Research Article

Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats

Number: 10 June 30, 2026
EN

Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats

Abstract

Permethrin is a synthetic pyrethroid widely used in agriculture, veterinary medicine, and public health, and its environmental persistence raises concerns regarding its potential toxicity in mammals. Transforming growth factors (TGF-α, TGF-β) and their receptors (EGFR, TGFBR1) are key regulators of cellular proliferation, differentiation, and immune responses; however, the effects of permethrin on these parameters remain insufficiently characterized in the literature. The present study evaluated the effects of acute (4 days) and subchronic (21 days) intraperitoneal permethrin exposure (75 and 150 mg/kg) on serum TGF-α and TGF-β levels, as well as EGFR and TGFBR1 levels in colon tissue supernatants in rats. Wistar rats were assigned to control, vehicle, and permethrin-treated groups. Biochemical parameters were quantified using ELISA and were statistically compared among groups. Permethrin exposure resulted in a significant decrease in serum TGF-α levels, whereas TGF-β levels were significantly increased. Following subchronic exposure, EGFR levels were elevated at both doses, while TGFBR1 levels were significantly reduced at 150 mg/kg (p<0.05). These findings suggest that permethrin may disrupt immune-related signaling pathways and suggest that these biomarkers may be useful indicators in environmental toxicity assessment.

Keywords

Ethical Statement

The experimental protocol complied with national and international guidelines for the ethical use of laboratory animals and received approval from the Aksaray University Local Ethics Committee for Animal Experiments (Approval No: 24, 30/06/2022). All procedures were carried out with careful consideration to minimize animal suffering and to limit the number of animals required for the study. The animals were not privately owned; they were obtained from an institutional animal facility. Therefore, no additional consent from third-party owners was required.

Thanks

The authors gratefully acknowledge Aksaray University for providing laboratory infrastructure and technical assistance during the course of this research. They also express their gratitude to the staff of the ASUBTAM Physiology and Histology Laboratory for their valuable assistance with the ELISA analyses.

References

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Publication Date

June 30, 2026

Submission Date

January 23, 2026

Acceptance Date

April 9, 2026

Published in Issue

Year 2026 Number: 10

APA
Örün, G. N., & Erdoğan, K. (2026). Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats. International Journal of Chemistry and Technology, 10, 1-7. https://doi.org/10.32571/ijct.1870016
AMA
1.Örün GN, Erdoğan K. Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats. Int. J. Chem. Technol. 2026;(10):1-7. doi:10.32571/ijct.1870016
Chicago
Örün, Gül Nihal, and Kenan Erdoğan. 2026. “Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats”. International Journal of Chemistry and Technology, nos. 10: 1-7. https://doi.org/10.32571/ijct.1870016.
EndNote
Örün GN, Erdoğan K (June 1, 2026) Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats. International Journal of Chemistry and Technology 10 1–7.
IEEE
[1]G. N. Örün and K. Erdoğan, “Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats”, Int. J. Chem. Technol., no. 10, pp. 1–7, June 2026, doi: 10.32571/ijct.1870016.
ISNAD
Örün, Gül Nihal - Erdoğan, Kenan. “Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats”. International Journal of Chemistry and Technology. 10 (June 1, 2026): 1-7. https://doi.org/10.32571/ijct.1870016.
JAMA
1.Örün GN, Erdoğan K. Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats. Int. J. Chem. Technol. 2026;:1–7.
MLA
Örün, Gül Nihal, and Kenan Erdoğan. “Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats”. International Journal of Chemistry and Technology, no. 10, June 2026, pp. 1-7, doi:10.32571/ijct.1870016.
Vancouver
1.Gül Nihal Örün, Kenan Erdoğan. Impact of Permethrin Exposure on TGF-α, TGF-β, EGFR, and TGFBR1 Levels in Rats. Int. J. Chem. Technol. 2026 Jun. 1;(10):1-7. doi:10.32571/ijct.1870016