Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri

Firuz Çelikoğlu; İrfan Papila; Çiğdem Papila; İ.seyhan Çelikoğlu

Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri

Year 2007, Volume: 38 Issue: 2, 69 - 79, 19.07.2014

Firuz Çelikoğlu İrfan Papila Çiğdem Papila İ.seyhan Çelikoğlu

Keywords

Girişimsel bronkoskopi, endobronşiyal intratümöral kemoterapi, akciğer kanseri tedavisi, lokorejyonal neoadjuvant kemoterapi

References

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 533-543.
2. Minna JD, Higgins GA, Glastein E. Cancer of the lung. In: Devita VT, Hellman S, Rosenberg SA (eds). Principles and practice of oncology, 2nd edn.Lppincott, Philadelphia, 1985; 518-526.
3. Jemal A, Murray T ,Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics. 2005. Ca Cancer J Clin 2005; 55: 10-30.
4. World health organization: Histological typing of lung cancer and pleural tumors. Berlin, Springer 1999.
5. Cersosomo RJ. Lung cancer: a review. Am J Health Syst Pharm 2002; 59: 611- 642.
6. Matthews M.J. Problems in morphology and behavior of bronchopulmonary malignant disease. Israel L, Chahinian A.P. eds. Lung cancer: Natural History, prognosis and therapy. Academic press New York 1976: 23-62.
7. Group L.L.C.S. Patterns of failure in patients with resected stage I and II non-small-cell carcinoma of the lung. Ann Surg 1987; 205: 67-71.
8. Kotlyarov EV, Rukosuyev AA. Long-term results and patterns of disease recurrence after radical operations for lung cancer. J Thorac Cardiovasc Surg 1991; 102: 24-28 [Abstract].
9. Wingo PA, Tong T,Bolden S, Cancer statistics 1995. Cancer J Clin 1995; 45: 8-30.
10. Nesbitt JC, Putnam JB, Walsh GL, et al. Survival in early stage non-small cell lung cancer. Ann Thorac Surg 1995; 60: 466-472.
11. Spiro SG, Porter JC. Lung Cancer—Where Are We Today? Current Advances in Staging and Nonsurgical Treatment. Am J Resp Critcl Care Med 2002; 166: 1166-1196.
12. Gatzemeir U, Von Pawel L, Gottfried M, et al. Phase III comparative study of high dose Cisplatin versus a combination of paclitaxel and Cisplatin in patients with advanced non-small lung cancer. Proc Am Soc Clin Oncol 1998; 17: 454a.
13. Ning S, Yu N, Brown D.M., Kanekal S, Knox SJ. Radiosensitization by intratumoral administration of cisplatin in a sustained-release drug delivery system. Radiother Oncol 1999; 50: 215-223.
14. Trovo MG, Minatel E, Veronesie A, Roncadin M, De Paoli A, Franchin G, et al. Combined radiotherapy and chemotherapy vs. radiotherapy alone in locally advanced bronchogenic carcinoma: a randomized study. Cancer 1990; 65: 400-404.
15. Trovo MG, Minatel E, Franchin G, Boccieri MG, Nascimben O, Bolzicco G, et al. Radiotherapy (RT) versus RT enhanced by cisplatin (CDPG) in stage III non small-cell lung cancer (NSCLC): randomized cooperative study. Lung Cancer 1991; 7: 158.
16. Shaake –Koning C, van den Bogaert W, Dalesio O, Festen J, Hoogenhout J. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 1992; 326: 524-530.
17. Shaake-Konig C, van den Bogaert W, Daleiso O, Festen J, Hoogenhout J. Radiosensitization by cytotoxic drugs. The EORTC experience by radiotherapy and lung cancer cooperative groups. Lung Cancer 1994, 10: 263-270.
18. Pradier O, Laderer K, Hille A, Weiss E, Christinsen H, Schmidberger. Concurrent low-dose cisplatin and thoracic radiotherapy in patients with inoperable stage III non-small-cell lung cancer: a phase II trial reference to the hemoglobin level as prognostic parameter. J Cancer Res Clin Oncol 2005; 131: 261-269.
19. Koca S, Oner –Dinçbafl F, Serdengeçti S, Yaman M, Ongen G, Demirci S, Molinas Mandel N, Turkan S, Atkovar G, Okkan S, Sozer K, Celikoglu S. Radiotherapy alone vs combined chemotherapy and radiotherapy in non-resectable non-small cell lung cancer: A phase III randomized clinical trial. Cerrahpasa J Med 1996; 27: 63-69.
