Research Article
BibTex RIS Cite

Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi

Year 2018, Volume: 8 Issue: 1, 11 - 17, 30.04.2018

Abstract

DOI: 10.26650/experimed.2018.430561


Amaç: Bu çalışmada replasman tedavisi alan
ve almayan kronik böbrek yetmezliği (KBY) hastalarının kan protein oksidasyon
ürünlerinin düzeylerini değerlendirmek ve hasta kişiler ile sağlıklı kişileri
karşılaştırmak için kontrol grubu (n=35) ve hasta grupları oluşturuldu.

Gereç ve Yöntem: Hasta grupları replasman
tedavisi almayan KBY hasta grubu (n=36), hemodiyaliz (HD) tedavisi gören hasta
grubu (n=64) ve periton diyaliz (PD) tedavisi gören hasta grubu (n=21) olmak
üzere şekillendirildi. Daha sonra ileri düzey okside protein ürünleri (AOPP) ve
ileri glikasyon son ürünleri (AGE)’in düzeyleri bakımından bu gruplar
değerlendirildi.

Bulgular: Sonuç olarak, replasman tedavisi
almayan KBY hasta grubunun AGE düzeyleri haricinde, diğer tüm grupların AOPP ve
AGE düzeylerinin kontrol grubuna göre artmış olduğu saptandı. İstatistiksel
olarak en önemli artışın ise HD hasta grubunda olduğu tespit edildi. Grup içi
değerlendirmeler sonucunda hiçbir grupta AOPP ve AGE düzeyleri arasında ilişki
saptanmadı.







Sonuç: Bu sonuçlara göre KBY’nin oksidatif
stresle birlikte seyrettiği, replasman tedavisi gören KBY hastalarında ve
özellikle de HD tedavisi gören hastalarda oksidatif stresin çok daha şiddetli
olduğu gözlemlendi. Son olarak, HD tedavisi gören gruptaki hastaların diyabet
olup olmamasının sonuçları etkilemediği görüldü.

