Association of Systemic Autoantibody Positivity with the Presence of Oligoclonal Bands and Disability in Multiple Sclerosis

Abstract

Objective: We aimed to determine the frequency of common systemic autoantibodies in patients with relapsing remitting multiple sclerosis (RRMS) and their association with the presence of
oligoclonal bands (OCB) and disease severity. Materials and Methods: A total of 150 definite RRMS patients and 150 healthy controls with no autoimmune disease were enrolled and thensera were examined for the presence of autoantibodies. Results: The positivity rates for antithyroid peroxidase antibody (anti-TPO) (20%), anti-cardiolipin (ACA) IgG (22%) and ACA
IgM (24%) antibodies were significantly higher than those of the healthy individuals (p<0.001). Age, gender, OCB positivity rates and average expanded disability status scale (EDSS) scores
were comparable among RRMS patients with and without autoantibodies. Conclusion: Our findings suggest that serum autoantibodies are not significantly associated with disease severity
or OCB formation and they are merely indicators of an increased susceptibility to autoimmune disease induction in MS patients.

Multipl Sklerozda Sistemik Otoantikor Pozitifliğinin Oligoklonal Band Varlığı ve Özürlülük ile İlişkisi

Abstract

Amaç: Rölapsing remiting multipl skleroz (RRMS) hastalarında sık gözlenen sistemik otoantikorlann sıklığının ve oligoklonal band (OKB) ve hastalık şiddeti ile iHşkilerinin belirlenmesi amaçlandı. Gereç ve Yöntem: Otoimmün hastalığı olmayan toplam 150 kesin RRMS hastası ve 150 sağlıklı kontrol çalışmaya alındı ve serumları otoantikor tayini için incelendi. Bulgular: RRMS olgularında anti-tiroid peroksidaz antikoru (anti-TPO) (%20), anti-kardiolipin (AKA) IgG (%22) ve AKA IgM (%24) antikorları sağlıklı kontrollerden belirgin derecede yüksekti (p < 0.001). Yaş, cinsiyet, OKB pozitifliği ve ortalama "expanded disability status scale" (EDSS) skorları açısından otoantikorlu ve otoantikorsuz RRMS olguları arasında fark yoktu. Sonuç: Bulgularımız serum otoantikorlannm hastalık şiddeti ve OKB oluşumu ile ilişkili olmadıklarım ve sadece MS hastalarında otoimmün hastalığa yakalanma riskindeki artışın bir göstergesi olduklarım düşündürmektedir.

Keywords

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