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Medicinal uses, chemical constituents and biological activities of Rumex abyssinicus: A Comprehensive review

Year 2022, Volume: 9 Issue: 4, 440 - 456, 21.12.2022
https://doi.org/10.21448/ijsm.1095643

Abstract

Rumex abyssinicus is a valuable medicinal plant species that is native to tropical Africa. Traditionally, R. abyssinicus is used to treat different disease such as, liver diseases, hepatitis, malaria, scabies, blood pressure, jaundice, wound and pneumonia. The purpose of the current study was to review the literature on the ethnomedicinal uses, chemical constitutes and biological activities of R. abyssinicus in an attempt to create information for future studies aimed towards exploring the therapeutic ability of the species. A scientific search engines, namely Google Scholar, PubMed, Scopus, Science Direct and Web of knowledge for the search terms: Rumex abyssinicus, ethnomedicinal studies, phytochemical investigations, and pharmacological activities were undertaken. The search strategy included all articles with descriptors that were available until December 30, 2021. Only published works in English have been used on this study. The data was collected using textual descriptions of the studies, tabulation, grouping, and figures. The principal phytochemicals of R. abyssinicus are anthraquinones, flavonoids, terepenoids and phenolic compounds. The in vitro and in vivo studies on the crude extracts and compounds of R. abyssinicus showed antibacterial, antioxidant, anticancer, anti-inflammatory, antifungal, wound healing, antialzeimer’s and hepatoprotective activities of it. R. abyssinicus afforded drug leads such as helminthosporin (4) with anti-alzheimer and physicon (3) with antifungal and antioxidant activity. R. abyssinicus have traditionally been used to cure a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, further studies on crude extracts and promising compounds are needed to find new drug candidates.

References

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  • Alelign, T., Chalchisa, D., Fekadu, N., Solomon, D., Sisay, T., Debella, A., & Petros, B. (2020). Evaluation of acute and sub-acute toxicity of selected traditional antiurolithiatic medicinal plant extracts in Wistar albino rats. Toxicology Reports, 7, 1356-1365. https://doi.org/10.1016/j.toxrep.2020.10.001
  • Assefa, T., Nigussie, N., Mullualem, D., Sinshaw, G., & Adimasu, Y. (2019). The Role of Medicinal Plants in Traditional Medicine in Adwa District, Tigray, Northern Ethiopia. Asian Plant Research Journal, 1-11.
  • Augustin, N., Nuthakki, V.K., Abdullaha, M., Hassan, Q.P., Gandhi, S.G., & Bharate, S.B. (2020). Discovery of helminthosporin, an anthraquinone isolated from Rumex abyssinicus Jacq as a dual cholinesterase inhibitor. ACS omega, 5(3), 1616-1624. https://doi.org/10.1021/acsomega.9b03 693
  • Awas, T. (2007). Plant diversity in Western Ethiopia: ecology, ethnobotany and conservation [Dictoral dessertation, University of Oslo]. University of Oslo Libraries. http://urn.nb.no/URN:NBN:no-15871
  • Awoke, S., & Gedamu, C. (2020). Chemical Studies and Antibacterial Activity of the Root of Rumex abyssinicus. Earthline Journal of Chemical Sciences, 4(2), 155-173.
  • Birhan, Y., Kitaw, S., Alemayehu, Y., & Mengesha, N. (2017). Ethnobotanical study of medicinal plants used to treat human diseases in Enarj Enawga district, East Gojjam zone, Amhara region, Ethiopia. SM Journal of Medicinal Plant Studies, 1(1), 1-9.
  • Birhanu, T., Abera, D., Ejeta, E., & Nekemte, E. (2015). Ethnobotanical study of medicinal plants in selected Horro Gudurru Woredas, Western Ethiopia. Journal of Biology, Agriculture and Healthcare, 5(1), 83-93.
  • Bussa, N., & Belayneh, A. (2019). Traditional medicinal plants used to treat cancer, tumors and inflammatory ailments in Harari Region, Eastern Ethiopia. South African Journal of Botany, 122, 360-368. https://doi.org/10.1016/j.sajb.2019.03.025
  • Chekole, G. (2017). Ethnobotanical study of medicinal plants used against human ailments in Gubalafto District, Northern Ethiopia. Journal of Ethnobiology and Ethnomedicine, 13(1), 55. https://doi.org/10.1186/s13002-017-0182-7
  • Dalle, M.G.G. (2019). Ethnobotanical Study of Medicinal Plants in Nagelle Arsi District, West Arsi Zone of Oromia, Ethiopia. Journal of Natural Sciences Research, 9(13).
  • Dinbiso, T.D., Tolosa, T.T., & Begna, F.D. (2020). Ethnoveterinary Practices of Medicinal Plants and Non-plant Remedies Used in Animal Health Management in Dawuro Zone, Southern Ethiopia. Resarch Square. https://doi.org/10.21203/rs.3.rs-94568/v2
  • Duguma, H. T. (2020). Wild edible plant nutritional contribution and consumer perception in Ethiopia. International Journal of Food Science, 2020.
  • Enyew, E., Muche, A., Endale, A., & Goshu, B. (2020). Evaluation of the Acute and Sub-Acute Toxic Effects of 80% Methanol Rhizome Extracts of Rumex abyssinicus jacq. (Plygonaceae) on Histopathology of Liver, Kidney and Some Blood Parameters. EC Pharmacology and Toxicology, 9(2), 01-12.
  • Eshete, M.A., Kelbessa, E., & Dalle, G. (2016). Ethnobotanical study of medicinal plants in Guji agro-pastoralists, Blue Hora District of Borana Zone, Oromia region, Ethiopia. Journal of Medicinal PlantsSstudies, 4(2), 170-184.
  • Eskedar, A. (2011). Ethnobotanical study on medicinal plants used by local communities in Debark Wereda, north Gondar zone, Amhara regional state, Ethiopia [MSc thesis, Addis Ababa University]. Addis Ababa University Libraries. http://etd.aau.edu.et/handle/123456789/4244
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Medicinal uses, chemical constituents and biological activities of Rumex abyssinicus: A Comprehensive review

