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RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ

Year 2005, Volume: 36 Issue: 2, 78 - 83, 17.07.2014

Rauf Tahamiler Tahamiler Salih Çanakçıoğlu Deniz Edizer

Abstract

Alerjik rinit ve non-alerjik rinit eozinofilik sendrom (NARES) hastalarında serum total immunoglobulin (Ig) E seviyesi, CD4 ve CD8 hücre sayısı ve CD4/CD8 oranı değerlendirilerek sağlıklı kontrol grubu sonuçlarıyla karşılaştırılmıştır. Alerjik rinit grubunda total IgE seviyesinin diğer gruplara kıyasla daha yüksek olduğu tespit edildi (p<0.05). CD4 sayısı, alerjik rinit ve NARES grubunda daha yüksek bulunsa da, bu yükseklik, gruplar arası karşılaştırmada anlamlı bulunmadı. CD8 sadece NARES grubunda kontrol grubuna nazaran anlamlı fark gösterdi. CD4/CD8 oranı ise, alerjik rinit ve NARES grubunda, kontrol grubuna göre daha yüksek bulundu ancak istatistiksel anlamlılık tespit edilmedi. NARES’li hastalarda total IgE ile CD4/CD8 oranı arasında korelasyon tespit edilirken, alerjik rinit hastalarında aynı korelasyona rastlanmadı. Hem alerjik rinit hem de NARES grubunda CD4 ve CD8 ile CD4/CD8 oranı arasında güçlü korelasyon görüldü. Sonuç olarak CD4 ve CD8 hücre sayısı ve bunların oranı rinitli hastaların değerlendirilmesinde tek başına kullanılamaz, ayrıca IgE ve lenfosit subgrupları arasında anlamlı bir ilişki tespit edilemedi.

Keywords

Alerjik rinit NARES IgE CD4 CD8

References

  • 1. Plewako H, Arvidsson M, Petruson K, Oancea I, Holmberg K, Adelroth E, Gustafsson H, Sandstrom T, Rak S. The effect of omalizumab on nasal allergic inflammation. J Allergy Clin Immunol. 2002; 110: 68-71.
  • 2. Benson M. Pathophysiological effects of glucocorticoids on nasal polyps: An update. Curr Opin Allergy Clin Immunol. 2005; 5: 31-5.
  • 3. Yang PC, Liu T, Zhang TY, Fan DS. The effect of the H2 antagonist cimetidine on the numbers of CD4+ and CD8+ cells in the nasal mucosa of patients allergic rhinitis. Clin otolaryngol 1997; 22: 93-95.
  • 4. Testa B, Mesolella C, Costa F, et al. Histamine 2 antagonists allergic rhinitis. Arch. Otolaryngol Head Neck Surg. 1986; 112: 432-433.
  • 5. Suemura M, Shino O, Deguchi Y, et al. Characterization and isolation of IgE class-specific supressor factor (IgETsF) I. The presence of the binding sites for IgE and of the H-2 gene products in IgE-TsF. J Immunol. 1981; 127; 452-465.
  • 6. Maggi E, Biswas P, del Prete G, et al. Accumulation of Th-2-like T cells in the conjuctiva of patients with vernal conjuctivitis. J Immunol 1981; 146: 1169-74.
  • 7. Levy F, Kritofic C, Heusser C, Brinkmann V. Role of IL- 13 in CD4 T cell dependent IgE production in atopy. Int. Arch Allergy Immunol 1997; 112: 49-58.
  • 8. Berciano FA, Crespo M, Bao CG, et al. Serum levels of total IgE in non-allergic children influence of genetic and environmental factors. Allergy 1987; 42: 276-283.
  • 9. Saito H, Asakura K, Ogawara H, Kataura A. T cell subsets and intercellular adhesion molecule-1 in human allergic nasal mucosa. Jpn. Otolaryngol, 1992; 95: 1800- 1807.
  • 10. Nishimoto K, Ukai K, Harada T, Jin C, Sakakura Y. Lymphocyte subsets of maxillary mucosa in chronic inflammation. Acta Otolaryngol (Stockh) 1988; 106: 291- 298.
  • 11. Hameleers DMH, Stop AE, Van Der Ven I, et al. Intraepithelial lymphocytes and non-lymphoid cells in the human nasal mucosa. Int. Arch Allergy Appl. Immunol 1989; 88: 317-322.
  • 12. Varney VA, Jacobson RM, Sudderick DS, et al. Immunohistology of the nasal mucosa following allergeninduced rhinitis. Am Rev Respir Dis 1992; 146: 170-176.
  • 13. Hamilos DL, Leung DYM, Wood R, Meyers A, Stephens JK, Barkan J, Meng Q, Cunningham L, Bean DK, Kay AB, Hamid Q. Chronic Hyperplastic Sinusitis: Association of tissue eosinophilia with mRNA expression of Granulocyte-macrophage Colony Stimulating Factor and interleukin-3. J Allergy Clin Immunol 1993; 92: 39- 48.
  • 14. Hamilos DL, Leung DYM, Wood R, Cunningham L, Bean DK, Yasruel Z, Schotman E, Hamid Q. Evidence for Distinct Cytokine Expression in Allergic Versus Nonallergic Chronic Sinusitis. J Allergic Clin Immunol 1995; 96: 537-544.
  • 15. Hamilos DL, Leung DYM, Wood R, Bean DK, Song YL, Schotman E, Hamid Q. Eosinophil infiltration in Nonallergic Chronic Hyperlastic Sinusitis with Nasal Polyposis (CHS/NP) is Associated with Endothelial VCAM-1 Upregulation and Expression of TNF-α. Am J Respir Cell Mol Biol 1996; 15: 443-450.
  • 16. Hamilos DL, Leung DYM, Huston DP, Kamil A, Wood R, Hamid QA. GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). Clin and Experimental Allergy 1998; 28: 1145-52.
  • 17. Hamilos DL. Immnunopathology of upper airway disease, 55th Annual Meeting. 1999; 4-5.
  • 18. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte-macrophage colonystimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am Rev Respir Dis 1993; 146: 109-114.
  • 19. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1993; 146: 109-114.
  • 20. Saito AE, Hamaleers DMH, Paula EMVR, Biewenga J, van der Baan S. Lymphocytes and nonlymphoid cells in the nasal mucosa of patients with nasal polyps and health subject. J Allergy Clin Immunol 1989; 84: 724-41.
  • 21. Beer DJ, Rocklin RE. Histamine induced suppressor cell activity. J Allergy Clin Immunol 1984; 73: 439-52.
  • 22. Kus J, TSE K, Enarson D, et al. Lymphocyte subpopulations in patients with allergic rhinitis. Allergy 1984; 39: 509-414.

