Akut lenfoblastik lösemi olgularının klinik seyir ve tedavi cevabı yönünden retrospektif değerlendirilmesi: Tek merkez deneyimi

Year 2020, Volume: 1 Issue: 2, 29 - 32, 30.12.2020

Senem Maral Murat Albayrak Hacer Berna Afacan Öztürk

Abstract

Amaç: Merkezimize başvuran erişkin akut lenfoblastik lösemi (ALL) hastalarının demografik özelliklerini, sağkalım verilerini incelemek ve prognoza etkili faktörleri belirlemek amaçlanmıştır.

Gereç ve Yöntemler: 2009-2018 yılları arasında merkezimize başvuran ve ALL tanısı konulan hastalar retrospektif olarak incelendi. Veriler ışığında hastaların laboratuvar verileri, uygulanan tedaviler, tedaviye yanıt oranları, genel ve hastalıksız sağkalım oranları hesaplandı.

Bulgular: Çalışmamıza toplamda 30 hasta (16 erkek ve 14 kadın) dahil edildi. Hastaların 5'i T hücreli, 23’ü B hücreli ve 2'si bifenotipik alt tipe sahipti. Ortalama takip süresi ortanca 31,5 ay (1-90 ay) olarak bulundu. Hastalarda genel sağkalım (OS) 26 ay (1-87ay), hastalıksız sağkalım (PFS) 21.5 ay (13-84 ay) idi.

Sonuç: Tanı ve takipte ALL hastalarının risk grubunun prognostik faktörler ışığında doğru olarak belirlenmesi ve tedavi yaklaşımının hastaya yönelik belirlenmesi prognoz açısından önemlidir. Her hastada yaşına, performans durumuna, prognostik faktörlerine uygun olabilecek bir tedavi yaklaşımı uygulanmalıdır.

Keywords

akut lenfoblastik lösemi, erişkin, sağkalım

Retrospective analysis of prognosis and treatment response ın acute lymphoblastic leukemia patıents: Single center experience

Abstract

Aim: The aim of the study is analyze the characteristics, survival and the prognostic factors of adult acute lymphoblastic leukemia (ALL) patients admitted to our center.

Material Methods: The ALL patients who admitted to our center between 2009 and 2018 and were were retrospectively analyzed. The data of laboratory and treatment approaches of patients were reviewed. Also the response rates, overall and disease-free survival rates were calculated.

Results: Totally thirty ALL patients (16 male,14 female) were included. Subtypes of patients were T-cell (5 patients), B-cell (23 patients) and biphenotypic (2 patients) ALL. During median 31.5 months (1-90 months) of follow-up time, overall survival (OS) was 26 months (1-87 months) and progression free survival (PFS) was 21.5 months (13-84 months).

Conclusion: Determine of prognostic risk factors of ALL patients is important during treatment decision. The treatment approaches should be assessed according to age, performance status and prognostic risk profile for each patient.

Keywords

acute lymphoblastic leukemia, adult, survival

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