Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts

Olorunsola Bamidele; Thomas Abu; Omonike Ogbole

doi:10.21448/ijsm.1746441

Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts

Abstract

Diabetes is the most common endocrine disorder globally, and adverse side effects frequently hinder the effectiveness of current diabetes pharmacotherapies. The study was therefore carried out to assess the in vitro antidiabetic and antioxidant potential of Globimetula oreophila aerial parts and Solanum erianthum leaves extracts, as well as analyze the bioactive compounds using an analytical high-pressure liquid chromatography (HPLC) coupled with an ultraviolet-visible (UV-VIS) detector and an online library. The toxicity of the plant extracts was also determined using the Brine Shrimp Lethality Assay (BSLA). G oreophila and S. erianthum displayed a radical scavenging activity of 23±0.34 and 39.8±0.63 µg/mL, in comparison with the positive standard, ascorbic acid, 1.517±0.12 µg/mL. The extracts exhibited a total phenolic content of 44.2 and 24.0 mg GAE/g, respectively. The BSLA results showed LC50 values of 993.5 and 387.4 µg/mL, compared with the positive standard, cyclophosphamide, LC50=16.3 µg/mL. The extracts also showed a notable enzyme-inhibitory effect (IC50=3.052 and 5.544 µg/mL) on α-amylase as compared to the positive control, acarbose, with an IC50=0.18 µg/mL. In the HPLC analysis of G. oreophila and S. erianthum, the UV-VIS detector detected 25 and 32 peaks, respectively; however, based on the reference library, 12 and 10 compounds with pharmacological potential were identified. Thus, these medicinal plants could serve as a natural alternative or complement to conventional diabetes medications, potentially reducing side effects. Moreover, it may lead to the discovery of novel bioactive compounds that can be utilized in drug development.

Keywords

Thanks

The authors express their gratitude to the Department of Pharmaceutical Biology and Biotechnology at Heinrich Heine University Düsseldorf, Germany, for granting access to the laboratory facilities utilized for the HPLC analysis.

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Details

Primary Language

English

Subjects

Pharmacognosy, Natural Products and Bioactive Compounds

Journal Section

Research Article

Authors

Olorunsola Bamidele
0000-0003-2155-1760
Nigeria

Thomas Abu ^*
0000-0002-1973-6873
Nigeria

Omonike Ogbole
0000-0002-6487-9494
Nigeria

Early Pub Date

July 25, 2026

Publication Date

September 2, 2026

Submission Date

July 20, 2025

Acceptance Date

April 5, 2026

Published in Issue

Year 2026 Volume: 13 Number: 3

DOI

https://doi.org/10.21448/ijsm.1746441

IZ

https://izlik.org/JA26CP98KT

Cite

RIS / Bibtex

APA

Bamidele, O., Abu, T., & Ogbole, O. (2026). Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts. International Journal of Secondary Metabolite, 13(3), 692-708. https://doi.org/10.21448/ijsm.1746441

AMA

1.Bamidele O, Abu T, Ogbole O. Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts. Int. J. Sec. Metabolite. 2026;13(3):692-708. doi:10.21448/ijsm.1746441

Chicago

Bamidele, Olorunsola, Thomas Abu, and Omonike Ogbole. 2026. “Phytochemical Constituents and Alpha-Amylase Inhibition of Nigerian Globimetula Oreophila (Hook.F.) Danser (Loranthaceae) and Solanum Erianthum D.Don (Solanaceae) Methanol Extracts”. International Journal of Secondary Metabolite 13 (3): 692-708. https://doi.org/10.21448/ijsm.1746441.

EndNote

Bamidele O, Abu T, Ogbole O (September 1, 2026) Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts. International Journal of Secondary Metabolite 13 3 692–708.

IEEE

[1]O. Bamidele, T. Abu, and O. Ogbole, “Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts”, Int. J. Sec. Metabolite, vol. 13, no. 3, pp. 692–708, Sept. 2026, doi: 10.21448/ijsm.1746441.

ISNAD

Bamidele, Olorunsola - Abu, Thomas - Ogbole, Omonike. “Phytochemical Constituents and Alpha-Amylase Inhibition of Nigerian Globimetula Oreophila (Hook.F.) Danser (Loranthaceae) and Solanum Erianthum D.Don (Solanaceae) Methanol Extracts”. International Journal of Secondary Metabolite 13/3 (September 1, 2026): 692-708. https://doi.org/10.21448/ijsm.1746441.

JAMA

1.Bamidele O, Abu T, Ogbole O. Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts. Int. J. Sec. Metabolite. 2026;13:692–708.

MLA

Bamidele, Olorunsola, et al. “Phytochemical Constituents and Alpha-Amylase Inhibition of Nigerian Globimetula Oreophila (Hook.F.) Danser (Loranthaceae) and Solanum Erianthum D.Don (Solanaceae) Methanol Extracts”. International Journal of Secondary Metabolite, vol. 13, no. 3, Sept. 2026, pp. 692-08, doi:10.21448/ijsm.1746441.

Vancouver

1.Olorunsola Bamidele, Thomas Abu, Omonike Ogbole. Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts. Int. J. Sec. Metabolite. 2026 Sep. 1;13(3):692-708. doi:10.21448/ijsm.1746441