THE RELATIONSHIP BETWEEN BAD OBSTETRIC HISTORY AND THROMBOPHILI

Year 2018, Volume: 3 Issue: 1, 1 - 9, 30.04.2018

Bulat Aytek Şık , Beyhan Badoğlu Serkan Kumbasar Sedat Bilecan Yaşam Kemal Akpak

https://doi.org/10.23884/ijhsrp.2018.3.1.01

Abstract

The aim was to evaluate the relationship of recurring miscarriages and in
utero mort fetus cases over 20 weeks of pregnancy (except for those caused by a
systemic disease or a known pathology) with thrombophilic conditions. Our study was conducted on the patients
who were admitted to our clinic with for follow ups or investigation of
recurring pregnancy losses. The included patients had had at least 2 fetal
losses over 8 weeks into their pregnancy or at least one loss over the 20th
gestational week and gave histories of hypertensive pathologies of pregnancy
such as preeclampsia or eclampsia. The control group comprised 81 patients who
had at least one pregnancy without any complication or fetal loss histories. In
our study, the ratios of Factor V Leiden mutation in the study group (106
cases) and the control group (81 cases) were %12 and %1.3 (p=0.01)
respectively. In the patient group, the MTHFR homozygous mutation was seen 3.3
times as much and Factor V Leiden heterozygous gene mutation was determined to
be seen 8.3 as much as the control group. There was a significant difference
between the study and control groups in terms of Protein C and S activity
(p<0.0001 ve p<0.001). In the study group, the detection rate of 
Protein C levels <%65
was 5.2 times more(OR 5.2 2.7-12.49), and the Protein S activity was 12.17
times higher than the control group. Thrombophilic cases may play many roles in the
pathologies which arise during pregnancies.

Keywords

thrombophilia, recurring miscarriages

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