Bazı 2-(4h-[1,2,4] Triazol-3-İl-sulfanil)-asetamid türevlerinin antioksidan ve antiproliferatif özellikleri

Year 2021, Volume: 7 Issue: 3, 472 - 479, 31.12.2021

Selahattin Demir Sibel Pekdemir Serhat Keser Arzu Karatepe Metin Koparır Mustafa Karatepe

https://doi.org/10.29132/ijpas.972632

Abstract

Bu çalışmada, bazı 2- (4H- [1,2,4] triazol-3-il-sulfanil)-asetamid türevleri bileşiklerinin L1210 kemirgen lösemi kanser hücre hattı üzerindeki sitotoksik etkileri araştırıldı. Aynı zamanda bu bileşiklerle muamele edilen Saccharomyces cerevisiae maya hücrelerinde lipid peroksidasyon derecesini gösteren MDA konsantrasyonu ve vitamin A, E ve C değerlerine etkisi araştırıldı. Ayrıca DPPH radikal süpürme yöntemi ile antioksidan özellikleri araştırıldı. Bileşiklerin Saccharomyces cerevisiae maya hücrelerinde A, E, C vitamin seviyeleri ve MDA konsantrasyonlarında istatistiksel olarak anlamlı bir fark yaratmadığı belirlendi. Çalışma gruplarının DPPH radikal süpürücü aktivite sonuçlarında antioksidan aktivite göstermediği görüldü. Antitümör aktivite sonuçlarına dayanarak, bileşiklerin genel olarak L1210 hücre hattı üzerinde etkili bir sitotoksik aktiviteye sahip olduğu bulundu.

Keywords

Antikanser, antioksidan, DPPH, MDA, vitamin

Antioxidant and antiproliferative properties of some 2- (4h- [1,2,4] Triazol-3-Yl-sulfanyl) -acetamide derivatives

Abstract

In this study, the cytotoxic effects of some 2- (4H- [1,2,4] triazol-3-yl-sulfanyl)-acetamide derivatives compounds on the L1210 rodent leukemia cancer cell line were investigated. At the same time, the effect on MDA concentration showing the degree of lipid peroxidation in Saccharomyces cerevisiae yeast cells treated with these compounds and vitamin A, E and C values were investigated. In addition, the antioxidant properties were investigated by the DPPH radical scavenging method. It was determined that the compounds did not make a statistically significant difference in the A, E, C vitamin levels and MDA concentrations in Saccharomyces cerevisiae yeast cells. It was observed that the study groups did not show antioxidant activity in DPPH radical scavenging activity results. Based on the antitumor activity results, the compounds were generally found to have an effective cytotoxic activity on the L1210 cell line.

Keywords

antioxidant, anticancer, DPPH, MDA, vitamin

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