Year 2019, Volume 6 , Issue 4, Pages 310 - 316 2020-01-15

In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors

Tuba AYDİN [1]


Glutathione reductase inhibitors are very popular antimalarial and anticancer agents. In this study, in vitro inhibition effects of β-sitosterol, stigmasterol, diosgenin and jervine which containing steroidal structure were determined against glutathione reductase enzyme. β-sitosterol, diosgenin and jervine were isolated from Veratrum album and stigmasterol was isolated from Artemisia dracunculus L. by chromatographic methods. According to the results obtained, IC50 values of β-sitosterol, stigmasterol, diosgenin and jervine were found as 1.2580, 5.2116, 0.1916 and 0.7701 µM, respectively. Among test compounds, diosgenin showed the strongest inhibitory effect against glutathione reductase with Swissdock docking figure. In current study first time, β-sitosterol, stigmasterol, diosgenin and jervine were found to be much more glutathione reductase inhibitors.
Secondary metabolites, Glutathione reductase, Inhibition, Docking
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Primary Language en
Subjects Biology
Published Date December
Journal Section Articles
Authors

Orcid: 0000-0002-7653-6480
Author: Tuba AYDİN (Primary Author)
Institution: AGRI IBRAHIM CECEN UNIVERSITY
Country: Turkey


Thanks The author gratefully thanks to Swissdock for data. The author faithfully thanks to Dr. Ahmet Cakir for supportings in the structure characterization and Dr. Murat Senturk for supportings in the enzyme inhibition researchs.
Dates

Publication Date : January 15, 2020

Bibtex @research article { ijsm628043, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {Prof. Dr. İzzet KARA}, publisher = {İzzet KARA}, year = {2020}, volume = {6}, pages = {310 - 316}, doi = {10.21448/ijsm.628043}, title = {In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors}, key = {cite}, author = {AYDİN, Tuba} }
APA AYDİN, T . (2020). In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors. International Journal of Secondary Metabolite , 6 (4) , 310-316 . DOI: 10.21448/ijsm.628043
MLA AYDİN, T . "In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors". International Journal of Secondary Metabolite 6 (2020 ): 310-316 <https://dergipark.org.tr/en/pub/ijsm/issue/50293/628043>
Chicago AYDİN, T . "In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors". International Journal of Secondary Metabolite 6 (2020 ): 310-316
RIS TY - JOUR T1 - In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors AU - Tuba AYDİN Y1 - 2020 PY - 2020 N1 - doi: 10.21448/ijsm.628043 DO - 10.21448/ijsm.628043 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 310 EP - 316 VL - 6 IS - 4 SN - -2148-6905 M3 - doi: 10.21448/ijsm.628043 UR - https://doi.org/10.21448/ijsm.628043 Y2 - 2019 ER -
EndNote %0 International Journal of Secondary Metabolite In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors %A Tuba AYDİN %T In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors %D 2020 %J International Journal of Secondary Metabolite %P -2148-6905 %V 6 %N 4 %R doi: 10.21448/ijsm.628043 %U 10.21448/ijsm.628043
ISNAD AYDİN, Tuba . "In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors". International Journal of Secondary Metabolite 6 / 4 (January 2020): 310-316 . https://doi.org/10.21448/ijsm.628043
AMA AYDİN T . In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors. Int. J. Sec. Metabolite. 2020; 6(4): 310-316.
Vancouver AYDİN T . In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors. International Journal of Secondary Metabolite. 2020; 6(4): 316-310.