Research Article
BibTex RIS Cite
Year 2017, , 14 - 19, 28.12.2017
https://doi.org/10.5152/EurJBiol.2017.1703

Abstract

References

  • 1. Zhivkov V, Chelibonova-lorer H. The relative rate of synthesis of liver uridine diphosphate sugars in D-galactosamine-treated rats. Int J Biochem 1975: 6; 429-33. 2. Catal T, Bolkent S. Combination of selenium and three naturally occurring antioxidants administration protects D-galactosamine-induced liver injury in rats. Biol Trace Elem Res 2008; 122(2): 127-36. 3. Choi JH, Kang JW, Kim DW, Sung YK, Lee SM. Protective effects of Mg-CUD against D-galactosamine-induced hepatotoxicity in rats. Eur J Pharmacol 2011; 657(1-3): 138-43. 4. Al-Chalabi A, Matevossian E, Thaden AK, Luppa P, Neiss A, Schuster T, et al. Evaluation of the Hepa Wash® treatment in pigs with acute liver failure. BMC Gastroenterol 2013; 13: 83. 5. Yang Q, Liu Y, Shi Y, Zheng M, He J, Chen Z. The role of intracellular high-mobility group box 1 in the early activation of Kupffer cells and the development of Con A-induced acute liver failure. Immunobiology 2013; 218(10): 1284-92. 6. Ytrebø LM, Rose CF. Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. Liver Int 2013; 33(4): 499-500. 7. Obayashi Y, Arisaka H, Yoshida S, Mori M, Takahashi M. Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway. Amino Acids 2012; 43(6): 2371-80. 8. Wu MJ, Gong X, Jiang R, Zhang L, Li XH, Wan JY. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol 2012; 25(4): 9233-34. 9. Fink T, Heymann P, Taha-Melitz S, Taha A, Wolf B, Rensing H, et al. Dobutamine pretreatment improves survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat. Shock 2013; 40(2): 129-35. 10. Kang JW, Kim DW, Choi JS, Kim YS, Lee S.M. Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice. Food Chem Toxicol 2013; 57: 132-9. 11. Peng XR, Liu JQ, Han ZH, Yuan XX, Luo HR, Qiu MH. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells. Food Chem 2013; 141(2): 920-6. 12. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011; 15(7): 1957-97. 13. Weeks BS, Hanna MS, Cooperstein D. Dietary selenium and selenoprotein function. Med Sci Monit 2012; 18(8): RA127-32. 14. Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta 2012; 1826(2): 443–57. 15. Zeng H, Cao JJ, Combs GF Jr. Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients 2013; 5(1): 97-110. 16. Niki E, Traber MG. A history of vitamin E. Ann Nutr Metab 2012; 61(3): 207-12. 17. von Lintig J. Provitamin A metabolism and functions in mammalian biology. Am J Clin Nutr 2012; 96(5): 1234-44. 18. Bjelakovic G, Gluud LL, Nikolova D, Bjelakovic M, Nagorni A, Gluud C. Antioxidant supplements for liver diseases. Cohrane Database Syst Rev 2011; 16(3): CD007749. 19. Kolachi NF, Kazi TG, Afridi HI, Kazi NG, Mughal MA, Khan S. Effects of selenium and zinc status in biological samples of hepatitis C patient after herbal and pharmaceutical supplements. Biol Trace Elem Res 2013; 152(2): 187-94. 20. Steinbrenner H, Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta 2009; 1790(11):1478-85. 21. Beutler E. Glutathione in red cell metabolism: a manuel of biochemical methods. 2nd ed, Grune and Stratton, New York, p. 112-4. (1975) 22. Reitman S, Frankel SA. Colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28(1): 56-63. 23. Walter K, Schütt C. Acid and alkaline phosphatase in serum (two point method). Methods of Enzymatic Analysis. Vol. 2. Bergmeyer HU editor, Boca Raton, FL, USA: Verlag Chemie GmbH pp. 856-60. (1974) 24. Szasz G. A kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem 1969; 15(2): 570-4. 25. Wroblewski F. Clinical significance of serum enzyme alterations with myocardial infarction. Am Heart J 1957; 54(2): 219-24. 26. Lorentz K, Weiss T, Kraas E. Sialic acid in human serum and cerebrospinal fluid. European J Clin Chem Clin Biochem 1986; 24(3): 189-98. 27. Caraway WT. Determinationof uric acid in serum by a carbonate method. Am J Clin Pathol 1955; 25(7): 840-5. 28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193(1): 265-75. 29. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105: 121-6. 30. Mylroie AA, Collins H, Umbles C, Kyle J. