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Year 2024, Volume: 4 Issue: 2, 74 - 81, 30.08.2024

Berna Özdem , Esra Erdoğan

https://doi.org/10.61139/ijdor.1535333

Abstract

References

  • 1. Alam MS. Department of Entomology, Sher-e-Bangla Agricultural University, Dhaka. 2016.
  • 2. Seidel V, Peyfoon E, Watson DG, Fearnley J. Comparative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Res 2008; 22(3):1256-1263.
  • 3. Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi J Biol Sci 2020; 27(6):3079-3086.
  • 4. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005; 366(9499):1809-1820.
  • 5. Piekarz T, Khabeer A, Faridi MA, Makhdoom G. The influence of toothpaste containing Australian Melaleuca alternifolia oil and ethanolic extract of Polish propolis on oral hygiene and microbiome in patients requiring conservative procedures. Molecules 2017; 22(1957):1-8.
  • 6. Saeed MA, Khabeer A, Faridi MA, Makhdoom G. Effectiveness of propolis in maintaining oral health: a scoping review. Can J Dent Hyg 2021; 55(2):167-176.
  • 7. Ahuja V, Ahuja A. Apitherapy—A sweet approach to dental diseases. Part II: Propolis. J Adv Oral Res 2011; 2(1):1-8.
  • 8. Etebarian A, Alhouei B, Mohammadi-Nasrabadi F, Esfarjani F. Propolis as a functional food and promising agent for oral health and microbiota balance: A review study. Food Sci Nutr 2024; 12(3):100-108.
  • 9. Martins ML, de Oliveira T, Jr LSC, Figueiredo SM, Arruda AM, Brilhante AM, et al. Efficacy of red propolis hydro-alcoholic extract in controlling Streptococcus mutans biofilm build-up and dental enamel demineralization. Arch Oral Biol 2018; 93:56-65.
  • 10. Bapat S, Nagarajappa R, Ramesh G, Bapat K. Effect of propolis mouth rinse on oral microorganisms—A randomized controlled trial. Clin Oral Investig 2021; 25(1):10-18.
  • 11. Özdem B. Microbiota: A Potential Therapy for Autism. J Immunol Clin Microbiol 2020; 5(2):97-105.
  • 12. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients 2019; 11(11):2705-2710.
  • 13. Veloz JJ, Alvear M, Salazar LA. Antimicrobial and antibiofilm activity against Streptococcus mutans of individual and mixtures of the main polyphenolic compounds found in Chilean propolis. Biomed Res Int 2019; 2019:7602343.
  • 14. Ünal F, Yıldız B. Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. Gazi Univ Fen Fak Derg 2022; 3(2):102-110.
  • 15. Oršolić N, Jazvinšćak Jembrek M. Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer. Int J Mol Sci 2022; 23(21):10479.
  • 16. da Silva Barboza A, Aitken-Saavedra JP, Ferreira ML, Aranha AMF, Lund RG. Are propolis extracts potential pharmacological agents in human oral health? -A scoping review and technology prospecting. J Ethnopharmacol 2021; 271:113846.
  • 17. Abo-Salem OM, El-Edel RH, Harisa G, El-Halawany N, Ghonaim MM. Experimental diabetic nephropathy can be prevented by propolis: Effect on metabolic disturbances and renal oxidative parameters. Pak J Pharm Sci 2009; 22(2):205-210.
  • 18. Ansorge S, Reinhold D, Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-β1 production of human immune cells. Z Naturforsch C 2003; 58(9-10):580-589.
  • 19. Peres MA, et al. Oral diseases: a global public health challenge. Lancet 2019; 394(10194):249-260.
  • 20. Fejerskov O, Nyvad B, Kidd E. Dental caries: The disease and its clinical management. John Wiley & Sons; 2015. 20-35.
  • 21. Cummins D. Dental caries: A disease which remains a public health concern in the 21st century–the exploration of a breakthrough technology for caries prevention. J Clin Dent 2013; 24(A1)
  • 22. Takahashi N, Nyvad B. The role of bacteria in the caries process: ecological perspectives. J Dent Res 2011; 90(3):294-303.
  • 23. Bowen W, Koo H. Biology of Streptococcus mutans-derived glucosyltransferases: Role in extracellular matrix formation of cariogenic biofilms. Caries Res 2011; 45(1):69-86.
  • 24. Zulhendri F, Felitti R, Fearnley J, Ravalia M. The use of propolis in dentistry, oral health, and medicine: A review. J Oral Biosci 2021; 63(1):23-34.
  • 25. Asgharpour F, Farahmand A, et al. Iranian propolis efficiently inhibits growth of oral streptococci and cancer cell lines. BMC Complement Altern Med 2019; 19(1):1-8.
  • 26. Özen T, Can Z, et al. In vitro activity of Turkish propolis samples against anaerobic bacteria causing oral cavity infections. Kafkas Univ Vet Fak Derg 2010; 16(4):555-560.
  • 27. Flemming HC, Wingender J. The biofilm matrix. Nat Rev Microbiol 2010; 8(9):623-633.
  • 28. Hall-Stoodley L, Costerton JW, Stoodley P. Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2004; 2(2):95-108.
  • 29. Morita K, et al. Association between salivary alpha-amylase and subjective and objective oral parafunctions in community-dwelling elderly individuals. J Dent Sci 2020; 15(3):310-314.
  • 30. Ali S, et al. Efficacy of propolis in remineralizing artificially induced demineralization of human enamel—An in vitro study. J Taibah Univ Med Sci 2021; 16(3):283-287.
  • 31. Fraire-Reyes IA, et al. Use and effectiveness of propolis on chronic periodontitis: A systematic review. Odovtos Int J Dent Sci 2022; 24(1):32-43.
  • 32. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci 2017; 11(1):72-81.
