Research Article
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Year 2021, Volume: 5 Issue: 2, 156 - 161, 31.12.2021

Uğur Güller

https://doi.org/10.32571/ijct.944620
Cited By: 2

Abstract

References

  • Blennow, K.; de Leon, M. J.; Zetterberg, H. Lancet (London, England) 2006, 368 (9533), 387-403.
  • Burns, A.; Iliffe, S. BMJ (Clinical researched) 2009, 338:b158.
  • Reitz, C.; Mayeux, R. Biochemical pharmacology 2014, 88 (4), 640-651.
  • Baptista, F. I.; Henriques, A. G.; Silva, A. M.; Wiltfang, J.; da Cruz e Silva, O. A. ACS chemical neuroscience 2014, 5 (2), 83-92.
  • Du, X.; Wang, X.; Geng, M. Translational neurodegeneration 2018, 7 (1), 1-7.
  • Hardy, J.; Selkoe, D. J. science 2002, 297 (5580), 353-356.
  • Tang, B. L.; Kumar, R. Ann Acad Med Singapore 2008, 37 (5), 406-5.
  • Coyle, J. T.; Price, D. L.; Delong, M. R. Science 1983, 219 (4589), 1184-1190.
  • Blokland, A., Brain Research Reviews 1995, 21 (3), 285-300.
  • Francis, P. T.; Palmer, A. M.; Snape, M.; Wilcock, G. K. Journal of Neurology, Neurosurgery & Psychiatry 1999, 66 (2), 137-147.
  • H Ferreira-Vieira, T.; M Guimaraes, I.; R Silva, F.; M Ribeiro, F. Current neuropharmacology 2016, 14 (1), 101-115.
  • Pope, C. N.; Brimijoin, S. Biochemical pharmacology 2018, 153, 205-216.
  • Greig, N. H.; Utsuki, T.; Yu, Q.-s.; Zhu, X.; Holloway, H. W.; Perry, T.; Lee, B.; Ingram, D. K.; Lahiri, D. K. Current medical research and opinion 2001, 17 (3), 159-165.
  • Ahmad, B.; Mukarram Shah, S.; Khan, H.; Hassan Shah, S. Journal of enzyme inhibition and medicinal chemistry 2007, 22 (6), 730-732.
  • Colovic, M. B.; Krstic, D. Z.; Lazarevic-Pasti, T. D.; Bondzic, A. M.; Vasic, V. M. Current neuropharmacology 2013, 11 (3), 315-335.
  • Sun, Y.; Lai, M. S.; Lu, C. J.; Chen, R. C. European journal of neurology 2008, 15 (3), 278-283.
  • Kozubek, A.; Tyman, J. H. P. Chem Rev 1999, 99 (1), 1-25.
  • Srimai, V.; Ramesh, M.; Parameshwar, K. S.; Parthasarathy, T. Medicinal Chemistry Research 2013, 22 (11), 5314-5323.
  • Worek, F.; Mast, U.; Kiderlen, D.; Diepold, C.; Eyer, P. Clinica Chimica Acta 1999, 288 (1-2), 73-90.
  • Bradford, M. M. Anal Biochem 1976, 72 (1-2), 248-254.
  • Guller, U.; Guller, P.; Ciftci, M. Altern Ther Health Med 2020.
  • Adem, S.; Akkemik, E.; Aksit, H.; Guller, P.; Tufekci, A. R.; Demirtas, I.; Ciftci, M. Medicinal Chemistry Research 2019, 28 (5), 711-722.
  • Cheung, J.; Rudolph, M. J.; Burshteyn, F.; Cassidy, M. S.; Gary, E. N.; Love, J.; Franklin, M. C.; Height, J. J. Journal of medicinal chemistry 2012, 55 (22), 10282-10286.
  • Morris, G. M.; Huey, R.; Lindstrom, W.; Sanner, M. F.; Belew, R. K.; Goodsell, D. S.; Olson, A. J, J Comput Chem 2009, 30 (16), 2785-2791.
  • Geula, C.; Mesulam, M. M. Cholinergic Systems in Alzheimer’s Disease, Alzheimer Disease. 2 ed.; Lippincott, Williams and Wilkins: Philadelphia, PA, 1999.
  • Dhanasekaran, S.; Perumal, P.; Palayan, M. Journal of Applied Pharmaceutical Science 2015, 5 (02), 012-016.
  • Forette, F. B. Alzheimer Hastalığında İlaç Geliştirilmesi: Tarihçesine Bakış ve Geleceğine İlişkin Öngörüler. In Alzheimer Hastalığının Farmakoterapisi, Gauthier, S., Ed. Yelkovan Yayıncılık: İstanbul, 2000; pp 1-5.
  • Bores, G. M.; Huger, F. P.; Petko, W.; Mutlib, A. E.; Camacho, F.; Rush, D. K.; Selk, D. E.; Wolf, V.; Kosley, R.; Davis, L. Journal of Pharmacology and Experimental Therapeutics 1996, 277 (2), 728-738.
  • Giacobini, E. Cholinesterase Inhibitors. In Enzymes of the cholinesterase family, Springer: 1995; pp 463-469.
  • Abbasi, M. A.; Hassan, M.; Siddiqui, S. Z.; Shah, S. A. A.; Raza, H.; Seo, S. Y. PeerJ 2018, 6, e4962.
  • Biscussi, B.; Sequeira, M. A.; Richmond, V.; Mañez, P. A.; Murray, A. P. Journal of Photochemistry and Photobiology A: Chemistry 2021, 113375.
  • Song, M.-q.; Min, W.; Wang, J.; Si, X.-X.; Wang, X.-J.; Liu, Y.-W.; Shi, D.-H. Journal of Molecular Structure 2021, 1229, 129784.
  • Zhao, Y.; Ye, F.; Xu, J.; Liao, Q.; Chen, L.; Zhang, W.; Sun, H.; Liu, W.; Feng, F.; Qu, W. Bioorganic & medicinal chemistry 2018, 26 (13), 3812-3824.
  • Lopes, J. P. B.; Silva, L.; da Costa Franarin, G.; Ceschi, M. A.; Lüdtke, D. S.; Dantas, R. F.; de Salles, C. M. C.; Silva-Jr, F. P.; Senger, M. R.; Guedes, I. A. Bioorganic & medicinal chemistry 2018, 26 (20), 5566-5577.
  • Krátký, M.; Štěpánková, Š.; Vorčáková, K.; Vinšová, J. Bioorganic chemistry 2018, 80, 668-673.
  • Guevara, J. A.; Trujillo, J. G.; Quintana, D.; Jiménez, H. A.; Arellano, M. G.; Bahena, J. R.; Tamay, F.; Ciprés, F. J. Medicinal Chemistry Research 2018, 27 (3), 989-1003.
  • Kurt, B. Z.; Gazioglu, I.; Kandas, N. O.; Sonmez, F. ChemistrySelect 2018, 3 (14), 3978-3983.
  • Güller, P.; Dağalan, Z.; Güller, U.; Çalışır, U.; Nişancı, B. Journal of Molecular Structure 2021, 1239, 130498.
  • Valencia, M. E.; Herrera-Arozamena, C.; de Andrés, L.; Pérez, C.; Morales-García, J. A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Viña, D.; Yáñez, M. European journal of medicinal chemistry 2018, 156, 534-553.
  • Güller, P. Journal of Molecular Structure 2021, 1228, 129790.
  • Zhang, X.-Z.; Xu, Y.; Jian, M.-M.; Yang, K.; Ma, Z.-Y. Medicinal Chemistry Research 2019, 28 (10), 1683-1693.
  • Fernandes, T. B.; Cunha, M. R.; Sakata, R. P.; Candido, T. M.; Baby, A. R.; Tavares, M. T.; Barbosa, E. G.; Almeida, W. P.; Parise‐Filho, R. Archiv der Pharmazie 2017, 350 (11), 1700163.

Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study

Year 2021, Volume: 5 Issue: 2, 156 - 161, 31.12.2021

Uğur Güller

https://doi.org/10.32571/ijct.944620
Cited By: 2

Abstract

Inhibitors of Acetylcholinesterase (Acetylcholine acetylhydrolase, AChE, E.C.3.1.1.7) are highly significant in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) due to the deep relationship with memory and acetylcholine. So investigation of natural AChE inhibitors having minimal side effects has become important. In this paper human erythrocytes AChE enzyme (0.032 EU mg-1 protein) was partially isolated by using DE-52 anion exchange chromatography. Then, primer effects of resorcinol derivatives on the enzyme activity were studied and IC50 values were found in the range of 2.74-363.61 µM. Besides, inhibition profiles were elucidated by molecular docking and the highest inhibition potency was observed in 4-hexylresorcinol with the free binding energy of -6.16 kcal mol-1. In conclusion, by using both in vitro and in silico approaches it was found that 4-hexylresorcinol had the highest inhibitory potential on human AChE. So, this compound may be used in drug design in memory-lost diseases.

Keywords

Acetylcholinesterase resorcinol inhibition molecular docking

References

  • Blennow, K.; de Leon, M. J.; Zetterberg, H. Lancet (London, England) 2006, 368 (9533), 387-403.
  • Burns, A.; Iliffe, S. BMJ (Clinical researched) 2009, 338:b158.
  • Reitz, C.; Mayeux, R. Biochemical pharmacology 2014, 88 (4), 640-651.
  • Baptista, F. I.; Henriques, A. G.; Silva, A. M.; Wiltfang, J.; da Cruz e Silva, O. A. ACS chemical neuroscience 2014, 5 (2), 83-92.
  • Du, X.; Wang, X.; Geng, M. Translational neurodegeneration 2018, 7 (1), 1-7.
  • Hardy, J.; Selkoe, D. J. science 2002, 297 (5580), 353-356.
  • Tang, B. L.; Kumar, R. Ann Acad Med Singapore 2008, 37 (5), 406-5.
  • Coyle, J. T.; Price, D. L.; Delong, M. R. Science 1983, 219 (4589), 1184-1190.
  • Blokland, A., Brain Research Reviews 1995, 21 (3), 285-300.
  • Francis, P. T.; Palmer, A. M.; Snape, M.; Wilcock, G. K. Journal of Neurology, Neurosurgery & Psychiatry 1999, 66 (2), 137-147.
  • H Ferreira-Vieira, T.; M Guimaraes, I.; R Silva, F.; M Ribeiro, F. Current neuropharmacology 2016, 14 (1), 101-115.
  • Pope, C. N.; Brimijoin, S. Biochemical pharmacology 2018, 153, 205-216.
  • Greig, N. H.; Utsuki, T.; Yu, Q.-s.; Zhu, X.; Holloway, H. W.; Perry, T.; Lee, B.; Ingram, D. K.; Lahiri, D. K. Current medical research and opinion 2001, 17 (3), 159-165.
  • Ahmad, B.; Mukarram Shah, S.; Khan, H.; Hassan Shah, S. Journal of enzyme inhibition and medicinal chemistry 2007, 22 (6), 730-732.
  • Colovic, M. B.; Krstic, D. Z.; Lazarevic-Pasti, T. D.; Bondzic, A. M.; Vasic, V. M. Current neuropharmacology 2013, 11 (3), 315-335.
  • Sun, Y.; Lai, M. S.; Lu, C. J.; Chen, R. C. European journal of neurology 2008, 15 (3), 278-283.
  • Kozubek, A.; Tyman, J. H. P. Chem Rev 1999, 99 (1), 1-25.
  • Srimai, V.; Ramesh, M.; Parameshwar, K. S.; Parthasarathy, T. Medicinal Chemistry Research 2013, 22 (11), 5314-5323.
  • Worek, F.; Mast, U.; Kiderlen, D.; Diepold, C.; Eyer, P. Clinica Chimica Acta 1999, 288 (1-2), 73-90.
  • Bradford, M. M. Anal Biochem 1976, 72 (1-2), 248-254.
