Anticancer effects of sodium selenate in human neuroblastoma, breast cancer, and melanoma cells

Year 2025, Volume: 12 Issue: 1, 225 - 234

Gökhan Dervişoğlu

Abstract

Sodium selenate (Na2SeO4) is one of the oxidized inorganic forms of selenium. Effects on cytotoxicity, total antioxidant level, total oxidant level, oxidative stress, and genotoxicity status and its anticancer effect on SH-SY5Y human neuroblastoma, MCF-7 human breast cancer, and 451Lu human melanoma cells were investigated in this study. Sodium selenate exhibited a highly cytotoxic effect at all concentrations (0.078125 - 10 mg/mL) against SH-SY5Y, MCF-7, and 451Lu cancer cell lines. In addition, sodium selenate reduced the total antioxidant levels, increased the total oxidant levels (except for SH-SY5Y), and induced oxidative stress significantly in SH-SY5Y, MCF-7, and 451Lu cells. However, in agarose gel electrophoresis images, it was observed that sodium selenate did not have any genotoxic effect on SH-SY5Y, MCF-7, and 451Lu cancer cells. Sodium selenate can be used in cancer treatment because of its antioxidant, as well as pro-oxidant and anticancer properties, which depend on the concentrations used.

Keywords

Sodium selenate, Oxidative stress, Anticancer, SH-SY5Y cells, MCF-7 cells, 451Lu cells

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