Research Article
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Potential Anti-Cancer Effects of Extra Virgin Olive Oil and Its Phenolic Extracts on Hepatocellular Carcinoma Cells

Year 2023, Volume: 7 Issue: 2, 112 - 122, 30.12.2023
https://doi.org/10.47947/ijnls.1397191

Abstract

In this study, three types of Extra Virgin olive oils (EVOO) grown in different regions of Türkiye (Kilis Yaglik, Ayvalik, Izmir Sofralik) and their phenolic extracts (EVOOP) were evaluated for their anti-cancer activity in hepatocellular carcinoma (HCC) cells (Hep40) and a complete profiling of the fatty acid, sterol and polyphenol content of these olive oils was performed by HPLC and GC method. It was shown that genetic diversity and differences in growing conditions of the olive oils studied significantly modified the phenolic composition. The biophenol content was found as 655.4 mg/kg, 508.75 mg/kg and 197.86 mg/kg in Kilis Yaglik, Izmir Sofralik and Ayvalık respectively. The highest content of oleocanthal was found in İzmir Sofralik EVOO (142.00 mg/kg) and its anti-proliferative effect was found to be high. The highest amount of hydroxytyrosol was found in Kilis Yaglik (42.14 mg/kg) and the highest amount of tyrosol was found in Izmir Sofralik (43.86 mg/kg). It was shown that there was a significant difference in the responses of polyphenols in Hep40 cells. The direct use of olive oil in Hep40 cells and the comparison with EVOOPs were evaluated for the first time in this study. The evaluation of the anti-cancer effect of EVOOs and EVOOPs was tested by MTT and the IC50 value of Ayvalik EVOO was found to be the lowest at %12.84. In EVOOPs, Izmir Sofralik was the most effective in Hep40 cells with an IC50 value of 35.40 µg/mL.

Ethical Statement

The authors declare that there is no conflict of interest and that the authors made this study's experimentation, analysis, writing, etc. all steps.

Supporting Institution

This research received financial support from the Coordination of Scientific Research Projects at Ankara University (Project number: 21L0430007).

Project Number

21L0430007

Thanks

We express our gratitude to Ankara University Scientific Research Projects Coordination Office for their support. Additionally, we acknowledge with gratitude the contributions of Hedef Ziraat (Izmir Sofralik), Buta Assos (Ayvalik), and Masmana (Kilis Yaglik), the companies from Türkiye that supplied olive oil for this study.

References

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Year 2023, Volume: 7 Issue: 2, 112 - 122, 30.12.2023
https://doi.org/10.47947/ijnls.1397191

