Research Article

Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology

Number: 10 June 23, 2026
EN

Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology

Abstract

The essential oil of Inula graveolens contains a major bioactive compound, bornyl acetate, and is used as a traditional medicine. The chemical agents, such as essential oil, bornyl acetate, and cisplatin, exhibit cytotoxic effects on various cancer cells, including human pulmonary carcinoma (A549), human cervical carcinoma (HeLa), human colorectal carcinoma (HT29), and human breast adenocarcinoma (MCF7), thereby diminishing their viability. Additionally, they have adverse effects on human amniotic cells (normal cells); therefore, this work aims to determine the minimum dose of the agent’s concentration that can maintain the viability of cancer cells at the lowest level without exterminating the human normal cells. Thus, RSM was employed as a mathematical and statistical method for modeling, analyzing, and optimizing agents and their impacts on human normal cells. It has been found that different doses of agents have different effects on cancer cells, and the aim is to optimize the use of agents with fewer trials. Therefore, various agent scenarios have been examined with RSM, and valuable information has been obtained for medical purposes that has been presented in detail.

Keywords

References

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Details

Primary Language

English

Subjects

Structural Biology, Food Engineering

Journal Section

Research Article

Publication Date

June 23, 2026

Submission Date

February 9, 2026

Acceptance Date

April 1, 2026

Published in Issue

Year 2026 Number: 10

APA
Taylan, O., Bulut, M., & Erenler, R. (2026). Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology. International Journal of Chemistry and Technology, 10, 1-18. https://doi.org/10.32571/ijct.1884419
AMA
1.Taylan O, Bulut M, Erenler R. Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology. Int. J. Chem. Technol. 2026;(10):1-18. doi:10.32571/ijct.1884419
Chicago
Taylan, Osman, Menekşe Bulut, and Ramazan Erenler. 2026. “Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology”. International Journal of Chemistry and Technology, nos. 10: 1-18. https://doi.org/10.32571/ijct.1884419.
EndNote
Taylan O, Bulut M, Erenler R (June 1, 2026) Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology. International Journal of Chemistry and Technology 10 1–18.
IEEE
[1]O. Taylan, M. Bulut, and R. Erenler, “Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology”, Int. J. Chem. Technol., no. 10, pp. 1–18, June 2026, doi: 10.32571/ijct.1884419.
ISNAD
Taylan, Osman - Bulut, Menekşe - Erenler, Ramazan. “Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology”. International Journal of Chemistry and Technology. 10 (June 1, 2026): 1-18. https://doi.org/10.32571/ijct.1884419.
JAMA
1.Taylan O, Bulut M, Erenler R. Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology. Int. J. Chem. Technol. 2026;:1–18.
MLA
Taylan, Osman, et al. “Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology”. International Journal of Chemistry and Technology, no. 10, June 2026, pp. 1-18, doi:10.32571/ijct.1884419.
Vancouver
1.Osman Taylan, Menekşe Bulut, Ramazan Erenler. Elucidating the Optimization Parameters of Essential Oil, Bornyl Acetate and Cisplatin in The Suppression of Cancer Cells Using Response Surface Methodology. Int. J. Chem. Technol. 2026 Jun. 1;(10):1-18. doi:10.32571/ijct.1884419