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Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer

Year 2023, , 317 - 325, 21.12.2023
https://doi.org/10.26650/EurJBiol.2023.1348427

Abstract

Reactive oxygen species (ROS) are a class of bioactive molecules that are the by-products of many cellular functions. These molecules are present in normal cells at homeostatic levels but have been studied extensively in cancer due to their dysregulation resulting in pro- and anti-tumorigenic environments. Completely understanding the paradoxical nature of ROS in cancer is imperative to fully realize its modulation as cancer therapy. Studies into ROS have shown far-reaching effects in cancer, including how ROS levels regulate signaling, response to treatment, drug resistance, etc. Many drugs were studied with the hopes of regulating the ROS levels in cancer; however, patient response varied. Plant-derived medications offered new avenues of drug treatment over the last few decades, and the phytochemical Curcumin gained ground as an interesting cancer therapeutic. Curcumin is an active phenolic compound used in traditional medicine around the world. Although it suffers from a poor pharmacokinetic profile, Curcumin exerts anti-tumorigenic, as well as ROS-modulating activities. Analogs and derivatives of Curcumin are under development to improve upon its anti-cancer properties and enhance its bioavailability, currently a major limitation of its usage. This review highlights ROS function in cancer treatment focused on ROS, including Curcumin and its analogs.

References

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Year 2023, , 317 - 325, 21.12.2023
https://doi.org/10.26650/EurJBiol.2023.1348427