References

  • 1. Venus S, Teresa M, Rosa S, et al., Oxidative stress and cancer: an overview. Ageing Res Rev 12: 376-390, 2013.
  • 2. Cevat Yazıcı, Kader Köse: Kronik Böbrek Yetmezliğinde Oksidatif Stres ‘‘Biyomarkır’’ları: Nefroloji Dergisi 13:117-124, 2004.
  • 3. Himmerfalb J, Hakim RM: Oxidative stress in uremia. Curr Opin Nephrol Hypertens 12: 593–598, 2003.
  • 4. Danielski M, Ikizler A, McMonagle E, et al., Linkage of Hypoalbuminemia, Inflammation, and Oxidative Stress in Patients Receiving Maintenance Hemodialysis Therapy. Am J Kidney Dis 42 (2): 286-294, 2003.
  • 5. Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, et al., Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304-1313, 1996.
  • 6. Massy ZA, Nguyen-Khoa T, Beauvais CH. Oxidative stress and chronic renal failure: markers and management. J Nephrol 15: 336-341, 2002.
  • 7. Vaziri ND. Oxidative Stress in Uremia: Nature, Mechanisms, and Potential Consequences. Semin Nephrol 24:469-473, 2004.
  • 8. Sundl I, Roob JM, Meinitzer A, et al., Antioxidant status of patients on peritoneal dialysis: Associations with inflammation and glycoxidative stress. Periton Dialysis Int 29: 89–101, 2008.
  • 9. Witowski J, Jorres A, Korybalska K, et al., Glucose degradation products in peritoneal dialysis fluids: do they harm? Kidney Int Suppl 84:148–151, 2003.
  • 10. Miyata T, Devuyst O, Kurokawa K, et al., Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes. Kidney Int 61:375–86, 2002.
  • 11. Lameire N, Vanholder R, De Smet R. Uremic toxins and peritoneal dialysis. Kidney Int 59: 292-297, 2001.
  • 12. Selmeci L, Seres L, Antal M, et al., Advanced oxidation protein products (AOPP) for monitoring oxidative stres in critically ill patients, fast and inexpensive automated technique; Clin Chem Lab Med 43(3): 294-297, 2005.
  • 13. Kaluosova M, Skrha J, Zima T. Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus. Physiol. Res. 51: 597-604, 2002.
  • 14. Toborek M, Wasik T, Drózdz M et al., Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. Metabolism 41: 1229–1232, 1992.
  • 15. Epperlein MM, Nourooz‐Zadeh J, Jayasena SD et al., Nature and biological significance of free radicals generated during bicarbonate hemodialysis. J Am Soc Nephrol 9: 457–46, 1998.
  • 16. Nguyen-Khoa T, Massy ZA. De Bandt PJ, et al., Oxidative stress and hemodialysis: role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 16: 335-340, 2001.
  • 17. Witko-Sarsat V, Friendlander M, Nguyen-Khoa T, et al., Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 161: 2524-2532, 1998.
  • 18. Descamps-Latscha B, Witko-Sarsat V. Importance of oxidatively modified proteins in chronic renal failure. Kidney Int 59:108-113, 2001.
  • 19. Chen MF, Chang CL, Liou SY. Increase in resting levels of superoxide anion in the whole blood of uremic patients on chronic hemodialysis. Blood Purif; 16: 290-300, 1998.
  • 20. Ward R, Meleisin K. Polymorphonuclear leukocyte oxidative burst is enhanced in patients with chronic renal insufficiency. J Am Soc Nephrol, 5: 1967-1702, 1994.
  • 21. Craddack PR, Hammerschmidt DE. Complement-mediated granulocyte activation and down-regulation during hemodialysis. ASAIO J 7: 50-56, 1984.
  • 22. Hörl HW, Riegel W, Schollmeyer P. Different complement and granulocyte activation in patient dialyzed with PMMA dialyzers. Clin Nephrol 25: 304-307, 1986.
  • 23. Stroncek DF, Keshaviah P, Craddock PR, et al., Effect of dialyzer reuse on complement activation and neutropenia in hemodialysis. J Lab Clin Med. 104: 304-311, 1984.
  • 24. Höllgren R, Venge P, Danielson BG. Neutrophil and eosinophil degranulation during hemodialysis are mediated by the dialysis membrane. Nephron 32: 329-334, 1982.
  • 25. Hörl WH, Riegel W, Steinhauer HB, et al., Granulocyte activation during hemodialysis. Clin Nephrol 26: 30-34, 1986.
  • 26. Dalle-Donne I, Rossi R, Giustarini D, et al., Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329:23-38, 2003.
  • 27. Mimic-Oka J, Simic T, Pljesa M, et al., Oxidative modification of plasma proteins in different stages of chronic renal failure. Med Biol 8:1-5, 2001.
  • 28. Witko-Sarsat V, Nguyen-Khoa T, Jungers P, et al., Advanced oxidation protein products as a novel molecular basis of oxidative stress in uremia. Nephrol Dial Transplant 14:76-78, 1999.
  • 29. Amore A, Coppo R. Immunological basis of inflammation in dialysis. Nephrol Daial Transplant 17: 16-24, 2002.
  • 30. Köken T, Kahraman A, Serteser M, et al., Hemodiyaliz ve Oksidatif Stres. Karatepe Tıp Dergisi 5 (Ek Sayı): 9-13, 2004.
  • 31. Donate T, Herreros A, Martinez E, et al., Protein oxidative stress in dialysis patients. Adv Perit Dial 18: 15-17, 2002.
  • 32. Kumano K, Yokota S, Go M, et al., Quantitative and qualitative changes of serum albumin in CAPD patients. Adv Perit Dial 8: 127-130, 1992.
  • 33. Miyata T, Sugiyama S, Saito A, et al., Reactive carbonyl compounds related uremic toxicity (carbonyl stress). Kidney Int 59: 25-31,2001.
  • 34. Himmelfarb J, Mc Monagle E, McMenamin E. Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 58: 2571-2578, 2000.
  • 35. Kalousov M, Krha J, Zima T. Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus. Physiol. Res. 51: 597-604, 2002.
  • 36. Kalousov M, Krha J, Tesar V, et al., Advanced Glycation End Products and Advanced Oxidation Protein Products in Hemodialyzed Patients. Blood Purif 20:531–536, 2002.
  • 37. Matteucci E, Biasci E, Giampietro O. Advanced oxidation protein products in plasma: stability during storage and correlation with other clinical characteistics. Acta Diabetol 38: 187-189, 2001.
  • 38. Witko-Sarsat V, Gausson V, Descamps-Latscha B. Are advanced oxidation protein products potential uremic toxins? Kidney Int 63:11-14, 2003.

Evaluation of Protein Oxidation Products in Patients With Chronic Renal Failure Receiving Dialysis or Not

Year 2018, Volume: 8 Issue: 1, 11 - 17, 30.04.2018

Abstract

DOI: 10.26650/experimed.2018.430561


Objective: In this study, control (n=35)
and groups were formed to evaluate the levels of blood protein oxidation
products in patients with chronic renal failure (CRF) who did and did not
receive replacement therapy and to compare the patients with healthy subjects.

