Review Article
PDF Zotero Mendeley EndNote BibTex Cite

Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review

Year 2021, Volume 1, Issue 1, 1 - 41, 15.12.2021

Abstract

The aim of this study was to present information about the traditional use and phytochemistry of T. polium, to discuss contradictory views about chemotaxonomy and its toxic effect on liver and kidneys, and to make suggestions about controversial areas and gaps in the literature. Literature data showed that T. polium has toxic effect on kidney tissue. Moreover, in some of the studies on the liver and in all clinical reports, T. polium has also been proven to have toxic effect on the liver. The components responsible for toxicity are thought to be neo-clerodane diterpenoids. However, it has been reported that flavonoids and some polyphenols in the plant also show antioxidant and anti-inflammatory effects. It has been concluded that more attention should be paid to the use of this plant. More clinical studies are needed to better understand the effects of T. polium on the liver. The effects of the plant on blood serum parameters and histological changes on the liver tissue should be documented in more detail. It was also concluded that that regular consumption of T. polium should be avoided for long periods of time.

References

  • Abadian, K., Keshavarz, Z., Mojab, F., Majd, H.A., Abbasi, N.M., 2016. Comparison the effect of mefenamic acid and Teucrium polium on the severity and systemic symptoms of dysmenorrhea. Complementary Therapies in Clinical Practice, 22, 12-15.
  • Abdollahi, M., Karimpour, H., Monsef-Esfehani, H.R., 2003. Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacological Research, 48, 31-35.
  • Abdulrazzaq, I.H., 2017. The Comparison Effect of Nickel (II) and Cadmium (II) Complexes with Aqueous Extract of Tecrium polium. L (Ja'adah) Plant on Hepatocellular Carcinoma Cell Line HeP2. Baghdad Science Journal, 14, 371-378.
  • Abu-rish, E.Y., Kasabri, V., Hudaib, M.M., Mashalla, S.H., AlAlawi, L.H., Tawaha, K., Mohammad, M.K., Mohamed, Y.S., Bustanji, Y., 2016. Evaluation of Antiproliferative Activity of Some Traditional Anticancer Herbal Remedies from Jordan. Tropical Journal of Pharmaceutical Research, 15, 469-474.
  • Aburjai, T., Hudaib, M., Cavrini, V., 2006. Composition of the essential oil from Jordanian germander (Teucrium polium L.). Journal of Essential Oil Research, 18, 97-99.
  • Afifi, F.U., Al-Khalidi, B., Khalil, E., 2005. Studies on the in vivo hypoglycemic activities of two medicinal plants used in the treatment of diabetes in Jordanian traditional medicine following intranasal administration. Journal of Ethnopharmacology, 100, 314-318.
  • Aghazadeh, S., Yazdanparast, R., 2010. Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clinical Nutrition, 29, 381-385.
  • Akgul, A., Akgul, A., Senol, S.G., Yildirim, H., Secmen, O., Dogan, Y., 2018. An ethnobotanical study in Midyat (Turkey), a city on the silk road where cultures meet. Journal of Ethnobiology and Ethnomedicine, 14, 12.
  • Al-Asmari, A.K., Al-Elaiwi, A., Athar, M.T., Tariq, M., Al Eid, A., Al-Asmary, S.M., 2014. A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine. Evidence-Based Complementary and Alternative Medicine, 890842.
  • Al-Qudah, T.S., Shibli, R.A., Alali, F.Q., 2011. In vitro propagation and secondary metabolites production in wild germander (Teucrium polium L.). In Vitro Cellular & Developmental Biology-Plant, 47, 496-505.
  • Al-Tikriti, A.A.A., Al-Khateeb, E., Abbas, M.A., 2017. Teucrium polium hexane extract downregulated androgen receptor in testis and decreased fertility index in rats. Human and Experimental Toxicology, 36, 1248-1255.
  • Alachkar, A., Jaddouh, A., Elsheikh, M.S., Bilia, A.R., Vincieri, F.F., 2011. Traditional Medicine in Syria: Folk Medicine in Aleppo Governorate. Natural Product Communications, 6, 79-84.
  • Alamdar, A., Naseri, G., Shahla, F., 2007. Isolation and identification of the major chemical components found in the upper parts of Teucrium polium plants grown in Khuzestan province of Iran. Chinese Journal of Chemistry, 25, 1171-1173.
  • Alhazimi, H.M.G., Miana, G.A., 1993. The Diterpenoids of Teucrium Species .2. Journal of the Chemical Society of Pakistan, 15, 215-226.
  • Ali-Shtayeh, M.S., Yaniv, Z., Mahajna, J., 2000. Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants. Journal of Ethnopharmacology, 73, 221-232.
  • Alizadeh, A.M., Sohanaki, H., Khaniki, M., Mohaghgheghi, M.A., Ghmami, G., Mosavi, M., 2011. The Effect of Teucrium polium Honey on the Wound Healing and Tensile Strength in Rat. Iranian Journal of Basic Medical Sciences, 14, 499-505.
  • Alzweiri, M., Al Sarhan, A., Mansi, K., Hudaib, M., Aburjai, T., 2011. Ethnopharmacological survey of medicinal herbs in Jordan, the Northern Badia region. Journal of Ethnopharmacology, 137, 27-35.
  • Amini, R., Nosrati, N., Yazdanparast, R., Molaei, M., 2009. Teucrium polium in prevention of steatohepatitis in rats. Liver International, 29, 1216-1221.
  • Amini, R., Yazdanparast, R., 2011. Efficacy of Teucrium polium crude extract for prevention of nonalcoholic steatohepatitis and its side effects. Clinical Biochemistry, 44, S351-S351.
  • Amini, R., Yazdanparast, R., Aghazadeh, S., Ghaffari, S.H., 2011. Teucrium polium reversed the MCD diet-induced liver injury in rats. Human and Experimental Toxicology, 30, 1303-1312.
  • Amraei, M., Ghorbani, A., Seifinejad, Y., Mousavi, S.F., Mohamadpour, M., Shirzadpour, E., 2018a. The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats. Journal of Inflammation Research, 11, 265-272.
  • Amraei, M., Mohamadpour, M., Mousavi, S.F., Ghorbani, A., Nargesi, S., 2018b. Studying the Effect of Hydroalcoholic Extract of Teucrium polium L. Leaves on Antioxidant Activity and Lipid Profile Alterations. Asian Journal of Pharmaceutics, 12, S603-S608.
  • Amraei, M., Seifinejad, Y., Mohamadpour, M., Ghorbani, A., Mousavi, S.F., Shirzadpour, E., 2017a. Antihyperlipidemic Effects of Hydroalcoholic Leaf Extract of Teucrium Polium in Hypercholesterolemic Rats. Indo American Journal of Pharmaceutical Sciences, 4, 4333-4339.
  • Amraei, M., Shirzadpour, E., Mousavi, S.F., Mohamadpour, S., Hasanbeigi, A., 2017b. The Effects of Teucrium polium L. On Atherosclerotic Plaques in Hypercholesterolemic in Rats. Indo American Journal of Pharmaceutical Sciences, 4, 3825-3829.
