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Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi

Year 2011, Volume: 1 Issue: 2, 9 - 13, 14.12.2011

Gökhan Bağcı Bedia Çakmakoğlu Zeynep Çinçin Selçuk Daşdemir Abdullah Özdemircan Zeynep Karaali Bedia Çakmakoğlu

Abstract

Bu çalışmanın amacı diyabetik koroner arter hastalığı gelişiminde MCP-1 A-2518G ve CCR2 G190Apoümorfizmlerinin etkilerini
araştırmaktır. Çalışmamızda 81 koroner arter hastalığı bulunan diyabetik hasta, 62 koroner arter hastalığı olmayan diyabet hastası
ve 62 sağlıklı kontrol kullanılarak genotipleme yapılmıştır. Diyabetik koroner arter hastalığı bulunan hasta grubuyla kontrol
grubu arasında MCP-1 A-2518G genotip (p:0,01 %2:9,11) ve allel dağılımı (p:0,01 %2:6,53) açısından istatistiksel olarak anlamlı
derecede fark vardır. MCP1 AA genotip frekansı KAH (+) DM'li hasta grubunda kontrole göre anlamlı şekilde yüksekken, MCP-
1 G allel frekansının kontrol grubunda yüksek olduğu tespit edilmiştir. Buna karşın CCR2 G190Apolimorfizrni dağılımı açısından
hasta grupları ve kontrol grubu arasında herhangi bir anlamlı farklılık saptanmamıştır. Sonuç olarak MCP-1 -2518 AA genotipinin
diyabetik koroner arter hastalığı gelişimine neden olurken, G allelinin hastalığa karşı koruyucu olduğu izlenimi edinilmiştir.

References

  • KouyamaK. Miyake K. Zenibayashi M,. Hirota Y. Teranishi T. Tamori Y. ve ark. (2007) Association of Serum MCP-1 Concentration and MCP-1 Polymorphism with Insulin Resistance in Japanese Individuals with Obese type 2 Diabetes Kobe J. Med. Sci. Vol. 53, 6, 345-354
  • Apostolakis S. Baritaki S. Kochiadakis G. E. Igoumenidis N. E. Panutsopulos D. Spandidos D.A. (2007) Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease Thrombosis Research 119, 6 3 - 7 1
  • Moon JY. Jeong. L. Lee S. Jeong K. Lee T. Dim CG. (2007) Association of Polymorphisms in Monocyte Chemoattractant Protein-1 Promoter with Diabetic Kidney Failure in Korean Patients with Type 2 Diabetes Mellitus. / Korean Med Sci ; 22: 810-4
  • Miller SA, Dykes DD and Polesky HF (1988). Simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16: 1215.
  • Abdi R, Iran TB, Sahagun-Ruiz A, Murphy PM, Brenner BM, Milford EL, McDermott DH. (2002). Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. / Am Soc Nephrol. 13: 754- 8.
  • Szalai C. Duba J. Prohâszka Z. Kalina A. Szabô T. Nagy B. Ve ark. (2001) Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 - 2518 G/G genotype in CAD patients Atherosclerosis :158 233-239
  • Jemaa R. Rojbani H. Kallel. A. A l i S.B. Feki M . Chabrak S. ve ark. (2008) Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients. Clinica ChimicaActa 390 122-125
  • Simeoni E. Hoffmann MM. Winkelmann BR. Ruiz J. Fleury S. Boehm. BO. ve ark (2004) Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus. Diabetologia 47:1574-1580
  • Yang B. Houlberg K. Millward A. Demaine A. (2004) Polimorphism of chemokin and receptors dabet and complications. Cytokine 26 114-121
  • Cam SF. Sekuri C. Sagcan A. Ercan E. Tengiz I . Alioglu E. Berdeli A. (2008). Effect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease The Scandinavian Journal of Clinical & Laboratory Investigation Vol. 68, No. 8, December 801-805
  • Cermakova Z. Petrkova J. Drabek J. ve ark. (2003) CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction. Immunol Lett; 88:53-5.
  • Ortlepp JR, Vesper K, Mevissen V, et al. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. JMol Med 2003;81:363-7.
  • Szalai C. Csaszar A. Czinner A. Szabo T. Panczel P. Madacsy L. ve ark. (1999) Chemokine Receptor CCR2 and CCR5 Polymorphisms in Children with Insulin- Dependent Diabetes Mellitus. Pediatric Research: Volume 46 (1) Temmuz 82-84
  • Voevoda MI. Ustinov SN. Yudin NS. Dolgikh MM. Kuznetsova TN Maksimov VN. (2002) Association of the CCR2 Chemokine Receptor Gene Polymorphism with Myocardial Infarction Doklady Biological Sciences, : 385, 367-370
  • Valdes AM, Wolfe ML, O'Brien EJ, Spurr NK, Gefter W, Rut A, Groot PH, Rader DJ. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterioscler Thromb Vase Biol. 2002 Nov 1;22(11): 1924-8.
  • Bjarnadottir K, Eiriksdottir G, Aspelund T, Gudnason V. (2006). Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on M I in the Icelandic population. Atherosclerosis 188 341-346
  • ChaSH. Lee JK. LeeJY. KimHT. RyuHJ. Han BG. (2007). Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease Clinica ChimicaActa. 382 129-133

Year 2011, Volume: 1 Issue: 2, 9 - 13, 14.12.2011

Gökhan Bağcı Bedia Çakmakoğlu Zeynep Çinçin Selçuk Daşdemir Abdullah Özdemircan Zeynep Karaali Bedia Çakmakoğlu