Year 2022, Volume: 9 Issue: 4, 440 - 456, 21.12.2022
https://doi.org/10.21448/ijsm.1095643

Abstract

Rumex abyssinicus is a valuable medicinal plant species that is native to tropical Africa. Traditionally, R. abyssinicus is used to treat different disease such as, liver diseases, hepatitis, malaria, scabies, blood pressure, jaundice, wound and pneumonia. The purpose of the current study was to review the literature on the ethnomedicinal uses, chemical constitutes and biological activities of R. abyssinicus in an attempt to create information for future studies aimed towards exploring the therapeutic ability of the species. A scientific search engines, namely Google Scholar, PubMed, Scopus, Science Direct and Web of knowledge for the search terms: Rumex abyssinicus, ethnomedicinal studies, phytochemical investigations, and pharmacological activities were undertaken. The search strategy included all articles with descriptors that were available until December 30, 2021. Only published works in English have been used on this study. The data was collected using textual descriptions of the studies, tabulation, grouping, and figures. The principal phytochemicals of R. abyssinicus are anthraquinones, flavonoids, terepenoids and phenolic compounds. The in vitro and in vivo studies on the crude extracts and compounds of R. abyssinicus showed antibacterial, antioxidant, anticancer, anti-inflammatory, antifungal, wound healing, antialzeimer’s and hepatoprotective activities of it. R. abyssinicus afforded drug leads such as helminthosporin (4) with anti-alzheimer and physicon (3) with antifungal and antioxidant activity. R. abyssinicus have traditionally been used to cure a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, further studies on crude extracts and promising compounds are needed to find new drug candidates.