20. Freitag L, Ernst A, Thomas M et al. Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumor control in patients with limited bronchogenic carcinoma. Thorax 2004; 59: 790-793.
21. Moghissi K, Dixon K. Is broncoscopic photodynamic therapy a therapeutic option in lung cancer? Eur Respir J 2003; 22: 535-541.
22. Kato H, Konaka C, Ono J, Kawate N, Nishimiya K, et al. Preoperative laser photodynamic therapy in lung cancer. J Thorac Cardiovasc Surc 1985; 90: 420-429.
23. Ginsberg RJ, Vokes EE, Ruben A. Non-small cell lung cancer. In: De Vita VT, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology, 5th ed. Philadelphia: JB Lippincott-Raven; 1997; 858-911.
24. Luomanen RKJ, Watson WL. Autopsy findings. In: Watson WL, ed. Lung cancer. A study of five thousand memorial hospital cases. St Louis, Mo: CV Mosby Co. 1968; 504-510.
25. Eichenhorn MS, Kvale PA, Miks VM et al. Initial combination therapy with laser photoresection and irradiation for inoperable non-small cell carcinoma of the lung. Chest 1986; 89: 782-785.
26. Vergnon JM, Schmitt T, Alamartine E et al. Initial combined cryotherapy and irradiation for unresectable non-small cell lung cancer. 1992; 102: 1436-1440.
27. Stanley K, Prognostic factors for survival in patients with inoperable lung cancer. J Nati Cancer Inst 1980; 65: 25-32.
28. Freitag I, Macha HN, Loddenkemper R. Interventional bronchoscopic procedures. Eur Respir Monogr. 2001; 6: 272-304.
29. Ernst A, Feller-Kopman D, Becker HD, Mehta AC.Central airway obstruction. Am J Respir Crit Care Med 2004; 169: 1278-1297.
30. Bolliger, CT, Mathur PN. Beamis JF, et al. ERS/ATS statement on interventional pulmonology. European Respiratory Society/American thoracic society. Eur Respir J 2002; 19: 356-373.
31. Bolliger CT, Sutedja TG, Strausz J, Freitag L. Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents. Eur Resp J 2006; 27: 1258-1271.
32. Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Resp J 2006; 28: 200-218.
33. Vergnon JM. Traitement palliative de l’obstruction bronchique tumoral. Pour qui, Pour quoi, Comment? Rev Mal Resp 1995; 12: 331-334.
34. Bolliger CT. Multimodality’s treatment of advanced pulmonary malignancies. (In: CT Bolliger, PN Mathur 8WDS) Interventional bronchoscopy. Progress in Respiratory research. Basel, Karger AG, 2000 Vol 30:187- 196.
35. Vergnon JM. Cancer bronchique de state IIIb et endoscopie interventionnelle. Rev Mal Respir 2006; 23: 68- 71.
36. Celikoglu F, Celikoglu SI, York AM, Goldberg PE. Intratumoral administration of cisplatin through a bronchoscope followed by irradiation for treatment of inoperable non-small cell obstructive lung cancer. Lung Cancer 2006; 51: 225-236.
37. Celikoglu SI, Celikoglu F, Goldberg PE. Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small-cell lung cancer with polypoid growth causing erroneous impression of advanced disease. Lung Cancer 2006; 54: 339-346.
38. Chetty KG, Moran EM, Sassoon CSH, et al. Effect of radiation therapy on bronchial obstruction due to bronchogenic carcinoma. Chest 1989; 95: 582-584.
39. Parrat E, Pujol J-L, Gautier, et al. Chest tumor response during lung cancer chemotherapy. Computed tomography versus fiberoptic bronchoscopy. Chest 1993; 103: 1495-1501.
40. Roth JA, Nguyen D, Lawrence DD, et al.Retrovirus –mediated wild type p53 gene transfertumors of patients with lung cancer. Nat Med 1996; 2: 985-999.
41. Weill D, Mack M, Roth J. et al. Adenoviral-mediated p53 gene transfer to non-small celllung cancer through endobronchial injection. Chest 2000; 118: 966-970.