  • Arasan, S., Kaya, I., 2015. Some Important Plants Used against Diabetes in Folkloric Medicine in Savur (Mardin/Turkey) Area and Their Application Areas. Scientific Papers-Series A-Agronomy, 58, 128-131.
  • Ardestani, A., Yazdanparast, R., 2007. Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food and Chemical Toxicology, 45, 2402-2411.
  • Asgharipour, M.R., Shabankare, H.G., 2017. Comparison of Chemical Composition of Teucrium polium L. Essential Oil Affected by Phenological Stages. Bangladesh Journal of Botany, 46, 583-588.
  • Baali, N., Belloum, Z., Baali, S., Chabi, B., Pessemesse, L., Fouret, G., Ameddah, S., Benayache, F., Benayache, S., Feillet-Coudray, C., Cabello, G., Wrutniak-Cabello, C., 2016. Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats. Nutrients, 8, 193.
  • Bahramikia, S., Ardestani, A., Yazdanparast, R., 2009. Protective effects of four Iranian medicinal plants against free radical-mediated protein oxidation. Food Chemistry, 115, 37-42.
  • Bahramikia, S., Yazdanparast, R., 2011. Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae). Clinical Biochemistry, 44, S336-S337.
  • Bahramikia, S., Yazdanparast, R., 2012. Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae). Phytotherapy Research, 26, 1581-1593.
  • Bakari, S., Ncir, M., Felhi, S., Hajlaoui, H., Saoudi, M., Gharsallah, N., Kadri, A., 2015. Chemical composition and in vitro evaluation of total phenolic, flavonoid, and antioxidant properties of essential oil and solvent extract from the aerial parts of Teucrium polium grown in Tunisia. Food Science and Biotechnology, 24, 1943-1949.
  • BaniHani, M.N., Al Manasra, A.R.A., 2009. Spontaneous regression in alveolar soft part sarcoma: case report and literature review. World Journal of Surgical Oncology, 7, 53.
  • Baradaran, A., Madihi, Y., Merrikhi, A., Rafieian-Kopaei, M., Nematbakhsh, M., Asgari, A., Khosravi, Z., Haghighian, F., Nasri, H., 2013. Nephrotoxicity of hydroalcoholic extract of Teucrium polium in Wistar rats. Pakistan Journal of Medical Sciences, 29, 329-333.
  • Bedir, E., Tasdemir, D., Calis, I., Zerbe, O., Sticher, O., 1999. Neo-clerodane diterpenoids from Teucrium polium. Phytochemistry, 51, 921-925.
  • Ben Othman, M., Salah-Fatnassi, K.B.H., Ncibi, S., Elaissi, A., Zourgui, L., 2017. Antimicrobial activity of essential oil and aqueous and ethanol extracts of Teucrium polium L. subsp gabesianum (LH) from Tunisia. Physiology and Molecular Biology of Plants, 23, 723-729.
  • Bendif, H., Lazali, M., Souilah, N., Miara, M.D., Kazernaviciute, R., Baranauskiene, R., Venskutonis, P.R., Maggi, F., 2018. Supercritical CO2 extracts and essential oils from Teucrium polium L. growing in Algeria: chemical composition and antioxidant activity. Journal of Essential Oil Research, 30, 488-497.
  • Bendjabeur, S., Benchabane, O., Bensouici, C., Hazzit, M., Baaliouamer, A., Bitam, A., 2018. Antioxidant and anticholinesterase activity of essential oils and ethanol extracts of Thymus algeriensis and Teucrium polium from Algeria. Journal of Food Measurement and Characterization, 12, 2278-2288.
  • Bezic, N., Vuko, E., Dunkic, V., Ruscic, M., Blazevic, I., Burcul, F., 2011. Antiphytoviral Activity of Sesquiterpene-Rich Essential Oils from Four Croatian Teucrium Species. Molecules, 16, 8119-8129.
  • Bhargava, V., Patel, S., Desai, K., 2013. Importance of terpenoids and essential oils in chemotaxonomic approach. International Journal of Herbal Medicine, 1, 14-21.
  • Boghrati, Z., Naseri, M., Rezaie, M., Pham, N., Quinn, R.J., Tayarani-Najaran, Z., Iranshahi, M., 2016. Tyrosinase inhibitory properties of phenylpropanoid glycosides and flavonoids from Teucrium polium L. var. gnaphalodes. Iranian Journal of Basic Medical Sciences, 19, 804-811.
  • Boroomand, N., Sadat-Hosseini, M., Moghbeli, M., Farajpour, M., 2018. Phytochemical components, total phenol and mineral contents and antioxidant activity of six major medicinal plants from Rayen, Iran. Natural Product Research, 32, 564-567.
  • Boulila, A., Bejaoui, A., Messaoud, C., Boussaid, M., 2008. Variation of volatiles in Tunisian populations of Teucrium polium L. (Lamiaceae). Chemistry & Biodiversity, 5, 1389-1400.
  • Bozov, P.I., Penchev, P.N., 2019. Neo-clerodane diterpenoids from Teucrium polium subsp. vincentinum (rouy) D. Wood. Phytochemistry Letters, 31, 237-241.
  • Bruno, M., Maggio, A.M., Piozzi, F., Puech, S., Rosselli, S., Simmonds, M.S.J., 2003. Neoclerodane diterpenoids from Teucrium polium subsp. polium and their antifeedant activity. Biochemical Systematics and Ecology, 31, 1051-1056.
  • Cakilcioglu, U., Sengun, M.T., Turkoglu, I., 2010. An ethnobotanical survey of medicinal plants of Yazikonak and Yurtbasi districts of Elazig province, Turkey. Journal of Medicinal Plants Research, 4, 567-572.
  • Cakilcioglu, U., Turkoglu, I., 2010. An ethnobotanical survey of medicinal plants in ivrice (Elazig-Turkey). Journal of Ethnopharmacology, 132, 165-175.
  • Chioibas, R., Susan, R., Susan, M., Mederle, O., Vaduva, D.B., Radulescu, M., Berceanu, M., Danciu, C., Khaled, Z., Draghici, G., Marti, D., 2019. Antimicrobial Activity Exerted by Total Extracts of Germander. Revista de Chimie, 70, 3242-3244.
  • Chitturi, S., Farrell, G.C., 2008. Hepatotoxic slimming aids and other herbal hepatotoxins. Journal of Gastroenterology and Hepatology, 23, 366-373.
  • Chizzola, R., 2006. Volatile compounds from some wild growing aromatic herbs of the Lamiaceae from southern France. Plant Biosystems, 140, 206-210.
  • Coban, T., Citoglu, G.S., Sever, B., Iscan, M., 2003. Antioxidant activities of plants used in traditional medicine in Turkey. Pharmaceutical Biology, 41, 608-613.
  • Cozzani, S., Muselli, A., Desjobert, J.M., Bernardini, A.F.O., Tomi, F., Casanova, J., 2005. Chemical composition of essential oil of Teucrium polium subsp. capitatum (L.) from Corsica. Flavour and Fragrance Journal, 20, 436-441.
  • Cuadrado, M.J.S., Bruno, M., Delatorre, M.C., Piozzi, F., Savona, G., Rodriguez, B., 1992. Rearranged Abietane Diterpenoids from the Root of 2 Teucrium Species. Phytochemistry, 31, 1697-1701.
  • D'Abrosca, B., Pacifico, S., Scognamiglio, M., D'Angelo, G., Galasso, S., Monaco, P., Fiorentino, A., 2013. A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. Natural Product Research, 27, 356-363.
