Investigation the Biological Activities of Chenopdium foliosum Methanol Extract

Abstract

Chenopodium cinsi Türkiye dahil hemen hemen dünyanın her yerinde yayılış göstermektedir. Bu cinse ait türler farklı ülkelerin geleneksel tıbbında çeşitli hastalıkların tedavisinde kullanılmaktadır. Chenopodium cinsinin farklı türleri anti-kanser, anti-mantar ve anti-bakteriyel etkiler göstermektedir. Chenopo-dium foliosum (C. folisoum) ile ilgili literatürde büyük bir boşluk bulunmak-tadır. Bu çalışmada C. folisoum bitkisinin metanol ekstraktının biyolojik ak-tiviteleri araştırıldı. Anti-kanser aktivitesi, HCT-116 ve A549 hücre hatlarında 3-(4,5-Dimetiltiazol-2-il)-2,5-difeniltetrazolyum bromür (MTT) analizi kullanılarak değerlendirildi. Anti-bakteriyel ve ati-fungal aktivitesi minimum inhibisyon konsantrasyonu (MIC) tahlili ile incelenmiştir. C. folisoum'un metanol ekstraktı, HCT116 ve A549 hücre hatlarının hücre canlılığını sırasıyla %73,4 ± %15,3 ve %78,7 ± %2,3'e düşürdüğü saptanmıştır. C. folisoum ayrıca candida albicans'ın (C. albicans) hücre canlılığını %91,2'ye düşürdüğü saptanmıştır. Elde edilen bulgular C. folisoum metanol ekstraktının HCT116, A549 ve C. albicans'a karşı hem antikanser hem de antifungal etkiye sahip olduğunu göstermektedir.

Keywords

• Chenopodium
• anti-cancer
• anti-bacterial
• anti-fungal

References

1. Gennari, C., Castoldi, D., and Sharon, O. (2007). Natural products with taxol-like anti-tumor activity: Synthetic approaches to eleutherobin and dictyostatin. Pure and Applied Chemistry, 79(2), 173–180.
2. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., and Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
3. Jermini, M., Dubois, J., Rodondi, P. Y., Zaman, K., Buclin, T., Csajka, C., Orcurto, A., and Rothuizen, L. E. (2019). Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic centre. Scientific Reports, 9(1), 5078.
4. Agarwal, G., Carcache, P. J. B., Addo, E. M., and Kinghorn, A. D. (2020). Current status and contemporary approaches to the discovery of antitumor agents from higher plants. Biotech-nology Advances, 38, 107337.
5. Gonzalez, C., and Schaeffer, A. J. (1999). Treatment of urinary tract infection: what’s old, what’s new, and what works. World Journal of Urology, 17(6), 372–382.
6. Santoro, F. R., Nascimento, A. L. B., Soldati, G. T., Ferreira Júnior, W. S., and Albuquerque, U. P. (2018). Evolutionary ethnobiology and cultural evolution: opportunities for research and dialog. Journal of Ethnobiology and Ethnomedicine, 14(1), 1–14.
7. Rababah, T. M., Hettiarachchy, N. S., and Horax, R. (2004). Total Phenolics and Antioxidant Activities of Fenugreek, Green Tea, Black Tea, Grape Seed, Ginger, Rosemary, Gotu Kola, and Ginkgo Extracts, Vitamin E, andtert-Butylhydroquinone. Journal of Agricultural and Food Chemistry, 52(16), 5183–5186.
8. Sahreen, S., Khan, M. R., and Khan, R. A. (2014). Effects of Carissa opaca fruits extracts on oxidative pulmonary damages and fibrosis in rats. BMC Complementary and Alternative Med-icine, 14, 1–9.

