The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy

Fusun Ak Sonat; Behzat Noyan

The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy

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The acute effect of topiramate (TPM) treatment on zinc ion translocation in hippocampus and antiepileptic effect on behaviour in SE has been researched in this study. It has also been tried to explain, whether TPM has a role on antiepileptic effect by affecting the zinc ions on the hippocampus.Fortynine male Sprague-Dawley rats, 3 months old, were randomly divided into seven equal groups (n=7 per group). The first group was the naive, the second group was the seizure-control, the third group was seizure+TPM (60 mg/kg, i.p.) treatment, the fourth group was seizure+TPM60+CaEDTA (100 mM,i.c.v.), the fifth group was seizure+TPM60+ZnCl2 (35 mg/kg, i.p.), the sixth group was seizure+CaEDTA, the seventh group was seizure+ZnCl2.Behavioral changes of rats were observed throughout the experiment.End of the study, rats were decapitated under anesthesia to rapidly remove their brains. Hippocampal staining was performed to investigate zinc translocation.Our results show that, there was not significant differences in the SE incidence,SE latency, 24-hour survival, and seizure scoreamong the groups. Also it was observed that TPM is not effective for the zinc hystochemistry in the brain when administered at the dose of 60 mg/kg.On the other hand,TPM can be effective for zinc translocation when it is administered in high doses. For this reason we need to work more.

Anahtar Kelimeler

Zinc,Topiramate,Hippocampus,Epilepsy,TSQ

References

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Details

Primary Language

English

Subjects

Veterinary Surgery

Journal Section

Research Article

Authors

Fusun Ak Sonat ^*

Behzat Noyan This is me

Publication Date

December 22, 2018

Submission Date

April 1, 2018

Acceptance Date

August 1, 2018

Published in Issue

Year 2018 Volume: 1 Number: 2

IZ

https://izlik.org/JA37TB86AM

Cite

RIS / Bibtex

APA

Ak Sonat, F., & Noyan, B. (2018). The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy. International Journal of Veterinary and Animal Research, 1(2), 30-33. https://izlik.org/JA37TB86AM

AMA

1.Ak Sonat F, Noyan B. The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy. International Journal of Veterinary and Animal Research. 2018;1(2):30-33. https://izlik.org/JA37TB86AM

Chicago

Ak Sonat, Fusun, and Behzat Noyan. 2018. “The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy”. International Journal of Veterinary and Animal Research 1 (2): 30-33. https://izlik.org/JA37TB86AM.

EndNote

Ak Sonat F, Noyan B (December 1, 2018) The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy. International Journal of Veterinary and Animal Research 1 2 30–33.

IEEE

[1]F. Ak Sonat and B. Noyan, “The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy”, International Journal of Veterinary and Animal Research, vol. 1, no. 2, pp. 30–33, Dec. 2018, [Online]. Available: https://izlik.org/JA37TB86AM

ISNAD

Ak Sonat, Fusun - Noyan, Behzat. “The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy”. International Journal of Veterinary and Animal Research 1/2 (December 1, 2018): 30-33. https://izlik.org/JA37TB86AM.

JAMA

1.Ak Sonat F, Noyan B. The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy. International Journal of Veterinary and Animal Research. 2018;1:30–33.

MLA

Ak Sonat, Fusun, and Behzat Noyan. “The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy”. International Journal of Veterinary and Animal Research, vol. 1, no. 2, Dec. 2018, pp. 30-33, https://izlik.org/JA37TB86AM.

Vancouver

1.Fusun Ak Sonat, Behzat Noyan. The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy. International Journal of Veterinary and Animal Research [Internet]. 2018 Dec. 1;1(2):30-3. Available from: https://izlik.org/JA37TB86AM