  • Dababneh, B.F., 2008. Antimicrobial activity of selected Jordanian medicinal plant extracts against pathogenic microorganisms. Journal of Food Agriculture & Environment, 6, 134-139.
  • Dag, M., Ozturk, Z., Aydinli, M., Koruk, I., Kadayifci, A., 2014a. Postpartum hepatotoxicity due to herbal medicine Teucrium polium. Annals of Saudi Medicine, 34, 541-543.
  • Dag, M.S., Aydinli, M., Ozturk, Z.A., Turkbeyler, I.H., Koruk, I., Savas, M.C., Koruk, M., Kadayifci, A., 2014b. Drug-and herb-induced liver injury: A case series from a single center. Turkish Journal of Gastroenterology, 25, 41-45.
  • Darabpour, E., Motamedi, H., Nejad, S.M.S., 2010. Antimicrobial properties of Teucrium polium against some clinical pathogens. Asian Pacific Journal of Tropical Medicine, 3, 124-127.
  • Darwish, R.M., Aburjai, T.A., 2010. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complementary and Alternative Medicine, 10, 9.
  • De Marino, S., Festa, C., Zollo, F., Incollingo, F., Raimo, G., Evangelista, G., Iorizzi, M., 2012. Antioxidant activity of phenolic and phenylethanoid glycosides from Teucrium polium L. Food Chemistry, 133, 21-28.
  • De Martino, L., Formisano, C., Mancini, E., De Feo, V., Piozzi, F., Rigano, D., Senatore, F., 2010. Chemical Composition and Phytotoxic Effects of Essential Oils from Four Teucrium Species. Natural Product Communications, 5, 1969-1976.
  • Delatorre, M.C., Piozzi, F., Rizk, A.F., Rodriguez, B., Savona, G., 1986. 19-Acetylteupolin-Iv, a Neoclerodane Diterpenoid from Teucrium polium subsp. pilosum. Phytochemistry, 25, 2239-2240.
  • Derakhshan, M., Niazmand, S., Sadeghian, A., Rezaee, R., Khajakaramodin, M., Derakhshan, R., Zarif, R., 2011. The evaluation of the effect of the Teucrium polium L. on infectivity of human influenza virus in vitro. Clinical Biochemistry, 44, S351-S351.
  • Djabou, N., Muselli, A., Allali, H., Dib, M.E., Tabti, B., Varesi, L., Costa, J., 2012. Chemical and genetic diversity of two Mediterranean subspecies of Teucrium polium L. Phytochemistry, 83, 51-62.
  • Eguren, L., Perales, A., Fayos, J., Savona, G., Paternostro, M., Piozzi, F., Rodriguez, B., 1981. New Clerodane Diterpenoid from Teucrium polium subsp. aureum - X-Ray Structure Determination. Journal of Organic Chemistry, 46, 3364-3367.
  • El Atki, Y., Aouam, I., El Kamari, F., Taroq, A., Lyoussi, B., Abdellaoui, A., 2019a. Antioxidant Activity of Two Wild Teucrium Species from Morocco. International Journal of Pharmaceutical Sciences and Research, 10, 2723-2729.
  • El Atki, Y., Aouam, I., El Kamari, F., Taroq, A., Lyoussi, B., Taleb, M., Abdellaoui, A., 2019b. Total phenolic and flavonoid contents and antioxidant activities of extracts from Teucrium polium growing wild in Morocco. Materials Today-Proceedings, 13, 777-783.
  • Elmasri, W.A., Hegazy, M.E.F., Aziz, M., Koksal, E., Amor, W., Mechref, Y., Hamood, A.N., Cordes, D.B., Pare, P.W., 2014. Biofilm blocking sesquiterpenes from Teucrium polium. Phytochemistry, 103, 107-113.
  • Elmasri, W.A., Hegazy, M.E.F., Mechref, Y., Pare, P.W., 2015a. Cytotoxic saponin poliusaposide from Teucrium polium. RSC Advances, 5, 27126-27133.
  • Elmasri, W.A., Hegazy, M.E.F., Mechref, Y., Pare, P.W., 2016a. Structure-antioxidant and anti-tumor activity of Teucrium polium phytochemicals. Phytochemistry Letters, 15, 81-87.
  • Elmasri, W.A., Yang, T.J., Hegazy, M.E.F., Mechref, Y., Pare, P.W., 2016b. Iridoid glycoside permethylation enhances chromatographic separation and chemical ionization. Rapid Communications in Mass Spectrometry, 30, 2033-2042.
  • Elmasri, W.A., Yang, T.J., Tran, P., Hegazy, M.E.F., Hamood, A.N., Mechref, Y., Pare, P.W., 2015b. Teucrium polium Phenylethanol and lridoid Glycoside Characterization and Flavonoid Inhibition of Biofilm-Forming Staphylococcus aureus. Journal of Natural Products, 78, 2-9.
  • Erbay, M.S., Sari, A., 2018. Plants used in traditional treatment against hemorrhoids in Turkey. Marmara Pharmaceutical Journal, 22, 110-132.
  • Esmaeili, M.A., Sadeghi, H., Pour, N.K., 2009a. Quercetin-3-rutinoside, a flavonol glycoside from Teucrium polium suppresses advanced glycation end products (AGEs) formation: A structural study. Planta Medica, 75, 954-955.
  • Esmaeili, M.A., Yazdanparast, R., 2004. Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. Journal of Ethnopharmacology, 95, 27-30.
  • Esmaeili, M.A., Zohari, F., Sadeghi, H., 2009b. Antioxidant and Protective Effects of Major Flavonoids from Teucrium polium on beta-Cell Destruction in a Model of Streptozotocin-Induced Diabetes. Planta Medica, 75, 1418-1420.
  • Essid, R., Rahali, F.Z., Msaada, K., Sghair, I., Hammami, M., Bouratbine, A., Aoun, K., Limam, F., 2015. Antileishmanial and cytotoxic potential of essential oils from medicinal plants in Northern Tunisia. Industrial Crops and Products, 77, 795-802.
  • Fanouriou, E., Kalivas, D., Daferera, D., Tarantilis, P., Trigas, P., Vahamidis, P., Economou, G., 2018. Hippocratic medicinal flora on the Greek Island of Kos: Spatial distribution, assessment of soil conditions, essential oil content and chemotype analysis. Journal of Applied Research on Medicinal and Aromatic Plants, 9, 97-109.
  • Farahmandfar, R., Asnaashari, M., Bakhshandeh, T., 2019. Influence of ultrasound-assist and classical extractions on total phenolic, tannin, flavonoids, tocopherol and antioxidant characteristics of Teucrium polium aerial parts. Journal of Food Measurement and Characterization, 13, 1357-1363.
  • Fiorentino, A., D'Abrosca, B., Pacifico, S., Scognamiglio, M., D'Angelo, G., Gallicchio, M., Chambery, A., Monaco, P., 2011. Structure elucidation and hepatotoxicity evaluation against HepG2 human cells of neo-clerodane diterpenes from Teucrium polium L. Phytochemistry, 72, 2037-2044.
  • Fiorentino, A., D'Abrosca, B., Pacifico, S., Scognamiglio, M., D'Angelo, G., Monaco, P., 2010. Abeo-Abietanes from Teucrium polium roots as protective factors against oxidative stress. Bioorganic & Medicinal Chemistry, 18, 8530-8536.
  • Forouzandeh, H., Azemi, M.E., Rashidi, I., Goudarzi, M., Kalantari, H., 2013. Study of the Protective Effect of Teucrium polium L. Extract on Acetaminophen-Induced Hepatotoxicity in Mice. Iranian Journal of Pharmaceutical Research, 12, 123-129.