Material and Method: The groups were the
CRF (n=36) group that did not receive replacement therapy, patients who were
undergoing hemodialysis (HD) (n=64), and patients who were undergoing
peritoneal dialysis (PD) (n=21). These groups were evaluated for the production
of advanced oxidation protein product (AOPP) and advanced glycated end product
(AGE) levels.

Results: As results, the AOPP and AGE
values of all groups increased compared to the control group, except for the
AGE levels of the patients with CRF who did not receive replacement therapy.
The most significant increase was found in the HD patient group. No
relationship was detected between the AOPP and AGE values in any group.







Conclusion: According to these results, CRF
is accompanied by oxidative stress, and the oxidative stress is much more
severe in patients with CRF receiving replacement therapy, particularly in
patients undergoing HD. Is unknown if the results of patients undergoing HD
were affected by the presence of diabetes.

References

  • 1. Venus S, Teresa M, Rosa S, et al., Oxidative stress and cancer: an overview. Ageing Res Rev 12: 376-390, 2013.
  • 2. Cevat Yazıcı, Kader Köse: Kronik Böbrek Yetmezliğinde Oksidatif Stres ‘‘Biyomarkır’’ları: Nefroloji Dergisi 13:117-124, 2004.
  • 3. Himmerfalb J, Hakim RM: Oxidative stress in uremia. Curr Opin Nephrol Hypertens 12: 593–598, 2003.
  • 4. Danielski M, Ikizler A, McMonagle E, et al., Linkage of Hypoalbuminemia, Inflammation, and Oxidative Stress in Patients Receiving Maintenance Hemodialysis Therapy. Am J Kidney Dis 42 (2): 286-294, 2003.
  • 5. Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, et al., Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304-1313, 1996.
  • 6. Massy ZA, Nguyen-Khoa T, Beauvais CH. Oxidative stress and chronic renal failure: markers and management. J Nephrol 15: 336-341, 2002.
  • 7. Vaziri ND. Oxidative Stress in Uremia: Nature, Mechanisms, and Potential Consequences. Semin Nephrol 24:469-473, 2004.
  • 8. Sundl I, Roob JM, Meinitzer A, et al., Antioxidant status of patients on peritoneal dialysis: Associations with inflammation and glycoxidative stress. Periton Dialysis Int 29: 89–101, 2008.
  • 9. Witowski J, Jorres A, Korybalska K, et al., Glucose degradation products in peritoneal dialysis fluids: do they harm? Kidney Int Suppl 84:148–151, 2003.
  • 10. Miyata T, Devuyst O, Kurokawa K, et al., Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes. Kidney Int 61:375–86, 2002.
  • 11. Lameire N, Vanholder R, De Smet R. Uremic toxins and peritoneal dialysis. Kidney Int 59: 292-297, 2001.
  • 12. Selmeci L, Seres L, Antal M, et al., Advanced oxidation protein products (AOPP) for monitoring oxidative stres in critically ill patients, fast and inexpensive automated technique; Clin Chem Lab Med 43(3): 294-297, 2005.
  • 13. Kaluosova M, Skrha J, Zima T. Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus. Physiol. Res. 51: 597-604, 2002.
  • 14. Toborek M, Wasik T, Drózdz M et al., Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. Metabolism 41: 1229–1232, 1992.
  • 15. Epperlein MM, Nourooz‐Zadeh J, Jayasena SD et al., Nature and biological significance of free radicals generated during bicarbonate hemodialysis. J Am Soc Nephrol 9: 457–46, 1998.
  • 16. Nguyen-Khoa T, Massy ZA. De Bandt PJ, et al., Oxidative stress and hemodialysis: role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 16: 335-340, 2001.
  • 17. Witko-Sarsat V, Friendlander M, Nguyen-Khoa T, et al., Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 161: 2524-2532, 1998.
  • 18. Descamps-Latscha B, Witko-Sarsat V. Importance of oxidatively modified proteins in chronic renal failure. Kidney Int 59:108-113, 2001.
  • 19. Chen MF, Chang CL, Liou SY. Increase in resting levels of superoxide anion in the whole blood of uremic patients on chronic hemodialysis. Blood Purif; 16: 290-300, 1998.
  • 20. Ward R, Meleisin K. Polymorphonuclear leukocyte oxidative burst is enhanced in patients with chronic renal insufficiency. J Am Soc Nephrol, 5: 1967-1702, 1994.
  • 21. Craddack PR, Hammerschmidt DE. Complement-mediated granulocyte activation and down-regulation during hemodialysis. ASAIO J 7: 50-56, 1984.
  • 22. Hörl HW, Riegel W, Schollmeyer P. Different complement and granulocyte activation in patient dialyzed with PMMA dialyzers. Clin Nephrol 25: 304-307, 1986.
  • 23. Stroncek DF, Keshaviah P, Craddock PR, et al., Effect of dialyzer reuse on complement activation and neutropenia in hemodialysis. J Lab Clin Med. 104: 304-311, 1984.
  • 24. Höllgren R, Venge P, Danielson BG. Neutrophil and eosinophil degranulation during hemodialysis are mediated by the dialysis membrane. Nephron 32: 329-334, 1982.
  • 25. Hörl WH, Riegel W, Steinhauer HB, et al., Granulocyte activation during hemodialysis. Clin Nephrol 26: 30-34, 1986.
  • 26. Dalle-Donne I, Rossi R, Giustarini D, et al., Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329:23-38, 2003.
  • 27. Mimic-Oka J, Simic T, Pljesa M, et al., Oxidative modification of plasma proteins in different stages of chronic renal failure. Med Biol 8:1-5, 2001.
  • 28. Witko-Sarsat V, Nguyen-Khoa T, Jungers P, et al., Advanced oxidation protein products as a novel molecular basis of oxidative stress in uremia. Nephrol Dial Transplant 14:76-78, 1999.
  • 29. Amore A, Coppo R. Immunological basis of inflammation in dialysis. Nephrol Daial Transplant 17: 16-24, 2002.
  • 30. Köken T, Kahraman A, Serteser M, et al., Hemodiyaliz ve Oksidatif Stres. Karatepe Tıp Dergisi 5 (Ek Sayı): 9-13, 2004.
  • 31. Donate T, Herreros A, Martinez E, et al., Protein oxidative stress in dialysis patients. Adv Perit Dial 18: 15-17, 2002.
  • 32. Kumano K, Yokota S, Go M, et al., Quantitative and qualitative changes of serum albumin in CAPD patients. Adv Perit Dial 8: 127-130, 1992.
  • 33. Miyata T, Sugiyama S, Saito A, et al., Reactive carbonyl compounds related uremic toxicity (carbonyl stress). Kidney Int 59: 25-31,2001.
  • 34. Himmelfarb J, Mc Monagle E, McMenamin E. Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 58: 2571-2578, 2000.
  • 35. Kalousov M, Krha J, Zima T. Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus. Physiol. Res. 51: 597-604, 2002.
  • 36. Kalousov M, Krha J, Tesar V, et al., Advanced Glycation End Products and Advanced Oxidation Protein Products in Hemodialyzed Patients. Blood Purif 20:531–536, 2002.
  • 37. Matteucci E, Biasci E, Giampietro O. Advanced oxidation protein products in plasma: stability during storage and correlation with other clinical characteistics. Acta Diabetol 38: 187-189, 2001.
  • 38. Witko-Sarsat V, Gausson V, Descamps-Latscha B. Are advanced oxidation protein products potential uremic toxins? Kidney Int 63:11-14, 2003.
There are 38 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Makale
Authors