References

  • Adamu, B.A., Emiru, Y.K., Sintayehu, B., Araya, E.M., Periasamy, G., & Hiben, M.G. (2020). In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of Rumex abyssinicus Jacq. Rhizome. Journal of Experimental Pharmacology, 12, 221. https://doi.org/10.2147/JEP.S258566
  • Alelign, T., Chalchisa, D., Fekadu, N., Solomon, D., Sisay, T., Debella, A., & Petros, B. (2020). Evaluation of acute and sub-acute toxicity of selected traditional antiurolithiatic medicinal plant extracts in Wistar albino rats. Toxicology Reports, 7, 1356-1365. https://doi.org/10.1016/j.toxrep.2020.10.001
  • Assefa, T., Nigussie, N., Mullualem, D., Sinshaw, G., & Adimasu, Y. (2019). The Role of Medicinal Plants in Traditional Medicine in Adwa District, Tigray, Northern Ethiopia. Asian Plant Research Journal, 1-11.
  • Augustin, N., Nuthakki, V.K., Abdullaha, M., Hassan, Q.P., Gandhi, S.G., & Bharate, S.B. (2020). Discovery of helminthosporin, an anthraquinone isolated from Rumex abyssinicus Jacq as a dual cholinesterase inhibitor. ACS omega, 5(3), 1616-1624. https://doi.org/10.1021/acsomega.9b03 693
  • Awas, T. (2007). Plant diversity in Western Ethiopia: ecology, ethnobotany and conservation [Dictoral dessertation, University of Oslo]. University of Oslo Libraries. http://urn.nb.no/URN:NBN:no-15871
  • Awoke, S., & Gedamu, C. (2020). Chemical Studies and Antibacterial Activity of the Root of Rumex abyssinicus. Earthline Journal of Chemical Sciences, 4(2), 155-173.
  • Birhan, Y., Kitaw, S., Alemayehu, Y., & Mengesha, N. (2017). Ethnobotanical study of medicinal plants used to treat human diseases in Enarj Enawga district, East Gojjam zone, Amhara region, Ethiopia. SM Journal of Medicinal Plant Studies, 1(1), 1-9.
  • Birhanu, T., Abera, D., Ejeta, E., & Nekemte, E. (2015). Ethnobotanical study of medicinal plants in selected Horro Gudurru Woredas, Western Ethiopia. Journal of Biology, Agriculture and Healthcare, 5(1), 83-93.
  • Bussa, N., & Belayneh, A. (2019). Traditional medicinal plants used to treat cancer, tumors and inflammatory ailments in Harari Region, Eastern Ethiopia. South African Journal of Botany, 122, 360-368. https://doi.org/10.1016/j.sajb.2019.03.025
  • Chekole, G. (2017). Ethnobotanical study of medicinal plants used against human ailments in Gubalafto District, Northern Ethiopia. Journal of Ethnobiology and Ethnomedicine, 13(1), 55. https://doi.org/10.1186/s13002-017-0182-7
  • Dalle, M.G.G. (2019). Ethnobotanical Study of Medicinal Plants in Nagelle Arsi District, West Arsi Zone of Oromia, Ethiopia. Journal of Natural Sciences Research, 9(13).
  • Dinbiso, T.D., Tolosa, T.T., & Begna, F.D. (2020). Ethnoveterinary Practices of Medicinal Plants and Non-plant Remedies Used in Animal Health Management in Dawuro Zone, Southern Ethiopia. Resarch Square. https://doi.org/10.21203/rs.3.rs-94568/v2
  • Duguma, H. T. (2020). Wild edible plant nutritional contribution and consumer perception in Ethiopia. International Journal of Food Science, 2020.
  • Enyew, E., Muche, A., Endale, A., & Goshu, B. (2020). Evaluation of the Acute and Sub-Acute Toxic Effects of 80% Methanol Rhizome Extracts of Rumex abyssinicus jacq. (Plygonaceae) on Histopathology of Liver, Kidney and Some Blood Parameters. EC Pharmacology and Toxicology, 9(2), 01-12.
  • Eshete, M.A., Kelbessa, E., & Dalle, G. (2016). Ethnobotanical study of medicinal plants in Guji agro-pastoralists, Blue Hora District of Borana Zone, Oromia region, Ethiopia. Journal of Medicinal PlantsSstudies, 4(2), 170-184.
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There are 72 citations in total.

Details

Primary Language English
Subjects Structural Biology, Pharmacology and Pharmaceutical Sciences
Journal Section Articles
Authors

Gashaw Nigussie 0000-0002-7758-6367

Mekdes Tola

Tiruwork Fanta 0000-0001-6854-6307

Publication Date December 21, 2022
Submission Date March 30, 2022
Published in Issue Year 2022 Volume: 9 Issue: 4

Cite

APA Nigussie, G., Tola, M., & Fanta, T. (2022). Medicinal uses, chemical constituents and biological activities of Rumex abyssinicus: A Comprehensive review. International Journal of Secondary Metabolite, 9(4), 440-456. https://doi.org/10.21448/ijsm.1095643
International Journal of Secondary Metabolite

e-ISSN: 2148-6905