  • Ghasemi, T., Keshavarz, M., Parviz, M., 2019a. Acute Hepatorenal Dose Dependent Toxicity of Teucrium polium Hydro Alcoholic Extract in Rat. International Journal of Pediatrics-Mashhad, 7, 10099-10107.
  • Ghasemi, T., Sohanaki, H., Keshavarz, M., Ghasemi, E., Parviz, M., 2019b. Low Dose Teucrium polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat A beta 25-35 Model of Alzheimer's Disease. Archives of Neuroscience, 6, e90893.
  • Gholivand, M.B., Piryaei, M., Abolghasemi, M.M., Maassoumi, S.M., 2013. Rapid Analysis of Volatile Components from Teucrium polium L. by Nanoporous Silica-polyaniline Solid Phase Microextraction Fibre. Phytochemical Analysis, 24, 69-74.
  • Goulas, V., Gomez-Caravaca, A.M., Exarchou, V., Gerothanassis, I.R., Segura-Carretero, A., Gutierrez, A.F., 2012. Exploring the antioxidant potential of Teucrium polium extracts by HPLC-SPE-NMR and on-line radical-scavenging activity detection. LWT-Food Science and Technology, 46, 104-109.
  • Grubesic, R.J., Kremer, D., Vladimir-Knezevic, S., Rodriguez, J.V., 2012. Analysis of polyphenols, phytosterols, and bitter principles in Teucrium L. species. Central European Journal of Biology, 7, 542-550.
  • Gunes, S., Savran, A., Paksoy, M.Y., Kosar, M., Cakilcioglu, U., 2017. Ethnopharmacological survey of medicinal plants in Karaisali and its surrounding (Adana-Turkey). Journal of Herbal Medicine, 8, 68-75.
  • Hachicha, S.F., Barrek, S., Skanji, T., Zarrouk, H., Ghrabi, Z.G., 2009. Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia. Chemistry of Natural Compounds, 45, 304-308.
  • Hasanein, P., Shahidi, S., 2012. Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Medical Science Monitor, 18, Br41-Br46.
  • Hasani-Ranjbar, S., Larijani, B., Abdollah, M., 2008. A systematic review of Iranian medicinal plants useful in diabetes mellitus. Archives of Medical Science, 4, 285-292.
  • Hasani-Ranjbar, S., Nayebi, N., Larijani, B., Abdollahi, M., 2010. A Systematic Review of the Efficacy and Safety of Teucrium Species, from Anti-oxidant to Anti-diabetic Effects. International Journal of Pharmacology, 6, 315-325.
  • Hayta, S., Polat, R., Selvi, S., 2014. Traditional uses of medicinal plants in Elazig (Turkey). Journal of Ethnopharmacology, 154, 613-623.
  • Heydarzade, A., Moravvej, G., 2012. Contact toxicity and persistence of essential oils from Foeniculum vulgare, Teucrium polium and Satureja hortensis against Callosobruchus maculatus (Fabricius) (Coleoptera: Bruchidae) adults. Turkiye Entomoloji Dergisi-Turkish Journal of Entomology, 36, 507-518.
  • Hosseinkhani, A., Falahatzadeh, M., Raoofi, E., Zarshenas, M.M., 2017. An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine. Journal of Evidence-Based Integrative Medicine, 22, 334-343.
  • Huseini, H.F., Abdolghaffari, A.H., Ahwazi, M., Jasemi, E., Yaghoobi, M., Ziaee, M., 2019. Topical Application of Teucrium polium Can Improve Wound Healing in Diabetic Rats. International Journal of Lower Extremity Wounds, 3, 1534734619868629.
  • Ibrahim, S.R.M., Abdallah, H.M., Mohamed, G.A., Farag, M.A., Alshali, K.Z., Alsherif, E.A., Ross, S.A., 2017. Volatile oil profile of some lamiaceous plants growing in Saudi Arabia and their biological activities. Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences, 72, 35-41.
  • Jaradat, N.A., Ayesh, O.I., Anderson, C., 2016. Ethnopharmacological survey about medicinal plants utilized by herbalists and traditional practitioner healers for treatments of diarrhea in the West Bank/Palestine. Journal of Ethnopharmacology, 182, 57-66.
  • Kabouche, A., Kabouche, Z., Ghannadi, A., Sajjadi, S.E., 2007. Analysis of the essential oil of Teucrium polium ssp. aurasiacum from Algeria. Journal of Essential Oil Research, 19, 44-46.
  • Kalantari, H., Azemi, E., Frouzandeh, H., Rashidi, I., 2012. Protective effects of Teucrium polium L. on acetaminophen induced hepatotoxicity. Toxicology Letters, 211, S192-S192.
  • Kamel, A., Sandra, P., 1994. Gas-Chromatography Mass-Spectrometry Analysis of the Volatile Oils of 2 Teucrium polium Varieties. Biochemical Systematics and Ecology, 22, 529-532.
  • Kandouz, M., Alachkar, A., Zhang, L., Dekhil, H., Chehna, F., Yasmeen, A., Al Moustafa, A.E., 2010. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex. Journal of Ethnopharmacology, 129(3), 410-415.
  • Kawashty, S.A., El-Din, E.M.G., Saleh, N.A.M., 1999. The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochemical Systematics and Ecology, 27, 657-660.
  • Kerbouche, L., Hazzit, M., Ferhat, M.A., Baaliouamer, A., Miguel, M.G., 2015. Biological Activities of Essential Oils and Ethanol Extracts of Teucrium polium subsp. capitatum (L.) Briq. and Origanum floribundum Munby. Journal of Essential Oil Bearing Plants, 18, 1197-1208.
  • Keykavousi, M., Tarzi, B.G., Mahmoudi, R., Bakhoda, H., Kabudari, A., Mahalleh, S.F.R.P., 2016. Study of Antibacterial Effects of Teucrium polium Essential Oil on Bacillus Cereus in Cultural Laboratory and Commercial Soup. Carpathian Journal of Food Science and Technology, 8, 193-201.
  • Khader, M., Bresgen, N., Eckl, P.M., 2010. Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants. Journal of Ethnopharmacology, 127, 319-324.
  • Khader, M., Eckl, P.M., Bresgen, N., 2007. Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. Journal of Ethnopharmacology, 112, 199-202.
  • Khaled-Khodja, N., Boulekbache-Makhlouf, L., Madani, K., 2014. Phytochemical screening of antioxidant and antibacterial activities of methanolic extracts of some Lamiaceae. Industrial Crops and Products, 61, 41-48.
  • Khalil, A., Dababneh, B.F., Al-Gabbiesh, A.H., 2009. Antimicrobial activity against pathogenic microorganisms by extracts from herbal Jordanian plants. Journal of Food Agriculture & Environment, 7, 103-106.
  • Khani, A., Heydarian, M., 2014. Fumigant and repellent properties of sesquiterpene-rich essential oil from Teucrium polium subsp. capitatum (L.). Asian Pacific Journal of Tropical Medicine, 7, 956-961.
  • Khazaei, M., Nematollahi-Mahani, S.N., Mokhtari, T., Sheikhbahaei, F., 2018. Review on Teucrium polium biological activities and medical characteristics against different pathologic situations. Journal of Contemporary Medical Sciences, 4, 1-6.
