The influence of vitamin U supplementation on liver injury of amiodarone-administered rats

Year 2016, Volume: 75 Issue: 1, 1 - 10, 15.05.2017

Serap Sancar Baş

Abstract

Amiodarone is a currently used drug with high efficacy for the treatment acute life-threatening
arrhythmias. Although the use of this drug is widespread, it is associated with unwanted systemic effects.
S-methylmethionine sulphonium, which is a derivative of the methionine amino acid, defined mostly
as vitamin U and various beneficial effects of Vit U have been demonstrated. The present study was
planned to determine whether the vitamin U exhibits preventive effects on amiodarone-induced liver
toxicity. Male Sprague-Dawley rats were randomly divided into four groups. Group I; control animals
receiving corn oil. Group II; control animals receiving Vit U (50 mg/kg) for 7 days orally. Group III;
animals receiving 100 mg/kg amiodarone for 7 days orally. Group IV; animals receiving Vit U orally
for 7 days (in the same dose and time) 1 h prior to the administration of amiodarone. Pretreatment
with vitamin U particularly decreased degenerative morphological changes such as picnotic nucleus
in hepatocytes, sinusoidal dilatation, hyperemia seen in amiodarone treated individuals. On the other
hand liver aspartate transaminase, alanine transaminase and alkaline phosphatase activities were
increased, catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase activities
were decreased in amiodarone group. Administration of vitamin U reversed these effects in amiodarone
group. In conclusion, it might be suggested that pretreatment with vitamin U have protective effects on
liver injury induced with amiodarone through decreasing oxidative stress. 

Keywords

Arrhythmia, amiodarone, liver injury, vitamin U

References

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