The Effect of Bee Products on Quality of Life, Anxiety, and Covid-19 Prognosis in Young Adolescents Who Experienced Covid-19

Year 2024, Volume: 5 Issue: 3, 152 - 160, 26.12.2024

Abdullah Sarman , Fatih Çakar , Eyyüp Demirpolat

https://doi.org/10.53811/ijtcmr.1471810

Abstract

Objective: This study aimed to evaluate the effects of bee products on quality of life, anxiety, and the prognosis of Covid-19 in young adolescents who had contracted the virus.

Material-Method: The population of this cross-sectional descriptive study comprised university students residing in a city center in Eastern Turkey. Data collection was conducted from January 2023 to January 2024, using a convenience sampling method, and included 514 participants. Data collection tools consisted of a sociodemographic characteristics information form, an apitherapy and nutritional supplement use form, the Turkish version of the SF-12 Health Survey, and the Coronavirus Anxiety Scale (CAS). Additionally, a Structural Equation Model was developed and tested to explore the relationship between the use of apitherapy products, fear of Covid-19, and quality of life.

Results: The study found that 25.3% of students used apitherapy methods during their Covid-19 illness, with honey being the most commonly used product (33.8%), and 50% of those who used these methods reported recovery from the disease. A significant difference was observed between the use of apitherapy methods and CAS scores, with those who used pollen reporting higher mean CAS scores. Gender, smoking status, and the use of apitherapy methods during Covid-19 were associated with fear of the virus.

Conclusion: This study highlighted the potential benefits of bee products for young adolescents during and after the Covid-19 pandemic. It is recommended that future studies include larger, multicenter samples and provide comparative results for further validation.

Keywords

Anxiety, Apitherapy, Bee products, Covid-19

Ethical Statement

Prior to initiating the study, approval was obtained from the Bingöl University Health Sciences Scientific Research and Publication Ethics Committee (15.12.2022-E.88524). Additionally, necessary permissions were secured from the relevant institution (23.12.2022-E.89519) for conducting research involving university students. All participants were informed about the study's purpose, and their consent was obtained before their inclusion. The entire study adhered to the principles outlined in the Declaration of Helsinki.

