Research Article
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Year 2021, Volume: 5 Issue: 1, 23 - 32, 01.06.2021
https://doi.org/10.47947/ijnls.915634

Abstract

References

  • Aliustaoğlu, M. (2009). Temel kanser fizyopatolojisi. Klinik Gelişim, 22(3), 46-49.
  • Amelina, C., Caruntu, I. D., Gıuşca, S. E., & Balan, R. A. (2010). Matrix metalloproteinases involvement in pathologic conditions. Romanian Journal of Morphology and Embryology, 51(2), 215–228.
  • Apakkan Aksun, S., Bayındır, O., & Özmen, D. (2001). Metalloproteinazlar, inhibitörleri ve ilişkili fizyolojik ve patolojik durumlar. Türkiye Klinikleri Tıp Bilimleri, 21, 332–342.
  • Aydın, O., Yıldız, L., Kefeli, M., Yüksel, C., Süllü, Y. (2006). Tiroid papiller karsinomlarda c-kit. Türk Patoloji Dergisi, 22(1), 17-20.
  • Campo, E., Maria, J., Merino, J., Liotta, L., Neumann, R., & Stetler-Stevenson, W. G. (1992). Distribution of the 72-kDa type IV collagenase in non-neoplastic and neoplastic thyroid tissue. Human Pathology, 23, 1395–1401.
  • Cho Mar, K., Eimoto, T., Tateyama, H., Arai, Y., Fujiyoshi Y., & Hamaguchi, M. (2006). Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions. Histopathology, 48, 286–294.
  • Cvejic, D., Savin, S., Paunovic, I., Tatic, S., & Havelka, M. (2000) İmmunohistochemical localization of matrix metalloproteinase-2(MMP-2) in medullary thyroid carcinoma. Archive of Oncology, 8, 95-97.
  • Franc, B. (2003). Observer variation of lesions of the thyroid. American Journal of Surgical Pathology, 27, 1177-1178.
  • Hewitt, R., & Dan, K. (1996). Stromal cell expression of components of matrix degrading protease systems in human cancer. Enzyme Protein, 49,163–173.
  • Kessenbrock, K., Plaks, V., & Werb, Z. (2010). Matrix Metalloproteinases: Regulators of the tumor microenvironment. Cell, 141(1), 52–67. https://doi.org/10.1016/j.cell.2010.03.015
  • Koyun, E., Karadag, R., Ozkanli, S., Oguztuzun, S., Kocdogan, A. K., & Ozsoy, I. (2020) Caspase-3, p53 and Bcl-2 expression in basal cell carcinoma of the eyelid. Advances in Dermatology and Allergology, 37(4), 535–539.
  • Liang, H., Zhong, Y., Luo, Z., Huang, Y., Lin, H., Luo, M., Zhan, S., Xie, K., Ma, Y., & Li, Q. Q. (2010). Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis. International Journal of Biological Markers, 25, 38–45.
  • Maeta, H,, Ohgi, S., & Terada, S. (2001). Protein expression of matrixmetalloproteinase 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroidcarcinomas. Virchows Archiv, 438, 121–128.
  • Matrisian, L. M. (1990). Metalloproteinases and the inhibitors in matrixremodeling. Trends in Genetics, 6(4), 121–125.
  • Mishunina, T. M., Kalinichenko, O. V., Tronko, M. D., & Statsenko, O. A. (2010). Caspase-3 activity in papillary thyroid carcinomas. Experimental Oncology, 32, 269-272.
  • Natali, P. G., Berlingieri, M. T., Nicotra, M. R., Santoro, E., Bigotti, A., & Ullrich, A. (1995). Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Research, 55, 1787-1791.
  • Saffar, H., Sanii, S., Emami, B., Heshmat, R., Panah, V. H , Azimi, S., & Tavangar, S. M. (2003). Evaluation of MMP2 and Caspase-3 expression in 107 cases of papillary thyroid carcinoma and its association with prognostic factors. Pathology-Research and Practice, 209, 195-199.
  • Sethi, C. S., Bailey, T. A., Luthert, P. J., & Chong, N. H. V. (2000) Matrix metalloproteinase biology applied to vitreoretinal disorders. British Journal of Ophthalmology, 84, 654–664.
  • Tan, H., Ye, K., Wang, Z., & Tang, H. (2008). Clinicopathologic evaluation of immunohistochemical CD147 and MMP2 expression in differentiated thyroid carcinoma. Japanese Journal of Clinical Oncology, 338, 528–533.
  • Tanaka, T., Umeki, K, Yamamoto, I., Kotani, T., Sakamoto, F., Noguchi, S., & Ohtaki, S. (1995). C-Kit proto-oncogene is more likely to lose expression in differentiated thyroid carcinoma than three thyroid-specific genes: thyroid peroxidase, thyroglobulin, and thyroid stimulating hormone receptor. Endocrine Journal, 42, 723-728.
  • Tian, X., Cong, M., Zhou, W., Zhu, J., & Liu, Q. (2008). Relationship between protein expression of VEGF-C, MMP-2 and lymph node metastasis in papillary thyroid cancer. Journal of International Medical Research, 36, 699–703.
  • Tryggvason, K., Hoyhtya, M., & Ryke, C. (1993). Type IV collagenases in invasive tumors. Breast Cancer Research and Treatment, 24, 209–218.
  • Zhang, H. Y., Meng, X., Du, Z. X., Fang, C. Q., Liu, G. L., Wang, H. Q., & Deng, W. W. (2009) Significance of survivin, caspase-3, and VEGF expression on thyroidcarcinoma. Clinical and Experimental Medicine, 9, 207–213.

Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis

Year 2021, Volume: 5 Issue: 1, 23 - 32, 01.06.2021
https://doi.org/10.47947/ijnls.915634

Abstract

A number of new molecular and genetic factors are currently being studied in determining the prognosis of thyroid papillary carcinoma. In our study, we aimed to determine if there was a relationship between prognostic factors and expression of Matrixmatalloproteniase 2 (MMP-2), the tyrosine-kinase receptor CD117 (c-kit) and caspase-3. MMP2, c-kit and caspase-3 by immunohistochemical (IHC) method were studied in both intact and pathological tissue of the thyroid gland removed after surgery in patients with thyroid papillary cancer. Prognostic factors such as age, histological stage, extrathyroidal spread, metastasis, tumor size were also evaluated. There was no statistically significant difference between prognosis and c-kit, MMP-2 and caspase-3 expression in patients (p>0.05). Clinicopathological parameters were thought to be more important than c-kit, caspase 3 and MMP2 in predicting prognosis in thyroid papillary cancers.

References

  • Aliustaoğlu, M. (2009). Temel kanser fizyopatolojisi. Klinik Gelişim, 22(3), 46-49.
  • Amelina, C., Caruntu, I. D., Gıuşca, S. E., & Balan, R. A. (2010). Matrix metalloproteinases involvement in pathologic conditions. Romanian Journal of Morphology and Embryology, 51(2), 215–228.
  • Apakkan Aksun, S., Bayındır, O., & Özmen, D. (2001). Metalloproteinazlar, inhibitörleri ve ilişkili fizyolojik ve patolojik durumlar. Türkiye Klinikleri Tıp Bilimleri, 21, 332–342.
  • Aydın, O., Yıldız, L., Kefeli, M., Yüksel, C., Süllü, Y. (2006). Tiroid papiller karsinomlarda c-kit. Türk Patoloji Dergisi, 22(1), 17-20.
  • Campo, E., Maria, J., Merino, J., Liotta, L., Neumann, R., & Stetler-Stevenson, W. G. (1992). Distribution of the 72-kDa type IV collagenase in non-neoplastic and neoplastic thyroid tissue. Human Pathology, 23, 1395–1401.
  • Cho Mar, K., Eimoto, T., Tateyama, H., Arai, Y., Fujiyoshi Y., & Hamaguchi, M. (2006). Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions. Histopathology, 48, 286–294.
  • Cvejic, D., Savin, S., Paunovic, I., Tatic, S., & Havelka, M. (2000) İmmunohistochemical localization of matrix metalloproteinase-2(MMP-2) in medullary thyroid carcinoma. Archive of Oncology, 8, 95-97.
  • Franc, B. (2003). Observer variation of lesions of the thyroid. American Journal of Surgical Pathology, 27, 1177-1178.
  • Hewitt, R., & Dan, K. (1996). Stromal cell expression of components of matrix degrading protease systems in human cancer. Enzyme Protein, 49,163–173.
  • Kessenbrock, K., Plaks, V., & Werb, Z. (2010). Matrix Metalloproteinases: Regulators of the tumor microenvironment. Cell, 141(1), 52–67. https://doi.org/10.1016/j.cell.2010.03.015
  • Koyun, E., Karadag, R., Ozkanli, S., Oguztuzun, S., Kocdogan, A. K., & Ozsoy, I. (2020) Caspase-3, p53 and Bcl-2 expression in basal cell carcinoma of the eyelid. Advances in Dermatology and Allergology, 37(4), 535–539.