Year 2005, Volume: 36 Issue: 2, 78 - 83, 17.07.2014

Rauf Tahamiler Tahamiler Salih Çanakçıoğlu Deniz Edizer

Abstract

References

  • 1. Plewako H, Arvidsson M, Petruson K, Oancea I, Holmberg K, Adelroth E, Gustafsson H, Sandstrom T, Rak S. The effect of omalizumab on nasal allergic inflammation. J Allergy Clin Immunol. 2002; 110: 68-71.
  • 2. Benson M. Pathophysiological effects of glucocorticoids on nasal polyps: An update. Curr Opin Allergy Clin Immunol. 2005; 5: 31-5.
  • 3. Yang PC, Liu T, Zhang TY, Fan DS. The effect of the H2 antagonist cimetidine on the numbers of CD4+ and CD8+ cells in the nasal mucosa of patients allergic rhinitis. Clin otolaryngol 1997; 22: 93-95.
  • 4. Testa B, Mesolella C, Costa F, et al. Histamine 2 antagonists allergic rhinitis. Arch. Otolaryngol Head Neck Surg. 1986; 112: 432-433.
  • 5. Suemura M, Shino O, Deguchi Y, et al. Characterization and isolation of IgE class-specific supressor factor (IgETsF) I. The presence of the binding sites for IgE and of the H-2 gene products in IgE-TsF. J Immunol. 1981; 127; 452-465.
  • 6. Maggi E, Biswas P, del Prete G, et al. Accumulation of Th-2-like T cells in the conjuctiva of patients with vernal conjuctivitis. J Immunol 1981; 146: 1169-74.
  • 7. Levy F, Kritofic C, Heusser C, Brinkmann V. Role of IL- 13 in CD4 T cell dependent IgE production in atopy. Int. Arch Allergy Immunol 1997; 112: 49-58.
  • 8. Berciano FA, Crespo M, Bao CG, et al. Serum levels of total IgE in non-allergic children influence of genetic and environmental factors. Allergy 1987; 42: 276-283.
  • 9. Saito H, Asakura K, Ogawara H, Kataura A. T cell subsets and intercellular adhesion molecule-1 in human allergic nasal mucosa. Jpn. Otolaryngol, 1992; 95: 1800- 1807.
  • 10. Nishimoto K, Ukai K, Harada T, Jin C, Sakakura Y. Lymphocyte subsets of maxillary mucosa in chronic inflammation. Acta Otolaryngol (Stockh) 1988; 106: 291- 298.
  • 11. Hameleers DMH, Stop AE, Van Der Ven I, et al. Intraepithelial lymphocytes and non-lymphoid cells in the human nasal mucosa. Int. Arch Allergy Appl. Immunol 1989; 88: 317-322.
  • 12. Varney VA, Jacobson RM, Sudderick DS, et al. Immunohistology of the nasal mucosa following allergeninduced rhinitis. Am Rev Respir Dis 1992; 146: 170-176.
  • 13. Hamilos DL, Leung DYM, Wood R, Meyers A, Stephens JK, Barkan J, Meng Q, Cunningham L, Bean DK, Kay AB, Hamid Q. Chronic Hyperplastic Sinusitis: Association of tissue eosinophilia with mRNA expression of Granulocyte-macrophage Colony Stimulating Factor and interleukin-3. J Allergy Clin Immunol 1993; 92: 39- 48.
  • 14. Hamilos DL, Leung DYM, Wood R, Cunningham L, Bean DK, Yasruel Z, Schotman E, Hamid Q. Evidence for Distinct Cytokine Expression in Allergic Versus Nonallergic Chronic Sinusitis. J Allergic Clin Immunol 1995; 96: 537-544.