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol Appl Pharmacol 1986; 82(3): 512–20. 31. Habig W, Jacoby WB. Assays for differentiation of glutathione-S-transferases. Methods Enzymol 1981; 77: 398-405. 32. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70(1): 158-69. 33. Wendel A. Glutathione peroxidase. Methods Enzymol 1981; 77: 325-33. 34. Ledwozyw A, Michalak J, Stepien A, Kadziolka A. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin Chim Acta 1986; 155(3): 275-83. 35. Tessier G, Villeneuve E, Villeneuve JP. Etiology and outcome of acute liver failure: experience from a liver transplantation centre in Montreal. Can J Gastroenterol 2002; 16(10): 672-6. 36. Kemelo MK, Horinek A, Canová NK, Farghali H. Comparative effects of quercetin and SRT1720 against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: biochemical and molecular biological investigations. Eur Rev Med Pharmacol Sci 2016; 20(2): 363-71. 37. Saracyn M, Zdanowski R, Brytan M, Kade G, Nowak Z, Patera J, et al. D-Galactosamine intoxication in experimental animals: Is it only an experimental model of acute liver failure? Med Sci Monit 2015; 21: 1469-77. 38. Choi JW, Kim IH, Kim YM, Lee MK Nam TJ. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure. Mol Med Rep 2016; 13(4): 3110-4. 39. Kemelo MK, Wojnarová L, Kutinová Canová N, Farghali H. D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection. Phsyiol Res 2014; 63(5): 615-23. 40. Das J, Ghosh J, Roy A, Sil PC. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. Toxicol Appl Pharmacol 2012; 260(1): 35-47. 41. Sheriff SA, Devaki T. Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats. Asian Pac J Trop Biomed 2012; 2(12): 975-80. 42. Dong M, Hong T, Liu S, Zhao J, Meng Y, Mu J. Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-galactosamine-induced hepatic injury. Mol Med Rep 2013; 7(6): 1919-23. 43. Gezginci-Oktayoglu S, Basaraner H, Yanardag R, Bolkent S. The effects of combined treatment of antioxidants on the liver injury in STZ diabetic rats. Dig Dis Sci 2009; 54(3): 538-46. 44. Koyuturk M, Sacan O, Karabulut S, Turk N, Bolkent S, Yanardag R, et al. The role of ghrelin on apoptosis, cell proliferation and oxidant-antioxidant system in the liver of neonatal diabetic rats. Cell Biol Int 2015; 39(7): 838-41. 45. Kim SJ, Choi HS, Cho HI, Jin YW, Lee EK, Ahn JY, et al. Protective effect of wild ginseng cambial meristematic cells on D-galactosamine-induced hepatotoxicity in rats. J Ginseng Res 2015; 39(4): 376-83. 46. Ma L, Gong X, Kuang G, Jiang R, Chen R, Wan J. Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice. Biochem Biophys Res Commun 2015; 461(2): 230-6. 47. Pan CW, Zhou GY, Chen WL, Zhuge L, Jin LX, Zheng Y, et al. Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury. Int Immunopharmacol 2015; 26(1): 80-5. 48. Ganai AA, Khan AA, Malik ZA, Farooqi H. Genistein modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating D-galactosamine induced fulminant hepatic failure in Wistar rats. Toxicol Appl Pharmacol 2015; 283(2): 139-46. 49. Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med 2014; 11(3): 118-23. 50. Li J, Zhang X, Huang H. Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Int Immunopharmacol 2014; 23(2): 523-9. 51. Ai G, Huang ZM, Liu QC, Han YQ, Chen X. The protective effect of total phenolics from Oenanthe javanica on acute liver failure induced by D-galactosamine. J Ethnopharmacol 2016; 186: 53-60. 52. Wang JB, Wang HT, Li LP, Yan YC, Wang W, Liu JY, et al. Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome. World J Gastroenterol 2015; 21(34): 9927-35. 53. Ozden S, Catalgol B, Gezginci-Oktayoglu S, Karatug A, Bolkent S, Alpertunga B. Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats. Toxicol Ind Health 2013; 29(1): 60-71. 54. Gezginci-Oktayoglu S, Sacan O, Bolkent S, Ipci Y, Kabasakal L, Sener G, Yanardag R. Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats. Acta Histochem 2014; 116(1): 32–9. 55. Oztay F, Gezginci-Oktayoglu S, Bayrak BB, Yanardag R, Bolkent S. Cathepsin B inhibition improves lung injury associated to D-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice. Mol Cell Biochem 2010; 333(1-2): 65-72.

