Research Article
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Year 2025, Volume: 6 Issue: 1, 29 - 35, 25.04.2025
https://doi.org/10.53811/ijtcmr.1572833

Abstract

References

  • Abi-Hanna A, Lake AM. Constipation and encopresis in childhood. Pediatrics in Review. 1998;19(1):23-30.
  • Benninga M, Candy DCA, Catto-Smith AG, et al. The Paris consensus on childhood constipation terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005;40(3):273-275.
  • Bennina MA, Voskuijl WP, Taminiau J. Childhood constipation: is there new light in the tunnel? J Pediatr Gastroenterol Nutr. 2004;39(5):448-464.
  • Lunniss PJ, Gladman MA, Benninga MA, et al. Pathophysiology of evacuation disorders. Neurogastroenterol Motil. 2009;21(2):31-40.
  • Baker SS, Liptak GS, Colletti RB, et al. Constipation in infans and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1990;29(5):612-626.
  • Van Ginkel R, Reitsma JB, Büller HA, et al. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003;125(2):357-363.
  • Gill HS, Guarner F. Probiotics and human health: a clinical perspective. Postgrad Med J. 2004;80(947):516-526.
  • NASPGHAN Nutrition Report Committee, Michail S, Sylvester F, et al. Clinical efficacy of probiotics: review of the evidence with focus on children. J Pediatr Gastroenterol Nutr. 2006;43(4):550-557.
  • Cherbuliez T. Apitherapy–the use of honeybee products, in Biotherapy-History, Principles and Practice: Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms. Springer. 2013:113-146.
  • Denisow B, Denisow-Pietrzyk M. Biological and theraoeutic properties of bee pollen: a review. J Sci Food Agric. 2016;96(13):4303-4309.
  • Morais M, Moreira L, Feás X, et al. Honeybee-collected pollen from five Portuguese Natural Parks: palynological origin, phenolic content, antioxidant properties and antimicrobial activity. Food Chem Toxicol. 2011;49(5):1096-1101.
  • Maruyama H, Sakamoto T, Araki Y, et al. Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema. BMC Complement Altern Med. 2010;10(30).
  • Pascoal A, Rodrigues S, Teixeira A, et al. Biological activities of commercial bee pollens: Antimicrobial, antimutagenic, antioxidant and anti-inflammatory. Food Chem Toxicol. 2014;2063:233-239.
  • Eraslan G, Kanbur M, Silici S. Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem Toxicol. 2009;47(1):86-91.
  • Mărgăoan R, Strant M, Varadi A, et al. Bee collected pollen and bee bread: Bioactive constituents and health benefits. Antioxidants. 2019;8(12):568.
  • Urcan AC, Al Marghitas L, Dezmirean DS, et al. Chemical composition and biological activities of beebread- Review. Animal Science and Biotechnologies. 2017;74(1):6.
  • Fratini F, Cilia G, Mancini S. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res. 2016;192:130-141.
  • Oršolić N. Bee venom in cancer therapy. Cancer and Metastasis Reviews. 2012;31:173-194.
  • Erejuwa OO, Sulaiman SA, Wahab MSA. Honey: A novel antioxidant. Molecules. 2012;17(4):4400-4423.
  • Markland AD, Palsson O, Goode PS, et al. Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey. Am J Gastroenterol. 2013;108(5):796-803.
  • Güneş FE, Imeryuz N, Akalin A, et al. Development and validation of a semi-quantitative food frequency questionnaire to assess dietary intake in Turkish adults. J Pak Med Assoc. 2015;65(7),756-763.
  • Murakami K, Okubo H, Sasaki S. Dietary intake in relation to self-reported constipation among Japanese women aged 18-20 years. Eur J Clin Nutr. 2006;60(5):650-657.
  • Murakami K, Sasaki S, Okubo H, et al. Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women. Eur J Clin Nutr. 2007;61(5):616-622.
  • Gibson RS. Principles of nutritional assessment. Oxford University Press, USA; 2005.
  • Jan A, Weir CB. BMI Classification percentile and cut off points. StatPearls: Treasure Island, USA; 2021.
  • Marshall AL, Smith BJ, Bauman AE, et al. Reliability and validity of a brief physical activity assessment for use by family doctors. Br J Sports Med. 2005;39(5):294-297.
  • Al Naggar Y, Giesy JP, Abdel-Daim MM, et al. Fighting against the second wave of COVID-19: Can honeybee products help protect against the pandemic? Saudi J Biol Sci. 2021;28(3):1519-1527.
  • Quigley EMM, Spiller RC. Constipation and the microbiome: Lumen versus mucosa! Gastroenterology. 2016;150(2):300-303.
  • Wintola OA, Sunmonu TO, Afolayan AJ. The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats. BMC Gastroenterol. 2010;10(95):1-5.
  • Abeshu MA, Geleta B. Medical uses of honey. Biology and Medicine. 2016;8(2):1-7.
  • Mohapatra DP, Thakur V, Brar SK. Antibacterial efficacy of raw and processed honey. Biotechnol Res Int. 2011;2011.
  • Osato MS, Reddy SG, Graham DY. Osmotic effect of honey on growth and viability of Helicobacter pylori. Dig Dis Sci. 1999;44(3):462-464.
  • Li Y, Long S, Liu Q, et al. Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice. Food Sci Nutr. 2020;8(8):4388-4398.
  • Shirah BH. The value of mountain Sidr Honey in treating and controlling chronic constipation: A prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients. Journal of Apitherapy. 2016;1(1):2-6.
  • Zhang S, Jiao T, Chen Y, et al. Methylglyoxal induces systemic symptomps of irritable bowel syndrome. PloS One. 2014;9(8):e105307.
  • Sugiyama T, Takahashi K, Mori H. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modülatör of the innate immune responses. Endocr Metab Immune Disord Drug Targets. 2012;12(4):368-376.
  • Jajali M, Ranjbar T, Mosallanezhad Z, et al. Effect of propolis intake on serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) levels in adults: A systematic review and meta-analyis of clinical trials. Complement Ther Med. 2020;50:102380.
  • Xue M, Liu Y, Xu H, et al. Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats. Biomed Pharmacother. 2019;18:109393.
  • Park J-H, Kim K-H, Lee W-R, et al. Protective effect of mellittin on inflammation and apoptosis in acute liver failure. Apoptosis. 2012;17(1):61-69.
  • Choi MS, Park S, Choi T, et al. Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4+CD25+ regulatory T cells in mice. Cytokine, 2013;61(1):256-265.
  • Habryka C, Kruczek M, Drygaś B. Bee products used in apitherapy. World Scientific News. 2016;48(2016):254-258.
  • Bogdanov S. Antiviral properties of the bee products: a review. Bee products against viruses and for COVID-19 prevention (review). 2020.

