THE PREVALENCE OF TAS2R38 GENE PHENOTYPES AMONG THE PATIENTS WITH SOME ENDOCRINE SYSTEM DISORDERS

Year 2017, , 37 - 43, 22.12.2017

Rusudan Khukhunaishvili Marina Koridze Sophiko Tskvitinidze Nato Zosidze Marina Nagervadze İrakli Parulava

https://doi.org/10.23884/ijhsrp.2017.2.2.01

Abstract

PTC (phenylthiocarbamide) is one of the
focuses of interest from the medical point of view since a number of
associations of the taster/nontaster status of PTC sensitivity with various
human diseases have been found. It is estimated that ability of sense of PTC
bitterness coded by a single gene TAS2R38. The threshold at which people can
taste phenylthiocarbamide (PTC) is bimodal, and some people are tasters while,
others are nontasters. In recent years, it is actively conducted the studies of
genetic markers in various endocrine disorders. Endocrine diseases,
particularly thyroid gland prevalence statistics in Georgia is very high. The
goal of our research was to study the phenotype of PTC sensitivity among the
patients with some endocrine system disorders in the population of Ajara region
of Georgia, particularly diabetes type II and different type of goiter
(nodular, diffuse etc.) to reveal any correlation between them. A total of 319
individuals including 136 patients with endocrine system and 183 randomly
chosen healthy individuals participated in this study. Obtained results shows,
that there is an increased incidence of diffuse toxic goiter in individuals
with recessive phenotype of TAS2R38 gene and who are unable to taste PTC
bitterness. While, PTC sensibility phenotype inclined to develop nodular
goiter. Thus PTC- Sensibility phenotype may be considered one of the genetic
markers in the forms of Goiter. 

Keywords

TAS2R38 gene, PTC sensitivity, taster, nontaster, nodular goiter, diffuse goiter

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