9. Russo, T. A., and Johnson, J. R. (2003). Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes and Infection, 5(5), 449–456.
10. Furtardo, G. H. C., d’Azevedo, P. A., Santos, A. F., Gales, A. C., Pignatari, A. C. C., and Medeiros, E. A. (2007). Intravenous polymyxin B for the treatment of nosocomial pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. International Journal of Antimicrobial Agents, 30(4), 315–319.
11. Shigemura, K., Arakawa, S., Sakai, Y., Kinoshita, S., Tanaka, K., and Fujisawa, M. (2006). Complicated urinary tract infection caused by Pseudomonas aeruginosa in a single institution (1999–2003). International Journal of Urology, 13(5), 538–542.
12. Kim, M., Christley, S., Khodarev, N. N., Fleming, I., Huang, Y., Chang, E. B., Zaborina, O., and Alverdy, J. C. (2015). Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. Journal of Trauma and Acute Care Sur-gery, 78(4), 823–829.
13. Shi, Q., Huang, C., Xiao, T., Wu, Z., and Xiao, Y. (2019). A retrospective analysis of Pseudomonas aeruginosa bloodstream infections: prevalence, risk factors, and outcome in carbapenem-susceptible and -non-susceptible infections. Antimicrobial Resistance and Infection Control, 8(1), 1–9.
14. Cheung, G. Y. C., Bae, J. S., and Otto, M. (2021). Pathogenicity and virulence of Staphy-lococcus aureus. Virulence, 12(1), 547–569.
15. Guo, Y., Song, G., Sun, M., Wang, J., and Wang, Y. (2020). Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus. Frontiers in Cellular and Infection Microbi-ology, 10, 107.
16. Guinea, J. (2014). Global trends in the distribution of Candida species causing candidemia. Clinical Microbiology and Infection, 20, 5–10.
17. Colombo, A. L., de Almeida Junior, J. N., and Guinea, J. (2017). Emerging multi-drug-resistant Candida species. Current Opinion in Infectious Diseases, 30(6), 528–538.
18. Yadav, N., Vasudeva, N., Singh, S., and Sharma, S. K. (2007). Medicinal properties of genus Chenopodium Linn. Natural Product Radiance, 6(2), 131–134.
19. Bano, A., Ahmad, M., Zafar, M., Sultana, S., Rashid, S., and Khan, M. A. (2014). Ethno-medicinal knowledge of the most commonly used plants from Deosai Plateau, Western Hima-layas, Gilgit Baltistan, Pakistan. Journal of Ethnopharmacology, 155(2), 1046–1052.
20. Kokanova-Nedialkova, Z., Bücherl, D., Nikolov, S., Heilmann, J., and Nedialkov, P. T. (2011). Flavonol glycosides from Chenopodium foliosum Asch. Phytochemistry Letters, 4(3), 367–371.
21. Özgen, U., Kaya, Y., and Houghton, P. (2012). Folk medicines in the villages of Ilıca District (Erzurum, Turkey). Turkish Journal of Biology, 36(1), 93–106.
22. Udegbunam, S. O., Udegbunam, R. I., Muogbo, C. C., Anyanwu, M. U., & Nwaehujor, C. O. (2014). Wound healing and antibacterial properties of methanolic extract of Pupalia lappacea Juss in rats. BMC Complementary and Alternative Medicine, 14(1).
23. Sharma, N., Arya, G., Kumari, R., Gupta, N., & Nimesh, S. (2019). Evaluation of Anticancer activity of Silver Nanoparticles on the A549 Human Lung Carcinoma Cell Lines through Alamar Blue Assay. Bio-Protocol, 9(1).
24. Rodriguez-Tudela, J. L., Arendrup, M. C., Barchiesi, F., Bille, J., Chryssanthou, E., Cuen-ca-Estrella, M., Dannaoui, E., Denning, D. W., Donnelly, J. P., Dromer, F., Fegeler, W., Lass-Flörl, C., Moore, C., Richardson, M., Sandven, P., Velegraki, A., & Verweij, P. (2008). EUCAST Definitive Document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clinical Microbiology and Infection, 14(4), 398–405.
25. CLSI, C. (2018). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. CLSI standard M07.
26. Acıbuca, V., and Budak, D. B. (2018). Dünya’da ve Türkiye’de Tıbbi ve Aromatik Bitkilerin Yeri ve Önemi. Çukurova Tarım ve Gıda Bilimleri Dergisi, 33(1), 37–44.
27. Bhargava, A., Shukla, S., Kumar, R., and Ohri, D. (2009). Metroglyph Analysis of Mor-phological Variation in Chenopodium spp. World Journal of Agricultural Sciences, 5(1), 117–120.
28. Khoobchandani, M., Ojeswi, B. K., Sharma, B., and Srivastava, M. M. (2009). Chenopodium Album Prevents Progression of Cell Growth and Enhances Cell Toxicity in Human Breast Cancer Cell Lines. Oxidative Medicine and Cellular Longevity, 2(3), 160–165.