  • Guller, U.; Guller, P.; Ciftci, M. Altern Ther Health Med 2020.
  • Adem, S.; Akkemik, E.; Aksit, H.; Guller, P.; Tufekci, A. R.; Demirtas, I.; Ciftci, M. Medicinal Chemistry Research 2019, 28 (5), 711-722.
  • Cheung, J.; Rudolph, M. J.; Burshteyn, F.; Cassidy, M. S.; Gary, E. N.; Love, J.; Franklin, M. C.; Height, J. J. Journal of medicinal chemistry 2012, 55 (22), 10282-10286.
  • Morris, G. M.; Huey, R.; Lindstrom, W.; Sanner, M. F.; Belew, R. K.; Goodsell, D. S.; Olson, A. J, J Comput Chem 2009, 30 (16), 2785-2791.
  • Geula, C.; Mesulam, M. M. Cholinergic Systems in Alzheimer’s Disease, Alzheimer Disease. 2 ed.; Lippincott, Williams and Wilkins: Philadelphia, PA, 1999.
  • Dhanasekaran, S.; Perumal, P.; Palayan, M. Journal of Applied Pharmaceutical Science 2015, 5 (02), 012-016.
  • Forette, F. B. Alzheimer Hastalığında İlaç Geliştirilmesi: Tarihçesine Bakış ve Geleceğine İlişkin Öngörüler. In Alzheimer Hastalığının Farmakoterapisi, Gauthier, S., Ed. Yelkovan Yayıncılık: İstanbul, 2000; pp 1-5.
  • Bores, G. M.; Huger, F. P.; Petko, W.; Mutlib, A. E.; Camacho, F.; Rush, D. K.; Selk, D. E.; Wolf, V.; Kosley, R.; Davis, L. Journal of Pharmacology and Experimental Therapeutics 1996, 277 (2), 728-738.
  • Giacobini, E. Cholinesterase Inhibitors. In Enzymes of the cholinesterase family, Springer: 1995; pp 463-469.
  • Abbasi, M. A.; Hassan, M.; Siddiqui, S. Z.; Shah, S. A. A.; Raza, H.; Seo, S. Y. PeerJ 2018, 6, e4962.
  • Biscussi, B.; Sequeira, M. A.; Richmond, V.; Mañez, P. A.; Murray, A. P. Journal of Photochemistry and Photobiology A: Chemistry 2021, 113375.
  • Song, M.-q.; Min, W.; Wang, J.; Si, X.-X.; Wang, X.-J.; Liu, Y.-W.; Shi, D.-H. Journal of Molecular Structure 2021, 1229, 129784.
  • Zhao, Y.; Ye, F.; Xu, J.; Liao, Q.; Chen, L.; Zhang, W.; Sun, H.; Liu, W.; Feng, F.; Qu, W. Bioorganic & medicinal chemistry 2018, 26 (13), 3812-3824.
  • Lopes, J. P. B.; Silva, L.; da Costa Franarin, G.; Ceschi, M. A.; Lüdtke, D. S.; Dantas, R. F.; de Salles, C. M. C.; Silva-Jr, F. P.; Senger, M. R.; Guedes, I. A. Bioorganic & medicinal chemistry 2018, 26 (20), 5566-5577.
  • Krátký, M.; Štěpánková, Š.; Vorčáková, K.; Vinšová, J. Bioorganic chemistry 2018, 80, 668-673.
  • Guevara, J. A.; Trujillo, J. G.; Quintana, D.; Jiménez, H. A.; Arellano, M. G.; Bahena, J. R.; Tamay, F.; Ciprés, F. J. Medicinal Chemistry Research 2018, 27 (3), 989-1003.
  • Kurt, B. Z.; Gazioglu, I.; Kandas, N. O.; Sonmez, F. ChemistrySelect 2018, 3 (14), 3978-3983.
  • Güller, P.; Dağalan, Z.; Güller, U.; Çalışır, U.; Nişancı, B. Journal of Molecular Structure 2021, 1239, 130498.
  • Valencia, M. E.; Herrera-Arozamena, C.; de Andrés, L.; Pérez, C.; Morales-García, J. A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Viña, D.; Yáñez, M. European journal of medicinal chemistry 2018, 156, 534-553.
  • Güller, P. Journal of Molecular Structure 2021, 1228, 129790.
  • Zhang, X.-Z.; Xu, Y.; Jian, M.-M.; Yang, K.; Ma, Z.-Y. Medicinal Chemistry Research 2019, 28 (10), 1683-1693.
  • Fernandes, T. B.; Cunha, M. R.; Sakata, R. P.; Candido, T. M.; Baby, A. R.; Tavares, M. T.; Barbosa, E. G.; Almeida, W. P.; Parise‐Filho, R. Archiv der Pharmazie 2017, 350 (11), 1700163.
There are 42 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Articles
Authors