Abstract

References

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  • Zhao RZ, Jiang S, Zhang L, Yu ZB. Mitochondrial electron trans-port chain, ROS generation and uncoupling (Review). Int J Mol Med. 2019;44(1):3-15. google scholar
  • Perillo B, Di Donato M, Pezone A, et al. ROS in cancer therapy: The bright side of the moon. Exp Mol Med. 2020;52(2):192-203. google scholar
  • Sena LA, Chandel NS. Physiological roles of mitochondrial re-active oxygen species. Mol Cell. 2012;48(2):158-167. google scholar
  • Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J. 1996;313 (Pt 1)(Pt 1):17-29. google scholar
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  • Nakamura H, Takada K. Reactive oxygen species in can-cer: Current findings and future directions. Cancer Sci. 2021;112(10):3945-3952. google scholar
  • Jelic MD, Mandic AD, Maricic SM, Srdjenovic BU. Oxidative stress and its role in cancer. J Cancer Res Ther. 2021;17(1):22-28. google scholar
  • Ishimoto T, Nagano O, Yae T, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell. 2011;19(3):387-400. google scholar
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  • Li W, Kong AN. Molecular mechanisms of Nrf2-mediated an-tioxidant response. Mol Carcinog. 2009;48(2):91-104. google scholar
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  • Arihara Y, Takada K, Kamihara Y, et al. Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma. Oncotarget. 2017;8(39):65889-65899. google scholar
  • Nakamura H, Takada K, Arihara Y, et al. Six-transmembrane epithelial antigen of the prostate 1 protects against increased ox-idative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer. Cancer Gene Ther. 2019;26(9-10):313-322. google scholar
  • Shiau JP, Chuang YT, Cheng YB, et al. Impacts of oxida-tive stress and PI3K/AKT/mTOR on metabolism and the fu-ture direction of investigating fucoidan-modulated metabolism. Antioxidants (Basel). 2022;11(5). doi:10.3390/antiox11050911 google scholar
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  • Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell. 2009;136(5):823-837. google scholar
  • Li Y, Zhang X, Wang Z, Li B, Zhu H. Modulation of redox homeostasis: A strategy to overcome cancer drug resistance. Front Pharmacol. 2023;14:1156538. doi:10.3389/fphar.2023.1156538 google scholar
  • Aggarwal V, Tuli HS, Varol A, et al. Role of reactive oxygen species in cancer progression: Molecular mecha-nisms and recent advancements. Biomolecules. 2019;9(11). doi:10.3390/biom9110735 google scholar
  • Yu G, Sun W, Shen Y, et al. PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis. Am J Transl Res. 2018;10(6):1793-1801. google scholar
  • Huang W, Zeng YC. A candidate for lung cancer treatment: arsenic trioxide. Clin Transl Oncol. 2019;21(9):1115-1126. google scholar
  • Massaro RR, Faiao-Flores F, Rebecca VW, et al. Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells. Pharmacol Res. 2017;119:242-250. google scholar
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  • Coriat R, Alexandre J, Nicco C, et al. Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir. J Clin Invest. 2014;124(1):262-272. google scholar
  • Wang J, Ren XR, Piao H, et al. Niclosamide-induced Wnt sig-naling inhibition in colorectal cancer is mediated by autophagy. Biochem J. 2019;476(3):535-546. google scholar
  • Disoma C, Zhou Y, Li S, Peng J, Xia Z. Wnt/beta-catenin signal-ing in colorectal cancer: Is therapeutic targeting even possible? Biochimie. 2022;195:39-53. google scholar
  • Lotfi N, Yousefi Z, Golabi M, et al. The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update. Front Immunol. 2023;14:1077531. doi:10.3389/fimmu.2023.1077531 google scholar
  • Shafer D, Tombes MB, Shrader E, et al. Phase I trial of dimethyl fumarate, temozolomide, and radiation therapy in glioblastoma. Neurooncol Adv. 2020;2(1):vdz052. doi:10.1093/noajnl/vdz052 google scholar
  • Howells LM, Iwuji COO, Irving GRB, et al. Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial. J Nutr. 2019;149(7):1133-1139. google scholar
  • Talib WH, Alsalahat I, Daoud S, Abutayeh RF, Mahmod AI. Plant-derived natural products in cancer research: extraction, mecha-nism of action, and drug formulation. Molecules. 2020;25(22). doi:10.3390/molecules25225319 google scholar
  • Hashem S, Ali TA, Akhtar S, et al. Targeting cancer sig-naling pathways by natural products: Exploring promising anti-cancer agents. Biomed Pharmacother. 2022;150:113054. doi:10.1016/j.biopha.2022.113054 google scholar
  • Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631-1652. google scholar
  • Choudhari AS, Mandave PC, Deshpande M, Ranjekar P, Prakash O. Phytochemicals in cancer treatment: From preclin-ical studies to clinical practice. Front Pharmacol. 2019;10:1614. doi:10.3389/fphar.2019.01614 google scholar
  • Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J Biol Chem. 1995;270(42):24995-5000. google scholar
  • Marin YE, Wall BA, Wang S, et al. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res. 2007;17(5):274-283. google scholar
  • Paul S, Sa G. Curcumin as an adjuvant to cancer immunotherapy. Front Oncol. 2021;11:675923. doi:10.3389/fonc.2021.675923 google scholar
  • Kim GY, Kim KH, Lee SH, et al. Curcumin inhibits immunostim-ulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 2005;174(12):8116-8124. google scholar
  • Giordano A, Tommonaro G. Curcumin and cancer. Nutrients. 2019;11(10). doi:10.3390/nu11102376 google scholar
  • Wang H, Zhang K, Liu J, et al. Curcumin regulates cancer pro-gression: Focus on ncRNAs and molecular signaling pathways. Front Oncol. 2021;11:660712. doi:10.3389/fonc.2021.660712 google scholar
  • Sadatsharifi M, Purgel M. Radical scavenger competition of alizarin and curcumin: A mechanistic DFT study on antioxidant activity. J Mol Model. 2021;27(6):166. doi:10.1007/s00894-021-04778-1 google scholar
  • Jakubczyk K, Druzga A, Katarzyna J, Skonieczna-Zydecka K. Antioxidant Potential of curcumin-a meta-analysis of randomized clinical trials. Antioxidants (Basel). 2020;9(11). doi:10.3390/antiox9111092 google scholar
  • Wang T, Wu X, Al Rudaisat M, Song Y, Cheng H. Cur-cumin induces G2/M arrest and triggers autophagy, ROS gen-eration and cell senescence in cervical cancer cells. J Cancer. 2020;11(22):6704-6715. google scholar
  • Larasati YA, Yoneda-Kato N, Nakamae I, Yokoyama T, Meiyanto E, Kato JY. Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth. Sci Rep. 2018;8(1):2039. doi:10.1038/s41598-018-20179-6 google scholar
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There are 75 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Themed Articles - Reviews
Authors

Christoffer Lambring 0009-0003-2921-5021

Liling Chen This is me 0009-0006-0191-1887

Claire Nelson This is me 0009-0008-9256-4634

Alyssa Stevens This is me 0009-0005-6799-0090

Wynashia Bratcher This is me 0009-0004-2385-6685

Riyaz Basha 0000-0002-4071-0993

Publication Date December 21, 2023
Submission Date August 23, 2023
Published in Issue Year 2023

Cite

AMA Lambring C, Chen L, Nelson C, Stevens A, Bratcher W, Basha R. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer. Eur J Biol. December 2023;82(2):317-325. doi:10.26650/EurJBiol.2023.1348427