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Year 2014, Volume: 2 Issue: 2, 102 - 107, 16.11.2015

Zafer Çiftçi , Mahmut Deniz , Halide Güneş Çiftçi Erdoğan Gültekin

Abstract

The idea of substituting the non-functioning human larynx with another one insipired many researchers and numerous studies associated with this topic have been performed so far. Following operations performed due to malignancies, the survival rates of the patients increased and hence quality of life became gradually more important. This is especially important for laryngectomees who had increased life spans due to of progresses in medical and surgical treatment of laryngeal cancer. As a consequence, the idea of performing a laryngeal transplantation to improve the quality of life is becoming more substantial. In this review, we aimed to recall the history of the laryngeal transplat procedure, overview the indications and ethico-medicolegal issues and discuss the opinions related with the future of the procedure in details

Keywords

Laryngeal transplantation quality of life reinnervation medico-legal

References

  • Bruce H. Haughey. Chapter 116: Total Laryngectomy and http://famona.tripod.com/ent/cummings/cumm116.pdf Erişim tarihi: 01.04.2014
  • Laryngopharyngectomy.
  • Potter CP, Birchall MA. Laryngectomees' views on laryngeal transplantation. Transpl Int. 1998;11(6):433- 8.
  • Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001;344(22):1676–9.
  • Farwell DG, Birchall MA, Macchiarini P, et al. Laryngotracheal
  • transplantation: technical modifications and functional outcomes. Laryngoscope. 2013;123(10):25028.
  • Gonfiotti A, Jaus MO, Barale D, Baiguera S, et al. The first tissue-engineered airway transplantation: 5-year follow-up results. Lancet. 2014;383(9913):238-44.
  • Daly JF. Is laryngeal transplantation justifiable? Laryngoscope. 1970;80(8):1251-5. Bailey 7. Barker E, M, Birchall M. Laryngeal transplantation. Transplantation Reviews 2002;16(2): 95-107.
  • Work WP, Boles R.Larynx: replantation in the dog. Arch Otolaryngol. 1965;82(4):401-2.
  • Boles R. Surgical replantation of the larynx in dogs: a progress report. Laryngoscope. 1966;76(6):1057
  • Silver CE, Liebert PS, Som ML. Autologous transplantation of the canine larynx. Arch Otolaryngol. 1967;86(1):95-102. 11. Ogura JH, Shumrick DA, Lapidot A. Some
  • observations on experimental laryngeal substitution in
  • laryngectomized dogs. Ann Otol Rhinol Laryngol. 1962;71:532-50.
  • Kluyskens P, Ringoir S. Follow-up of a human larynx transplantation. Laryngoscope. 1970;80(8):1244-50
  • Tucker HM. Laryngeal transplantation: current status 1974. Laryngoscope. 1975;85(5):787-96.
  • Strome S, Sloman-Moll E, Samonte BR, Wu J, Strome M. Rat model for a vascularized laryngeal allograft. Ann Otol Rhinol Laryngol. 1992;101(11):950-3.
  • Strome M, Wu J, Strome S, Brodsky G.A comparison of preservation techniques in a vascularized rat laryngeal transplant model. Laryngoscope. 1994;104(6 Pt 1):666-8.
  • Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001; 344(22): 1676–1679.
  • Lorenz RR, Strome M. Total Laryngeal Transplant Explanted: 14 Years of Lessons Learned. Otolaryngol Head Neck Surg. 2014 Jan 16. [Epub ahead of print]
  • Birchall MA, Lorenz RR, Berke GS, Genden EM, Haughey BH, Siemionow M, Strome M. Laryngeal transplantation in 2005: a review. Am J Transplant. Review. 2006;6(1):20-6.
  • Barthel SW, Dan O, Myles J et al. Effect of in vitro radiation requirements and rejection rates in rat laryngeal transplantation. Ann Otol Rhinol Laryngol. 2001; 110(1) :20-4. on cyclosporine 20. Lorenz RR, Dan O. Immunosuppressive effect of irradiation in the murine laryngeal transplantation model: a controlled trial. Ann Otol Rhinol Laryngol. 2003;112(8):712-5 et al.
  • Akst LM, Siemionow M, Dan O. et al. Induction of tolerance in a rat model of laryngeal transplantation . Transplantation. 2003;76(12):1763-70.
  • Genden EM, Urken ML. Laryngeal and tracheal trnsplantation: ethical limitations. Mt Sinai J Med. 2003;70(3):163-5.
  • http://www.rcseng.ac.uk/publications/docs/laryngeal- transplantation-working-party-final- report/@@download/pdffile/rcs_laryngeal_transplant.p df. Erişim tarihi: 01.04.2014

