Research Article
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Year 2023, , 70 - 85, 26.06.2023
https://doi.org/10.26650/EurJBiol.2023.1299300

Abstract

References

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Screening of Antibiotics Biodegradability from Wastewater

Year 2023, , 70 - 85, 26.06.2023
https://doi.org/10.26650/EurJBiol.2023.1299300

Abstract

Objective: One of the sources of environment antibiotics contamination is wastewater treatment plants (WWTPs), there by constituting a global public health risk. This present study aimed to investigate the biodegradability of antibiotics and antiseptics and highlights the biodegradation of Ciprofloxacin as a sole carbon source by a bacterium isolated from the sludge "El Kouwaer," WWTP located in Mascara.
Materials and Methods: In the present study, biodegradability of some antibiotics and antiseptic were tested at 50 mg/l concentration through active sludge microorganisms by Manometric Respirometry Method (OECD 301F). Further analysis of 16S rRNA gene sequencing used to identify MK4 strain isolated from the sludge. Furthermore, ATR-FTIR spectroscopy was conducted in order to identify its biodegradation in the presence of different carbon sources and LCMS/MS spectrometry were used to identify the metabolite degradation.
Results: Our Results revealed that four antibiotics tested were readily biodegradable (60%) as Ciprofloxacin, Doxycycline, Amoxicillin, Ampicillin, and Penicillin. Conversely, other was not readily biodegradable, such as Azithromycin (36.11%), Cephalexin (36.20%), and Metronidazole (33.33%). Meanwhile, the remaining antibiotics under examination were degraded, with Sulfamethoxazole (25.75%), Clarithromycin (25.36%), and Nifuroxazide (16.33%) recording degradation. Ciprofloxacin was chosen to represent the most biodegraded antibiotic. Based on 16S rRNA gene, MK4 strain was related to Klebsiella oxytoca (99.99%). ATR-FTIR revealed that the strain K. oxytoca MK4 caused changes in the structure of the Ciprofloxacin, in the presence of various sources of carbon, with varying effects on bacterial growth and biodegradation.
Conclusion: In this study, the identified strain K. oxytoca MK4 facilitated the degradation of Ciprofloxacin.

References

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There are 90 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research Articles
Authors

Souhila Saım 0000-0001-5818-7363

Mokrani Slimane This is me 0000-0003-0664-9241

Isabel Martínez-alcalá This is me 0000-0002-4109-3253

Ramazan Erenler This is me 0000-0002-0505-3190

Publication Date June 26, 2023
Submission Date May 19, 2023
Published in Issue Year 2023

Cite

AMA Saım S, Slimane M, Martínez-alcalá I, Erenler R. Screening of Antibiotics Biodegradability from Wastewater. Eur J Biol. June 2023;82(1):70-85. doi:10.26650/EurJBiol.2023.1299300