The Relationship Between The Use of Apitherapy Products and The Frequency of Constipation in Adults

Year 2025, Volume: 6 Issue: 1, 29 - 35, 25.04.2025
https://doi.org/10.53811/ijtcmr.1572833

Abstract

Objective:
This study aims to reveal the effectiveness of apitherapy products on constipation, as well as other possible risk factors, in individuals with functional constipation.
Material-Method:
This cross-sectional study was conducted with 652 adults (460 men and 192 women) between the ages of 18-65 in Turkey. Constipation was defined as defecation frequency of less than 3 times a week. Dietary fluid and fiber intake was assessed by the 62-item food consumption frequency (FFQ). The use of bee products was questioned in terms of quantity and frequency. Physical activity status was questioned with a 3-question short form.
Results:
It was determined that 17.8% of the cohort (19.1% males, 14.6% females) had constipation. The percentage of constipation was higher in underweight individuals (28.5%) compared to other BMI groups. Individuals with chronic diseases have a higher percentage of constipation (22.4%) than those without the disease. A significant relationship was found between constipation and fiber intake (p = 0.001). Honey (p=0.013) and royal jelly (p=0.030) intake was significantly higher in individuals without constipation than in individuals with constipation.
Conclusion:
The rate of functional constipation is high in Turkish adults. Fiber intake, presence of chronic disease and BMI affect constipation. Constipation is lower in those who consume honey and royal jelly from bee products. Interventional studies are needed on the use of bee products to reduce the symptoms and frequency of constipation.