  • 33. Albandar JM, Tinoco E. Global epidemiology of periodontal diseases in children and young persons. Periodontol 2000 2002; 29(1):153-176.
  • 34. Lang NP, Bartold PM. Periodontal health. J Periodontol 2018; 89(S1)
  • 35. Peycheva S, et al. Effect of Bulgarian propolis on the oral microflora in adolescents with plaque-induced gingivitis. Rev Bras Farmacogn 2019; 29(2):271-277.
  • 36. El-Tayeb M, Abu-Seida A, El Ashry S, El-Hady S. Evaluation of antibacterial activity of propolis on regenerative potential of necrotic immature permanent teeth in dogs. BMC Oral Health 2019; 19(1):1-12.
  • 37. Nam S, Choi Y, Jang S, Shim Y, Han G. Antimicrobial activity of propolis on different oral bacteria. Indian J Sci Technol 2016; 9(1):1-4.
  • 38. Cai X, Fang Z, Dou J, Yu A, Zhai G. Bioavailability of quercetin: problems and promises. Curr Med Chem 2013; 20(20):2572-2582.
  • 39. Marsh PD. Dental plaque as a biofilm and a microbial community–implications for health and disease. BMC Oral Health 2006; 6(Suppl 1)
  • 40. Likitpongpipat N, et al. Promotion of dental pulp wound healing in New Zealand white rabbits’ teeth by Thai propolis product. J Vet Dent 2019; 36(1):17-24.
  • 41. Lisbona-González MJ, et al. Effect of propolis paste and mouthwash formulation on healing after teeth extraction in periodontal disease. Plants 2021; 10(8):1603.
  • 42. Niedzielska I, et al. The influence of ethanolic extract of Brazilian green propolis gel on hygiene and oral microbiota in patients after mandible fractures. Biomed Res Int 2016; 2016:9190814.
  • 43. Addy M, West NX. The role of toothpaste in the aetiology and treatment of dentine hypersensitivity. Toothpastes 2013; 23(1):75-87.
  • 44. Gillam D, Orchardson R. Advances in the treatment of root dentine sensitivity: mechanisms and treatment principles. Endod Topics 2006; 13(1):13-33.
  • 45. Samir Z, Qasim AA. Effect of Different Natural Herbal Products on Microhardness of Eroded Enamel Surface: An in Vitro Study. Al-Rafidain Dent J 2023; 23(3):263-273.
  • 46. Torwane NA, et al. A clinical efficacy of 30% ethanolic extract of Indian propolis and Recaldent in management of dentinal hypersensitivity: A comparative randomized clinical trial. Eur J Dent 2013; 7(4):461-468.
  • 47. Hwu YJ, Lin FY. Effectiveness of propolis on oral health: a systematic review. JBI Evid Synth 2013; 11(2):28-61.
  • 48. Tavares JAO, da Silva FA, Santos TML, Caneppele TMF, Augusto MG. The effectiveness of propolis extract in reducing dentin hypersensitivity: A systematic review. Arch Oral Biol 2021; 131:105248.
  • 49. AlQahtani SM, et al. Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study. Gels 2023; 9(2):483.
  • 50. Fernandes PM, et al. Brazilian organic propolis for prevention and treatment of radiation-related oral acute toxicities in head and neck cancer patients: A double-blind randomized clinical trial. Front Pharmacol 2022; 13:973255.
  • 51. Kumazawa S, Hamasaka T, Nakayama T. Antioxidant activity of propolis of various geographic origins. Food Chem 2004; 84(3):329-339.
  • 52. Oršolić N. A review of propolis antitumor action in vivo and in vitro. J ApiProd ApiMed Sci 2010; 2(1):1-20. 53. Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004; 4(4):277-284.
  • 54. Chaturvedi AK, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29(32):4294-4301.
  • 55. Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3):209-249.
  • 56. Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie 2000; 31(1):3-15.
  • 57. Sepúlveda C, Núñez O, Torres A, Guzmán L, Wehinger S. Antitumor activity of propolis: Recent advances in cellular perspectives, animal models and possible applications. Food Rev Int 2020; 36(5):429-455.
  • 58. Ahn MR, Kumazawa S, Hamasaka T, Bang KS, Nakayama T. Antioxidant activity and constituents of propolis collected in various areas of China. Food Chem 2007; 101(4):1383-1392.
  • 59. Salim EI, Abd El-Magid AD, Farara KM, Maria D. Antitumoral and antioxidant potential of Egyptian propolis against the PC3 prostate cancer cell line. Asian Pac J Cancer Prev 2015; 16(17):7641-7651.
  • 60. Öznurhan F, et al. antimicrobial efficacy of chlorhexidine and licorice mouthwashes in children. Meandros Med Dent J 2019; 20(1):10-15.
  • 61. Kurek-Gorecka A, et al. The influence of propolis on dental plaque reduction and the correlation between dental plaque and severity of COVID-19 complications—a literature review. Molecules 2021; 26(18):5516.
  • 62. Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia 2002; 73(S1)
  • 63. Chan GC, Cheung KW, Sze DM. The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 2013; 44(3):262-273.
  • 64. Emami Kazemabad MJ, Sadeghi HM, Nabavi SF, Nabavi SM, Bishayee A. Pharmacotherapeutic potential of pomegranate in age-related neurological disorders. Front Aging Neurosci 2022; 14:955735.
  • 65. Negara JP, No JSR. Immunomodulatory and in vivo antiplasmodial activities of propolis extracts. Am J Pharmacol Toxicol 2009; 4(2):75-79.
  • 66. Mendonça I. Propolis as an adjunct to prevention and treatment of radiotherapy- and chemotherapy-induced oral mucositis. Nurs Palliat Care 2016; 1(3):97-100.
  • 67. Kuo CC, Wang RH, Wang HH, Li CH. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer 2018; 26(3):4001-4009.

