Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

Abstract

In this study, it was aimed to use pyrrole monomer and single-walled carbon nanotube (SWCNT) in the production of modified electrodes, and to examine the electrochemical properties of these electrodes. Bulk electrolysis technique was used for growing polypyrrole. The applicability of the polypyrrole and SWCNT-based electrodes was tested by electrochemically detecting active substances such as levodopa (LD) and benserazide (BS) used in the treatment of Parkinson's disease. During the design and analysis phase of the modified electrode, many electroanalytical optimization and validation parameters were examined. The developed modified electrode gave linear responses with DPV technique in concentration ranges of 10 - 50 μM for LD and 10 - 50 μM for BS. In addition, limits of detection in these wide linear ranges were obtained as very low. Limits of detection were calculated as 2.4 μM and 1.2 μM for LD and BS, respectively. In addition, the applicability of the designed electrode and method was tested in urine and drug samples. The selectivity of this electrode was carried out in placebo solutions containing the interfering species. It is advantageous that the drug active ingredients are easily, selectively and quickly determined at this modified electrode in the presence of components that affect the analysis. Eventually, very satisfactory results in terms of analytical performance and applicability have been achieved with the designed electrode.

Keywords

• Electropolymerization
• Parkinson
• polypyrrole
• single-walled carbon nanotube
• voltammetry

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