  • Khodadadi, S., Zabihi, N.A., Niazmand, S., Abbasnezhad, A., Mahmoudabady, M., Rezaee, S.A., 2018. Teucrium polium improves endothelial dysfunction by regulating eNOS and VCAM-1 genes expression and vasoreactivity in diabetic rat aorta. Biomedicine & Pharmacotherapy, 103, 1526-1530.
  • Khoshnood-Mansoorkhani, M.J., Moein, M.R., Oveisi, N., 2010. Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice. Iranian Journal of Pharmaceutical Research, 9, 395-401.
  • Kiyani, N., Ostad, S.N., Arbabi, S., 2011. Evaluation of acute and sub chronic hepatotoxicity of hydroalcoholic extract of Teucrium polium L. in non-diabetic rats. Planta Medica, 77, 1324-1324.
  • Kovacevic, N.N., Lakusic, B.S., Ristic, M.S., 2001. Composition of the essential oils of seven Teucrium species from Serbia and Montenegro. Journal of Essential Oil Research, 13, 163-165.
  • Krishnaiah, D., Sarbatly, R., Nithyanandam, R., 2011. A review of the antioxidant potential of medicinal plant species. Food and Bioproducts Processing, 89, 217-233.
  • Kulevanova, S., Panovska, T.K., Stefkov, G., Gjorgoski, I., Bogdanova, M., Petrushevska, G., 2006. Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride induced hepatic injury in rats. Planta Medica, 72, 1033-1033.
  • Ladjel, S., Laamara, K., Alhillo, M.R.Y., Pais, M., 1994. Neoclerodane Diterpenoids from Teucrium polium subsp. aurasianum. Phytochemistry, 37, 1663-1666.
  • Lianopoulou, V., Bosabalidis, A.M., Patakas, A., Lazari, D., Panteris, E., 2014. Effects of chilling stress on leaf morphology, anatomy, ultrastructure, gas exchange, and essential oils in the seasonally dimorphic plant Teucrium polium (Lamiaceae). Acta Physiologiae Plantarum, 36, 2271-2281.
  • Ljubuncic, P., Azaizeh, H., Portnaya, I., Cogan, U., Said, O., Abu Saleh, K., Bomzon, A., 2005. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel. Journal of Ethnopharmacology, 99, 43-47.
  • Ljubuncic, P., Dakwar, S., Portnaya, I., Cogan, U., Azaizeh, H., Bomzon, A., 2006. Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evidence-Based Complementary and Alternative Medicine, 3, 329-338.
  • Mahjoub, S., Davari, S., Moazezi, Z., Qujeq, D., 2012. Effect of Teucrium polium flower extract on the activities of nucleoside diphosphate kinase and acetyl-CoA carboxylase in normal and diabetic rats. African Journal of Pharmacy and Pharmacology, 6, 1106-1110.
  • Mahmoudabady, M., Talebian, F.S., Zabihi, N.A., Rezaee, S.A., Niazmand, S., 2018. Teucrium polium L. Improved Heart Function and Inhibited Myocardial Apoptosis in Isolated Rat Heart Following Ischemia-Reperfusion Injury. Journal of Pharmacopuncture, 21, 159-167.
  • Mahmoudi, R., Zare, P., Hassanzadeh, P., Nosratpour, S., 2014. Effect of Teucrium polium Essential Oil on the Physicochemical and Sensory Properties of Probiotic Yoghurt. Journal of Food Processing and Preservation, 38, 880-888.
  • Mahmoudi, R., Zare, P., Nosratpour, S., 2015. Application of Teucrium polium Essential Oil and Lactobacillus casei in Yoghurt. Journal of Essential Oil Bearing Plants, 18, 477-481.
  • Malakov, P.Y., Boneva, I.M., Papanov, G.Y., Spassov, S.L., 1988. Teulamifin-B, a Neo-Clerodane Diterpenoid from Teucrium lamiifolium and Teucrium polium. Phytochemistry, 27, 1141-1143.
  • Malakov, P.Y., Papanov, G.Y., Ziesche, J., 1982. Teupolin-Iii, a Furanoid Diterpene from Teucrium polium. Phytochemistry, 21, 2597-2598.
  • Mashreghi, M., Niknia, S., 2012. The Effect of Peganum harmala and Teucrium polium Alcoholic Extracts on Growth of Escherichia coli O157. Jundishapur Journal of Microbiology, 5, 511-515.
  • Masoudi, S., 2018. Volatile Constituents from Different Parts of Three Lamiacea Herbs from Iran. Iranian Journal of Pharmaceutical Research, 17, 365-376.
  • Mattei, A., Rucay, P., Samuel, D., Feray, C., Reynes, M., Bismuth, H., 1995. Liver-Transplantation for Severe Acute Liver-Failure after Herbal Medicine (Teucrium polium) Administration. Journal of Hepatology, 22, 597-597.
  • Mazokopakis, E., Lazaridou, S., Tzardi, M., Mixaki, J., Diamantis, I., Ganotakis, E., 2004. Acute cholestatic hepatitis caused by Teucrium polium L. Phytomedicine, 11, 83-84.
  • Mazokopakis, E.E., Papadakis, J.A., Kofteridis, D.P., 2007. Unusual causes of intrahepatic cholestatic liver disease. World Journal of Gastroenterology, 13, 1879-1882.
  • Menichini, F., Conforti, F., Rigano, D., Formisano, C., Piozzi, F., Senatore, F., 2009. Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece. Food Chemistry, 115, 679-686.
  • Milosevic-Djordjevic, O., Radovic Jakovljevic, M., Markovic, A., Stankovic, M., Ciric, A., Marinkovic, D., Grujicic, D., 2018. Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes. Turkish Journal of Biology, 42, 152-162.
  • Mimidis, K.P., Papadopoulos, V.P., Baltatzidis, G., Giatromanolaki, A., Sivridis, E., Kartalis, G., 2009. Severe acute cholestasis caused by Teucrium polium. Journal of Gastrointestinal and Liver Diseases, 18, 387-388.
  • Mitic, V., Jovanovic, O., Stankov-Jovanovic, V., Zlatkovic, B., Stojanovic, G., 2012. Analysis of the Essential Oil of Teucrium polium ssp. capitatum from the Balkan Peninsula. Natural Product Communications, 7, 83-86.
  • Mitreski, I., Stanoeva, J.P., Stefova, M., Stefkov, G., Kulevanova, S., 2014. Polyphenols in Representative Teucrium Species in the Flora of R. Macedonia: LC/DAD/ESI-MSn Profile and Content. Natural Product Communications, 9, 175-180.
  • Monfared, S.S.M.S., Pournourmohammadi, S., 2010. Teucrium polium Complex with Molybdate Enhance Cultured Islets Secretory Function. Biological Trace Element Research, 133, 236-241.
  • Mosaddegh, M., Naghibi, F., Moazzeni, H., Pirani, A., Esmaeili, S., 2012. Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. Journal of Ethnopharmacology, 141, 80-95.
  • Mousavi, S.E., Shahriari, A., Ahangarpour, A., Vatanpour, H., Jolodar, A., 2012. Effects of Teucrium polium Ethyl acetate Extract on Serum, Liver and Muscle Triglyceride Content of Sucrose-Induced Insulin Resistance in Rat. Iranian Journal of Pharmaceutical Research, 11, 347-355.
  • Movahedi, A., Basir, R., Rahmat, A., Charaffedine, M., Othman, F., 2014. Remarkable Anticancer Activity of Teucrium polium on Hepatocellular Carcinogenic Rats. Evidence-Based Complementary and Alternative Medicine, 2014, 726724.