42. Liebers U, Kuhn H, Arnold W, Wolf G, Witt G. Gene transfer into solid tumors- mechanical determinants for efficiency of adenovirus-mediated gene transfere. Am J Resp Crit Care Med 2000: A89.
43. Goldberg EP, Hadba HR, Almond BA, Marotta JS Intratumoral cancer chemotherapy and immunotherapy: opportunities for non-systemic preoperative drug delivery. J pharm Pharmacol. 2002; 54: 159-180.
44. Celikoglu SI, Karayel T, Demirci S, Celikoglu F, Serdengecti S, et al. Direct injection of several anticancer drugs into endobronchial malignant tumor in the palliation of major airway obstruction (abstract). Eur Respir J 1991; 4: 303.
45. Celikoglu SI, Celikoglu F, Karayel T, Demirci S, Cagatay T. Direct injection of anticancer drugs into endobronchial tumors for major airway obstruction. Post Grad Med J 1997; 73: 159-162.
46. Celikoglu F, Celikoglu SI. Intratumoral chemotherapy with 5-Fluorouracil for palliation of bronchial cancer in patients with severe airway obstruction. J Pharmacy and Pharmacology 2003; 55: 1441-1444.
47. Seymour CW, Krimsky WS, Sager J, Kruklitis J, Lund ME et al. Transbronchial needle injection : A systemic review of a new diagnostic and therapeutic paradigm. Respiration 2006; 73: 78-89.
48. Liu M, Ma P, Lu Z. Local chemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma. Chin J Tuberc Respir Dis 2000; 23: 550-551.
49. Celikoglu SI, Celikoglu F, Goldberg PE. Intratumoral chemotherapy through a flexible bronchoscope. J Bronchol 2004; 11: 260-265.
50. McLaughlin.CA, Goldberg EP., Chap. 10 in Targeted Drugs, ed. EP Goldberg, Local chemo- and immuno therapy by intratumor drug injection: opportunities for polymer-drug compositions. Wiley Interscience, NY 1983, 231-268.
51. Goldberg EP, Almond BA, Hadba AR et al. Nano-mesosphere drug carriers for localized cancer chemotherapy. Proc NSTI Nanotech 2006; 2: 1-4.
52. Lardinois D, Brack T, Gaspert A, et al Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small-cell-lung cancer. Eur J Cardio-Thorac Surg 2003; 23: 824-827.
53. Baitchev G, Gorchev G, Deliisky T, Popovska S, Raitcheva TZ. Perioperative locoregional application of mitoxantron in patients with early breast carcinoma. J Chemother 2001; 13: 440-443.
54. Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 1995; 60: 615-622.
55. Yokomise H, Gotoh M, Okamoto T et al. Induction chemotherapy (carboplatintaxane and concurrent 50- Gy radiayion for bulky cN2, N3 non-small cell lung cancer. J Thorac Cardiovasc Surg 2007; 133: 1179- 1185.
56. Çeliko¤lu S, Karayel T, Çeliko¤lu F, Demirci S, Yanarda¤ H, Gülbaran Z, Serdengeçti S. Büyük hava yollar›nda obstrüksiyon yapan bronfl kanserlerinde fleksibl bronkoskop arac›l›¤› ile çeflitli antikanser ilaçlar›n direkt enjeksiyonunun palyatif tedavideki de¤eri (ön bildiri). ‹stanbul T›p Fak Mecm 1993; 56: 32-40.
57. Çeliko¤lu S, Karayel T, Demirci S, Çeliko¤lu F, Gülbaran Z, Yanarda¤ H. Bronkojenik karsinomda fleksibl fiberoptik bronkoskop arc›l›¤› ile lazer fotorezeksiyonu. ‹stanbul T›p Fak Mecm 1994; 57: 60-63.
58. Seely JM, Mayo JR, Millers RR, Mullers NL. T1 lung cancer: prevalence of mediastinal nodal metastases and diagnostic accuracy of CT. Radiology 1993; 186: 129-132.
59. Harvey LR, Glazer GM, Gross BH, Francia IR, Orringer MB, The role of CT in staging radiographic T1N0M0 lung cancer. Am J Roentgenol 1986; 146: 285-290.
60. Naruke T, Goya T, Tsuchiya R, Suemasu K. The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 1960; 39: 555-572.
61. Noppen M, Amjadi K. Do pulmonologists need to tighten up their sphincter tone? Do pulmonologists need more guts? Respiration 2006; 73: 18-19.
62. Lam S, Kennedy T, Ungar M, et al. Localisation of bronchial neoplastic lesions by fluorescence bronchoscopy. Chest 1998; 113: 696-702.

