A Review of Anti-diabetic Activity of Gymnema sylvestre and Pterocarpus marsupium: Special Emphasis on its Combination in 4DM

Year 2019, Volume: 3 Issue: 2, 40 - 51, 01.12.2019

Aminul Islam , Leroy Rebello Sreesudha Chepyala

Abstract

Gymnema
sylvestre is
a significant herb in traditional system of medicine and as well as in
Ayurveda. The triterpene saponins which includes gymnemic acids, gymnosaponins
and a polypeptide gurmarin are the main bioactive principle of Gymnema sylvestre and these
phytoconstituents are mainly responsible for its antidiabetic property; Gymnema sylvestre also exhibits a wide
range of therapeutic actions like anti-inflammatory, anti-hypercholesteromia,
cardioprotective activity etc. It also is used in arthritis, diuretic, anemia,
osteoporosis, asthma, indigestion etc. Pterocarpus
marsupium is also a medicinal plant which is well known for its
anti-diabetic property and other various therapeutic usages. This is a woody
tree, mainly the heart wood contains the bioactive principle pterostilbene, (-)
epicatechin, pterosupin, marsupin, tannins etc. which are responsible for its
anti-diabetic activity. 4DM is a combination of Gymnema sylvestre and Pterocarpus
marsupium - a product of Biotex Life Solutions (India). The preparation is
equally proportionate, i.e. in a 1:1 ratio. Gymnema
sylvestre and Pterocarpus marsupium
extraction has been done in a specific standardized condition to obtain 25%
Gymnemic acid and 5% Pterostilbene respectively.

Keywords

Gymema sylvestre, Pterocarpus marsupium, Antidiabetic Activity

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