  • Niazmand, S., Esparham, M., Hassannia, T., Derakhshan, M., 2011. Cardiovascular effects of Teucrium polium L. extract in rabbit. Pharmacognosy Magazine, 7, 260-264. Niazmand, S., Fereidouni, E., Mahmoudabady, M., Hosseini, M., 2017. Teucrium polium-induced Vasorelaxation Mediated by Endothelium-dependent and Endothelium-independent Mechanisms in Isolated Rat Thoracic Aorta. Pharmacognosy Research, 9, 372-377.
  • Nikpour, H., Mousavi, M., Asadollahzadeh, H., 2018. Qualitative and quantitative analysis of Teucrium polium essential oil components by GC-MS coupled with MCR and PARAFAC methods. Phytochemical Analysis, 29, 590-600.
  • Nor, N.H.M., Othman, F., Tohit, E.R.M., Noor, S.M., Razali, R., Hassali, H.A., Hassan, H., 2019. In Vitro Antiatherothrombotic Effects of Extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus Benth. Evidence-Based Complementary and Alternative Medicine, 3245836.
  • Oganesyan, G.B., Galstyan, A.M., Mnatsakanyan, V.A., Shashkov, A.S., Agababyan, R.V., 1991. Phenylpropanoid Glycosides of Teucrium polium. Chemistry of Natural Compounds, 27, 556–559.
  • Orhan, I., Aslan, M., 2009. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. Journal of Ethnopharmacology, 122, 327-332.
  • Pacifico, S., D'Abrosca, B., Scognamiglio, M., D'Angelo, G., Gallicchio, M., Galasso, S., Monaco, P., Fiorentino, A., 2012. NMR-based metabolic profiling and in vitro antioxidant and hepatotoxic assessment of partially purified fractions from Golden germander (Teucrium polium L.) methanolic extract. Food Chemistry, 135, 1957-1967.
  • Panovska, T.K., Kulevanova, S., 2005. Effect of some Teucrium species (lamiaceae) on lipid peroxidation in rat liver microsomes. Fresenius Environmental Bulletin, 14, 957-959.
  • Pellow, J., Nienhuis, C., 2018. Medicinal plants for primary dysmenorrhoea: A systematic review. Complementary Therapies in Medicine, 37, 13-26.
  • Pesaraklu, A., Mianabadi, M., Bagherieh-Najjar, M.B., 2011. Comparison of antioxidant properties of Teucrium polium from Golestan, North Khorasan, and Semnan Provinces. Clinical Biochemistry, 44, S261-S261.
  • Polat, R., Satil, F., 2012. An ethnobotanical survey of medicinal plants in Edremit Gulf (Balikesir - Turkey). Journal of Ethnopharmacology, 139, 626-641.
  • Polymeros, D., Kamberoglou, D., Tzias, V., 2002. Acute cholestatic hepatitis caused by Teucrium polium (golden germander) with transient appearance of antimitochondrial antibody. Journal of Clinical Gastroenterology, 34, 100-101.
  • Proestos, C., Sereli, D., Komaitis, M., 2006. Determination of phenolic compounds in aromatic plants by RP-HPLC and GC-MS. Food Chemistry, 95, 44-52.
  • Purnavab, S., Ketabchi, S., Rowshan, V., 2015. Chemical composition and antibacterial activity of methanolic extract and essential oil of Iranian Teucrium polium against some of phytobacteria. Natural Product Research, 29, 1376-1379.
  • Rad, F.A., Jafari, M., Khezrinejad, N., Miandoab, M.P., 2014. An Efficient Plant Regeneration System via Direct Organogenesis with in vitro Flavonoid Accumulation and Analysis of Genetic Fidelity among Regenerants of Teucrium polium L. Horticulture Environment and Biotechnology, 55, 568-577.
  • Raei, F., Ashoori, N., Eftekhar, F., Yousefzadi, M., 2014. Chemical composition and antibacterial activity of Teucrium polium essential oil against urinary isolates of Klebsiella pneumoniae. Journal of Essential Oil Research, 26, 65-69.
  • Rafieian-Kopaei, M., Nasri, H., Baradaran, A., 2014. Teucrium polium: Liver and kidney effects. Journal of Research in Medical Sciences, 19, 478-479.
  • Rahmouni, F., Badraoui, R., Amri, N., Elleuch, A., El-Feki, A., Rebai, T., Saoudi, M., 2019. Hepatotoxicity and nephrotoxicity in rats induced by carbon tetrachloride and the protective effects of Teucrium polium and vitamin C. Toxicology Mechanisms and Methods, 29, 313-321.
  • Rahmouni, F., Saoudi, M., Amri, N., El-Feki, A., Rebai, T., Badraoui, R., 2018. Protective effect of Teucrium polium on carbon tetrachloride induced genotoxicity and oxidative stress in rats. Archives of Physiology and Biochemistry, 124, 1-9.
  • Rasekh, H.R., Kamali-Nejad, M., Hosseinzadeh, L., 2004. Sub-chronic toxicity of Teucrium polium in rats. Toxicology and Applied Pharmacology, 197, 221-221.
  • Ravan, S., Khani, A., Sufi, S., 2019. Fumigant toxicity and sublethal effects of Teucrium polium essential oil on Aphis fabae scopoli A. Chinese Herbal Medicines, 11, 231-235.
  • Rezvannejad, E., Nasirifar, E., Lotfi, S., Abdolinasab, M., 2019. Study and comparison of antibacterial activities of extracts of Zataria multiflora and Teucrium polium on Penibacillus alvei. Journal of the Hellenic Veterinary Medical Society, 70, 1421-1428.
  • Rizk, A.M., Hammouda, F.M., Rimpler, H., Kamel, A., 1986. Constituents of Plants Growing in Qatar .11. Iridoids and Flavonoids of Teucrium polium Herb. Planta Medica, 87-88.
  • Sabzeghabaie, A., Asgarpanah, J., 2016. Essential oil composition of Teucrium polium L. fruits. Journal of Essential Oil Research, 28, 77-80.
  • Sadeghi, H., Jamalpoor, S., Shirzadi, M.H., 2014a. Variability in essential oil of Teucrium polium L. of different latitudinal populations. Industrial Crops and Products, 54, 130-134.
  • Sadeghi, Z., Kuhestani, K., Abdollahi, V., Mahmood, A., 2014b. Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. Journal of Ethnopharmacology, 153, 111-118.
  • Sadrizadeh, N., Khezri, S., Dehghan, P., Mahmoudi, R., 2018. Antibacterial Effect of Teucrium polium Essential Oil and Lactobacillus casei Probiotic on Escherichia coli O157:H7 in Kishk. Applied Food Biotechnology, 5, 131-140.
  • Salbi, M., Madani, M., Modaresi, M., 2016. The Effects of Teucrium polium Ethanolic Extract on Blood Cell Parameters of Candida Albicans Infected Mice. Iranian Journal of Public Health, 45, 14-14.
  • Saltan, N., Kose, Y.B., Iscan, G., Demirci, B., 2019. Essential Oil Composition and Anticandidal Activity of Teucrium polium L. Fresenius Environmental Bulletin, 28, 1174-1178.
  • Savvidou, S., Goulis, J., Glavazis, I., Patslaoura, K., Hytiroglou, P., Arvanitakis, C., 2007. Herb-induced hepatitis by Teucrium polium L.: report of two cases and review of the literature. European Journal of Gastroenterology & Hepatology, 19, 507-511.
