Investigation of Shielding Parameters of Fast Neutrons for Some Chemotherapy Drugs by Different Calculation Methods

Abstract

In this study, we investigated the neutron attenuation properties of twelve different chemotherapy drugs utilizing various computational techniques. The computed fast neutron effective removal cross-section (ΣR, cm-1) results were compared with empirical formulas, Monte Carlo simulation data obtained from MCNP, MRCsC, and Phy-X/PSD computer program results. Additionally, within each calculation method, the half-value layer (HVL) and the mean free path (λ) values were determined. Our calculations revealed that, when compared to water and paraffin, Gemcitabine, Etoposide, Vincristine, and Doxorubicin exhibited the highest ΣR values, while Oxaliplatin exhibited the lowest ΣR value. Understanding and determining the radiation properties of drugs, especially in treatment methods involving radiation, will provide an advantage for both patients and clinical personnel.

Keywords

• Chemotherapy drugs
• Neutron shielding
• Removal cross section
• MRCsC
• Phy-X/PSD

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