References

  • Abi-Hanna A, Lake AM. Constipation and encopresis in childhood. Pediatrics in Review. 1998;19(1):23-30.
  • Benninga M, Candy DCA, Catto-Smith AG, et al. The Paris consensus on childhood constipation terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005;40(3):273-275.
  • Bennina MA, Voskuijl WP, Taminiau J. Childhood constipation: is there new light in the tunnel? J Pediatr Gastroenterol Nutr. 2004;39(5):448-464.
  • Lunniss PJ, Gladman MA, Benninga MA, et al. Pathophysiology of evacuation disorders. Neurogastroenterol Motil. 2009;21(2):31-40.
  • Baker SS, Liptak GS, Colletti RB, et al. Constipation in infans and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1990;29(5):612-626.
  • Van Ginkel R, Reitsma JB, Büller HA, et al. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003;125(2):357-363.
  • Gill HS, Guarner F. Probiotics and human health: a clinical perspective. Postgrad Med J. 2004;80(947):516-526.
  • NASPGHAN Nutrition Report Committee, Michail S, Sylvester F, et al. Clinical efficacy of probiotics: review of the evidence with focus on children. J Pediatr Gastroenterol Nutr. 2006;43(4):550-557.
  • Cherbuliez T. Apitherapy–the use of honeybee products, in Biotherapy-History, Principles and Practice: Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms. Springer. 2013:113-146.
  • Denisow B, Denisow-Pietrzyk M. Biological and theraoeutic properties of bee pollen: a review. J Sci Food Agric. 2016;96(13):4303-4309.
  • Morais M, Moreira L, Feás X, et al. Honeybee-collected pollen from five Portuguese Natural Parks: palynological origin, phenolic content, antioxidant properties and antimicrobial activity. Food Chem Toxicol. 2011;49(5):1096-1101.
  • Maruyama H, Sakamoto T, Araki Y, et al. Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema. BMC Complement Altern Med. 2010;10(30).
  • Pascoal A, Rodrigues S, Teixeira A, et al. Biological activities of commercial bee pollens: Antimicrobial, antimutagenic, antioxidant and anti-inflammatory. Food Chem Toxicol. 2014;2063:233-239.
  • Eraslan G, Kanbur M, Silici S. Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem Toxicol. 2009;47(1):86-91.
  • Mărgăoan R, Strant M, Varadi A, et al. Bee collected pollen and bee bread: Bioactive constituents and health benefits. Antioxidants. 2019;8(12):568.
  • Urcan AC, Al Marghitas L, Dezmirean DS, et al. Chemical composition and biological activities of beebread- Review. Animal Science and Biotechnologies. 2017;74(1):6.
  • Fratini F, Cilia G, Mancini S. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res. 2016;192:130-141.
  • Oršolić N. Bee venom in cancer therapy. Cancer and Metastasis Reviews. 2012;31:173-194.
  • Erejuwa OO, Sulaiman SA, Wahab MSA. Honey: A novel antioxidant. Molecules. 2012;17(4):4400-4423.
  • Markland AD, Palsson O, Goode PS, et al. Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey. Am J Gastroenterol. 2013;108(5):796-803.
  • Güneş FE, Imeryuz N, Akalin A, et al. Development and validation of a semi-quantitative food frequency questionnaire to assess dietary intake in Turkish adults. J Pak Med Assoc. 2015;65(7),756-763.
  • Murakami K, Okubo H, Sasaki S. Dietary intake in relation to self-reported constipation among Japanese women aged 18-20 years. Eur J Clin Nutr. 2006;60(5):650-657.
  • Murakami K, Sasaki S, Okubo H, et al. Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women. Eur J Clin Nutr. 2007;61(5):616-622.
  • Gibson RS. Principles of nutritional assessment. Oxford University Press, USA; 2005.