  • Sayyad, R., Farahmandfar, R., 2017. Influence of Teucrium polium L. essential oil on the oxidative stability of canola oil during storage. Journal of Food Science and Technology-Mysore, 54, 3073-3081.
  • Scognamiglio, M., D'Abrosca, B., Pacifico, S., Isidori, M., Esposito, A., Fiorentino, A., 2012. Mediterranean Wild Plants As Useful Sources of Potential Natural Food Additives. Emerging Trends in Dietary Components for Preventing and Combating Disease, 1093, 209-235.
  • Selimoglu, T., Gokce, A., Yanar, D., 2015. Fumigant toxicity of some plant essential oils to Acanthoscelides obtectus (Say) (Coleoptera: Bruchidae). Turkiye Entomoloji Dergisi-Turkish Journal of Entomology, 39, 109-118.
  • Sevindik, E., Abaci, Z.T., Yamaner, C., Ayvaz, M., 2016. Determination of the chemical composition and antimicrobial activity of the essential oils of Teucrium polium and Achillea millefolium grown under North Anatolian ecological conditions. Biotechnology & Biotechnological Equipment, 30, 375-380.
  • Seyyednejad, S.M., Motamedi, H., 2010. A Review on Native Medicinal Plants in Khuzestan, Iran with Antibacterial Properties. International Journal of Pharmacology, 6, 551-560.
  • Sezer, R.G., Bozaykut, A., 2012. Pediatric hepatotoxicity associated with Polygermander (Teucrium polium). Clinical Toxicology, 50, 153-153.
  • Shabankare, H.G., Asgharipour, M.R., Fakheri, B., 2015. Morpho-chemical Diversity among Iranian Teucrium polium L. (Lamiaceae) Populations in Fars Province. Journal of Agricultural Science and Technology, 17, 705-716.
  • Sharififar, F., Dehghn-Nudeh, G., Mirtajaldini, M., 2009. Major flavonoids with antioxi- ant activity from Teucrium polium L. Food Chemistry, 112, 885-888.
  • Sheikhbahaei, F., Khazaei, M., Nematollahi-Mahani, S.N., 2018. Teucrium polium Extract Enhances the Anti-Angiogenesis Effect of Tranilast on Human Umbilical Vein Endothelial Cells. Advanced Pharmaceutical Bulletin, 8, 131-139.
  • Simonyan, K.V., Chavushyan, V.A., 2015. Neuroprotective activity of hydroponic Teucrium polium following bilateral ovariectomy. Metabolic Brain Disease, 30, 785-792.
  • Stankovic, M.S., Mila, J., Franko, B., Milos, M., Politeo, O., Carev, I., 2011. Biological effects and phenolic content of felty germander (Teucrium polium L. subsp polium). Planta Medica, 77, 1397-1397.
  • Stankovic, M.S., Niciforovic, N., Mihailovic, V., Topuzovic, M., Solujic, S., 2012. Antioxidant activity, total phenolic content and flavonoid concentrations of different plant parts of Teucrium polium L. subsp polium. Acta Societatis Botanicorum Poloniae, 81, 117-122.
  • Starakis, I., Siagris, D., Leonidou, L., Mazokopakis, E., Tsamandas, A., Karatza, C., 2006. Hepatitis caused by the herbal remedy Teucrium polium L. European Journal of Gastroenterology & Hepatology, 18, 681-683.
  • Stefkov, G., Kulevanova, S., Miova, B., Dinevska-Kjovkarovska, S., Molgaard, P., Jager, A.K., Josefsen, K., 2011. Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats. Pharmaceutical Biology, 49, 885-892.
  • Stefova, M., Stafilov, T., Kulevanova, S., Stefkov, G., Bankova, V.S., 2007. QSRR of flavones: Evaluation of substituent contributions to RP HPLC retention. Journal of Liquid Chromatography & Related Technologies, 30, 1035-1049.
  • Suboh, S.M., Bilto, Y.Y., Aburjai, T.A., 2004. Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Phytotherapy Research, 18, 280-284.
  • Tadjrobehkar, O., Abdollahi, H., 2014. A Novel Reduction Strategy of Clarithromycin Resistance in Helicobacter pylori. Jundishapur Journal of Microbiology, 7, e13081.
  • Talaei Khozani, T., Dehghani, F., Panjehshahin, M.R., Karbalay-Doost, S., 2005. Histopathological and histochemical study of the effects of Teucrium polium on the kidney in rat. Virchows Archiv, 447, 375-375.
  • Tepe, B., Degerli, S., Arslan, S., Malatyali, E., Sarikurkcu, C., 2011. Determination of chemical profile, antioxidant, DNA damage protection and antiamoebic activities of Teucrium polium and Stachys iberica. Fitoterapia, 82, 237-246.
  • Tepe, B., Malatyali, E., Degerli, S., Berk, S., 2012. In vitro amoebicidal activities of Teucrium polium and T. chamaedrys on Acanthamoeba castellanii trophozoites and cysts. Parasitology Research, 110, 1773-1778.
  • Tuncturk, R., Tuncturk, M., Eryigit, T., 2019. Chemical Contents of Some Species of Teucrium Genus Distributed in Van Flora. KSU Tarim Ve Doga Dergisi-KSU Journal of Agriculture and Nature, 22, 138-142.
  • Uysal, I., Gucel, S., Tutenocakli, T., Ozturk, M., 2012. Studies on the Medicinal Plants of Ayvacik-Canakkale in Turkey. Pakistan Journal of Botany, 44, 239-244.
  • Vasileiadou, E., Karanikolas, E., Chrysagis, D., Kolokotroni, D., Papamihalis, E., Banti, A., Sidiropoulos, L., 2003. Teucrium polium L. (golden germander) - Induced hepatitis: Report of 5 cases. Journal of Hepatology, 38, 195-195.
  • Venditti, A., Frezza, C., Trancanella, E., Zadeh, S.M.M., Foddai, S., Sciubba, F., Delfini, M., Serafini, M., Bianco, A., 2017. A new natural neo-clerodane from Teucrium poli um L. collected in Northern Iran. Industrial Crops and Products, 97, 632-638.
  • Verykokidouvitsaropoulou, E., Vajias, C., 1986. Methylated Flavones from Teucrium polium. Planta Medica, 401-402.
  • Vladimir-Knezevic, S., Blazekovic, B., Kindl, M., Vladic, J., Lower-Nedza, A.D., Brantner, A.H., 2014. Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family. Molecules, 19, 767-782.
  • Vokou, D., Bessiere, J.M., 1985. Volatile Constituents of Teucrium polium. Journal of Natural Products, 48, 498-499.
  • Yaldiz, G., Caliskan, U.K., Aka, C., 2017. In Vitro Screening of Natural Drug Potentials for Mass Production. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 45, 292-300.
  • Yousefi, M., Afshari, R., Sadeghi, M., Salari, R., 2018. Measurement of Methanol and Ethanol Contents in Most Commonly Used Herbal Distillates Produced by Three Famous Brands. Iranian Journal of Public Health, 47, 901-907.
  • Zabihi, N.A., Mousavi, S.M., Mahmoudabady, M., Soukhtanloo, M., Sohrabi, F., Niazmand, S., 2018. Teucrium polium L. Improves Blood Glucose and Lipids and Ameliorates Oxidative Stress in Heart and Aorta of Diabetic Rats. International Journal of Preventive Medicine, 9, 110.
  • Zendehdel, M., Taati, M., Jadidoleslami, M., Bashiri, A., 2011. Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice. Iranian Journal of Veterinary Research, 12, 292-297.

