramonti P, Amorosi V, Scuderi N. Ten tears of experience in chronic ulsers and malignant transformation. Int Wound J 2013, doi: 10.1111/iwj.12134.
  • Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s Ulcer: modern analysis of an ancient problem. Plast Reconstr Surg 2009; 123(1): 184-91.
  • Cocchetto V, Magrin P, Paulo RA, Aidé M, Monte Razo L, Pantaleão L. Squamous cell carsinoma in chornic wound: Marjolin ulcer. Derm Online J 2013; 19(2):7.
  • Alamı M, Mahfoud M, El Bardouni A, Berrada MS, El
  • Yaacoubi M. Squamous cell carcinoma arising from chronic osteomyelitis. Acta Orthop Traumatol Turc 2011; 45(3): 144-8.
  • Burns T, Breattnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology. Massachusetts: Blackwell; 2004.
  • Kundakçı N, Erdem C. Lepra ve diğer mikobakteriyel
  • deri infeksiyonları. Dermatoloji’de. Ed. Tüzün Y, Gürer MA, Serdaroğlu S, Oğuz O, Aksungur VL. 3. Baskı. İstanbul, Nobel Tıp Kitabevi, 2008; 433-58.
  • Dormand EL, Ridha H, Vesely MJ. Long-term outcome of Squamous Cell Carcinoma of the upper and lower limbs. J Plast Reconstr Aesthet Surg. 2010; 63: 1705- 11.
  • Samira Y, Sérgio H, Michalany NS, de Almeida FA,
  • Jane T. Squamous cell carcinoma in chronic ulcer in lepromatous leprosy. Dermatol Surg 2009; 35: 2025- 30.
  • Enoch S, Miller DR, Price PE, Harding KG: Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature. Int Wound J 2004; 1: 165-75
  • Trent JT, Kirsner RS. Wound and Malignancy. Adv Skin Wound Care 2003; 16: 31-4. 12. Wolff K,
  • Goldsmith L, Katz S, Gilchrest
  • B, Paller A, Leffell D. Fitzpatrick’s Dermatology in
  • General Medicine. 7ed. United States : McGraw-Hill, 2008; 319-74.
  • Melo CR, Melo SR. Carsinoma cuniculatum of the buttock: an unusual case with an inverted growth. Dermatologica 1989; 179: 38-41.
  • Karadağ AS, Akdeniz N, Çalka Ö, Çeçen İ, Bayram İ,
  • Ceylan F. Plantar Ülser Zemininde Skuamöz Hücreli Karsinom Gelişen Bir Lepra Olgusu. Dermatoz 2010; 1(4): 185-7.
  • Kumaravel S. Neoplastic transformation of chronic ulcers in leprosy patients: a retrospespective study of 23 consecutive cases. Indian J lepr 1998; 70: 179-87.
  • Combemale P, Bousquet M, Kanitakis J, Bernard P. Malignant transformation of leg ulcer: a retrospective study of 85 cases. J Eur Acad Dermatol Venereol 2007; 21: 935-47.
  • Weedon D. Weedon’s Skin Pathology. 3rd ed. London:
  • Churchill Livingstone Elsevier, 2010: 982-95.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Araştırma Makaleleri
Authors

Bilsev İnce

Mehmet Dadacı This is me

Zeynep Altuntaş This is me

Fatma Bilgen

Publication Date November 16, 2015
Published in Issue Year 2014 Volume: 2 Issue: 2

Cite

APA İnce, B., Dadacı, M., Altuntaş, Z., Bilgen, F. (2015). Kronik Yara Görünümlü Karsinomlar. International Journal of Basic and Clinical Medicine, 2(2), 58-62.
AMA İnce B, Dadacı M, Altuntaş Z, Bilgen F. Kronik Yara Görünümlü Karsinomlar. International Journal of Basic and Clinical Medicine. November 2015;2(2):58-62.
Chicago İnce, Bilsev, Mehmet Dadacı, Zeynep Altuntaş, and Fatma Bilgen. “Kronik Yara Görünümlü Karsinomlar”. International Journal of Basic and Clinical Medicine 2, no. 2 (November 2015): 58-62.
EndNote İnce B, Dadacı M, Altuntaş Z, Bilgen F (November 1, 2015) Kronik Yara Görünümlü Karsinomlar. International Journal of Basic and Clinical Medicine 2 2 58–62.
IEEE B. İnce, M. Dadacı, Z. Altuntaş, and F. Bilgen, “Kronik Yara Görünümlü Karsinomlar”, International Journal of Basic and Clinical Medicine, vol. 2, no. 2, pp. 58–62, 2015.
ISNAD İnce, Bilsev et al. “Kronik Yara Görünümlü Karsinomlar”. International Journal of Basic and Clinical Medicine 2/2 (November 2015), 58-62.
JAMA İnce B, Dadacı M, Altuntaş Z, Bilgen F. Kronik Yara Görünümlü Karsinomlar. International Journal of Basic and Clinical Medicine. 2015;2:58–62.
MLA İnce, Bilsev et al. “Kronik Yara Görünümlü Karsinomlar”. International Journal of Basic and Clinical Medicine, vol. 2, no. 2, 2015, pp. 58-62.
Vancouver İnce B, Dadacı M, Altuntaş Z, Bilgen F. Kronik Yara Görünümlü Karsinomlar. International Journal of Basic and Clinical Medicine. 2015;2(2):58-62.
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