The Investigation of The Effects of Topiramate Treatment on The Role of Zinc Ions in Experimental Epilepsy

Year 2018, Volume: 1 Issue: 2, 30 - 33, 22.12.2018

Fusun Ak Sonat , Behzat Noyan

Abstract

The acute effect of topiramate (TPM) treatment on zinc ion translocation in hippocampus and antiepileptic effect on behaviour in SE has been researched in this study. It has also been tried to explain, whether TPM has a role on antiepileptic effect by affecting the zinc ions on the hippocampus.Fortynine male Sprague-Dawley rats, 3 months old, were randomly divided into seven equal groups (n=7 per group).  The first group was the naive, the second group was the seizure-control, the third group was seizure+TPM (60 mg/kg, i.p.) treatment, the fourth group was seizure+TPM60+CaEDTA (100 mM,i.c.v.), the fifth group was seizure+TPM60+ZnCl2 (35 mg/kg, i.p.), the sixth group was seizure+CaEDTA, the seventh group was seizure+ZnCl2.Behavioral changes of rats were observed throughout the experiment.End of the study, rats were decapitated under anesthesia to rapidly remove their brains. Hippocampal staining was performed to investigate zinc translocation.Our results show that, there was not significant differences in the SE incidence,SE latency, 24-hour survival, and  seizure scoreamong the groups. Also it was observed that TPM is not effective for the zinc hystochemistry in the brain when administered at the dose of 60 mg/kg.On the other hand,TPM can be effective for zinc translocation when it is administered in high doses. For this reason we need to work more.

Keywords

Zinc, Topiramate, Hippocampus, Epilepsy, TSQ

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