Cihan Coşkun 0000-0001-8288-8741

Alev Kural This is me 0000-0003-1459-4316

Macit Koldaş This is me 0000-0001-8967-2708

Publication Date April 30, 2018
Published in Issue Year 2018 Volume: 8 Issue: 1

Cite

APA Coşkun, C., Kural, A., & Koldaş, M. (2018). Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi, 8(1), 11-17.
AMA Coşkun C, Kural A, Koldaş M. Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. April 2018;8(1):11-17.
Chicago Coşkun, Cihan, Alev Kural, and Macit Koldaş. “Diyaliz Tedavisi Uygulanan Ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi 8, no. 1 (April 2018): 11-17.
EndNote Coşkun C, Kural A, Koldaş M (April 1, 2018) Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi 8 1 11–17.
IEEE C. Coşkun, A. Kural, and M. Koldaş, “Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi”, Deneysel Tıp Araştırma Enstitüsü Dergisi, vol. 8, no. 1, pp. 11–17, 2018.
ISNAD Coşkun, Cihan et al. “Diyaliz Tedavisi Uygulanan Ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi 8/1 (April 2018), 11-17.
JAMA Coşkun C, Kural A, Koldaş M. Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2018;8:11–17.
MLA Coşkun, Cihan et al. “Diyaliz Tedavisi Uygulanan Ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi, vol. 8, no. 1, 2018, pp. 11-17.
Vancouver Coşkun C, Kural A, Koldaş M. Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2018;8(1):11-7.