2014 Yılında Larengeal Transplantasyonun Geldiği Nokta

Year 2014, Volume: 2 Issue: 2, 102 - 107, 16.11.2015

Zafer Çiftçi , Mahmut Deniz , Halide Güneş Çiftçi Erdoğan Gültekin

Abstract

İşlev görmeyen insan larenksinin yerine başka bir larenksin konulabilmesi düşüncesi son 50 yıldan beri bu konuda yapılan birçok çalışmaya ilham konusu olmuştur. Kanser ameliyatları sonrasında hastaların sağ kalımlarının artmasının yanı sıra, yaşam kalitelerinin de artması gittikçe ön plana çıkmaktadır. Bu durum özellikle cerrahi ve medikal tedavilerdeki gelişmelere paralel olarak yaşam sürelerinde artış sağlanmış olan total larenjektomili hastalar için çok önemlidir. Sonuç olarak, yaşam kalitesini artırmak amacıyla larenks tranplantasyonu yapılması düşüncesi önemli hale gelmektedir. Bu derlemede bu konu ile ilgili tarihsel gelişim sürecinin yanı sıra, endikasyonlara ve etiko-mediko-legal konulara değinilmesi ve larengeal transplantasyonun geleceği ile ilgili görüşlerin detaylı bir şekilde ele alınması amaçlanmıştır.

Keywords

Larengeal transplant yaşam kalitesi reinnervasyon mediko-legal

References

  • Bruce H. Haughey. Chapter 116: Total Laryngectomy and http://famona.tripod.com/ent/cummings/cumm116.pdf Erişim tarihi: 01.04.2014
  • Laryngopharyngectomy.
  • Potter CP, Birchall MA. Laryngectomees' views on laryngeal transplantation. Transpl Int. 1998;11(6):433- 8.
  • Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001;344(22):1676–9.
  • Farwell DG, Birchall MA, Macchiarini P, et al. Laryngotracheal
  • transplantation: technical modifications and functional outcomes. Laryngoscope. 2013;123(10):25028.
  • Gonfiotti A, Jaus MO, Barale D, Baiguera S, et al. The first tissue-engineered airway transplantation: 5-year follow-up results. Lancet. 2014;383(9913):238-44.
  • Daly JF. Is laryngeal transplantation justifiable? Laryngoscope. 1970;80(8):1251-5. Bailey 7. Barker E, M, Birchall M. Laryngeal transplantation. Transplantation Reviews 2002;16(2): 95-107.
  • Work WP, Boles R.Larynx: replantation in the dog. Arch Otolaryngol. 1965;82(4):401-2.
  • Boles R. Surgical replantation of the larynx in dogs: a progress report. Laryngoscope. 1966;76(6):1057
  • Silver CE, Liebert PS, Som ML. Autologous transplantation of the canine larynx. Arch Otolaryngol. 1967;86(1):95-102. 11. Ogura JH, Shumrick DA, Lapidot A. Some
  • observations on experimental laryngeal substitution in
  • laryngectomized dogs. Ann Otol Rhinol Laryngol. 1962;71:532-50.
  • Kluyskens P, Ringoir S. Follow-up of a human larynx transplantation. Laryngoscope. 1970;80(8):1244-50
  • Tucker HM. Laryngeal transplantation: current status 1974. Laryngoscope. 1975;85(5):787-96.
  • Strome S, Sloman-Moll E, Samonte BR, Wu J, Strome M. Rat model for a vascularized laryngeal allograft. Ann Otol Rhinol Laryngol. 1992;101(11):950-3.
  • Strome M, Wu J, Strome S, Brodsky G.A comparison of preservation techniques in a vascularized rat laryngeal transplant model. Laryngoscope. 1994;104(6 Pt 1):666-8.
  • Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001; 344(22): 1676–1679.
  • Lorenz RR, Strome M. Total Laryngeal Transplant Explanted: 14 Years of Lessons Learned. Otolaryngol Head Neck Surg. 2014 Jan 16. [Epub ahead of print]
  • Birchall MA, Lorenz RR, Berke GS, Genden EM, Haughey BH, Siemionow M, Strome M. Laryngeal transplantation in 2005: a review. Am J Transplant. Review. 2006;6(1):20-6.
  • Barthel SW, Dan O, Myles J et al. Effect of in vitro radiation requirements and rejection rates in rat laryngeal transplantation. Ann Otol Rhinol Laryngol. 2001; 110(1) :20-4. on cyclosporine 20. Lorenz RR, Dan O. Immunosuppressive effect of irradiation in the murine laryngeal transplantation model: a controlled trial. Ann Otol Rhinol Laryngol. 2003;112(8):712-5 et al.
  • Akst LM, Siemionow M, Dan O. et al. Induction of tolerance in a rat model of laryngeal transplantation . Transplantation. 2003;76(12):1763-70.
  • Genden EM, Urken ML. Laryngeal and tracheal trnsplantation: ethical limitations. Mt Sinai J Med. 2003;70(3):163-5.
  • http://www.rcseng.ac.uk/publications/docs/laryngeal- transplantation-working-party-final- report/@@download/pdffile/rcs_laryngeal_transplant.p df. Erişim tarihi: 01.04.2014
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Derlemeler
Authors

