Polymer – flufenamic acid delivery systems for injured skin

Year 2022, , 114 - 121, 31.12.2022

Minodora Maria Marın Mihaela Violeta Ghıca Alpaslan Kaya , Denisa Ioana Udeanu Madalina Albu Kaya , Cristina-elena Dınu-pîrvu Lăcrămioara Popa Valentina Anuța Razvan Mihai Prısada

https://doi.org/10.32571/ijct.1135548

Abstract

Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.

Keywords

Collagen sponges, microcapsules, flufenamic acid, kinetic release, wound healing

Supporting Institution

UEFISCDI

Project Number

PED 160/03.01.2017,code PN-III-P2-2.1-PED-2016-0813

Thanks

This work was in the frame of PN-III-Experimental Demonstration Project

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