Do Therapeutic Exercises Improve Kinesophobia and Health-Related Quality of Life in Adult Hemophilia Patients? A randomized controlled trial.

Year 2020, Volume: 3 Issue: 1, 11 - 19, 20.06.2020

Volkan Deniz , Nevin Atalay Güzel

https://doi.org/10.33438/ijdshs.690280

Cited By: 2

Abstract

Objectives: Pain, risk of injury and physical limitations
lead to the development of kinesophobia and decrease in health-related quality
of life in hemophilia patients. The aim of this study was to investigate the effects
of therapeutic exercises on kinesophobia and health-related quality of life in
adult hemophilia patients. Material and
Methods: A total of 24 patients aged 18 to 42 years were included in the study.
Patients were randomly allocated to the control and exercise groups.Tampa Scale
of Kinesiophobia (TSK) was used for evaluation of kinesiophobia, Short Form-36
(SF-36) and Haemophilia Adult Quality of Life (Hem-A-Qol) were
used to assess health related quality of life. These evaluation scales were applied on the
participants of both groups before and at the end of the study. Therapeutic
exercises were administered to the exercise group three days a week for two months. Results: At  baseline
in
physical, sociodemographic-clinical data, SF-36 and Hem-A-Qol scores there was
not a significant difference between groups (p>0.05). However in
kinesophobia level, there was a significant difference in favor of the control
group (p<0.05). After the exercise
program, there was a significant
decrease in kinesophobia and increase in total SF-36 score in the exercise group
compared to the control group (p<0.05).
However there
was a decrease clinically in favor of the exercise group in total Hem-A-Qol
value, whereas this difference was not statistically meaningful (p>0.05). Conclusions:
Therapeutic
exercises are simple and safe treatment modalities that can be used to improve kinesophobia
and health-related quality of life in adult hemophilia patients. This improvement
can be attributed to physical wellness caused by exercises.