Year 2007, Volume: 38 Issue: 2, 69 - 79, 19.07.2014

Firuz Çelikoğlu İrfan Papila Çiğdem Papila İ.seyhan Çelikoğlu

References

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 533-543.
2. Minna JD, Higgins GA, Glastein E. Cancer of the lung. In: Devita VT, Hellman S, Rosenberg SA (eds). Principles and practice of oncology, 2nd edn.Lppincott, Philadelphia, 1985; 518-526.
3. Jemal A, Murray T ,Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics. 2005. Ca Cancer J Clin 2005; 55: 10-30.
4. World health organization: Histological typing of lung cancer and pleural tumors. Berlin, Springer 1999.
5. Cersosomo RJ. Lung cancer: a review. Am J Health Syst Pharm 2002; 59: 611- 642.
6. Matthews M.J. Problems in morphology and behavior of bronchopulmonary malignant disease. Israel L, Chahinian A.P. eds. Lung cancer: Natural History, prognosis and therapy. Academic press New York 1976: 23-62.
7. Group L.L.C.S. Patterns of failure in patients with resected stage I and II non-small-cell carcinoma of the lung. Ann Surg 1987; 205: 67-71.
8. Kotlyarov EV, Rukosuyev AA. Long-term results and patterns of disease recurrence after radical operations for lung cancer. J Thorac Cardiovasc Surg 1991; 102: 24-28 [Abstract].
9. Wingo PA, Tong T,Bolden S, Cancer statistics 1995. Cancer J Clin 1995; 45: 8-30.
10. Nesbitt JC, Putnam JB, Walsh GL, et al. Survival in early stage non-small cell lung cancer. Ann Thorac Surg 1995; 60: 466-472.
11. Spiro SG, Porter JC. Lung Cancer—Where Are We Today? Current Advances in Staging and Nonsurgical Treatment. Am J Resp Critcl Care Med 2002; 166: 1166-1196.
12. Gatzemeir U, Von Pawel L, Gottfried M, et al. Phase III comparative study of high dose Cisplatin versus a combination of paclitaxel and Cisplatin in patients with advanced non-small lung cancer. Proc Am Soc Clin Oncol 1998; 17: 454a.
13. Ning S, Yu N, Brown D.M., Kanekal S, Knox SJ. Radiosensitization by intratumoral administration of cisplatin in a sustained-release drug delivery system. Radiother Oncol 1999; 50: 215-223.
14. Trovo MG, Minatel E, Veronesie A, Roncadin M, De Paoli A, Franchin G, et al. Combined radiotherapy and chemotherapy vs. radiotherapy alone in locally advanced bronchogenic carcinoma: a randomized study. Cancer 1990; 65: 400-404.
15. Trovo MG, Minatel E, Franchin G, Boccieri MG, Nascimben O, Bolzicco G, et al. Radiotherapy (RT) versus RT enhanced by cisplatin (CDPG) in stage III non small-cell lung cancer (NSCLC): randomized cooperative study. Lung Cancer 1991; 7: 158.
16. Shaake –Koning C, van den Bogaert W, Dalesio O, Festen J, Hoogenhout J. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 1992; 326: 524-530.
17. Shaake-Konig C, van den Bogaert W, Daleiso O, Festen J, Hoogenhout J. Radiosensitization by cytotoxic drugs. The EORTC experience by radiotherapy and lung cancer cooperative groups. Lung Cancer 1994, 10: 263-270.
18. Pradier O, Laderer K, Hille A, Weiss E, Christinsen H, Schmidberger. Concurrent low-dose cisplatin and thoracic radiotherapy in patients with inoperable stage III non-small-cell lung cancer: a phase II trial reference to the hemoglobin level as prognostic parameter. J Cancer Res Clin Oncol 2005; 131: 261-269.
19. Koca S, Oner –Dinçbafl F, Serdengeçti S, Yaman M, Ongen G, Demirci S, Molinas Mandel N, Turkan S, Atkovar G, Okkan S, Sozer K, Celikoglu S. Radiotherapy alone vs combined chemotherapy and radiotherapy in non-resectable non-small cell lung cancer: A phase III randomized clinical trial. Cerrahpasa J Med 1996; 27: 63-69.
