A Case of T-cell Lymphoma Initially Presenting with Eosinophilia: Evaluation of Clinical and Pathological Findings

Abstract

Objective: Hypereosinophilia is a rare clinical entity, often detected through routine hemograms. Its clinical significance stems from its association with myeloid/lymphoid neoplasms and the organ damage it causes. Case Report: In this case report, a patient who was being treated in the coronary intensive care unit for decompensated heart failure and whose routine complete blood count revealed eosinophilia underwent a bone marrow biopsy and a tru-cut biopsy of the involved lymph nodes. The results of both biopsies were consistent with T-cell lymphoma. The patient was placed on the CHOP protocol. Conclusion: Eosinophilia has a wide etiology spectrum, occurring in both hematological malignancies and benign conditions such as collagen tissue diseases. Therefore, patients with persistent eosinophilia on complete blood counts, even in the absence of clinical findings, should be referred to specialized centers.

Keywords

• Hypereosinophilia
• lymphoma
• rhinitis
• vasculitis

Supporting Institution

Samsun University

Ethical Statement

A written informed consent form was obtained from the patient.

Eozinofili ile Başlayan ve Sonrasında T Hücreli Lenfoma Tanısı Konan Bir Olgu: Klinik ve Patolojik Bulguların Değerlendirilmesi

Abstract

Amaç: Hipereozinofili nadir görülen, çoğu zaman rutin hemogram tetkiklerinden tespit edilebilen klinik bir durumdur. Klinik olarak önemi miyeloid ve lenfoid neoplazmlar ile olan ilişkisi ve neden olduğu organ hasarıdır. Olgu Sunumu: Bu olgu sunumunda dekompanse kalp yetmezliği sebebiyle koroner yoğun bakım ünitesinde tedavi gören ve rutin tam kan sayımlarında eozinofili saptanan hastaya kemik iliği biyopsisi yapıldı ve patolojik lenf nodlarından tru-cut biyopsi uygulandı. Her iki biyopsinin sonucu da T hücreli lenfoma ile uyumlu geldi. Hastaya CHOP (Siklofosfamid, Doksorubisin, Vinkristin, Prednizon) protokolü uygulandı. Sonuç: Eozinofili hem hematolojik malignitelere hem de kollajen doku hastalıkları gibi benign sebeplerle ortaya çıkabilen geniş bir etyolojik yelpazeye sahiptir. Bu sebeple klinik bulguları olmasa bile tam kan sayımında sebat eden eozinofiliye sahip olan hastalar bu konuda uzmanlaşmış merkezlere sevk edilmelidir.

Keywords

• Hipereozinofili
• lenfoma
• rinit
• vaskülit

Supporting Institution

Samsun Üniversitesi

Ethical Statement

Yazılı bilgilendirilmiş onam formu hastaya imzalatılmıştır.

References

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