Effects of Propolis on Oral Health and Oral Cavity Cancers

Year 2024, Volume: 4 Issue: 2, 74 - 81, 30.08.2024

Berna Özdem , Esra Erdoğan

https://doi.org/10.61139/ijdor.1535333

Abstract

For centuries, people have used apitherapy, the therapeutic use of bee products like propolis, honey, bee venom, wax, pollen, and royal jelly, to prevent and treat various diseases. Propolis is well-known for its antimicrobial, anti-inflammatory, anticancer, and antioxidant properties. It contains over 300 bioactive compounds, including flavonoids, phenolics, and aromatic substances. Recent studies have highlighted its growing application in dentistry, especially in products like toothpaste, mouthwashes, and sprays, which have demonstrated efficacy in preventing dental caries, reducing gum inflammation, and accelerating the healing of oral ulcers. Moreover, due to its antioxidant capacity, propolis may help mitigate oxidative stress, potentially contributing to the prevention of oral cancer. Given its therapeutic potential in both oral health and oncology, propolis emerges as a promising natural treatment option. However, further in-depth studies are required to fully elucidate its clinical potential and verify its efficacy and safety.

Keywords

Propolis Oral Health Oral Cancer Antimicrobial Antioxidant

References

  • 1. Alam MS. Department of Entomology, Sher-e-Bangla Agricultural University, Dhaka. 2016.
  • 2. Seidel V, Peyfoon E, Watson DG, Fearnley J. Comparative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Res 2008; 22(3):1256-1263.
  • 3. Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi J Biol Sci 2020; 27(6):3079-3086.
  • 4. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005; 366(9499):1809-1820.
  • 5. Piekarz T, Khabeer A, Faridi MA, Makhdoom G. The influence of toothpaste containing Australian Melaleuca alternifolia oil and ethanolic extract of Polish propolis on oral hygiene and microbiome in patients requiring conservative procedures. Molecules 2017; 22(1957):1-8.
  • 6. Saeed MA, Khabeer A, Faridi MA, Makhdoom G. Effectiveness of propolis in maintaining oral health: a scoping review. Can J Dent Hyg 2021; 55(2):167-176.
  • 7. Ahuja V, Ahuja A. Apitherapy—A sweet approach to dental diseases. Part II: Propolis. J Adv Oral Res 2011; 2(1):1-8.
  • 8. Etebarian A, Alhouei B, Mohammadi-Nasrabadi F, Esfarjani F. Propolis as a functional food and promising agent for oral health and microbiota balance: A review study. Food Sci Nutr 2024; 12(3):100-108.
  • 9. Martins ML, de Oliveira T, Jr LSC, Figueiredo SM, Arruda AM, Brilhante AM, et al. Efficacy of red propolis hydro-alcoholic extract in controlling Streptococcus mutans biofilm build-up and dental enamel demineralization. Arch Oral Biol 2018; 93:56-65.
  • 10. Bapat S, Nagarajappa R, Ramesh G, Bapat K. Effect of propolis mouth rinse on oral microorganisms—A randomized controlled trial. Clin Oral Investig 2021; 25(1):10-18.
  • 11. Özdem B. Microbiota: A Potential Therapy for Autism. J Immunol Clin Microbiol 2020; 5(2):97-105.
  • 12. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients 2019; 11(11):2705-2710.
  • 13. Veloz JJ, Alvear M, Salazar LA. Antimicrobial and antibiofilm activity against Streptococcus mutans of individual and mixtures of the main polyphenolic compounds found in Chilean propolis. Biomed Res Int 2019; 2019:7602343.
  • 14. Ünal F, Yıldız B. Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. Gazi Univ Fen Fak Derg 2022; 3(2):102-110.
  • 15. Oršolić N, Jazvinšćak Jembrek M. Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer. Int J Mol Sci 2022; 23(21):10479.
  • 16. da Silva Barboza A, Aitken-Saavedra JP, Ferreira ML, Aranha AMF, Lund RG. Are propolis extracts potential pharmacological agents in human oral health? -A scoping review and technology prospecting. J Ethnopharmacol 2021; 271:113846.