20. Freitag L, Ernst A, Thomas M et al. Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumor control in patients with limited bronchogenic carcinoma. Thorax 2004; 59: 790-793.
21. Moghissi K, Dixon K. Is broncoscopic photodynamic therapy a therapeutic option in lung cancer? Eur Respir J 2003; 22: 535-541.
22. Kato H, Konaka C, Ono J, Kawate N, Nishimiya K, et al. Preoperative laser photodynamic therapy in lung cancer. J Thorac Cardiovasc Surc 1985; 90: 420-429.
23. Ginsberg RJ, Vokes EE, Ruben A. Non-small cell lung cancer. In: De Vita VT, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology, 5th ed. Philadelphia: JB Lippincott-Raven; 1997; 858-911.
24. Luomanen RKJ, Watson WL. Autopsy findings. In: Watson WL, ed. Lung cancer. A study of five thousand memorial hospital cases. St Louis, Mo: CV Mosby Co. 1968; 504-510.
25. Eichenhorn MS, Kvale PA, Miks VM et al. Initial combination therapy with laser photoresection and irradiation for inoperable non-small cell carcinoma of the lung. Chest 1986; 89: 782-785.
26. Vergnon JM, Schmitt T, Alamartine E et al. Initial combined cryotherapy and irradiation for unresectable non-small cell lung cancer. 1992; 102: 1436-1440.
27. Stanley K, Prognostic factors for survival in patients with inoperable lung cancer. J Nati Cancer Inst 1980; 65: 25-32.
28. Freitag I, Macha HN, Loddenkemper R. Interventional bronchoscopic procedures. Eur Respir Monogr. 2001; 6: 272-304.
29. Ernst A, Feller-Kopman D, Becker HD, Mehta AC.Central airway obstruction. Am J Respir Crit Care Med 2004; 169: 1278-1297.
30. Bolliger, CT, Mathur PN. Beamis JF, et al. ERS/ATS statement on interventional pulmonology. European Respiratory Society/American thoracic society. Eur Respir J 2002; 19: 356-373.
31. Bolliger CT, Sutedja TG, Strausz J, Freitag L. Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents. Eur Resp J 2006; 27: 1258-1271.
32. Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Resp J 2006; 28: 200-218.
33. Vergnon JM. Traitement palliative de l’obstruction bronchique tumoral. Pour qui, Pour quoi, Comment? Rev Mal Resp 1995; 12: 331-334.
34. Bolliger CT. Multimodality’s treatment of advanced pulmonary malignancies. (In: CT Bolliger, PN Mathur 8WDS) Interventional bronchoscopy. Progress in Respiratory research. Basel, Karger AG, 2000 Vol 30:187- 196.
35. Vergnon JM. Cancer bronchique de state IIIb et endoscopie interventionnelle. Rev Mal Respir 2006; 23: 68- 71.
36. Celikoglu F, Celikoglu SI, York AM, Goldberg PE. Intratumoral administration of cisplatin through a bronchoscope followed by irradiation for treatment of inoperable non-small cell obstructive lung cancer. Lung Cancer 2006; 51: 225-236.
37. Celikoglu SI, Celikoglu F, Goldberg PE. Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small-cell lung cancer with polypoid growth causing erroneous impression of advanced disease. Lung Cancer 2006; 54: 339-346.
38. Chetty KG, Moran EM, Sassoon CSH, et al. Effect of radiation therapy on bronchial obstruction due to bronchogenic carcinoma. Chest 1989; 95: 582-584.
39. Parrat E, Pujol J-L, Gautier, et al. Chest tumor response during lung cancer chemotherapy. Computed tomography versus fiberoptic bronchoscopy. Chest 1993; 103: 1495-1501.
40. Roth JA, Nguyen D, Lawrence DD, et al.Retrovirus –mediated wild type p53 gene transfertumors of patients with lung cancer. Nat Med 1996; 2: 985-999.
41. Weill D, Mack M, Roth J. et al. Adenoviral-mediated p53 gene transfer to non-small celllung cancer through endobronchial injection. Chest 2000; 118: 966-970.
42. Liebers U, Kuhn H, Arnold W, Wolf G, Witt G. Gene transfer into solid tumors- mechanical determinants for efficiency of adenovirus-mediated gene transfere. Am J Resp Crit Care Med 2000: A89.
