CARRIERS OF CHROMOSOME TRANSLOCATIONS FROM THREE MEN WITH AZOOSPERMIA

Year 2019, Volume: 4 Issue: 2, 145 - 150, 27.08.2019

Gülbahar Güzel Erdal , Mahmut Balkan

https://doi.org/10.23884/ijhsrp.2019.4.2.08

Abstract

Male infertility is liable for half of the genetic
infertility cases. Robertsonian and Reciprocal translocations are the major
chromosomal rearrangements in the infertile population. In this study, we aimed
to submit a Robertsonian and two Reciprocal translocations in three couples
with a history of male
infertility with azoospermia. Chromosomal
analysis of the one couple in the male partner appeared with an abnormal karyotype
with 45, XY, rob (13,14) chromosomal constitution, while the female partner
revealed normal 46, XX karyotype. The other two couple revealed in the male
partner with reciprocal translocations, while the female partners showed normal
46, XX karyotype; one of infertile males has karyotype with 46,XY, rcp (19:10),
and other infertile male with
46,XY,rcp(6:14) chromosomal
constitution. The cytogenetic analysis is mandatory to identify any probable
chromosomal anomalies for couples with primer infertility. Couples with
repeated abortions should be offered prenatal diagnosis in the case of future
pregnancies. Chromosome translocation carriers should be
counseled to use advanced technologies such as assisted reproductive technology
such as PGD.

Keywords

male infertility, chromosome abnormalities

Supporting Institution

Dicle University Research Fund DUBAP, Project No. TIP.18.036.

Project Number

TIP.18.036

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