  • 17. Abo-Salem OM, El-Edel RH, Harisa G, El-Halawany N, Ghonaim MM. Experimental diabetic nephropathy can be prevented by propolis: Effect on metabolic disturbances and renal oxidative parameters. Pak J Pharm Sci 2009; 22(2):205-210.
  • 18. Ansorge S, Reinhold D, Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-β1 production of human immune cells. Z Naturforsch C 2003; 58(9-10):580-589.
  • 19. Peres MA, et al. Oral diseases: a global public health challenge. Lancet 2019; 394(10194):249-260.
  • 20. Fejerskov O, Nyvad B, Kidd E. Dental caries: The disease and its clinical management. John Wiley & Sons; 2015. 20-35.
  • 21. Cummins D. Dental caries: A disease which remains a public health concern in the 21st century–the exploration of a breakthrough technology for caries prevention. J Clin Dent 2013; 24(A1)
  • 22. Takahashi N, Nyvad B. The role of bacteria in the caries process: ecological perspectives. J Dent Res 2011; 90(3):294-303.
  • 23. Bowen W, Koo H. Biology of Streptococcus mutans-derived glucosyltransferases: Role in extracellular matrix formation of cariogenic biofilms. Caries Res 2011; 45(1):69-86.
  • 24. Zulhendri F, Felitti R, Fearnley J, Ravalia M. The use of propolis in dentistry, oral health, and medicine: A review. J Oral Biosci 2021; 63(1):23-34.
  • 25. Asgharpour F, Farahmand A, et al. Iranian propolis efficiently inhibits growth of oral streptococci and cancer cell lines. BMC Complement Altern Med 2019; 19(1):1-8.
  • 26. Özen T, Can Z, et al. In vitro activity of Turkish propolis samples against anaerobic bacteria causing oral cavity infections. Kafkas Univ Vet Fak Derg 2010; 16(4):555-560.
  • 27. Flemming HC, Wingender J. The biofilm matrix. Nat Rev Microbiol 2010; 8(9):623-633.
  • 28. Hall-Stoodley L, Costerton JW, Stoodley P. Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2004; 2(2):95-108.
  • 29. Morita K, et al. Association between salivary alpha-amylase and subjective and objective oral parafunctions in community-dwelling elderly individuals. J Dent Sci 2020; 15(3):310-314.
  • 30. Ali S, et al. Efficacy of propolis in remineralizing artificially induced demineralization of human enamel—An in vitro study. J Taibah Univ Med Sci 2021; 16(3):283-287.
  • 31. Fraire-Reyes IA, et al. Use and effectiveness of propolis on chronic periodontitis: A systematic review. Odovtos Int J Dent Sci 2022; 24(1):32-43.
  • 32. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci 2017; 11(1):72-81.
  • 33. Albandar JM, Tinoco E. Global epidemiology of periodontal diseases in children and young persons. Periodontol 2000 2002; 29(1):153-176.
  • 34. Lang NP, Bartold PM. Periodontal health. J Periodontol 2018; 89(S1)
  • 35. Peycheva S, et al. Effect of Bulgarian propolis on the oral microflora in adolescents with plaque-induced gingivitis. Rev Bras Farmacogn 2019; 29(2):271-277.
  • 36. El-Tayeb M, Abu-Seida A, El Ashry S, El-Hady S. Evaluation of antibacterial activity of propolis on regenerative potential of necrotic immature permanent teeth in dogs. BMC Oral Health 2019; 19(1):1-12.
  • 37. Nam S, Choi Y, Jang S, Shim Y, Han G. Antimicrobial activity of propolis on different oral bacteria. Indian J Sci Technol 2016; 9(1):1-4.
  • 38. Cai X, Fang Z, Dou J, Yu A, Zhai G. Bioavailability of quercetin: problems and promises. Curr Med Chem 2013; 20(20):2572-2582.
  • 39. Marsh PD. Dental plaque as a biofilm and a microbial community–implications for health and disease. BMC Oral Health 2006; 6(Suppl 1)
  • 40. Likitpongpipat N, et al. Promotion of dental pulp wound healing in New Zealand white rabbits’ teeth by Thai propolis product. J Vet Dent 2019; 36(1):17-24.
  • 41. Lisbona-González MJ, et al. Effect of propolis paste and mouthwash formulation on healing after teeth extraction in periodontal disease. Plants 2021; 10(8):1603.