43. Goldberg EP, Hadba HR, Almond BA, Marotta JS Intratumoral cancer chemotherapy and immunotherapy: opportunities for non-systemic preoperative drug delivery. J pharm Pharmacol. 2002; 54: 159-180.
44. Celikoglu SI, Karayel T, Demirci S, Celikoglu F, Serdengecti S, et al. Direct injection of several anticancer drugs into endobronchial malignant tumor in the palliation of major airway obstruction (abstract). Eur Respir J 1991; 4: 303.
45. Celikoglu SI, Celikoglu F, Karayel T, Demirci S, Cagatay T. Direct injection of anticancer drugs into endobronchial tumors for major airway obstruction. Post Grad Med J 1997; 73: 159-162.
46. Celikoglu F, Celikoglu SI. Intratumoral chemotherapy with 5-Fluorouracil for palliation of bronchial cancer in patients with severe airway obstruction. J Pharmacy and Pharmacology 2003; 55: 1441-1444.
47. Seymour CW, Krimsky WS, Sager J, Kruklitis J, Lund ME et al. Transbronchial needle injection : A systemic review of a new diagnostic and therapeutic paradigm. Respiration 2006; 73: 78-89.
48. Liu M, Ma P, Lu Z. Local chemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma. Chin J Tuberc Respir Dis 2000; 23: 550-551.
49. Celikoglu SI, Celikoglu F, Goldberg PE. Intratumoral chemotherapy through a flexible bronchoscope. J Bronchol 2004; 11: 260-265.
50. McLaughlin.CA, Goldberg EP., Chap. 10 in Targeted Drugs, ed. EP Goldberg, Local chemo- and immuno therapy by intratumor drug injection: opportunities for polymer-drug compositions. Wiley Interscience, NY 1983, 231-268.
51. Goldberg EP, Almond BA, Hadba AR et al. Nano-mesosphere drug carriers for localized cancer chemotherapy. Proc NSTI Nanotech 2006; 2: 1-4.
52. Lardinois D, Brack T, Gaspert A, et al Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small-cell-lung cancer. Eur J Cardio-Thorac Surg 2003; 23: 824-827.
53. Baitchev G, Gorchev G, Deliisky T, Popovska S, Raitcheva TZ. Perioperative locoregional application of mitoxantron in patients with early breast carcinoma. J Chemother 2001; 13: 440-443.
54. Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 1995; 60: 615-622.
55. Yokomise H, Gotoh M, Okamoto T et al. Induction chemotherapy (carboplatintaxane and concurrent 50- Gy radiayion for bulky cN2, N3 non-small cell lung cancer. J Thorac Cardiovasc Surg 2007; 133: 1179- 1185.
56. Çeliko¤lu S, Karayel T, Çeliko¤lu F, Demirci S, Yanarda¤ H, Gülbaran Z, Serdengeçti S. Büyük hava yollar›nda obstrüksiyon yapan bronfl kanserlerinde fleksibl bronkoskop arac›l›¤› ile çeflitli antikanser ilaçlar›n direkt enjeksiyonunun palyatif tedavideki de¤eri (ön bildiri). ‹stanbul T›p Fak Mecm 1993; 56: 32-40.
57. Çeliko¤lu S, Karayel T, Demirci S, Çeliko¤lu F, Gülbaran Z, Yanarda¤ H. Bronkojenik karsinomda fleksibl fiberoptik bronkoskop arc›l›¤› ile lazer fotorezeksiyonu. ‹stanbul T›p Fak Mecm 1994; 57: 60-63.
58. Seely JM, Mayo JR, Millers RR, Mullers NL. T1 lung cancer: prevalence of mediastinal nodal metastases and diagnostic accuracy of CT. Radiology 1993; 186: 129-132.
59. Harvey LR, Glazer GM, Gross BH, Francia IR, Orringer MB, The role of CT in staging radiographic T1N0M0 lung cancer. Am J Roentgenol 1986; 146: 285-290.
60. Naruke T, Goya T, Tsuchiya R, Suemasu K. The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 1960; 39: 555-572.
61. Noppen M, Amjadi K. Do pulmonologists need to tighten up their sphincter tone? Do pulmonologists need more guts? Respiration 2006; 73: 18-19.
62. Lam S, Kennedy T, Ungar M, et al. Localisation of bronchial neoplastic lesions by fluorescence bronchoscopy. Chest 1998; 113: 696-702.