  • Liang, H., Zhong, Y., Luo, Z., Huang, Y., Lin, H., Luo, M., Zhan, S., Xie, K., Ma, Y., & Li, Q. Q. (2010). Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis. International Journal of Biological Markers, 25, 38–45.
  • Maeta, H,, Ohgi, S., & Terada, S. (2001). Protein expression of matrixmetalloproteinase 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroidcarcinomas. Virchows Archiv, 438, 121–128.
  • Matrisian, L. M. (1990). Metalloproteinases and the inhibitors in matrixremodeling. Trends in Genetics, 6(4), 121–125.
  • Mishunina, T. M., Kalinichenko, O. V., Tronko, M. D., & Statsenko, O. A. (2010). Caspase-3 activity in papillary thyroid carcinomas. Experimental Oncology, 32, 269-272.
  • Natali, P. G., Berlingieri, M. T., Nicotra, M. R., Santoro, E., Bigotti, A., & Ullrich, A. (1995). Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Research, 55, 1787-1791.
  • Saffar, H., Sanii, S., Emami, B., Heshmat, R., Panah, V. H , Azimi, S., & Tavangar, S. M. (2003). Evaluation of MMP2 and Caspase-3 expression in 107 cases of papillary thyroid carcinoma and its association with prognostic factors. Pathology-Research and Practice, 209, 195-199.
  • Sethi, C. S., Bailey, T. A., Luthert, P. J., & Chong, N. H. V. (2000) Matrix metalloproteinase biology applied to vitreoretinal disorders. British Journal of Ophthalmology, 84, 654–664.
  • Tan, H., Ye, K., Wang, Z., & Tang, H. (2008). Clinicopathologic evaluation of immunohistochemical CD147 and MMP2 expression in differentiated thyroid carcinoma. Japanese Journal of Clinical Oncology, 338, 528–533.
  • Tanaka, T., Umeki, K, Yamamoto, I., Kotani, T., Sakamoto, F., Noguchi, S., & Ohtaki, S. (1995). C-Kit proto-oncogene is more likely to lose expression in differentiated thyroid carcinoma than three thyroid-specific genes: thyroid peroxidase, thyroglobulin, and thyroid stimulating hormone receptor. Endocrine Journal, 42, 723-728.
  • Tian, X., Cong, M., Zhou, W., Zhu, J., & Liu, Q. (2008). Relationship between protein expression of VEGF-C, MMP-2 and lymph node metastasis in papillary thyroid cancer. Journal of International Medical Research, 36, 699–703.
  • Tryggvason, K., Hoyhtya, M., & Ryke, C. (1993). Type IV collagenases in invasive tumors. Breast Cancer Research and Treatment, 24, 209–218.
  • Zhang, H. Y., Meng, X., Du, Z. X., Fang, C. Q., Liu, G. L., Wang, H. Q., & Deng, W. W. (2009) Significance of survivin, caspase-3, and VEGF expression on thyroidcarcinoma. Clinical and Experimental Medicine, 9, 207–213.
There are 23 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research articles
Authors

Arzu Boztaş 0000-0002-4702-8559

Hakan Buluş 0000-0001-7439-8099

Gülçin Güler Şimşek 0000-0001-7710-4631

Altan Aydın 0000-0002-2981-2833

Arzu Koçdoğan This is me 0000-0002-3689-3061

Volkan Ateş 0000-0002-2349-0140

Serpil Oğuztüzün 0000-0002-5892-3735

Publication Date June 1, 2021
Submission Date April 14, 2021
Acceptance Date May 4, 2021
Published in Issue Year 2021 Volume: 5 Issue: 1

Cite

APA Boztaş, A., Buluş, H., Güler Şimşek, G., Aydın, A., et al. (2021). Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis. International Journal of Nature and Life Sciences, 5(1), 23-32. https://doi.org/10.47947/ijnls.915634