  • 42. Niedzielska I, et al. The influence of ethanolic extract of Brazilian green propolis gel on hygiene and oral microbiota in patients after mandible fractures. Biomed Res Int 2016; 2016:9190814.
  • 43. Addy M, West NX. The role of toothpaste in the aetiology and treatment of dentine hypersensitivity. Toothpastes 2013; 23(1):75-87.
  • 44. Gillam D, Orchardson R. Advances in the treatment of root dentine sensitivity: mechanisms and treatment principles. Endod Topics 2006; 13(1):13-33.
  • 45. Samir Z, Qasim AA. Effect of Different Natural Herbal Products on Microhardness of Eroded Enamel Surface: An in Vitro Study. Al-Rafidain Dent J 2023; 23(3):263-273.
  • 46. Torwane NA, et al. A clinical efficacy of 30% ethanolic extract of Indian propolis and Recaldent in management of dentinal hypersensitivity: A comparative randomized clinical trial. Eur J Dent 2013; 7(4):461-468.
  • 47. Hwu YJ, Lin FY. Effectiveness of propolis on oral health: a systematic review. JBI Evid Synth 2013; 11(2):28-61.
  • 48. Tavares JAO, da Silva FA, Santos TML, Caneppele TMF, Augusto MG. The effectiveness of propolis extract in reducing dentin hypersensitivity: A systematic review. Arch Oral Biol 2021; 131:105248.
  • 49. AlQahtani SM, et al. Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study. Gels 2023; 9(2):483.
  • 50. Fernandes PM, et al. Brazilian organic propolis for prevention and treatment of radiation-related oral acute toxicities in head and neck cancer patients: A double-blind randomized clinical trial. Front Pharmacol 2022; 13:973255.
  • 51. Kumazawa S, Hamasaka T, Nakayama T. Antioxidant activity of propolis of various geographic origins. Food Chem 2004; 84(3):329-339.
  • 52. Oršolić N. A review of propolis antitumor action in vivo and in vitro. J ApiProd ApiMed Sci 2010; 2(1):1-20. 53. Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004; 4(4):277-284.
  • 54. Chaturvedi AK, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29(32):4294-4301.
  • 55. Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3):209-249.
  • 56. Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie 2000; 31(1):3-15.
  • 57. Sepúlveda C, Núñez O, Torres A, Guzmán L, Wehinger S. Antitumor activity of propolis: Recent advances in cellular perspectives, animal models and possible applications. Food Rev Int 2020; 36(5):429-455.
  • 58. Ahn MR, Kumazawa S, Hamasaka T, Bang KS, Nakayama T. Antioxidant activity and constituents of propolis collected in various areas of China. Food Chem 2007; 101(4):1383-1392.
  • 59. Salim EI, Abd El-Magid AD, Farara KM, Maria D. Antitumoral and antioxidant potential of Egyptian propolis against the PC3 prostate cancer cell line. Asian Pac J Cancer Prev 2015; 16(17):7641-7651.
  • 60. Öznurhan F, et al. antimicrobial efficacy of chlorhexidine and licorice mouthwashes in children. Meandros Med Dent J 2019; 20(1):10-15.
  • 61. Kurek-Gorecka A, et al. The influence of propolis on dental plaque reduction and the correlation between dental plaque and severity of COVID-19 complications—a literature review. Molecules 2021; 26(18):5516.
  • 62. Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia 2002; 73(S1)
  • 63. Chan GC, Cheung KW, Sze DM. The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 2013; 44(3):262-273.
  • 64. Emami Kazemabad MJ, Sadeghi HM, Nabavi SF, Nabavi SM, Bishayee A. Pharmacotherapeutic potential of pomegranate in age-related neurological disorders. Front Aging Neurosci 2022; 14:955735.
  • 65. Negara JP, No JSR. Immunomodulatory and in vivo antiplasmodial activities of propolis extracts. Am J Pharmacol Toxicol 2009; 4(2):75-79.
  • 66. Mendonça I. Propolis as an adjunct to prevention and treatment of radiotherapy- and chemotherapy-induced oral mucositis. Nurs Palliat Care 2016; 1(3):97-100.
  • 67. Kuo CC, Wang RH, Wang HH, Li CH. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer 2018; 26(3):4001-4009.
There are 66 citations in total.

