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Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran

Year 2019, Volume: 6 Issue: 1, 62 - 78, 16.03.2019
https://doi.org/10.21448/ijsm.514968

Abstract

Medicinal plants used in the treatment of diseases earlier times are potential sources of new drugs. The present study was undertaken to study the chemical composition, antioxidant and antibacterial activity of certain medicinal plants of Iran by gas chromatography and mass spectrometry (GC/MS), DPPH and disk diffusion method. According to the results of GC/MS, there are 46 kinds of chemical compounds including mucilage, fatty acids, flavonoid and diterpenes in flower of Echium khuzistanicum. There are aldehydes (7.9%), phenols (7.5%), fatty acids (5.8%) and furfural (5.4%) in the methanol extract of Echinops cephalotes. Furfural, steroids, vitamin B and flavonoids are the main compounds of Marrubium anisodan. Results of the antibacterial test showed that Staphylococcus aureus and Bacillus subtilis were more sensitive to methanol extract of Echium khuzistanicum root. Pseudomonas auruginosa was more sensitive to DMSO extract of Marrubium anisodan at 600 mg/ml concentration. Maximum flavonoid and phenol contents were belonging to Echinops cephalotes. Marrubium anisodan showed the best DPPH free radical scavenging activity.

References

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Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran

Year 2019, Volume: 6 Issue: 1, 62 - 78, 16.03.2019
https://doi.org/10.21448/ijsm.514968

Abstract

Medicinal plants used in
the treatment of diseases earlier times are potential sources of new drugs. The
present study was undertaken to study the
chemical composition, antioxidant
and antibacterial activity of certain medicinal plants of Iran by
gas chromatography and mass spectrometry (GC/MS), DPPH and disk diffusion method. According to the
results of GC/MS, there are 46 kinds of chemical compounds including mucilage,
fatty acids, flavonoid and diterpenes in flower of Echium khuzistanicum.
There are aldehydes (7.9%), phenols (7.5%), fatty acids (5.8%) and furfural
(5.4%) in the methanol extract of Echinops cephalotes. Furfural,
steroids, vitamin B and flavonoids are the main compounds of Marrubium
anisodan
. Results of the antibacterial test showed that Staphylococcus
aureus
and Bacillus subtilis were more sensitive to methanol extract
of Echium khuzistanicum root. Pseudomonas auruginosa was more
sensitive to DMSO extract of Marrubium anisodan at 600 mg/ml
concentration. Maximum flavonoid and phenol contents were belonging to Echinops
cephalotes
. Marrubium anisodan showed the best DPPH free radical
scavenging activity.

