The synthesizing of different hydrogel nanocarriers for oral insulin delivery

Year 2020, Volume: 4 Issue: 1, 16 - 21, 30.06.2020

Pelin Peker Burcu Okutucu

https://doi.org/10.32571/ijct.679553

Abstract

Diabetes is seen as the global health problem of the world due to the high risk of complications and the increasing prevalence of death. The routine diagnosis of diabetes is the injection of insulin. This treatment has a lot of side effects known to the patient (infection at injection sites, irritation, etc.). In order to overcome such conditions in the treatment of diabetes and provide faster recovery, many different delivery systems for insulin are being studied. Hydrogels are interesting polymers with hydrophobic structure that can be designed in 3D networks for oral insulin delivery. In this study, we studied the synthesis of biodegradable, biocompatible, low-toxicity therapeutic hydrogels. Acrylamide (ACR):carboxymethyl cellulose (CMC) (ACR/CMC), Acrylamide (ACR): Chitosan (Chi) and Chitosan:glutaraldehyde hydrogels were prepared. The CMC was used in acrylamide-based hydrogels for both comonomer and biocompatibility. The swelling capacity of hydrogels and the in vitro release of insulin from hydrogels were studied at different pH. Insulin release studies have shown that ACR/CMC hydrogels are a good and new alternative as an oral insulin carrier.

Keywords

Hydrogel, insulin, delivery systems, diabetes, acrylamide

Project Number

17FEN008

References

• 1. Hu, C.; Weiping, J. Adv. Drug Deliver Rev. 2019, 139, 3-15.
• 2. Khursheed, R.; Singh, K. S.; Wadhwa, S.; Kapoor, B.; Gulati, M.; Kumar, R.; Ramanunny, A. K.; Awasthi, A.; Dua, K. Eur. J. Pharmacol. 2019, 862, 172625-172662.
• 3. Tan, S. Y.; Wong, J. L. M.; Sim, Y. J.; Wong, S. S.; Elhassan, S. A. M.; Tan, S. H.; Lim, G. P. L.; Tay, N. W. R.; Annan, N. C.; Bhattamisra, S. K.; Candasamy, M. Diabetes Metab. Syndr. 2019, 13, 364-372.
• 4. Vega-Villa, K. R.; Takemoto, J. K.; Yáñez, J. A.; Remsberg, C. M.; Forrest, M. L.; Davies Neal, M. Adv. Drug Deliver Rev. 2008, 60, 929-938.
• 5. Ciappellano, S. G.; Tedesco, E.; Venturini, M.; Benetti F. Adv. Drug Deliver Rev. 2016, 106, 381-401
• 6. Chaturvedi, K.; Ganguly, K.; Nadagouda, M. N.; Aminabhavi, T.M. J. Control. Release 2013, 165, 129-138.
• 7. Nur, M.; Vasiljevic, T. Int. J. Biol. Macromol. 2017, 103, 889-901.
• 8. Kumar, A.; Lahiri, S. S.; Singh, H. Int. J. Pharmacol. 2006, 323, 117-124.
• 9. Taleb, M. F. A. Int. J. Biol. Macromol. 2013, 62, 341-347.
• 10. Wonga, C. Y.; Al-Salamia, H.; Dassa C.R. Int. J. Pharmacol. 2018, 537, 223-244.
• 11. Pande, P. P. IJMS. 2017, 12, 11-14.
• 12. Mahinroosta, M.; Farsangi, Z. J.; Allahverdi, A.; Shakoori, Z. Mater. Today Chem. 2018, 8, 42-55.
• 13. Kabiri, K.; Zohuriaan-Mehr, M. J. Iran. Polym. J. 2008, 17, 451-477.
• 14. Li, X.; Fu, M.; Wu, J.; Zhang, C.; Deng, X.; Dhinakar, A.; Huang, W.; Qian, H.; Ge, L. Acta Biomater. 2017, 51, 294-303.
• 15. Li, Y.; Huang, G.; Zhang, X.; Li, B.; Chen, Y.; Lu, T.; Lu, T. J.; Xu, F. Adv. Funct. Mater. 2012, 23, 660-672.
• 16. Zhao, W.; Jin, X.; Cong, Y.; Liu, Y.; Fu, J. J. Chem. Technol. Biot. 2013, 88, 327-339.
• 17. Sharpe, L. A.; Daily, A. M.; Horava, S. D.; Peppas, N. A. Expert. Opin. Drug Del. 2014, 11, 901-915.
• 18. Basu, P.; Narendrakumar, U.; Arunachalam, R.; Devi, S.; Manjubala, I. ACS Omega. 2018, 3 (10), 12622-12632.
• 19. Barbucci, R.; Magnani, A.; Consumi, M. Macromolecules 2000, 33, 7475-7480
• 20. Ng, S. F.; Jumaat, N. Eur. J. Pharm Sci. 2014, 51, 173-179.
• 21. Miller, G. L. Anal. Chem. 1959, 31, 426-428.
• 22. Nizam, El-Din, H.M.; Abd Alla, S. G.; El-Naggar, A. W .M. Radiat. Phys. Chem. 2010, 79, 725-730.
• 23. Varaprasad, K.; Narayana Reddy, N.; Mithil Kumar, N.; Vimala, K.; Ravindra, S.; Mohana Raju, K. Int. J. Polym. Mater. Po. 2010, 59 (12), 981-993.
• 24. Mirzaei, E. B.; Ramazani, S. A. A.; Shafiee, M.; Danaei, M. Int. J. Polym. Mater. Po. 2013, 62, 605-611.
• 25. Nur Raihan, M.; Nadras, O.; Zulkifl, A.; Fauzi, R. Adv. Mater. Res. 2013, 812, 20-29.
• 26. Chavda, H. V.; Patel, C. N. Int. J. Pharm. Investig. 2011, 1 (1), 17-21.