Abstract
Background and Design.- Classic aganglionosis is detected in only 50% of patients
presenting with clinical symptoms of Hirschsprung’s disease; neuronal intestinal dysplasia
(NID) is the real pathology in 20-40% of this group. Herein, the outcome of cases
presenting with complaints related to bowel dysmotility and diagnosed to have NID, is evaluated.
Results.- 8 NID cases, admitted to our unit had gastrointestinal decompression, barium enema and anorectal manometry, performed routinely. The full thickness rectal biopsies, peroperative colonic biopsy and anal myectomy samples were histopathologically evaluated with hematoxylin eosin stain (HE). Those cases histopathologically labeled as NID were either given oral Cisapride or surgically treated and followed up. In our domestic environment deprived of immunohistochemical facilities, diagnosis of NID is dependent on the combined experience of the pathologist, using the HE stain, and the clinical presentation of the cases.
Conclusion.- Anorectal manometry and barium enema, provide nonspecific information for NID and pathology reveals the most important diagnostic criteria.
* Anahtar Kelimeler: Nöronal intestinal displazi, Hirschsprung
hastalığı, Konstipasyon
*Key Words: Neuronal intestinal
dysplasia, Hirshsprung’s disease, constipation
Keywords
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Araştırmalar |
| Authors | |
| Publication Date | July 23, 2014 |
| Published in Issue | Year 2001 Volume: 32 Issue: 1 |