Zafer Çiftçi

Mahmut Deniz

Halide Güneş Çiftçi This is me

Erdoğan Gültekin

Publication Date November 16, 2015
Published in Issue Year 2014 Volume: 2 Issue: 2

Cite

APA Çiftçi, Z., Deniz, M., Güneş Çiftçi, H., Gültekin, E. (2015). 2014 Yılında Larengeal Transplantasyonun Geldiği Nokta. International Journal of Basic and Clinical Medicine, 2(2), 102-107.
AMA Çiftçi Z, Deniz M, Güneş Çiftçi H, Gültekin E. 2014 Yılında Larengeal Transplantasyonun Geldiği Nokta. International Journal of Basic and Clinical Medicine. November 2015;2(2):102-107.
Chicago Çiftçi, Zafer, Mahmut Deniz, Halide Güneş Çiftçi, and Erdoğan Gültekin. “2014 Yılında Larengeal Transplantasyonun Geldiği Nokta”. International Journal of Basic and Clinical Medicine 2, no. 2 (November 2015): 102-7.
EndNote Çiftçi Z, Deniz M, Güneş Çiftçi H, Gültekin E (November 1, 2015) 2014 Yılında Larengeal Transplantasyonun Geldiği Nokta. International Journal of Basic and Clinical Medicine 2 2 102–107.
IEEE Z. Çiftçi, M. Deniz, H. Güneş Çiftçi, and E. Gültekin, “2014 Yılında Larengeal Transplantasyonun Geldiği Nokta”, International Journal of Basic and Clinical Medicine, vol. 2, no. 2, pp. 102–107, 2015.
ISNAD Çiftçi, Zafer et al. “2014 Yılında Larengeal Transplantasyonun Geldiği Nokta”. International Journal of Basic and Clinical Medicine 2/2 (November 2015), 102-107.
JAMA Çiftçi Z, Deniz M, Güneş Çiftçi H, Gültekin E. 2014 Yılında Larengeal Transplantasyonun Geldiği Nokta. International Journal of Basic and Clinical Medicine. 2015;2:102–107.
MLA Çiftçi, Zafer et al. “2014 Yılında Larengeal Transplantasyonun Geldiği Nokta”. International Journal of Basic and Clinical Medicine, vol. 2, no. 2, 2015, pp. 102-7.
Vancouver Çiftçi Z, Deniz M, Güneş Çiftçi H, Gültekin E. 2014 Yılında Larengeal Transplantasyonun Geldiği Nokta. International Journal of Basic and Clinical Medicine. 2015;2(2):102-7.
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