Year 2020, Volume 7 , Issue 1, Pages 54 - 62 2020-03-20

Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts

Erdi Can AYTAR [1] , Ali ÖZMEN [2]

Many species of mushrooms have been used since ancient times, especially in Asian countries, as a food supplement and in the medical field due to their different biological activities. Nowadays, especially in Japan, Korea and China, various mushroom extracts have been used as potential additives in chemotherapy and radiation treatments. In this study, anticancer activity and apoptotic effect of Rhizopogon roseolus were investigated. The methanol and water extracts of mushroom were tested against HL- 60 human cancer cell line. Antiproliferative effects of the extracts were evaluated by using MTT method and apoptosis and necrosis ratios of the cells treated with extracts were determined by using Hoechst/Propidium iodide (HO/PI) staining method. According to obtained data, antiprolifarative effect of the methanol extract was higher than water extract and this effect was a concentration depending manner. Both of the extracts were shown higher apoptotic effect than necrotic effect on the HL-60 cell line.
Rhizopogon roseolus, Mushroom, Apoptosis, Cell culture, HL-60
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Primary Language en
Subjects Biology
Published Date March
Journal Section Articles

Orcid: 0000-0001-6045-0183
Author: Erdi Can AYTAR (Primary Author)
Country: Turkey

Orcid: 0000-0000-0000-0000
Author: Ali ÖZMEN
Country: Turkey

Thanks We thanks to Prof.Dr. Hasan Hüseyin Doğan for the mushroom identified.

Publication Date : March 20, 2020

Bibtex @research article { ijsm675618, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {Prof. Dr. İzzet KARA}, publisher = {İzzet KARA}, year = {2020}, volume = {7}, pages = {54 - 62}, doi = {10.21448/ijsm.675618}, title = {Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts}, key = {cite}, author = {AYTAR, Erdi Can and ÖZMEN, Ali} }
APA AYTAR, E , ÖZMEN, A . (2020). Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts. International Journal of Secondary Metabolite , 7 (1) , 54-62 . DOI: 10.21448/ijsm.675618
MLA AYTAR, E , ÖZMEN, A . "Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts". International Journal of Secondary Metabolite 7 (2020 ): 54-62 <>
Chicago AYTAR, E , ÖZMEN, A . "Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts". International Journal of Secondary Metabolite 7 (2020 ): 54-62
RIS TY - JOUR T1 - Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts AU - Erdi Can AYTAR , Ali ÖZMEN Y1 - 2020 PY - 2020 N1 - doi: 10.21448/ijsm.675618 DO - 10.21448/ijsm.675618 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 54 EP - 62 VL - 7 IS - 1 SN - -2148-6905 M3 - doi: 10.21448/ijsm.675618 UR - Y2 - 2020 ER -
EndNote %0 International Journal of Secondary Metabolite Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts %A Erdi Can AYTAR , Ali ÖZMEN %T Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts %D 2020 %J International Journal of Secondary Metabolite %P -2148-6905 %V 7 %N 1 %R doi: 10.21448/ijsm.675618 %U 10.21448/ijsm.675618
ISNAD AYTAR, Erdi Can , ÖZMEN, Ali . "Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts". International Journal of Secondary Metabolite 7 / 1 (March 2020): 54-62 .
AMA AYTAR E , ÖZMEN A . Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts. Int. J. Sec. Metabolite. 2020; 7(1): 54-62.
Vancouver AYTAR E , ÖZMEN A . Cytotoxic and Apoptotic Activities of Rhizopogon roseolus (Corda) Th.Fr. Extracts. International Journal of Secondary Metabolite. 2020; 7(1): 62-54.