There are 62 citations in total.

Details

Primary Language	Turkish
Journal Section	Derlemeler
Authors	Firuz Çelikoğlu This is me İrfan Papila This is me Çiğdem Papila This is me İ.seyhan Çelikoğlu This is me
Publication Date	July 19, 2014
Published in Issue	Year 2007 Volume: 38 Issue: 2

Cite

APA	Çelikoğlu, F., Papila, İ., Papila, Ç., Çelikoğlu, İ. (2014). Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri. Cerrahpaşa Tıp Dergisi, 38(2), 69-79.
AMA	Çelikoğlu F, Papila İ, Papila Ç, Çelikoğlu İ. Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri. Cerrahpaşa Tıp Dergisi. July 2014;38(2):69-79.
Chicago	Çelikoğlu, Firuz, İrfan Papila, Çiğdem Papila, and İ.seyhan Çelikoğlu. “Endobronﬂiyal Giriﬂimsel Yöntemler Ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri”. Cerrahpaşa Tıp Dergisi 38, no. 2 (July 2014): 69-79.
EndNote	Çelikoğlu F, Papila İ, Papila Ç, Çelikoğlu İ (July 1, 2014) Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri. Cerrahpaşa Tıp Dergisi 38 2 69–79.
IEEE	F. Çelikoğlu, İ. Papila, Ç. Papila, and İ. Çelikoğlu, “Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri”, Cerrahpaşa Tıp Dergisi, vol. 38, no. 2, pp. 69–79, 2014.
ISNAD	Çelikoğlu, Firuz et al. “Endobronﬂiyal Giriﬂimsel Yöntemler Ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri”. Cerrahpaşa Tıp Dergisi 38/2 (July 2014), 69-79.
JAMA	Çelikoğlu F, Papila İ, Papila Ç, Çelikoğlu İ. Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri. Cerrahpaşa Tıp Dergisi. 2014;38:69–79.
MLA	Çelikoğlu, Firuz et al. “Endobronﬂiyal Giriﬂimsel Yöntemler Ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri”. Cerrahpaşa Tıp Dergisi, vol. 38, no. 2, 2014, pp. 69-79.
Vancouver	Çelikoğlu F, Papila İ, Papila Ç, Çelikoğlu İ. Endobronﬂiyal Giriﬂimsel Yöntemler ve Intratümöral Kemoterapinin Akciğer Kanserinin Tedavi Stratejisindeki Yeri. Cerrahpaşa Tıp Dergisi. 2014;38(2):69-7.

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