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine-Induced Hepatotoxicity in Rats

Year 2017, , 14 - 19, 28.12.2017
https://doi.org/10.5152/EurJBiol.2017.1703

Abstract

The
protective effects of a combination of antioxidants on histopathological
changes and biochemical parameters were examined in D-galactosamine
(D-GaIN)-induced hepatotoxicity in rats. Physiological saline solution was
injected intraperitoneally into the control group, while D-GaIN (500 mg kg-1)
was administered intraperitoneally into the experimental animals. The
combination of 100 mg/kg/day ascorbic acid, 100 mg/kg/day alpha tocopherol, 15
mg/kg/day beta carotene, and 0.2 mg/kg/day sodium selenate was administered
orally to intact control rats for 3 days. The same antioxidant combination was
given to the D-GaIN group. Liver and blood samples were used for
histopathological and biochemical assays. Liver tissues were significantly
damaged by D-GaIN administration based on the histopathological findings. Serum
aspartate and alanine transaminase, gamma glutamyl transpeptidase, alkaline
phosphatase, lactate dehydrogenase, sialic acid, and uric acid levels
increased. Serum and liver glutathione levels decreased, and serum superoxide
dismutase, glutathione peroxidase, and glutathione-S-transferase, catalase
activities as well as lipid peroxidation values increased in the D-GaIN group.
In contrast, administration of the antioxidants reversed the histopathological
and biochemical changes in the liver of animals administered D-GaIN. In
conclusion, the administration of a combination of antioxidants suppressed
histopathological changes and biochemical parameters in rats given D-GaIN.