References

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  • [2] Ali, S.S., Kasoju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A., Bora, U. (2008). "Indian medicinal herbs as sources of antioxidants". Food. Res. Int., vol 41, pp. 1-15.
  • [3] Wu, C., Chen, F., Wang, X., Kim, H.-J., He, G.-q., Haley-Zitlin, V., Huang, G. (2006). "Antioxidant constituents in feverfew (Tanacetum parthenium) extract and their chromatographic quantification". Food. Chem., vol 96, pp. 220-227.
  • [4] Granato, D., Shahidi, F., Wrolstad, R., Kilmartin, P., Melton, L.D., Hidalgo, F.J., Miyashita, K., van Camp, J., Alasalvar, C., Ismail, A.B. (2018). "Antioxidant activity, total phenolics and flavonoids contents: should we ban in vitro screening methods?". Food. Chem, vol 264, pp. 471-475.
  • [5] Pokhrel, H., Baishya, S., Phukan, B., Pillai, D., Rather, M.A. (2018). "Occurrence and Distribution of Multiple Antibiotic Resistance Bacteria of Public Health Significance in Backwaters and Aquaculture Farm". Int. J. Curr. Microbiol. App. Sci., vol 7, pp. 975-987.
  • [6] O’Bryan, C.A., Crandall, P.G., Ricke, S.C. (2018). "Antimicrobial Resistance in Foodborne Pathogens, Food and Feed Safety Systems and Analysis", 1th ed.; Elsevier: Netherland, 2018; pp. 99-115; 9780128118351.
  • [7] Ali, M., Khan, T., Fatima, K., Ali, Q.u.A., Ovais, M., Khalil, A.T., Ullah, I., Raza, A., Shinwari, Z.K., Idrees, M. (2018). "Selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions". Phytother. Res., vol 32, pp. 199-215.
  • [8] Khatamsaz, M. (2002). "Flora of Iran: Boraginacea"3rd ed.; Research Institute of forests and rangelands: Tehran, 2002; pp. 78-85.
  • [9] Gao, H., Liu, L., Qu, Z.Y., Wei, F.X., Wang, S.Q. , Chen, G., Qin, L., Jiang, F.Y., Wang, Y.C., Shang, L., Gao, C.Y. (2011). "Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro". Biol. Pharm. Bull., vol 34, pp. 197-202.
  • [10] Kim, J.Y., Jeong, H.J., Park, J.Y., Kim, Y.M., Park, S.J., Cho, J.K., Park, K.H., Ryu, Y.B., Lee, W.S. (2012). "Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases". Bioorg. Med. Chem., vol 20, pp. 1740-1748.
  • [11] Lee, Y.J., Choi, S.Y., Yang, J.H. (2014). "NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells". Sci. Total. Environ., vol 1, pp. 491-492.
  • [12] Li, F., Yin, Z., Zhou, B., Xue, F., Yang, W., Chang, R., Ma, K., Qiu, Y. (2015). "Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee". Int. Immunopharmacol, vol 29, pp. 656-662.
  • [13] Papageorgiou, V.P., Assimopoulou, A.N., Couladouros, E.A., Hepworth, D., Nicolaou, K.C. (1999). "The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products". Angewandte. Chemie. International. Edition, vol 38, pp. 270-301.
  • [14] Skrzypczak, A., Przystupa, N., Zgadzaj, A., Parzonko, A., Syklowska-Baranek, K., Paradowska, K., Nalecz-Jawecki, G. (2015). "Antigenotoxic, anti-photogenotoxic and antioxidant activities of natural naphthoquinone shikonin and acetylshikonin and Arnebia euchroma callus extracts evaluated by the umu-test and EPR method". Toxicol. In Vitro, vol 30, pp. 364-372.
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  • [16] Fan, C., Xie, Y., Dong, Y., Su, Y., Upton, Z. (2015). "Investigating the potential of Shikonin as a novel hypertrophic scar treatment". J. Biomed. Sci., vol 22, pp. 1-13.
  • [17] Bursal, E., Aras, A., Kılıç, Ö. (2018). "Evaluation of antioxidant capacity of endemic plant Marrubium astracanicum subsp. macrodon: Identification of its phenolic contents by using HPLC-MS/MS". Nat. Prod. Res., vol pp. 1-5.
  • [18] Hymete, A., Iversen, T.H., Rohloff, J., Erko, B. (2005). "Screening of Echinops ellenbeckii and Echinops longisetus for biological activities and chemical constituents". Phytomedicine, vol 12, pp. 675-679.
  • [19] Ebrahimzadeh, M.A., Pourmorad, F., Bekhradnia, A.R. (2008). "Iron chelating activity, phenol and flavonoid content of some medicinal plants from Iran". Afr. J. Biotechnol., vol 7, pp.3188-3192 .
  • [20] Chang, W.C.S., Soon, C.K., Bong, S.H., Hye, K.C., Min, J.A., Sang, H.P., Soo,K.K. (2002). "Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison". Plant. Sci., vol 163, pp. 1161-1168.
  • [21] Singleton, V.L., Rossi, J.A. (1965). "Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents." Am. J. Enol. Viticult., vol 16, pp. 144-158.
  • [22] Shah, S.H.R, ZAhid, M., Mohammad, S., Mohammad. M.M., Aziz, U.R. (2016). "Evaluation of in vitro antioxidant and thrombolytic studies of some N-(2, 3-dihydro-1, 4-benzodioxan-6-yl)-4-methylbenzenesulfonamide-N-acetamide derivatives". J. Chem. Pharm. Res., vol 8, pp. 424-431.
  • [23] Mangena, T., Muyima, N. (1999). "Comparative evaluation of the antimicrobial activities of essential oils of Artemisia afra, Pteronia incana and Rosmarinus officinalis on selected bacteria and yeast strains". Lett. Appl. Microbiol., vol 28, pp. 291-296.
  • [24] Shi, W., Marcus, S.L., Lowary, T.L. (2010). "Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents". Carbohydr. Res., vol 345, pp. 10-22.
  • [25] Martinez, A., Rodriguez, M.E., Wells, M.L., York, S.W., Preston, J.F., Ingram, L.O. (2001). "Detoxification of dilute acid hydrolysates of lignocellulose with lime". Biotech. Prog., vol 17, pp. 287-293.
  • [26] Boopathy, R., Bokang, H., Daniels, L. (1993). "Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria". J. Ind. Microbiol, vol 11, pp. 147-150.
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There are 63 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Articles
Authors

Samira Mohammadi This is me 0000-0002-1909-7717

Khosro Piri This is me

Mehri Dinarvand This is me

Publication Date March 16, 2019
Submission Date July 14, 2018
Published in Issue Year 2019 Volume: 6 Issue: 1

Cite

APA Mohammadi, S., Piri, K., & Dinarvand, M. (2019). Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran. International Journal of Secondary Metabolite, 6(1), 62-78. https://doi.org/10.21448/ijsm.514968
International Journal of Secondary Metabolite

e-ISSN: 2148-6905