References

• Weis WA, Ripari N, Conte FL, et al. An overview about apitherapy and its clinical applications. Phytomedicine Plus. 2022;2(2):100239. doi:10.1016/j.phyplu.2022.100239
• Doko T, Salaric I, Bazdaric K. Complementary and alternative medicine use among croatian health studies students - a single center cross-sectional study. Acta Med Acad. 2020;49(3):240-248. doi:10.5644/ama2006-124.313
• Al Naggar Y, Giesy JP, Abdel-Daim MM, Javed Ansari M, Al-Kahtani SN, Yahya G. Fighting against the second wave of Covid-19: Can honeybee products help protect against the pandemic? Saudi J Biol Sci. 2021;28(3):1519-1527. doi:10.1016/j.sjbs.2020.12.031
• Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;2015(3):CD005083. doi:10.1002/14651858.CD005083.pub4
• Tasca KI, Conte FL, Alves ACMM, et al. Propolis ıntake by people living with HIV: Biochemical profile, nutritional status, and safety. J Herb Med. 2024;43:100834. doi:10.1016/j.hermed.2023.100834
• Yaghoobi R, Kazerouni A, Kazerouni O. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: A review. Jundishapur J Nat Pharm Prod. 2013;8(3):100-104. doi:10.17795/jjnpp-9487
• Elmahallawy EK, Mohamed Y, Abdo W, El-Gohary FA, Ahmed Awad Ali S, Yanai T. New insights into potential benefits of bioactive compounds of bee products on Covid-19: A review and assessment of recent research. Front Mol Biosci. 2021;7:618318. doi:10.3389/fmolb.2020.618318
• Nicola M, Alsafi Z, Sohrabi C, et al. The socio-economic implications of the coronavirus pandemic (Covid-19): A review. Int J Surg. 2020;78:185-193. doi:10.1016/j.ijsu.2020.04.018
• Belli S, Balbi B, Prince I, et al. Low physical functioning and impaired performance of activities of daily life in Covid-19 patients who survived hospitalisation. Eur Respir J. 2020;56(4):2002096. doi:10.1183/13993003.02096-2020
• Saverino A, Zsirai E, Sonabend R, et al. Health related quality of life in Covid-19 survivors discharged from acute hospitals: Results of a short-form 36-item survey. F1000Research. 2021;10:282. doi:10.12688/f1000research.50781.1
• van der Sar - van der Brugge S, Talman S, Boonman - de Winter LJM, et al. Pulmonary function and health-related quality of life after Covid-19 pneumonia. Respir Med. 2021;176:106272. doi:10.1016/j.rmed.2020.106272
• Méndez R, Balanzá-Martínez V, Luperdi SC, et al. Long-term neuropsychiatric outcomes in Covid-19 survivors: A 1-year longitudinal study. J Intern Med. 2022;291(2):247-251. doi:10.1111/joim.13389
• Nandasena HMRKG, Pathirathna ML, Atapattu AMMP, Prasanga PTS. Quality of life of Covid 19 patients after discharge: Systematic review. PLoS One. 2022;17(2):e0263941. doi:10.1371/journal.pone.0263941
• Alinia C, Yaghmaei S, Abdullah FZ, et al. The health-related quality of life in Iranian patients with Covid-19. BMC Infect Dis. 2021;21(1):459. doi:10.1186/s12879-021-06170-z
• Malik P, Patel K, Pinto C, et al. Post-acute Covid-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis. J Med Virol. 2022;94(1):253-262. doi:10.1002/jmv.27309
• Naik H, Wilton J, Tran KC, Janjua NZ, Levin A, Zhang W. Long-term health-related quality of life in working-age Covid-19 survivors: A cross-sectional study. Am J Med. 2024;In Press:1-12. doi:10.1016/j.amjmed.2024.05.016
• Doğan R, Kaplan Serin E, Bağcı N. Fear of Covid 19 and social effects in liver transplant patients. Transpl Immunol. 2021;69:101479. doi:10.1016/j.trim.2021.101479
• Gritsenko V, Skugarevsky O, Konstantinov V, et al. Covid 19 fear, stress, anxiety, and substance use among Russian and Belarusian university students. Int J Ment Health Addict. 2021;19(6):2362-2368. doi:10.1007/s11469-020-00330-z
• Belen H. A longitudinal examination of the association between fear of Covid-19, resilience, and mental health during Covid-19 outbreak. Psychol Health Med. 2023;28(1):253-259. doi:10.1080/13548506.2022.2073378
• Huarcaya-Victoria J, Villarreal-Zegarra D, Podestà A, Luna-Cuadros MA. Psychometric properties of a Spanish Version of the Fear of Covid-19 Scale in General Population of Lima, Peru. Int J Ment Health Addict. 2022;20(1):249-262. doi:10.1007/s11469-020-00354-5