Keywords

hemophilia, kinesophobia, quality of life

References

• Bullinger, M., von Mackensen, S. (2008). Psycho-social determinants of quality of life in children and adolescents with haemophilia—a cross-cultural approach. Clin Psychol Psychother. 15(3): 164-172.
• Calatayud, J., Pérez-Alenda, S., Carrasco, JJ., Escriche, A., Cruz-Montecinos, C., Andersen, LL., Bonanad, S., Querol, F., Casaña, J. (2019). Upper-Body Exercises With External Resistance Are Well Tolerated and Enhance Muscle Activity in People With Hemophilia. Phys Ther. Apr 1;99(4):411-419.
• Cruz-Díaz, D., Romeu, M., Velasco-González, C., Martínez-Amat, A., Hita-Contreras, F. (2018). The effectiveness of 12 weeks of Pilates intervention on disability, pain and kinesiophobia in patients with chronic low back pain: a randomized controlled trial. Clin Rehabil. Sep;32(9):1249-1257.
• Cuesta-Barriuso, R,, Torres-Ortuño, A., Nieto-Munuera, J., López-Pina, JA. (2017). Effectiveness of an Educational Physiotherapy and Therapeutic Exercise Program in Adult Patients With Hemophilia: A Randomized Controlled Trial. Arch Phys Med Rehabil. May;98(5):841-848.
• Fischer, K., de Kleijn, P., Negrier, C., et al. (2016). The association of haemophilic arthropathy with health-related quality of life: a post hoc analysis. Haemophilia;22(6):833-840.
• Fischer, K., Van der Bom, JG., Mauser-Bunschoten, EP., Roosendal, G., Van dem Berg, HM. (2005). Effects of haemophilic arthropathy on health related quality of life and socio-economic parameters. Haemophilia;11:43-8.
• Hartl, HK., Reitter, S., Eidher, U., Ramschak, H., Ay, C., Pabinger I. (2008). The impact of severe haemophilia on the social status and quality of life among Austrian haemophiliacs. Haemophilia;14(4): 703-708.
• Heijnen, L., de Kleijn, P. (1999). Physiotherapy for the treatment of articular contractures in haemophilia. Haemophilia; 5(Suppl.1): 16–9.
• Kori, S., Miller, R., Todd, DD. (1990). Kinesiophobia: a new view of chronic pain behavior. Pain Manag;3:35–43.
• Lehmeier, A., Ar, MC., Sadri, S., Yürüyen, M., Başlar, Z. (2018). Participation in Physical and Sportive Activities among Adult Turkish People with Hemophilia: A Single-Center Experience. Turk J Haematol. Mar 1;35(1):81-82.
• Llewellyn, CD., Miners, AH., Lee, CA., Harrington, C., Weinman, J. (2003). The illness perceptions and treatment beliefs of individuals with severe haemophilia and their role in adherence to home treatment. Psychol Health;18:185-200.
• Luque-Suarez, A., Martinez-Calderon, J., Falla, D. (2018). Role of kinesiophobia on pain, disability and quality of life in people suffering from chronic musculoskeletal pain: a systematic review. Br J Sports Med. Apr 17.
• Meier, ML., Stämpfli, P., Vrana, A., et al. (2015). Fear avoidance beliefs in back pain-free subjects are reflected by amygdala-cingulate responses. Front Hum Neurosci;9:1–10.
• Mercan, A., Sarper, N., Inanir, M., Mercan, HI., Zengin, E., Kiliç, SÇ., Gökalp, AS. (2010). Hemophilia-Specific Quality of Life Index (Haemo-QoL and Haem-A-QoL questionnaires) of children and adults: result of a single center from Turkey. Pediatr Hematol Oncol. Sep;27(6):449-61.
• Monticone, M., Ferrante, S., Rocca, B., Salvaderi, S., Fiorentini, R., Restelli, M., Foti, C. (2013). Home-based functional exercises aimed at managing kinesiophobia contribute to improving disability and quality of life of patients undergoing total knee arthroplasty: a randomized controlled trial. Arch Phys Med Rehabil. Feb;94(2):231-9.
• Rambod, M., Sharif, F., Molazem, Z., Khair, K., von Mackensen, S. (2018). Health-Related Quality of Life and Psychological Aspects of Adults with Hemophilia in Iran. Clin Appl Thromb Hemost. Oct;24(7):1073-1081.
• Scalone, L., Mantovani, LG., Mannucci, PM., Gringery, A. (2006). The COCIS Study Investigators. Quality of life associated to the orthopaedic status in haemophilic patients with inhibitors. Haemophilia;12: 154-62.
• Sethy, D., Sahoo, S. (2018). Kinesiophobia after complex regional pain syndrom etypeone in a case of stroke hemiplegia and effect of cognitive behavior therapy. Indian J Psychiatry. Jan-Mar;60(1):152-154.
• Steimer, T. (2002). The biology of fear- and anxiety-related behaviors. Dialogues Clin Neurosci;4:231–49.
• Tiktinsky, R., Falk, B., Heim, M., Martinovitz, U. (2002). The effect of resistance training on the frequency of bleeding in haemophilia patients: a pilot study. Haemophilia; 8: 22–7.
• Tunca Yılmaz, Ö., Yakut, Y., Uygur, F. (2011). Tampa Kinezyofobi Ölçeği’nin Türkçe versiyonu ve test-tekrar test güvenirliği. Fizyoterapi ve Rehabilitasyon, 22(1), 44-49.
• Vlaeyen, JW., Kole-Snijders, AM., Boeren, RG., vanEek, H. (1995). Fear of movement/(re) injury in chronic low back pain and its relation to behaviora lperformance. Pain;62:363–72.
• Vlaeyen, J. W., Kole-Snijders, A. M., Rotteveel, A. M., Ruesink, R., Heuts, P. H. (1995). The role of fear of movement/(re) injury in pain disability. Journal of Occupational Rehabilitation, 5(4), 235-252.
• Von Mackensen, S., Campos, IG., Acquadro, C., Strandberg-Larsen, M. (2013). Cross-cultural adaptation and linguistic validation of agegroup- specific haemophilia patient-reported outcome (PRO) instruments for patients and parents. Haemophilia;19(2): e73-e83.
• Von Mackensen, S., Gringeri, A., Ravera, S., et al. (2005). Validation of the haemophilia-specific quality of life questionnaire for adult patients with haemophilia (Haem-A-QoL). Haematologica.;20(2):115-156.
• Von Mackensen, S., Gringeri, A. (2009). Quality of life in hemophilia. In: Preedy VR, Watson RReds. Handbook of Disease Burdens and Quality of Life Measures. Heidelberg: Springer, Vol. 3, Chapter 12: 1895–920.
• White, GC., Rosendaal, F., Aledort, LM., Lusher, JM., Rothschild, C., Ingerslev, J. (2001). Definitions in hemophilia. recommendation of the scientific subcommittee on factor VIII andfactor IX of the scientific and standardization committee of the international society on thrombosis and haemostasis. ThrombHaemost; 85(3):560.
• Witkop, M., Neff, A., Buckner, TW., et al. (2017). Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the pain, functional impairment, and quality of life (P-FiQ) study. Haemophilia;23(4):556-565.