29. Baldi, A., and Choudhary, N. K. (2013). In vitro antioxidant and hepatoprotective potential of chenopodium album extract. International Journal of Green Pharmacy, 7(1).
30. Gawlik‐Dziki, U., Świeca, M., Maciej Sułkowski, M., Dziki, D., Baraniak, B., and Czyż, J. (2013). Antioxidant and anticancer activities of Chenopodium quinoa leaves extracts – In vitro study. Food and Chemical Toxicology, 57, 154–160.
31. Miranda, M., Delatorre-Herrera, J., Vega‐Gálvez, A., Jorquera, E., Quispe‐Fuentes, I., and Martínez, E. A. (2014). Antimicrobial Potential and Phytochemical Content of Six Diverse Sources of Quinoa Seeds (Chenopodium quinoa Willd.). Agricultural Sciences, 05(11), 1015–1024.
32. Kokanova-Nedialkova, Z., Nedialkov, P. T., and Nikolov, S. D. (2014). Pharmacognostic investigations of the aerial parts of Chenopodium foliosum Asch. and radical-scavenging ac-tivities of five flavonoids isolated from methanol extract of the plant. Pharmacognosy Journal, 6(4), 43–48.
33. Kaur, R., Kapoor, K., and Kaur, H. (2011). Plants as a source of anticancer agents. Journal of Natural Product and Plant Resources, 1(1), 119–124.
34. Sala, A., Recio, M. C., Giner, R. M., Máñez, S., Tournier, H., Schinella, G., and Rı́osJ. L. (2002). Anti-inflammatory and antioxidant properties of Helichrysum italicum. Journal of Pharmacy and Pharmacology, 54(3), 365–371.
35. Harun-ur-Rashid, Md., Gafur, M. A., Sadik, Md. G., and Rahman, Md. A. A. (2002). Bio-logical Activities of a New Acrylamide Derivative from Ipomoea turpethum. Pakistan Journal of Biological Sciences, 5(9), 968–969.
36. Kokanova-Nedialkova, Z., Nedialkov, P., and Momekov, G. (2018). Saponins from the roots of Chenopodium bonus-henricus L. Natural Product Research, 33(14), 2024–2031.
37. Nascimento, F. R. F., Cruz, G. V. B., Pereira, P. V. S., Maciel, M. C. G., Silva, L. A., Azevedo, A. C., Barroqueiro, E. S. B., and Guerra, R. N. M. (2006). Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment. Life Sciences, 78(22), 2650–2653.
38. Potawale, S. E., Luniya, K. P., Mantri, R. A., Mehta, U. K., Waseem, Md., Sadiq, Md., Vetal, Y. D., and Deshmukh, R. S. (2008). Chenopodium ambrosioides: An ethnopharmacological review. Pharmacologyonline, 2, 272–286.
39. Dembitsky, V., Shkrob, I., and Hanus, L. O. (2008). Ascaridole and related peroxides from the genus Chenopodium. Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic, 152(2), 209–215.
40. Efferth, T., Olbrich, A., Sauerbrey, A., Ross, D. D., Gebhart, E., and Neugebauer, M. (2022). Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sen-sitive and multidrug-resistant tumor cells. Anticancer Research, 22(6C), 4221–4224. https://pubmed.ncbi.nlm.nih.gov/12553060/
41. Nedialkov , P. T., Kokanova-Nedialkova, Z., Bücherl, D., Momekov, G., Heilmann, J., & Nikolov, S. (2012). 30-normedicagenic acid glycosides from Chenopodium foliosum. Natural Product Communications, 7(11). https://pubmed.ncbi.nlm.nih.gov/23285798/
42. Nejad, B. S., and Deokule, S. S. (2009). Anti-dermatophytic activity of Drynaria quercifolia (L.) J. Smith. Jundishapur Journal of Microbiology, 2(1), 25–30.
43. Khan, S. U., Ullah, F., Mehmood, S., Fahad, S., Ahmad Rahi, A., Althobaiti, F., Dessoky, E. S., Saud, S., Danish, S., and Datta, R. (2021). Antimicrobial, antioxidant and cytotoxic properties of Chenopodium glaucum L. PLOS ONE, 16(10).
44. Kaur, N., and Kaur, G. (2018). Effect of processing on nutritional and antinutritional composition of bathua (Chenopodium album) leaves. Journal of Applied and Natural Science, 10(4), 1149–1155.
45. Ajaib, M., Hussain, T., Farooq, S., and Ashiq, M. (2016). Analysis of Antimicrobial and Antioxidant Activities of Chenopodium ambrosioides An Ethnomedicinal Plant. Journal of Chemistry, 1–11.
46. Jardim, C. M., Jham, G. N., Dhingra, O. D., and Freire, M. M. (2010). Chemical composition and antifungal activity of the hexane extract of the Brazilian Chenopodium ambrosioides L. Journal of the Brazilian Chemical Society, 21(10), 1814–1818.