• Menezes K, Garcia L, Fernanda Felipe D. Perception of patient of quality of life after Covid-19. Med (Ribeirao Preto Online). 2024;57(1):e-207790. doi:10.11606/issn.2176-7262.rmrp.2024.207790
• Cohen J. Statistical power analysis. Curr Dir Psychol Sci. 1992;1(3):98-101.
• Soylu C, Kütük B. SF-12 Reliability and Validity of the Turkish Version of SF-12 Health Survey. Türk Psikiyatr Derg. 2022;33(2):108-117. doi:10.5080/u25700
• Ahorsu DK, Lin CY, Imani V, Saffari M, Griffiths MD, Pakpour AH. The Fear of Covid-19 Scale: Development and Initial Validation. Int J Ment Health Addict. 2022;20(3):1537-1545. doi:10.1007/s11469-020-00270-8
• Ladikli N, Bahadır E, Nurefşan Yumuşak F, Akkuzu H, Karaman G, Türkkan Z. The Reliability and Validity of Turkish Version of Coronavirus Anxiety Scale Uluslararası Sos Bilim Derg. 2020;3(2):71-80.
• Pallant J. SPSS Survival Manual: A Step by Step Guide to Data Analysis Using IBM SPSS. 7th ed. Routledge; 2020. doi:10.4324/9781003117452
• Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: A comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev. 2017;2017:1259510. doi:10.1155/2017/1259510
• Khalil ML. Biological activity of bee propolis in health and disease. Asian Pacific J Cancer Prev. 2006;7(1):22-31.
• Kolayli S, Keskin M. Chapter 7-Natural bee products and their apitherapeutic applications. In: Atta-ur-Rahman BTS in NPC, ed. Bioactive Natural Products. Elsevier; 2020:175-196. doi:10.1016/B978-0-12-817907-9.00007-6
• Singh DB, Singh S, Gulati M, Singh H, Arora R, Arora S. Herbal Products in Hypertension: Paradox or, Paragon. In: Herbal Medicine: Back to the Future. Vascular Health. 2nd ed. Bentham Science Publishers; 2019:76-124. doi:10.2174/9789811403743119020004
• Taylor S, Landry CA, Paluszek MM, Fergus TA, McKay D, Asmundson GJG. Development and initial validation of the Covid Stress Scales. J Anxiety Disord. 2020;72:102232. doi:10.1016/j.janxdis.2020.102232
• Jorm AF, Christensen H, Griffiths KM, Parslow RA, Rodgers B, Blewitt KA. Effectiveness of complementary and self-help treatments for anxiety disorders. Med J Aust. 2004;181(S7):S29-46. doi:10.5694/j.1326-5377.2004.tb06352.x
• Yeung KS, Hernandez M, Mao JJ, Haviland I, Gubili J. Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phyther Res. 2018;32(5):865-891. doi:10.1002/ptr.6033
• Bonardi O, Wang Y, Li K, et al. Effects of Covid-19 mental health interventions among children, adolescents, and adults not quarantined or undergoing treatment due to Covid-19 infection: A systematic review of randomised controlled trials. Can J Psychiatry. 2022;67(5):336-350. doi:10.1177/07067437211070648
• Jayawardena R, Sooriyaarachchi P, Chourdakis M, Jeewandara C, Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on Covid-19: A review. Diabetes Metab Syndr. 2020;14(4):367-382. doi:10.1016/j.dsx.2020.04.015
• Ismail N, Zulkifli M, Wan Ismail WI. Therapeutic potentials of bee products for treatment of Covid-19. IIUM Med J Malaysia. 2022;21(1):19-29. doi:10.31436/imjm.v21i1.1893
• Wijayasinghe YS, Bhansali P, Viola RE, Kamal MA, Poddar NK. Natural products: A rich source of antiviral drug lead candidates for the management of Covid-19. Curr Pharm Des. 2021;27(33):3526-3550. doi:10.2174/1381612826666201118111151
• Wister A, Chittenden M, McCoy B, Wilson K, Allen T, Wong M. Using alternative therapies to manage chronic illness among older adults: an examination of the health context, predisposing and enabling processes. Can J Aging. 2002;21(1):47-62. doi:10.1017/S0714980800000635
• Wolf M, Emberger-Klein A, Menrad K. Usage of Natural Health Products (NHPs) for respiratory diseases: User characteristics and NHP-Consumption behavior during the Covid-19 pandemic in Germany. BMC Complement Med Ther. 2023;23(1):372. doi:10.1186/s12906-023-04180-9
• Zeng N, Chen X, Liu Z. Natural products and nanotechnology against Coronavirus disease 2019. Front Chem. 2022;10:PMC8866311. doi:10.3389/fchem.2022.819969
• Nilashi M, Samad S, Yusuf SYM, Akbari E. Can complementary and alternative medicines be beneficial in the treatment of Covid-19 through improving immune system function? J Infect Public Health. 2020;13(6):893-896. doi:10.1016/j.jiph.2020.05.009