Effects of Ganoderma lucidum in some neurological diseases

Abstract

Ganoderma lucidum has been widely used in Asian countries for hundreds of years to promote health and longevity. The pharmacological functions of which had been reported, are the activation of innate immune responses, suppression of tumour and modulation of cell proliferations. Effective fractions of Ganoderma lucidum polysaccharides had already been reported to regulate the immune system. In recent years, studies on the neuroprotective effects of G. lucidum have begun to intensify. G. lucidum is believed to have a neuro-protective effect and this notion is supported by work carried out by scientists. Spesifically wherein a mixture of triterpenoid compounds in G. lucidum promoted neuronal survival and reduced fatigue. In addition, the potential use of this fungus for the treatment of neurological diseases has also been examined. It was shown that long-term consumption of G. lucidum can decrease the progression of Alzheimer’s disease. This observed neuroprotective effect is achieved by promotion of neuritogenesis and reduction of senescence of the neurons. To summarize the studies on the neuroprotective effects of the intended G. lucidum, we want to shed some light on those who wish to study in this regard.

Keywords

• Alzheimer,Epilepsy,Ganoderma lucidum,Parkinson

References

1. Chen, L.W., Wang, Y.Q., Wei, L.C., Shi, M., Chan, Y.S., 2007. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS & Neurological Disorders Drug Targets, 6(4), 273-281.
2. Cheung, W.M., Hui, W.S., Chu, P.W., Chiu, S.W., Ip, N.Y., 2000. Ganoderma extract activates map kinases and induces the neuronal differentiation of rat pheochromocytoma pc12 cells. FEBS Letters, 486(3), 291-296.
3. Ding, H., Zhou, M., Zhang, R.P., Xu, S.L., 2010. Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia. Acta Physiologica Sinica, 62(6), 547-554.
4. Gao, Y., Deng, X.G., Sun, Q.N., Zhong, Z.Q., 2010. Ganoderma spore lipid inhibits N-methyl-N-nitrosourea-induced retinal photoreceptor apoptosis in vivo. Experimental Eye Research, 90(3), 397-404.
5. Gokce, E.C., Kahveci, R., Atanur, O.M., Gurer, B., Aksoy, N., Gokce, A., Sargon, M.F., Cemil, B., Erdogan, B., Kahveci, O., 2015. Neuroprotective effects of GLpolysaccharides against traumatic spinal cord injury in rats. Injury, 46(11), 2146-2155.
6. Guo, S.S., Cui, X.L., Rausch, W.D., 2016. Ganoderma lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. American Journal of Neurodegenerative Disease, 5(2), 131-144.
7. Huang, S., Mao, J., Ding, K., Zhou, Y., Zeng, X., Yang, W., Wang, P., Zhao, C., Yao, J., Xia, P., Pei, G., 2017. Polysaccharides from Ganoderma lucidum Promote cognitive function and neural progenitor proliferation in mouse model of alzheimer's disease. Stem Cell Reports, 8(1), 84-94.
8. Ji, Z., Tang, Q., Zhang, J., Yang, Y., Jia, W., Pan, Y., 2007. Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. Journal of Ethnopharmacology, 112, 445–450.

9. Jin, X., Ruiz Beguerie, J., Sze, D.M., Chan, G.C., 2012. Ganoderma lucidum (Reishi mushroom) for cancer treatment. The Cochrane Database of Systematic Reviews, 6, 1-38.
10. Lai, C.S., Yu, M.S., Yuen, W.H., So, K.F., Zee, S.Y., Chang, R.C., 2008. Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Research, 1190, 215-224.
11. Li, J., Zhang, J., Chen, H., Chen, X., Lan, J. , Liu, C., 2013. Complete mitochondrial genome of the medicinal mushroom Ganoderma lucidum. PLoS One, 8(8), 1-12.
12. Mizushina, Y., Takahashi, N., Hanashima, L., Koshino, H., Esumi, Y., Uzawa, J., Sugawara, F., Sakaguchi, K., 1999. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorganic and Medical Chemistry, 7(9), 2047-2052.
13. Paterson, R.R., 2006. Ganoderma - a therapeutic fungal biofactory. Phytochemistry, 67(18), 1985-2001.
14. Qin, C., Wu, S.Q., Chen, B.S., Wu, X.X., Qu, K.Y., Liu, J.M., Zhang, G.F., Xu, Y.F., Shu, S., Sun, L., Li, Y.Y., Zhu, H., Huang, L., Ma, C.M., Xu, Y.H., Han, Y.L., Lu, Y.Z., 2017. Pathological changes in APP/PS-1 transgenic mouse models of alzheimer's disease treated with Ganoderma lucidum Preparation. Acta Academiae Medicinae Sinicae, 39(4), 552-561.
15. Sanodiya, B.S., Thakur, G.S., Baghel, R.K., Prasad, G.B., Bisen, P.S., 2009. Ganoderma lucidum: a potent pharmacological macrofungus. Current Pharmaceutical Biotechnology, 10(8), 717-742.
16. Sharma, D., Singh, V.P., Singh, N.K., 2017. A review on phytochemistry and pharmacology of medicinal as well as poisonous mushrooms. Mini Reviews in Medicinal Chemistry, 17.
17. Sun, X., Wang, H., Han, X., Chen, S., Zhu, S., Dai, J., 2014. Fingerprint analysis of polysaccharides from different Ganoderma by HPLC combined with chemometrics methods. Carbohydrate Polymers, 114, 432-439.
18. Tuchman, R., Moshe, S.L., Rapin, I., 2009. Convulsing toward the pathophysiology of autism. Brain and Development, 31(2), 95–103.
19. Wang, S.Q., Li, X.J., Zhou, S., Sun, D.X., Wang, H., Cheng, P.F., Ma, X.R., Liu, L., Liu, J.X., Wang, F.F., Liang, Y.F., Wu, J.M., 2013. Intervention effects of Ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin. PLoS One, 8(4), 1-7.
20. Wang, S.Q., Li, X.J., Qiu, H.B., Jiang, Z.M., Simon, M., Ma, X.R., Liu, L., Liu, J.X., Wang, F.F., Liang, Y.F., Wu, J.M., Di, W.H., Zhou, S., 2014. Anti-epileptic effect of GLpolysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII α in epileptic hippocampal neurons. PLoS One, 9(10), 1-8.
21. Zhang, W., Zeng, Y.S., Wang, Y., Liu, W., Cheng, J.J., Chen, S.J., 2006. Primary study on proteomics about Ganoderma lucidum spores promoting survival and axon regeneration of injured spinal motor neurons in rats. Journal of Chinese Integrative Medicine, 4(3), 298-302.
22. Zhao, H.B., Lin, S.Q., Liu, J.H., Lin, Z.B., 2004. Polysaccharide extract isolated from GL protects rat cerebral cortical neurons from hypoxia/reoxygenation injury. Journal of Pharmacological Science, 95(2), 294-298.