References

  • 1. Zhivkov V, Chelibonova-lorer H. The relative rate of synthesis of liver uridine diphosphate sugars in D-galactosamine-treated rats. Int J Biochem 1975: 6; 429-33. 2. Catal T, Bolkent S. Combination of selenium and three naturally occurring antioxidants administration protects D-galactosamine-induced liver injury in rats. Biol Trace Elem Res 2008; 122(2): 127-36. 3. Choi JH, Kang JW, Kim DW, Sung YK, Lee SM. Protective effects of Mg-CUD against D-galactosamine-induced hepatotoxicity in rats. Eur J Pharmacol 2011; 657(1-3): 138-43. 4. Al-Chalabi A, Matevossian E, Thaden AK, Luppa P, Neiss A, Schuster T, et al. Evaluation of the Hepa Wash® treatment in pigs with acute liver failure. BMC Gastroenterol 2013; 13: 83. 5. Yang Q, Liu Y, Shi Y, Zheng M, He J, Chen Z. The role of intracellular high-mobility group box 1 in the early activation of Kupffer cells and the development of Con A-induced acute liver failure. Immunobiology 2013; 218(10): 1284-92. 6. Ytrebø LM, Rose CF. Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. Liver Int 2013; 33(4): 499-500. 7. Obayashi Y, Arisaka H, Yoshida S, Mori M, Takahashi M. Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway. Amino Acids 2012; 43(6): 2371-80. 8. Wu MJ, Gong X, Jiang R, Zhang L, Li XH, Wan JY. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol 2012; 25(4): 9233-34. 9. Fink T, Heymann P, Taha-Melitz S, Taha A, Wolf B, Rensing H, et al. Dobutamine pretreatment improves survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat. Shock 2013; 40(2): 129-35. 10. Kang JW, Kim DW, Choi JS, Kim YS, Lee S.M. Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice. Food Chem Toxicol 2013; 57: 132-9. 11. Peng XR, Liu JQ, Han ZH, Yuan XX, Luo HR, Qiu MH. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells. Food Chem 2013; 141(2): 920-6. 12. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011; 15(7): 1957-97. 13. Weeks BS, Hanna MS, Cooperstein D. Dietary selenium and selenoprotein function. Med Sci Monit 2012; 18(8): RA127-32. 14. Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta 2012; 1826(2): 443–57. 15. Zeng H, Cao JJ, Combs GF Jr. Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients 2013; 5(1): 97-110. 16. Niki E, Traber MG. A history of vitamin E. Ann Nutr Metab 2012; 61(3): 207-12. 17. von Lintig J. Provitamin A metabolism and functions in mammalian biology. Am J Clin Nutr 2012; 96(5): 1234-44. 18. Bjelakovic G, Gluud LL, Nikolova D, Bjelakovic M, Nagorni A, Gluud C. Antioxidant supplements for liver diseases. Cohrane Database Syst Rev 2011; 16(3): CD007749. 19. Kolachi NF, Kazi TG, Afridi HI, Kazi NG, Mughal MA, Khan S. Effects of selenium and zinc status in biological samples of hepatitis C patient after herbal and pharmaceutical supplements. Biol Trace Elem Res 2013; 152(2): 187-94. 20. Steinbrenner H, Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta 2009; 1790(11):1478-85. 21. Beutler E. Glutathione in red cell metabolism: a manuel of biochemical methods. 2nd ed, Grune and Stratton, New York, p. 112-4. (1975) 22. Reitman S, Frankel SA. Colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28(1): 56-63. 23. Walter K, Schütt C. Acid and alkaline phosphatase in serum (two point method). Methods of Enzymatic Analysis. Vol. 2. Bergmeyer HU editor, Boca Raton, FL, USA: Verlag Chemie GmbH pp. 856-60. (1974) 24. Szasz G. A kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem 1969; 15(2): 570-4. 25. Wroblewski F. Clinical significance of serum enzyme alterations with myocardial infarction. Am Heart J 1957; 54(2): 219-24. 26. Lorentz K, Weiss T, Kraas E. Sialic acid in human serum and cerebrospinal fluid. European J Clin Chem Clin Biochem 1986; 24(3): 189-98. 27. Caraway WT. Determinationof uric acid in serum by a carbonate method. Am J Clin Pathol 1955; 25(7): 840-5. 28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193(1): 265-75. 29. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105: 121-6. 30. Mylroie AA, Collins H, Umbles C, Kyle J. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol Appl Pharmacol 1986; 82(3): 512–20. 31. Habig W, Jacoby WB. Assays for differentiation of glutathione-S-transferases. Methods Enzymol 1981; 77: 398-405. 32. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70(1): 158-69. 33. Wendel A. Glutathione peroxidase. Methods Enzymol 1981; 77: 325-33. 