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Reviews
Authors

Arzuhan SIHOGLU TEPE
KILIS 7 ARALIK UNIVERSITY
0000-0001-8290-9880
Türkiye


Mehmet OZASLAN This is me
GAZIANTEP UNIVERSITY
0000-0001-9380-4902
Türkiye


Ibrahım Halil KILIC This is me
GAZIANTEP UNIVERSITY
0000-0002-0272-5131
Türkiye


Sibel BAYIL OGUZKAN This is me
GAZIATNEP UNIVERSITY
0000-0003-0254-6915
Türkiye

Publication Date December 15, 2021
Application Date June 24, 2021
Acceptance Date June 30, 2021
Published in Issue Year 2021, Volume 1, Issue 1

Cite

Bibtex @review article { ijpbp975574, journal = {International Journal of Plant Based Pharmaceuticals}, issn = {}, eissn = {2791-7509}, address = {Kilis 7 Aralık Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, 79000, Merkez-KİLİS}, publisher = {Kilis 7 Aralik University}, year = {2021}, volume = {1}, pages = {1 - 41}, doi = {}, title = {Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review}, key = {cite}, author = {Sıhoglu Tepe, Arzuhan and Ozaslan, Mehmet and Kılıc, Ibrahım Halil and Bayıl Oguzkan, Sibel} }
APA Sıhoglu Tepe, A. , Ozaslan, M. , Kılıc, I. H. & Bayıl Oguzkan, S. (2021). Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review . International Journal of Plant Based Pharmaceuticals , 1 (1) , 1-41 . Retrieved from https://dergipark.org.tr/en/pub/ijpbp/issue/64282/975574
MLA Sıhoglu Tepe, A. , Ozaslan, M. , Kılıc, I. H. , Bayıl Oguzkan, S. "Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review" . International Journal of Plant Based Pharmaceuticals 1 (2021 ): 1-41 <https://dergipark.org.tr/en/pub/ijpbp/issue/64282/975574>
Chicago Sıhoglu Tepe, A. , Ozaslan, M. , Kılıc, I. H. , Bayıl Oguzkan, S. "Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review". International Journal of Plant Based Pharmaceuticals 1 (2021 ): 1-41
RIS TY - JOUR T1 - Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review AU - Arzuhan Sıhoglu Tepe , Mehmet Ozaslan , Ibrahım Halil Kılıc , Sibel Bayıl Oguzkan Y1 - 2021 PY - 2021 N1 - DO - T2 - International Journal of Plant Based Pharmaceuticals JF - Journal JO - JOR SP - 1 EP - 41 VL - 1 IS - 1 SN - -2791-7509 M3 - UR - Y2 - 2021 ER -
EndNote %0 International Journal of Plant Based Pharmaceuticals Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review %A Arzuhan Sıhoglu Tepe , Mehmet Ozaslan , Ibrahım Halil Kılıc , Sibel Bayıl Oguzkan %T Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review %D 2021 %J International Journal of Plant Based Pharmaceuticals %P -2791-7509 %V 1 %N 1 %R %U
ISNAD Sıhoglu Tepe, Arzuhan , Ozaslan, Mehmet , Kılıc, Ibrahım Halil , Bayıl Oguzkan, Sibel . "Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review". International Journal of Plant Based Pharmaceuticals 1 / 1 (December 2021): 1-41 .
AMA Sıhoglu Tepe A. , Ozaslan M. , Kılıc I. H. , Bayıl Oguzkan S. Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review. Int. J. Plant Bas. Pharm.. 2021; 1(1): 1-41.
Vancouver Sıhoglu Tepe A. , Ozaslan M. , Kılıc I. H. , Bayıl Oguzkan S. Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review. International Journal of Plant Based Pharmaceuticals. 2021; 1(1): 1-41.
IEEE A. Sıhoglu Tepe , M. Ozaslan , I. H. Kılıc and S. Bayıl Oguzkan , "Traditional uses, phytochemistry, and toxic potential of Teucrium polium L.: A comprehensive review", International Journal of Plant Based Pharmaceuticals, vol. 1, no. 1, pp. 1-41, Dec. 2021

Open Access Policy: This journal (IJPBP) adopted Budapest Open Access Initiative definition. The journal follows Committee on Publication Ethics (COPE) guidelines on the Code of Conduct and supports open access.

Indexed by

- Google Scholar

- Index Copernicus World of Journals

- CiteFactor

- ResearchBib

- ASOS Index