Year 2016, Volume 3 , Issue 1, Pages 21 - 26 2016-07-14

Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions

Bartlomiej Palecz [1] , Adam Buczkowski [2] , Henryk Piekarski [3] , Özge Kılınçarslan [4]


The thermodynamics of complex formation of polyamideamine dendrimers: cationic PAMAM G4-NH2, neutral PAMAM G4-OH and anionic PAMAM G3.5-COONa with gemcitabine hydrochloride, an antitumor drug, in water at a temperature of 250C was studied. The investigations were carried out with the use of ITC measurements allowing one to determine the number of the drug molecules bonded by the dendrimer macromolecule, the equilibrium constants of the complex formed and the values of enthalpy and entropy of their formation. The measurements results obtained show different numbers of the drug molecules bonded by dendrimer macromolecules depending on the properties of their terminal groups.
PAMAM dendrimers G-4, gemcitabine hydrochloride, isothermal titration calorimetry
  • Buczkowski, A., Olesinski, T., Zbicinska, E., Urbaniak, P., & Palecz , B. (2015). Spectroscopic and calorimetric studies of formation of the supramolecular complexes of PAMAM G5-NH2 and G5-OH dendrimers with 5-fluorouracil in aqueous solution. Int J Pharm., 490, 102-111.
  • Buczkowski, A., & Palecz, B. (2014). Study of the interactions of PAMAM-NH2 G4 dendrimer with selected natural amino acids in aqueous solutions. J. Chem. Thermodyn., 70, 95-100.
  • Buczkowski, A., Sekowski, S., Grala, A., Palecz, D., Milowska, K., Urbaniak, P., et al. (2011). Interaction between PAMAM-NH2 G4 dendrimer and 5-fluorouracil in aqueous solution. Int J Pharm., 408, 266-270.
  • Buczkowski, A., Urbaniak, P., & Palecz, B. (2012). Thermochemical and spectroscopic studies on the supramolecular complex of PAMAM-NH2 G4 dendrimer and 5- fluorouracil in aqueous solution. Int J Pharm., 428, 178– 182.
  • Buczkowski, A., Urbaniak, P., & Palecz, B. (2013). Interaction between PAMAM-NH2 G4 dendrimer and paracetamol in aqueous solution. J. Mol. Liq., 186, 70-75.
  • Kanchi, S., Suresh, G., Priyakumar, U. D., Ayappa, K. G., & Maiti, P. K. (2015). Molecular dynamics study of the structure, flexibility, and hydrophilicity of PETIM dendrimers: a comparison with PAMAM dendrimers. Journal of Physical Chemistry B, 119, 12990- 13001.
  • Kesharwani, P., Jain, K., & Jain, N. K. (2014). Dendrimer as nanocarrier for drug delivery. Prog. Polym. Sci., 39, 268-307. Medina, S. H., & El-Sayed, M. E. H. (2009). Dendrimers as carriers for delivery of chemotherapeutic agents. Chem. Rev., 109, 3141–3157.
  • Niu, Y., Sun, L., & Crooks, R. M. (2003). Determination of the intrinsic proton binding constants for poly(amidoamine) dendrimers via potentiometric pH titration. Macromolecules, 36, 5725-5731.
  • Vlahov, I. R., & Leamon, C. P. (2012). Engineering folate-drug conjugates to target cancer: from chemistry to clinic. Bioconjugate Chemistry, 23, 1357-1369.
  • Yavuz, B., Pehlivan, S. B., Vural, I., & Ünlü, N. (2015). In Vitro/In Vivo Evaluation of Dexamethasone - PAMAM Dendrimer Complexes for Retinal Drug Delivery. J. Pharm. Sci., 104, 3814-3823
Subjects Biology
Other ID JA37PJ64TJ
Published Date January
Journal Section Articles
Authors

Author: Bartlomiej Palecz

Author: Adam Buczkowski

Author: Henryk Piekarski

Author: Özge Kılınçarslan

Dates

Publication Date : July 14, 2016

Bibtex @research article { ijsm240699, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {Prof. Dr. İzzet KARA}, publisher = {İzzet KARA}, year = {2016}, volume = {3}, pages = {21 - 26}, doi = {10.21448/ijsm.240699}, title = {Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions}, key = {cite}, author = {Palecz, Bartlomiej and Buczkowski, Adam and Piekarski, Henryk and Kılınçarslan, Özge} }
APA Palecz, B , Buczkowski, A , Piekarski, H , Kılınçarslan, Ö . (2016). Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions. International Journal of Secondary Metabolite , 3 (1) , 21-26 . DOI: 10.21448/ijsm.240699
MLA Palecz, B , Buczkowski, A , Piekarski, H , Kılınçarslan, Ö . "Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions". International Journal of Secondary Metabolite 3 (2016 ): 21-26 <https://dergipark.org.tr/en/pub/ijsm/issue/22523/240699>
Chicago Palecz, B , Buczkowski, A , Piekarski, H , Kılınçarslan, Ö . "Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions". International Journal of Secondary Metabolite 3 (2016 ): 21-26
RIS TY - JOUR T1 - Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions AU - Bartlomiej Palecz , Adam Buczkowski , Henryk Piekarski , Özge Kılınçarslan Y1 - 2016 PY - 2016 N1 - doi: 10.21448/ijsm.240699 DO - 10.21448/ijsm.240699 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 21 EP - 26 VL - 3 IS - 1 SN - -2148-6905 M3 - doi: 10.21448/ijsm.240699 UR - https://doi.org/10.21448/ijsm.240699 Y2 - 2015 ER -
EndNote %0 International Journal of Secondary Metabolite Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions %A Bartlomiej Palecz , Adam Buczkowski , Henryk Piekarski , Özge Kılınçarslan %T Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions %D 2016 %J International Journal of Secondary Metabolite %P -2148-6905 %V 3 %N 1 %R doi: 10.21448/ijsm.240699 %U 10.21448/ijsm.240699
ISNAD Palecz, Bartlomiej , Buczkowski, Adam , Piekarski, Henryk , Kılınçarslan, Özge . "Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions". International Journal of Secondary Metabolite 3 / 1 (July 2016): 21-26 . https://doi.org/10.21448/ijsm.240699
AMA Palecz B , Buczkowski A , Piekarski H , Kılınçarslan Ö . Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions. Int. J. Sec. Metabolite. 2016; 3(1): 21-26.
Vancouver Palecz B , Buczkowski A , Piekarski H , Kılınçarslan Ö . Thermodynamic Interaction between PAMAM G4-NH2, G4-OH, G3.5-COONa Dendrimers and Gemcitabine in Water Sotutions. International Journal of Secondary Metabolite. 2016; 3(1): 26-21.


Authors of the Article
Bartlomiej Palecz [1]
Adam Buczkowski [2]
Henryk Piekarski [3]
Özge Kılınçarslan [4]