Abstract

References

  • KouyamaK. Miyake K. Zenibayashi M,. Hirota Y. Teranishi T. Tamori Y. ve ark. (2007) Association of Serum MCP-1 Concentration and MCP-1 Polymorphism with Insulin Resistance in Japanese Individuals with Obese type 2 Diabetes Kobe J. Med. Sci. Vol. 53, 6, 345-354
  • Apostolakis S. Baritaki S. Kochiadakis G. E. Igoumenidis N. E. Panutsopulos D. Spandidos D.A. (2007) Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease Thrombosis Research 119, 6 3 - 7 1
  • Moon JY. Jeong. L. Lee S. Jeong K. Lee T. Dim CG. (2007) Association of Polymorphisms in Monocyte Chemoattractant Protein-1 Promoter with Diabetic Kidney Failure in Korean Patients with Type 2 Diabetes Mellitus. / Korean Med Sci ; 22: 810-4
  • Miller SA, Dykes DD and Polesky HF (1988). Simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16: 1215.
  • Abdi R, Iran TB, Sahagun-Ruiz A, Murphy PM, Brenner BM, Milford EL, McDermott DH. (2002). Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. / Am Soc Nephrol. 13: 754- 8.
  • Szalai C. Duba J. Prohâszka Z. Kalina A. Szabô T. Nagy B. Ve ark. (2001) Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 - 2518 G/G genotype in CAD patients Atherosclerosis :158 233-239
  • Jemaa R. Rojbani H. Kallel. A. A l i S.B. Feki M . Chabrak S. ve ark. (2008) Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients. Clinica ChimicaActa 390 122-125
  • Simeoni E. Hoffmann MM. Winkelmann BR. Ruiz J. Fleury S. Boehm. BO. ve ark (2004) Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus. Diabetologia 47:1574-1580
  • Yang B. Houlberg K. Millward A. Demaine A. (2004) Polimorphism of chemokin and receptors dabet and complications. Cytokine 26 114-121
  • Cam SF. Sekuri C. Sagcan A. Ercan E. Tengiz I . Alioglu E. Berdeli A. (2008). Effect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease The Scandinavian Journal of Clinical & Laboratory Investigation Vol. 68, No. 8, December 801-805
  • Cermakova Z. Petrkova J. Drabek J. ve ark. (2003) CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction. Immunol Lett; 88:53-5.
  • Ortlepp JR, Vesper K, Mevissen V, et al. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. JMol Med 2003;81:363-7.
  • Szalai C. Csaszar A. Czinner A. Szabo T. Panczel P. Madacsy L. ve ark. (1999) Chemokine Receptor CCR2 and CCR5 Polymorphisms in Children with Insulin- Dependent Diabetes Mellitus. Pediatric Research: Volume 46 (1) Temmuz 82-84
  • Voevoda MI. Ustinov SN. Yudin NS. Dolgikh MM. Kuznetsova TN Maksimov VN. (2002) Association of the CCR2 Chemokine Receptor Gene Polymorphism with Myocardial Infarction Doklady Biological Sciences, : 385, 367-370
  • Valdes AM, Wolfe ML, O'Brien EJ, Spurr NK, Gefter W, Rut A, Groot PH, Rader DJ. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterioscler Thromb Vase Biol. 2002 Nov 1;22(11): 1924-8.
  • Bjarnadottir K, Eiriksdottir G, Aspelund T, Gudnason V. (2006). Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on M I in the Icelandic population. Atherosclerosis 188 341-346
  • ChaSH. Lee JK. LeeJY. KimHT. RyuHJ. Han BG. (2007). Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease Clinica ChimicaActa. 382 129-133
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Makale
Authors

Gökhan Bağcı This is me

Bedia Çakmakoğlu This is me

Zeynep Çinçin This is me

Selçuk Daşdemir This is me

Abdullah Özdemircan This is me

Zeynep Karaali This is me

Bedia Çakmakoğlu This is me

Publication Date December 14, 2011
Published in Issue Year 2011 Volume: 1 Issue: 2

Cite

APA Bağcı, G., Çakmakoğlu, B., Çinçin, Z., Daşdemir, S., et al. (2011). Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi, 1(2), 9-13.
AMA Bağcı G, Çakmakoğlu B, Çinçin Z, Daşdemir S, Özdemircan A, Karaali Z, Çakmakoğlu B. Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. December 2011;1(2):9-13.
Chicago Bağcı, Gökhan, Bedia Çakmakoğlu, Zeynep Çinçin, Selçuk Daşdemir, Abdullah Özdemircan, Zeynep Karaali, and Bedia Çakmakoğlu. “Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G Ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi 1, no. 2 (December 2011): 9-13.
EndNote Bağcı G, Çakmakoğlu B, Çinçin Z, Daşdemir S, Özdemircan A, Karaali Z, Çakmakoğlu B (December 1, 2011) Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi 1 2 9–13.
IEEE G. Bağcı, “Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi”, Deneysel Tıp Araştırma Enstitüsü Dergisi, vol. 1, no. 2, pp. 9–13, 2011.
ISNAD Bağcı, Gökhan et al. “Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G Ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi 1/2 (December 2011), 9-13.
JAMA Bağcı G, Çakmakoğlu B, Çinçin Z, Daşdemir S, Özdemircan A, Karaali Z, Çakmakoğlu B. Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2011;1:9–13.
MLA Bağcı, Gökhan et al. “Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G Ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi”. Deneysel Tıp Araştırma Enstitüsü Dergisi, vol. 1, no. 2, 2011, pp. 9-13.
Vancouver Bağcı G, Çakmakoğlu B, Çinçin Z, Daşdemir S, Özdemircan A, Karaali Z, Çakmakoğlu B. Diyabetik Koroner Arter Hastalığında Monosit Kemotaktik Proteini (MCP-1) A-2518G ve CCR2 Reseptörü G190A Gen Polimorfîzmlerinin İncelenmesi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2011;1(2):9-13.
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