Abstract

Project Number

21L0430007

References

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  • Antoniou, C., & Hull, J. (2021). The anti-cancer effect of Olea europaea L. products: A review. Current Nutrition Reports, 10, 99-124. https://doi.org/10.1007/s13668-021-00350-8
  • Bakrim, S., El Omari, N., El Hachlafi, N., Bakri, Y., Lee, L.-H., & Bouyahya, A. (2022). Dietary phenolic compounds as anti-cancer natural drugs: recent update on molecular mechanisms and clinical trials. Foods, 11 (21), 3323. https://doi.org/10.3390/foods11213323
  • Bouyahya, A., Omari, N. E., Bakrim, S., Hachlafi, N. E., Balahbib, A., Wilairatana, P., & Mubarak, M. S. (2022). Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anti-cancer Drugs. Cancers, 14(19), 4573. https://doi.org/10.3390/cancers14194573
  • Boselli, E., Di Lecce, G., Strabbioli, R., Pieralisi, G., & Frega, N. G. (2009). Are virgin olive oils obtained below 27° C better than those produced at higher temperatures?. LWT-Food Science and Technology, 42 (3), 748-757. https://doi.org/10.1016/j.lwt.2008.09.018
  • Choi, S., Kim, B. K., Yon, D. K., Lee, S. W., Lee, H. G., Chang, H. H., Park, S., Koyanagi, A., Jacob, L., & Dragioti, E. (2023). Global burden of primary liver cancer and its association with underlying aetiologies, sociodemographic status, and sex differences from 1990–2019: A DALY-based analysis of the Global Burden of Disease 2019 study. Clinical and molecular hepatology, 29(2), 433. https://doi.org/10.3350/cmh.2022.0316
  • Coccia, A., Mosca, L., Puca, R., Mangino, G., Rossi, A., & Lendaro, E. (2016). Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells. Oncol Rep, 36 (6), 3095-3104. https://doi.org/10.3892/or.2016.5150
  • Daher, S., Massarwa, M., Benson, A. A., & Khoury, T. (2018). Current and future treatment of hepatocellular carcinoma: an updated comprehensive review. Journal of Clinical and Translational Hepatology, 6 (1), 69. https://doi.org/10.14218/JCTH.2017.00031
  • Donne, R., & Lujambio, A. (2022). The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma. Hepatology. https://doi.org/10.1002/hep.32740
  • Emma, M. R., Augello, G., Di Stefano, V., Azzolina, A., Giannitrapani, L., Montalto, G., Cervello, M., & Cusimano, A. (2021). Potential uses of olive oil secoiridoids for the prevention and treatment of cancer: A narrative review of preclinical studies. International Journal of Molecular Sciences, 22 (3), 1234. https://doi.org/10.3390/ijms22031234
  • Fang, X., Yan, Q., Liu, S., & Guan, X.-Y. (2022). Cancer stem cells in hepatocellular carcinoma: intrinsic and extrinsic molecular mechanisms in stemness regulation. International journal of molecular sciences, 23 (20), 12327. https://doi.org/10.3390/ijms232012327
  • Finicelli, M., Di Salle, A., Galderisi, U., & Peluso, G. (2022). The Mediterranean diet: an update of the clinical trials. Nutrients, 14 (14), 2956. doi/10.3390/nu14142956
  • George, E. S., Sood, S., Broughton, A., Cogan, G., Hickey, M., Chan, W. S., Sudan, S., & Nicoll, A. J. (2021). The association between diet and hepatocellular carcinoma: a systematic review. Nutrients, 13 (1), 172. https://doi.org/10.1016/j.cgh.2005.12.007
  • Goren, L., Zhang, G., Kaushik, S., Breslin, P. A. S., Du, Y. N., & Foster, D. A. (2019). (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLoS One, 14 (8), e0216024. https://doi.org/10.1371/journal.pone.0216024
  • Hashim, Y. Z., Worthington, J., Allsopp, P., Ternan, N. G., Brown, E. M., McCann, M. J., Rowland, I. R., Esposto, S., Servili, M., & Gill, C. I. (2014). Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo. Food Funct, 5 (7), 1513-1519. https://doi.org/10.1039/c4fo00090k
  • Hatimy, A., & Kadmiri, N. E. (2021). Benefits of phenolic compounds isolated from olive oil on prevention of cancer. Health Sciences, 2 (1), 3. https://doi.org/10.3390/ijms19082305
  • Hosseini-Zare, M. S., Sarhadi, M., Zarei, M., Thilagavathi, R., & Selvam, C. (2021). Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review. European Journal of Medicinal Chemistry, 210, 113072. https://doi.org/10.1016/j.ejmech.2020.113072
  • Huang, D. Q., Singal, A. G., Kono, Y., Tan, D. J., El-Serag, H. B., & Loomba, R. (2022). Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer. Cell Metabolism, 34 (7), 969-977. https://doi.org/10.1016/j.cmet.2022.05.003
  • IOC (2017).International Olive Council. Determination of composition of triacylglycerols and composition and content of di-acylglycerols by capillary gas chromatography, in vegetable oils. https://www.internationaloliveoil.org/wp-content/uploads/2019/11/Method-COI-T.20-Doc.-No-23-Rev.1-2017-2.pdf
  • Jain, D., Murti, Y., Khan, W. U., Hossain, R., Hossain, M. N., Agrawal, K. K., Ashraf, R. A., Islam, M. T., Janmeda, P., & Taheri, Y. (2021). Roles of therapeutic bioactive compounds in hepatocellular carcinoma. Oxidative Medicine and Cellular Longevity, 2021. https://doi.org/10.1155/2021/9068850
  • Jovtchev, G., Stankov, A., Georgieva, A., Dobreva, A., Bakalova, R., Aoki, I., & Mileva, M. (2018). Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil–in vitro model study. Biotechnology & Biotechnological Equipment, 32 (2), 513-519. https://doi.org/10.1080/13102818.2017.1423245
  • Kapoor, D. U., Yele, S., & Prajapati, B. G. (2023). Biophenols for cancer treatment: Current perspective and future potential. International Journal of Pharmaceutical Chemistry and Analysis, 10, 100-109. https://doi.org/10.18231/j.ijpca.2023.019
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There are 54 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other), Food Sciences (Other)
Journal Section Research articles
Authors

Gül Kahraman 0000-0001-8724-8954

Mücahit Taha Özkaya 0000-0002-6571-5985

Özlem Yıldırım 0000-0003-1018-0335

Project Number 21L0430007
Early Pub Date December 8, 2023
Publication Date December 30, 2023
Submission Date November 28, 2023
Acceptance Date December 8, 2023
Published in Issue Year 2023 Volume: 7 Issue: 2

Cite

APA Kahraman, G., Özkaya, M. T., & Yıldırım, Ö. (2023). Potential Anti-Cancer Effects of Extra Virgin Olive Oil and Its Phenolic Extracts on Hepatocellular Carcinoma Cells. International Journal of Nature and Life Sciences, 7(2), 112-122. https://doi.org/10.47947/ijnls.1397191