  • Jan A, Weir CB. BMI Classification percentile and cut off points. StatPearls: Treasure Island, USA; 2021.
  • Marshall AL, Smith BJ, Bauman AE, et al. Reliability and validity of a brief physical activity assessment for use by family doctors. Br J Sports Med. 2005;39(5):294-297.
  • Al Naggar Y, Giesy JP, Abdel-Daim MM, et al. Fighting against the second wave of COVID-19: Can honeybee products help protect against the pandemic? Saudi J Biol Sci. 2021;28(3):1519-1527.
  • Quigley EMM, Spiller RC. Constipation and the microbiome: Lumen versus mucosa! Gastroenterology. 2016;150(2):300-303.
  • Wintola OA, Sunmonu TO, Afolayan AJ. The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats. BMC Gastroenterol. 2010;10(95):1-5.
  • Abeshu MA, Geleta B. Medical uses of honey. Biology and Medicine. 2016;8(2):1-7.
  • Mohapatra DP, Thakur V, Brar SK. Antibacterial efficacy of raw and processed honey. Biotechnol Res Int. 2011;2011.
  • Osato MS, Reddy SG, Graham DY. Osmotic effect of honey on growth and viability of Helicobacter pylori. Dig Dis Sci. 1999;44(3):462-464.
  • Li Y, Long S, Liu Q, et al. Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice. Food Sci Nutr. 2020;8(8):4388-4398.
  • Shirah BH. The value of mountain Sidr Honey in treating and controlling chronic constipation: A prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients. Journal of Apitherapy. 2016;1(1):2-6.
  • Zhang S, Jiao T, Chen Y, et al. Methylglyoxal induces systemic symptomps of irritable bowel syndrome. PloS One. 2014;9(8):e105307.
  • Sugiyama T, Takahashi K, Mori H. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modülatör of the innate immune responses. Endocr Metab Immune Disord Drug Targets. 2012;12(4):368-376.
  • Jajali M, Ranjbar T, Mosallanezhad Z, et al. Effect of propolis intake on serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) levels in adults: A systematic review and meta-analyis of clinical trials. Complement Ther Med. 2020;50:102380.
  • Xue M, Liu Y, Xu H, et al. Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats. Biomed Pharmacother. 2019;18:109393.
  • Park J-H, Kim K-H, Lee W-R, et al. Protective effect of mellittin on inflammation and apoptosis in acute liver failure. Apoptosis. 2012;17(1):61-69.
  • Choi MS, Park S, Choi T, et al. Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4+CD25+ regulatory T cells in mice. Cytokine, 2013;61(1):256-265.
  • Habryka C, Kruczek M, Drygaś B. Bee products used in apitherapy. World Scientific News. 2016;48(2016):254-258.
  • Bogdanov S. Antiviral properties of the bee products: a review. Bee products against viruses and for COVID-19 prevention (review). 2020.
There are 42 citations in total.

Details

Primary Language English
Subjects Traditional, Complementary and Integrative Medicine (Other)
Journal Section Research Articles
Authors

Ayfer Beyaz Coşkun 0000-0003-2029-5435

Semra Türkoğlu 0000-0001-7682-0513

Ezgi Böler 0009-0008-0528-7457

Zehra Betül Tomar 0009-0006-0891-137X

Esra Güven 0009-0009-8762-2278

Publication Date April 25, 2025
Submission Date October 24, 2024
Acceptance Date March 10, 2025
Published in Issue Year 2025 Volume: 6 Issue: 1

Cite

APA Beyaz Coşkun, A., Türkoğlu, S., Böler, E., Tomar, Z. B., et al. (2025). The Relationship Between The Use of Apitherapy Products and The Frequency of Constipation in Adults. International Journal of Traditional and Complementary Medicine Research, 6(1), 29-35. https://doi.org/10.53811/ijtcmr.1572833

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