Uğur Güller 0000-0003-0704-5984

Publication Date December 31, 2021
Published in Issue Year 2021 Volume: 5 Issue: 2

Cite

APA Güller, U. (2021). Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study. International Journal of Chemistry and Technology, 5(2), 156-161. https://doi.org/10.32571/ijct.944620
AMA Güller U. Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study. Int. J. Chem. Technol. December 2021;5(2):156-161. doi:10.32571/ijct.944620
Chicago Güller, Uğur. “Resorcinol Derivatives As Human Acetylcholinesterase Inhibitor: An In Vitro and In Silico Study”. International Journal of Chemistry and Technology 5, no. 2 (December 2021): 156-61. https://doi.org/10.32571/ijct.944620.
EndNote Güller U (December 1, 2021) Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study. International Journal of Chemistry and Technology 5 2 156–161.
IEEE U. Güller, “Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study”, Int. J. Chem. Technol., vol. 5, no. 2, pp. 156–161, 2021, doi: 10.32571/ijct.944620.
ISNAD Güller, Uğur. “Resorcinol Derivatives As Human Acetylcholinesterase Inhibitor: An In Vitro and In Silico Study”. International Journal of Chemistry and Technology 5/2 (December 2021), 156-161. https://doi.org/10.32571/ijct.944620.
JAMA Güller U. Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study. Int. J. Chem. Technol. 2021;5:156–161.
MLA Güller, Uğur. “Resorcinol Derivatives As Human Acetylcholinesterase Inhibitor: An In Vitro and In Silico Study”. International Journal of Chemistry and Technology, vol. 5, no. 2, 2021, pp. 156-61, doi:10.32571/ijct.944620.
Vancouver Güller U. Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study. Int. J. Chem. Technol. 2021;5(2):156-61.

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