34. Ledwozyw A, Michalak J, Stepien A, Kadziolka A. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin Chim Acta 1986; 155(3): 275-83. 35. Tessier G, Villeneuve E, Villeneuve JP. Etiology and outcome of acute liver failure: experience from a liver transplantation centre in Montreal. Can J Gastroenterol 2002; 16(10): 672-6. 36. Kemelo MK, Horinek A, Canová NK, Farghali H. Comparative effects of quercetin and SRT1720 against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: biochemical and molecular biological investigations. Eur Rev Med Pharmacol Sci 2016; 20(2): 363-71. 37. Saracyn M, Zdanowski R, Brytan M, Kade G, Nowak Z, Patera J, et al. D-Galactosamine intoxication in experimental animals: Is it only an experimental model of acute liver failure? Med Sci Monit 2015; 21: 1469-77. 38. Choi JW, Kim IH, Kim YM, Lee MK Nam TJ. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure. Mol Med Rep 2016; 13(4): 3110-4. 39. Kemelo MK, Wojnarová L, Kutinová Canová N, Farghali H. D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection. Phsyiol Res 2014; 63(5): 615-23. 40. Das J, Ghosh J, Roy A, Sil PC. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. Toxicol Appl Pharmacol 2012; 260(1): 35-47. 41. Sheriff SA, Devaki T. Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats. Asian Pac J Trop Biomed 2012; 2(12): 975-80. 42. Dong M, Hong T, Liu S, Zhao J, Meng Y, Mu J. Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-galactosamine-induced hepatic injury. Mol Med Rep 2013; 7(6): 1919-23. 43. Gezginci-Oktayoglu S, Basaraner H, Yanardag R, Bolkent S. The effects of combined treatment of antioxidants on the liver injury in STZ diabetic rats. Dig Dis Sci 2009; 54(3): 538-46. 44. Koyuturk M, Sacan O, Karabulut S, Turk N, Bolkent S, Yanardag R, et al. The role of ghrelin on apoptosis, cell proliferation and oxidant-antioxidant system in the liver of neonatal diabetic rats. Cell Biol Int 2015; 39(7): 838-41. 45. Kim SJ, Choi HS, Cho HI, Jin YW, Lee EK, Ahn JY, et al. Protective effect of wild ginseng cambial meristematic cells on D-galactosamine-induced hepatotoxicity in rats. J Ginseng Res 2015; 39(4): 376-83. 46. Ma L, Gong X, Kuang G, Jiang R, Chen R, Wan J. Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice. Biochem Biophys Res Commun 2015; 461(2): 230-6. 47. Pan CW, Zhou GY, Chen WL, Zhuge L, Jin LX, Zheng Y, et al. Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury. Int Immunopharmacol 2015; 26(1): 80-5. 48. Ganai AA, Khan AA, Malik ZA, Farooqi H. Genistein modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating D-galactosamine induced fulminant hepatic failure in Wistar rats. Toxicol Appl Pharmacol 2015; 283(2): 139-46. 49. Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med 2014; 11(3): 118-23. 50. Li J, Zhang X, Huang H. Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Int Immunopharmacol 2014; 23(2): 523-9. 51. Ai G, Huang ZM, Liu QC, Han YQ, Chen X. The protective effect of total phenolics from Oenanthe javanica on acute liver failure induced by D-galactosamine. J Ethnopharmacol 2016; 186: 53-60. 52. Wang JB, Wang HT, Li LP, Yan YC, Wang W, Liu JY, et al. Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome. World J Gastroenterol 2015; 21(34): 9927-35. 53. Ozden S, Catalgol B, Gezginci-Oktayoglu S, Karatug A, Bolkent S, Alpertunga B. Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats. Toxicol Ind Health 2013; 29(1): 60-71. 54. Gezginci-Oktayoglu S, Sacan O, Bolkent S, Ipci Y, Kabasakal L, Sener G, Yanardag R. Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats. Acta Histochem 2014; 116(1): 32–9. 55. Oztay F, Gezginci-Oktayoglu S, Bayrak BB, Yanardag R, Bolkent S. Cathepsin B inhibition improves lung injury associated to D-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice. Mol Cell Biochem 2010; 333(1-2): 65-72.
There are 1 citations in total.

Details

Journal Section Research Articles
Authors

Tunc Catal This is me

Sevim Tunali

Sehnaz Bolkent This is me

Refiye Yanardag This is me

Publication Date December 28, 2017
Submission Date August 24, 2017
Published in Issue Year 2017

Cite

AMA Catal T, Tunali S, Bolkent S, Yanardag R. An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine-Induced Hepatotoxicity in Rats. Eur J Biol. June 2017;76(1):14-19. doi:10.5152/EurJBiol.2017.1703