Details

Primary Language English
Subjects Oral Medicine and Pathology
Journal Section Reviews
Authors

Berna Özdem 0000-0002-4481-2866

Esra Erdoğan 0000-0003-1626-6033

Publication Date August 30, 2024
Submission Date August 18, 2024
Acceptance Date August 23, 2024
Published in Issue Year 2024 Volume: 4 Issue: 2

Cite

APA Özdem, B., & Erdoğan, E. (2024). Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU International Journal of Dentistry and Oral Research, 4(2), 74-81. https://doi.org/10.61139/ijdor.1535333
AMA Özdem B, Erdoğan E. Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU Int J Dent Oral Res. August 2024;4(2):74-81. doi:10.61139/ijdor.1535333
Chicago Özdem, Berna, and Esra Erdoğan. “Effects of Propolis on Oral Health and Oral Cavity Cancers”. HRU International Journal of Dentistry and Oral Research 4, no. 2 (August 2024): 74-81. https://doi.org/10.61139/ijdor.1535333.
EndNote Özdem B, Erdoğan E (August 1, 2024) Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU International Journal of Dentistry and Oral Research 4 2 74–81.
IEEE B. Özdem and E. Erdoğan, “Effects of Propolis on Oral Health and Oral Cavity Cancers”, HRU Int J Dent Oral Res, vol. 4, no. 2, pp. 74–81, 2024, doi: 10.61139/ijdor.1535333.
ISNAD Özdem, Berna - Erdoğan, Esra. “Effects of Propolis on Oral Health and Oral Cavity Cancers”. HRU International Journal of Dentistry and Oral Research 4/2 (August 2024), 74-81. https://doi.org/10.61139/ijdor.1535333.
JAMA Özdem B, Erdoğan E. Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU Int J Dent Oral Res. 2024;4:74–81.
MLA Özdem, Berna and Esra Erdoğan. “Effects of Propolis on Oral Health and Oral Cavity Cancers”. HRU International Journal of Dentistry and Oral Research, vol. 4, no. 2, 2024, pp. 74-81, doi:10.61139/ijdor.1535333.
Vancouver Özdem B, Erdoğan E. Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU Int J Dent Oral Res. 2024;4(2):74-81.
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