  • 15. Hamilos DL, Leung DYM, Wood R, Bean DK, Song YL, Schotman E, Hamid Q. Eosinophil infiltration in Nonallergic Chronic Hyperlastic Sinusitis with Nasal Polyposis (CHS/NP) is Associated with Endothelial VCAM-1 Upregulation and Expression of TNF-α. Am J Respir Cell Mol Biol 1996; 15: 443-450.
  • 16. Hamilos DL, Leung DYM, Huston DP, Kamil A, Wood R, Hamid QA. GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). Clin and Experimental Allergy 1998; 28: 1145-52.
  • 17. Hamilos DL. Immnunopathology of upper airway disease, 55th Annual Meeting. 1999; 4-5.
  • 18. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte-macrophage colonystimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am Rev Respir Dis 1993; 146: 109-114.
  • 19. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1993; 146: 109-114.
  • 20. Saito AE, Hamaleers DMH, Paula EMVR, Biewenga J, van der Baan S. Lymphocytes and nonlymphoid cells in the nasal mucosa of patients with nasal polyps and health subject. J Allergy Clin Immunol 1989; 84: 724-41.
  • 21. Beer DJ, Rocklin RE. Histamine induced suppressor cell activity. J Allergy Clin Immunol 1984; 73: 439-52.
  • 22. Kus J, TSE K, Enarson D, et al. Lymphocyte subpopulations in patients with allergic rhinitis. Allergy 1984; 39: 509-414.
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Araştırmalar
Authors

Rauf Tahamiler Tahamiler This is me

Salih Çanakçıoğlu This is me

Deniz Edizer This is me

Publication Date July 17, 2014
Published in Issue Year 2005 Volume: 36 Issue: 2

Cite

APA Tahamiler, R. T., Çanakçıoğlu, S., & Edizer, D. (2014). RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ. Cerrahpaşa Tıp Dergisi, 36(2), 78-83.
AMA Tahamiler RT, Çanakçıoğlu S, Edizer D. RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ. Cerrahpaşa Tıp Dergisi. July 2014;36(2):78-83.
Chicago Tahamiler, Rauf Tahamiler, Salih Çanakçıoğlu, and Deniz Edizer. “RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ”. Cerrahpaşa Tıp Dergisi 36, no. 2 (July 2014): 78-83.
EndNote Tahamiler RT, Çanakçıoğlu S, Edizer D (July 1, 2014) RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ. Cerrahpaşa Tıp Dergisi 36 2 78–83.
IEEE R. T. Tahamiler, S. Çanakçıoğlu, and D. Edizer, “RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ”, Cerrahpaşa Tıp Dergisi, vol. 36, no. 2, pp. 78–83, 2014.
ISNAD Tahamiler, Rauf Tahamiler et al. “RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ”. Cerrahpaşa Tıp Dergisi 36/2 (July 2014), 78-83.
JAMA Tahamiler RT, Çanakçıoğlu S, Edizer D. RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ. Cerrahpaşa Tıp Dergisi. 2014;36:78–83.
MLA Tahamiler, Rauf Tahamiler et al. “RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ”. Cerrahpaşa Tıp Dergisi, vol. 36, no. 2, 2014, pp. 78-83.
Vancouver Tahamiler RT, Çanakçıoğlu S, Edizer D. RİNİTLİ HASTALARDA CD4 VE CD8 LENFOSİT SUBGRUPLARI VE IgE İLİŞKİSİ. Cerrahpaşa Tıp Dergisi. 2014;36(2):78-83.