Evaluation of the in-vitro anti-inflammatory activity of Malva sylvestris leaves extract

Year 2025, Volume: 12 Issue: 1, 181 - 187

Idir Moualek , Karima Benarab Karim Houalı

Abstract

The primary aim of this research endeavor was to thoroughly evaluate and explore the potential anti-inflammatory properties exhibited by leaf extracts obtained from the Malva sylvestris plant species. In order to investigate the anti-inflammatory capabilities, a comprehensive set of in vitro experimental procedures was carried out to meticulously examine and gauge the extract's efficacy to stabilize human erythrocyte cell membranes under various stressful conditions, including exposure to varying concentrations of sodium chloride (NaCl), elevated temperatures, and oxidation induced by hypochlorous acid (HOCl). Additionally, the extract's potential to inhibit the denaturation of albumin, a process linked to inflammation, was evaluated. The findings revealed that the aqueous Malva sylvestris leaf extract exhibited notable anti-inflammatory properties by protecting red blood cell membranes from disruption caused by hypotonic NaCl solutions, heat stress, and oxidative damage from HOCl. These results suggest that the extract possesses significant anti-inflammatory potential and could be utilized as a natural remedy to mitigate inflammatory processes within the body. In summary, the aqueous extract derived from Malva sylvestris leaves demonstrated remarkable anti-inflammatory activity in vitro, making it a promising candidate for further exploration and potential therapeutic applications in the management of inflammatory conditions.

Keywords

Malva sylvestris, Anti-inflammatory, Anti-hemolytic activity, Red blood cell, Natural extracts

Ethical Statement

CHU-UMMTO-No: 0104/2024

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